Synthetic Route of 61-82-5,Some common heterocyclic compound, 61-82-5, name is 1H-1,2,4-Triazol-5-amine, molecular formula is C2H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 1.0 mmol of p-nitrobenzaldehyde, 1.0 mmol of ethyl acetoacetate, 1.0 mmol of 3-amino-1,2,4-triazole, and 0.18 g of magnetic nanosulfonic acid to 9 ml of ethanol-dimethylformamide, respectively. In an aqueous solution (V (ethanol): V (dimethylformamide): V (water) = 7: 2: 1) in a 50 ml three-necked flask with a stirrer and a condenser tube, stir well at room temperature. Heating to 86 C for 146min, TLC (thin plate chromatography) detection, raw material spots disappeared, magnetic nanosulfonic acid catalyst was adsorbed with a magnet while hot, the remaining reaction solution was cooled to room temperature, a large amount of solids were precipitated, the solids were crushed, and left to stand , Suction filtration, the obtained filter residue was washed with ethanol and vacuum-dried to obtain 7- (4-nitrophenyl) -5-methyl-4,7-dihydro- [1,2,4] triazolo [1, 5-a] Pyrimidine-6-carboxylic acid ethyl ester, the purity by liquid chromatography was 99.1%, and the calculated purity was 83%. The adsorbed magnetic nanosulfonic acid was put into the filtrate after suction filtration without any treatment, and p-nitrobenzaldehyde, ethyl acetoacetate, and 3-amino-1,2,4-triazole were directly added for repeated use.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-1,2,4-Triazol-5-amine, its application will become more common.
Reference:
Patent; Ma’anshan Tai Bo Chemical Technology Co., Ltd.; Lu Hua; Shen Jianzhong; (11 pag.)CN110540540; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics