Reference of 6523-49-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6523-49-5 name is 4-(1,2,4-Triazol-1-yl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
N’ – [5 -(3 -Chloro-propoxy)-2-cyano-4-methyoxy-phenyl] -N,N-dimethyl- formamidine (WO03055491, 580 mgs)5 4-(l,2,4-triazolyl)aniline (314 mgs) and AcOH(4 mL) were heated to 90 for 1 hr before cooling. The oil was concentrated and the resultant slurry dissolved in MeOH, sonicated and the resultant white powder filtered and dried to produce the title compound (765 mg). 1H NMR delta 9.65 (s, IH), 9.25 (s, IH), 8.5 (s, IH), 8.23 (s, IH), 8.02 (d, 2H, J9Hz ), 7.89 (s, IH), 7.87 (d, 2H, J=9), 7.24 (s, IH), 4.28 (t, 2H, J=6), 3.95 (s, 3H), 3.83(t, 2H, J6Hz), 2.27 (q, 2H, J6Hz); LC-MS rt 2.13 m/z 411 ES+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(1,2,4-Triazol-1-yl)aniline, and friends who are interested can also refer to it.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics