Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 27996-86-7, name is 4-[1,2,4]Triazol-1-yl-benzaldehyde belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 4-[1,2,4]Triazol-1-yl-benzaldehyde
A mixture of beta ionone (0.48 g, 0.507 ml, 2.5 mmol), 4-(1H-1,2,4-triazol-1-yl) benzaldehydes (0.346 g, 2 mmol), cetyltrimethyl ammonium bromide (0.028 g, 0.20 mmol), sodium hydroxide (0.240 g, 6 mmol) and water (10 ml) was stirred at room temperature for 24 h. Reaction progress was monitored by TLC and compound was extracted with ethyl acetate (2 × 30 ml). The combined organic extract was washed with water (2 × 30 ml), brine solution (25 ml), dried (Na2SO4) and the solvent was removed in vacuum. The crude product was purified by column chromatography (SiO2, 60-120 mesh). Elution with 10 % ethyl acetate in hexane furnished a yellow coloured solid (0.164 g, 24%). Mp: 103-104OC; IR (KBr, cm-1): 2929, 1643 (C=O), 1590 (C=N); 1H NMR (CDCl3, 300 MHz): delta 1.05 (s, 6 H, CH3-8? and CH3-9?), 1.41-1.45 (m, 2H, CH2-5?), 1.55-1.61 (m, 2H, CH2-4?), 1.77 (s, 3H, CH3-7?), 2.04 (t, J = 6 Hz, 2 H, H-3?), 6.42 (d, J = 16 Hz, 1H, H-4), 6.96 (d, J = 16 Hz, 1H, H-2), 7.48 (d, J = 16 Hz, 1H, H-5), 7.61 (d, J = 16 Hz, 1H, H-1), 7.67 (brs, 4H, H-2?, H-3?, H-5? and H-6?), 8.06 (s, 1H, H-3???), 8.55 (s, 1H, H-5???); 13C NMR (CDCl3, 75 MHz): delta 18.86, 21.89, 2×28.87, 33.76, 34.18, 39.85, 2×120.08, 126.64, 129.35, 2×129.63, 134.87, 136.50, 137.26, 137.89, 140.69, 140.82, 143.54, 152.78, 188.66; ESI-MS m/z: 348 [M+1]+; Analysis calculated for C22H25N3O: C, 76.05; H, 7.25; N, 12.09; Found: C, 76.10; H, 7.19; N, 12.11.
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 27996-86-7
Reference:
Article; Suryawanshi; Tiwari, Avinash; Kumar, Santosh; Shivahare, Rahul; Mittal, Monika; Kant, Padam; Gupta, Suman; Bioorganic and Medicinal Chemistry Letters; vol. 23; 10; (2013); p. 2925 – 2928;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics