Electric Literature of 135242-93-2, These common heterocyclic compound, 135242-93-2, name is (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of (1 -methyl-1 H-1 ,2, 4-triazol-3-yl)methanol (400 mg, 3.54 mmol) and iodobenzene diacetate (1 .25 g, 3.89 mmol) in dichloromethane (1 0 mL) was added TEMPO ((2,2,6,6-tetramethylpiperidin-1 -yl)oxyl) (56 mg, 354 muetaiotaomicronIota). The mixture was stirred at 1 5- 20C for 2h. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate = 1 :2) to give 1 -methyl-1 H-1 ,2,4-triazole-3- carbaldehyde (300 mg, 2.70 mmol, 76% yield).1H NMR (chloroform-c 400 MHz) delta 1 0.01 (s, 1 H), 8.1 9 (s, 1 H), 4.06 (s, 3H).
Statistics shows that (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol is playing an increasingly important role. we look forward to future research findings about 135242-93-2.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
1,2,3-Triazole – Wikipedia,
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