Now Is The Time For You To Know The Truth About 4922-98-9

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New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Phenyl-1H-1,2,4-triazol-3-amine

General procedure: 3-Amino-1,2,4-triazole 8a?f (1.0 mmol), o-hydroxybenzaldehyde9a?e (1.0 mmol), acetone (10) (0.22 ml,3.0 mmol), and abs. EtOH (2 ml) were mixed in amicrowave process vial, and then 4 N solution of HCl indioxane (0.07 ml, 0.3 mmol) was added. The mixture wasirradiated at 150°C for 30 min. The reaction mixture wascooled by an air flow and stirred for 24 h at roomtemperature for complete precipitation of the product. Theprecipitate was filtered off, washed with EtOH (1 ml) andEt2O (3×1 ml), and dried. Compounds 1a?w were obtainedin a form of white solids.

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Reference:
Article; Guemue?, Mustafa K.; Gorobets, Nikolay Yu.; Sedash, Yuriy V.; Chebanov, Valentin A.; Desenko, Sergey M.; Chemistry of Heterocyclic Compounds; vol. 53; 11; (2017); p. 1261 – 1267; Khim. Geterotsikl. Soedin.; vol. 53; 11; (2017); p. 1261 – 1267,7;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Our Top Choice Compound: 15988-11-1

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 15988-11-1.

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 15988-11-1, name is 4-Phenyl-1,2,4-triazolidine-3,5-dione belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 15988-11-1

General procedure: A mixture of malononitrile (1.0 mmol), aromatic aldehyde (1.0 mmol), 4-ar ylurazole (1.0 mmol), and nano-ZrO2(20 mol %) was heated at 100C for 30-40 min. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to room temperature. The solid residue was dissolved in hot ethanol and centrifuged to separate the catalyst. By recrystallization from ethanol, pure products were obtained.

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 15988-11-1.

Reference:
Article; Anaraki-Ardakani, Hossein; Heidari-Rakati, Tayebe; Oriental Journal of Chemistry; vol. 32; 3; (2016); p. 1625 – 1629;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Our Top Choice Compound: 1455-77-2

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Related Products of 1455-77-2, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Then, an amidation step is carried out, the reaction equation being as follows: The 1.49g (15mmol, 1eq) of the compound of Formula III-1 3,5-amino-1,2,4-triazole, 3.64 g (36 mmol, 2.4 eq) of triethylamine were dissolved in 50 mL of dichloromethane,50 mL of a dichloromethane solution containing 9.39 g of the compound shown by the formula 11-1 (4- (4′-nitrophenyl) benzoyl chloride) was slowly added dropwise at 0 ° C. After completion of the dropwise addition,The reaction solution was allowed to react at room temperature for 24 h,Subsequently, the reaction solution was washed with 200 mL of pure water, After the layers were separated, the organic phase was washed twice with saturated sodium carbonate solution and then dried over anhydrous magnesium sulfate,The organic phase was evaporated to give a crude product,The crude product was recrystallized to give 6.52 g of the compound of formula IV-1,The yield was 80percent.

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Reference:
Patent; Fuyang Xinyihua Material Technology Co., Ltd; Wu, Jingwei; (17 pag.)CN105294664; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The Best Chemistry compound: 162848-16-0

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Related Products of 162848-16-0, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 162848-16-0, name is 4-[1,2,4]Triazol-1-yl-benzoic acid, molecular formula is C9H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Example 5: Synthesis of 4-[l,2,4]triazol-l-yl-benzoic acid 3-(2-methyl-l,2,3,4- tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide (Cpd 178, Table 1); Dissolve 4-[l,2,4]triazol-l-yl-benzoic acid (29 mg, 0.15 mmol) and CDI (Nu,Nu’- carbonyldiimidazole) (25 mg, 0.15 mmol) in DMF (2 mL) and stir the mixture for 1 h. To this add 3-aminomethyl-N-(2-methyl-l,2,3,4-tetrahydro-isoquinolin-7-yl)-benzamide dihydrochloride (50 mg, 0.14 mmol) and triethylamine (0.095 mL, 0.68 mmol) and stir the mixture overnight. Dilute the mixture with water (1 mL) and trifluoroacetic acid (0.2 mL) and purify by prep-HPLC (5 -70 , CH3CN/H20) to give the desired product 4- [l,2,4]triazol-l-yl-benzoic acid 3-(2-methyl-l,2,3,4-tetrahydro-isoquinolin-7- ylcarbamoyl)-benzylamide (51 mg, 0.086 mmol). MS, electrospray 467.4 (M+H), rt 1.05 min.

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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KOWALSKI, Jennifer A.; LI, Xiang; MARSHALL, Daniel Richard; SCHLYER, Sabine; SIBLEY, Robert; SMITH-KEENAN, Lana Louise; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; YOUNG, Erick Richard Roush; ZHANG, Yunlong; WO2012/6203; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Why Are Children Getting Addicted To 4314-22-1

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New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 4314-22-1, name is 2-(1H-1,2,3-Triazol-1-yl)acetic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H5N3O2

Oxalyl chloride (0.95 mL, 11 mmol) was added dropwise to a suspension of 2- (1- 1, 2,3-triazolyl)) acetic acid (Step B, 1.27 g, 10 mmol) in 10 mL CH2C12 containing 0.05 mL DMF. Vigorous effervescence was observed. This mixture was stirred at room temperature for 4 h and cooled to-78C. A solution of N. O- dimethylhydroxylamine hydrochloride (1.2 g, 13 mmol) and diisopropylethyl amine (6.0 mL, 35 mmol) in 10 mL CH2C12 was added slowly over 3 min. The mixture was then allowed to warm to room temperature and stirred overnight. The reaction mixture was then diluted with ether until no additional precipitate appeared. The solid was filtered and washed with ether. The filtrate was concentrated and the residue was purified on silica gel using EtOAc as solvent to provide the title compound as amorphous solid. 1H NMR (400 MHz, CDC13) : 8 3.252 (s, 3H0, 3.812 (s, 3H), 5.379 (s, 2H), 7.753 & 7.761 (s’s, 2H).

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Reference:
Patent; MERCK & CO., INC.; WO2003/87037; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The Shocking Revelation of Electric Literature of 7411-23-6

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Application of 7411-23-6, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: 3,5-Dibromo-1,2,4-triazole (1; 658 mg, 2.9 mmol) and p-quinonemethide precursor 7 (2.9 mmol) were refluxed for 4 h in DMF (10mL). Products were isolated analogously to compound 4a.

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Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some tips on 288-88-0

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 288-88-0.

Application of 288-88-0, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Preparation of 1-phenyl-1H-[1,2,4]triazole [0220] Following General Procedure A (90 0C, 30 hours), 1/-/-[1 ,2,4]triazole (104 mg, 1.5 mmol) is coupled with iodo-benzene (112 muL, 1.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes = 50/50) to provide 120 mg (83 % isolated yield) of the desired product as a light yellow solid. 007/001836_ 49 -IdentificationMp: 460C.1H NMR (400 MHz, CDCI3): delta 8.49 (s, 1 H1 H8), 8.03 (s, 1H, H7), 7.58-7.61 (m, 2H, H2i6), 7.40-7.44 (t, 2H1 H3,5), 7.31-7.33 (t, 1 H, H4).13C NMR (100 MHz, CDCI3): delta 152.62 (C7), 140.91 (C8), 136.99 (C1), 129.77 (C3,5), 128.21 (C4), 120.04 (C2i6).IR (KBr) : v (cm’1) = 3105, 2924, 2852, 1600, 1514, 1416, 1359, 1278, 1223,1152, 1055, 981 , 876, 754, 681 , 671 , 503.GC/MS: rt = 15.28 min, M/Z = 145.HRMS: 146.0721 (M+H). Theoretical: 146.0718

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 288-88-0.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.); Ecole Nationale Superieure de Chimie de Montpellier; WO2008/4088; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 252742-72-6

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 252742-72-6

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 252742-72-6, name is 3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 252742-72-6

Example 54 (3R*,4R*)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methyl-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]piperidine-4-carboxamide hydrochloride To a solution of the compound (0.30 g) obtained in Example 12 and potassium carbonate (0.083 mg) in 1percent H2O-DMF (5.0 mL) was added 5-(chloromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (0.094 g) at 0°C, and the mixture was stirred at room temperature for 14 hr. The reaction mixture was poured into water, and the product was extracted with ethyl acetate. The organic layer was washed with brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by preparative HPLC. 1H-NMR(CDCl3)delta: 1.70-2.00 (1H, m), 2.05-2.40 (6H, m), 2.75-3.10 (6H, m), 3.45-3.49 (2H, m), 3.65-3.80 (1H, m), 4.16 (1H, d, J=15.0Hz), 4.88 (1H, d, J=15.0Hz), 6.70-6.80 (2H, m), 7.00-7.18 (1H, m), 7.33-7.40 (2H, m), 7.70-7.82 (1H, m), 10.21 (1H, br s), 10.3-11.0 (1H, br) The obtained product was treated with 1 equivalent of 4N hydrogen chloride/ethyl acetate solution to give the title compound as a white powder (0.28 g, 78percent). MS(ESI+): 574(M-HCl+H)

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 252742-72-6

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1705176; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The Best Chemistry compound: 74205-82-6

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Application of 74205-82-6, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 74205-82-6, name is (1H-1,2,4-Triazol-1-yl)methanol, molecular formula is C3H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: A mixture containing 25 ml of acetonitrile, two equivalents of (3,5-dimethyl-1H-pyrazol-1-yl) methanol (compound 2), and one equivalent of N,N-Diethyl-propanediamine was stirred at room temperature for 4 days. Next, the solvent was concentrated at a reduced pressure, washed with brine and dichloromethane. The organic solution was dried with MgSO4, and the solvent was concentrated at reduced pressure to yield compound 3 as light yellow oil.

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Reference:
Article; Bendaha, Hasnae; Yu, Lisa; Touzani, Rachid; Souane, Rachid; Giaever, Guri; Nislow, Corey; Boone, Charles; El Kadiri, Sghir; Brown, Grant W.; Bellaoui, Mohammed; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4117 – 4124;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Extended knowledge of 41253-21-8

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Reference of 41253-21-8, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

in a 2000 L finished synthesis kettle, 138 kg of sodium triazole sodium salt was dissolved in 15 kg of formamide. Adding N,N-dimethylformamide mother liquor, slowly raising the temperature to 80 C at a rate of 55 C / h, and reacting at 80 C for 8 hours, Then, N,N-dimethylformamide was recovered under a vacuum of -0.085 MPa for 2.7 hours. After the completion of the collection, the mixture is transferred to a high-vacuum distillation still for fractional distillation, and the mixture is fractionated under a vacuum of 1.33 kPa and a temperature of 227 C for 8 hours, and cooled to room temperature to obtain a fluorosilazole; wherein, the formula of the specific alkylation reaction is as follows: Formula (3).

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Reference:
Patent; Shanxi Hengrun Chemical Co., Ltd.; Fan Ming; Li Cangzhen; Chen Dunguo; Chao Liumin; Wang Jianqiao; Yin Weixin; (7 pag.)CN108864165; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics