A common heterocyclic compound, 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, molecular formula is C11H9F2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 217448-86-7.
Mixture of 10 g (0.039 mol) of methyl- l-(2,6-difluorobenzyl)-lH-l,2,3-triazole-4- carboxylate, and 150 ml of methanolic ammonia solution was stirred at ambient temperature. The reaction mixture was heated to 45C for 22 hours. Cooled to ambient temperature. Solid was filtered, washed with methanol and dried under reduced pressure. Yield 69 g (87%); HPLC purity: 99.83%.
The synthetic route of Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LUPIN LIMITED; SIYAN, Rajinder, Singh; AHER, Yogesh, Subhas; BHISE, Nandu, Baban; SINGH, Girij, Pal; GOHEL, Sunilkumar Vinubhai; WO2013/105029; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics