956317-36-5, The chemical industry reduces the impact on the environment during synthesis 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, I believe this compound will play a more active role in future production and life.
To a solution of 11 (1.27 g,6.26 mmol) and 12 (1.5 g, 5.69 mmol) in DCM (30 mL) was added DIPEA (2.2 g,17.07 mmol) and HATU (3.24 g, 8.54 mmol). Then the mixture was stirred at r.t. for 2h. The reaction mixture was diluted with water and extracted with DCM (100 mL x 5).The organics were washed with brine, dried over Na2SO4 and concentrated to give acrude product. The crude product was purified by column chromatography withPE/EtOAc = 1:5 to give 1 as cis-isomer (1.9 g, yield: 74.5%). 1H NMR (400MHz,CHLOROFORM-d) delta= 7.85(d, J=8.0 Hz, 1H), 7.71 (br, s, 2H), 7.32 – 7.21 (m, 3H),7.17 (d, J=8.0, 1H), 6.99(d, J=2.0, 1H), 3.95~3.93 (m, 2H), 3.92~3.90(m, 2H), 3.75 ~3.51 (m, 3H), 3.15 ~ 3.10 (m, 3H), 2.40 (s, 3H). MS (ESI): m/z 449.0 [M + H]+ .
The chemical industry reduces the impact on the environment during synthesis 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Article; Wu, Songliang; Sun, Yu; Hu, Yi; Zhang, Hongmei; Hou, Lijuan; Liu, Xing; Li, Yufeng; He, Haiying; Luo, Zhi; Chen, Yuan; Wang, Yuhe; Shi, Weihua; Shen, Liang; Cao, Changqing; Liang, Wei; Xu, Qing; Lv, Qiang; Lan, Jiong; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1458 – 1462;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics