Related Products of 13423-60-4, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 13423-60-4, name is 1-Phenyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 113 1-phenyl-4-(hepr-1-yl)triazolium bromide 0.150 g (0.002 mol) 1-phenyltriazole 1 (actually, 0.3 g, there were still 2 eq. DMF contained in the educt) and 0.97 ml (1.110 g, 0.006 mol) 1-bromoheptane 2 are combined in a pressure tube. The reaction mixture was stirred 12 h at 110 C. The reaction mixture is cooled down and the same volume petroleum ether is added. The precipitated solid is filtered off, washed with petroleum ether, and dried in HV. M 324.26 C15H22N3Br Yield: 0.225 g (69%) 1H-NMR DM-170 (300 MHz/DMSO): delta (ppm)=0.87 (t, 3H, 13-H); 1.30 (m, 8H, 9/10/11/12H); 1.95 (qui, 21-1,8-H); 4.34 (t, 2H, 7-H); 7.68 (m, 3H, 5/5’/6H); 7.95 (d, 2H, 4/4′-H); 9.55 (s, 1H, 1-H); 11.10 (s, 1H, 2-H) 13C-NMR DM-170 (300 MHz/DMSO):
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Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics