Day: August 20, 2021

Application of 288-36-8, New Advances in Chemical Research in 2021.Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Step 3: 4-(2H-1.2.3-Triazol-2-yl)thiophene-3-carboxylic acid (Intermediate F) To a mixture of the product from step 2 (7.9 g, 38 mmol), cesium carbonate (24.8 g,76 mmol) and Cul (2.88 g, 7.6 mmol) in DMF (200 mL) were added 2H-[l,2,3]triazole (5.24 g,76 mmol) and N,N’-dimethyl-cyclohexane-l,2-diamine (0.9 g, 6.5 mmol) and the mixture was heated to 110 C overnight. The cooled reaction mixture was adjusted to ~pH=12 with 1M sodium hydroxide aqueous solution and extracted with EtOAc (50 mL x 3). The aqueous layer was adjusted to ~pH=4 with 1M HC1 aqueous solution and extracted with EtOAc (50 mLx4). The extracts was dried over Na2SC>4, filtered. The filtrate was concentrated in vacuo and the residue was purified by chromatography on silica (petroleum ether : EtOAc =10: 1) to provide the title compound. LRMS m/z (M+H) 196.0 found, 196.0 required.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1H-1,2,3-Triazole, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 60166-43-0, name is 1,4-Dimethyl-1H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 60166-43-0

Under the protection of N2, a tetrahydrofuran (5.0 mL) solution of 1,4-dimethyl-1,2,3-triazole (0.56 g, 5.77 mol) was added dropwise to a tetrahydrofuran (5.0 mL) solution of butyllithium (2.77mL, 6.27 mol, 2.4 mol/L n-hexane solution) at -78C, and the resulting mixture was kept at -70C and reacted for 1h. Then chlorotributyltin (1.71 mL, 6.34 mol) was added. The system became clear, and was gradually warmed to room temperature. Water and ethyl acetate were added to the reaction flask, stirred for 15 min, and filtered through Celite filler, and the Celite filler was rinsed with ethyl acetate. After the filtrate was layered, the aqueous phase was extracted with ethyl acetate once. The ethyl acetate phases were combined, washed with a saturated sodium chloride aqueous solution, dried with anhydrous sodium sulfate, and concentrated to obtain a black residue. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (5:1) to obtain a luminous yellow oily product (1.40g, 63%). 1H NMR (400 MHz, CDCl3) delta 4.03 (s, 3H), 2.35 (s, 3H), 1.45-1.54 (m, 6H), 1.28-1.40 (m, 6H), 1.16-1.21 (m, 6H), 0.91 (t, 9H).

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 60166-43-0.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; LI, Jijun; WU, Wei; ZHU, Yan; WANG, Huting; ZHAO, Lijia; HE, Weinan; SUN, Yinghui; PENG, Yong; HAN, Yongxin; (108 pag.)EP3412669; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 7411-23-6, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of 3,5-dibromo-1H-1,2,4-triazole (700 mg, 3.1 mmol), 2,2′-bipyridyl (60 mg, 0.39 mmol), copper(II) acetate (140 mg, 0.77 mmol), potassium carbonate (852 mg, 6.2 mmol) and cyclopropylboronic acid (795 mg, 9.3 mmol) was dissolved in toluene (5 mL) and water (1.5mL) and stirred at 70 C for 18 h. The reaction mixture was cooled to RT, quenched with NH4Cl (sat. aq.) and the products extracted in DCM. The combined organic fractions were dried with a phase separator and reduced in vacuo. The crude mixture was dissolved in DCM and dry-loaded onto silica. Purification via silica column chromatography eluting with 10-60% EtOAc in Pet. Ether afforded 5-dibromo-1-cyclopropyl-1,2,4-triazole and 1-allyl-3,5-dibromo-1,2,4-triazole (123 mg, 0.46 mmol, 15% yield) as an inseparable mixture. UPLC-MS (ES+, Method A): 1.52 min, m/z 267.9 [M+H]+

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3,5-Dibromo-1H-1,2,4-triazole, hurry up and to see.

Reference:
Patent; REDX PHARMA PLC; JONES, Clifford, D.; BUNYARD, Peter; PITT, Gary; BYRNE, Liam; PESNOT, Thomas; GUISOT, Nicolas, E.S.; (318 pag.)WO2019/145729; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 423165-07-5, name is exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

[Ill] Synthesis of tert-butyl 3-(3-(3-isopropyl-5-methyl-4H-l .2.4-triazol-4-ylV8- azabicvclor3.2.11octan-8-ylVl-phenyl-3-d9-propylcarbamate 107-dz (Yla = Ylb = D. Y2a = gamma2b = gamma2c = H). To a solution of amine 103 (0.20 g, 0.86 mmol), and 3-tert-butyl-3- phenylpropyl-1-di -aldehyde 111 (0.26 g, 1.03 mmol, 1.2 equiv) in CH2Cl2 (5 mL), at room temperature, was added Na2SO4. The mixture was stirred for 15 min followed by the addition OfNaCNBD3 (69 mg, 1.03 mmol, 1.2 equiv). The resultant mixture was stirred at room temperature for 15 h, diluted with 10 % K2CO3, and extracted with CH2Cl2 (3 x 20 mL). The combined organic extracts were washed with brine solution, dried over MgSO4, filtered and concentrated in vacuo to afford 107-d2, which was carried on to the next step without purification.; Amine 103 was combined with appropriately deuterated aldehyde 111 in CH2Cl2 (5 mL), Na2SO4 and NaCNBD3 to afford 107.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane, in my other articles.

Reference:
Patent; CONCERT PHARMACEUTICALS INC.; WO2008/63600; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 423165-07-5, name is exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 423165-07-5

General procedure: A mixture of trisallene 3 (0.25 mmol), aryl/heteroaryl iodides (0.90 mmol), nucleophiles (0.90 mmol), Pd2(dba)3 (7.5 mol %), TFP (tri-(2-furyl)phosphine) (30 mol %), and K2CO3 (2.25 mmol) in MeCN (5 mL) was stirred and heated at 80 C (oil bath temperature) until the starting material was completely consumed as monitored by TLC (see Table 1). The mixture was cooled and solvent removed under vacuo. The residue was dissolved in CHCl3 (25 mL) and extracted with H2O (20 mL) three times. The organic layer was dried over anhydrous MgSO4 and evaporated under rotatory evaporator to give the crude product, which was purified by flash chromatography.

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 423165-07-5.

Reference:
Article; Gueltekin, Zeynep; Elboray, Elghareeb E.; Aly, Moustafa F.; Abbas-Temirek, Hussien H.; Shepherd, Helena J.; Grigg, Ronald; Tetrahedron; vol. 70; 33; (2014); p. 4934 – 4941;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles

0.2mmol, 0.0252g H2atrc, 0.2mmol, 0.0389g 4,4?-bipy and 0.2mmol, 0.0520g CdSO4·8/3H2O mixed with 10mL H2O and 5mL EtOH were placed in a 25mL Teflon-lined stainless-steel autoclave. The mixture was kept inside a furnace at 110C for 5 days, and then naturally cooled to ambient temperature. The colorless platelet crystals of 1 suitable for X-ray diffraction were collected after soak clearing with water and ethanol. Yield based on Hatrz: 23.1mg, 39.48%. IR data (in KBr, cm-1) for 1: 3428(m), 3339(m), 3268(w), 3204(w), 3147(w), 2987(w), 2859(w), 1643(m), 1592(m), 1528(w), 1413(w), 1362(w), 1278(w), 1125(s), 1055(m), 882(w), 805(w), 600(w), 460(w).

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 3641-13-2.

Reference:
Article; Liu, Bing; Feng, Hui-Jun; Zhang, Zong-Hui; Xu, Ling; Jiao, Huan; Journal of Molecular Structure; vol. 1098; (2015); p. 240 – 245;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 288-36-8, New Advances in Chemical Research in 2021.Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

The molar ratio of 9,10-dibromoanthracene: 1H-1,2,4-triazole: potassium carbonate: copper oxide is 2: 10-15: 30: 1In the magnet,A 50 mL three-necked round bottom flask equipped with a reflux condenser and a thermometer was charged with CuO (0.0398 mg, 0.5 mmol)Potassium carbonate (2.0731 g, 15 mmol),Triazole (0.345 mg, 5 mmol),9,10-dibromoanthracene (0.3360 g, 1 mmol),20 mL DMF.Start stirring at 100 oC,Reaction for 24 hours.After the reaction,The reaction solution was cooled to room temperature,Filtration, the filtrate was added 100 mL of water,Precipitation precipitation, filtration,The filter cake was collected in a yield of 60%.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 288-36-8, Happy reading!

Reference:
Patent; Tianjin Normal University; Wang Zhongliang; Yang Xi; Guo Changcheng; Shang Yuntao; Zhang Zhigang; Wang Ying; (11 pag.)CN106188104; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 7170-01-6, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: To 3,6-dichloropyridazine (500 mg, 3.36 mmol) in 5 mL DMF are added 1H-1,2,4-triazole (460 mg, 6.71 mmol) and cesium carbonate (2.41 g, 7.38 mmol) and the reaction mixture is stirred at 60 C. for 18 h. The mixture is quenched with water and the precipitation is filtered, washed and dried to give 0.7 g of the product. (0171) C8H6N8 (M=214.19 g/mol) (0172) ESI-MS: 215 [M+H]+ (0173) 1H NMR (400 MHz, DMSO-d6) delta=9.66 (s, 1H), 8.47 (s, 1H), 8.44 (s, 1H)

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 3-Methyl-1H-1,2,4-triazole.

Reference:
Patent; Boehringer Ingelheim International GmbH; Larsen, Janus Schreiber; Binder, Florian; Cui, Yunhai; Hucke, Oliver; Lipinski, Radoslaw; Montel, Florian; Ostermeier, Markus; Perera, Alexandre; Peters, Stefan; US2020/24261; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 15988-11-1, New Advances in Chemical Research in 2021.Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, 15988-11-1, name is 4-Phenyl-1,2,4-triazolidine-3,5-dione, molecular formula is C8H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: A mixture of arylaldehyde (1 mmol), malononitrile (1mmol), 4-phenylurazole (1mmol ) and NaBr (0.05 g, 0.5 mmol ) in EtOH (20 mL) was stirred with a magnetic stirrer and electrolyzed in an undivided cell equipped with a graphite anode, and an iron cathode at ambient temperature under a constant current density of 10mA/cm2( electrodes square 5 cm2), until the catalytic quantity of 0.1 F/mol of electricity was passed. After electrolysis process, the mixture was filtered, then it was rinsed twice with cold ethanol to obtained corresponding product.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 4-Phenyl-1,2,4-triazolidine-3,5-dione is helpful to your research.

Reference:
Article; Khandan-Barani, Khatereh; Dodangeh, Mohammad; Kangani, Mehrnoosh; Maghsoodlou, Malek-Taher; Oriental Journal of Chemistry; vol. 32; 2; (2016); p. 1255 – 1260;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 41253-21-8, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

(i) Preparation of crude anastrozole Into a IL, three-necked RB flask was charged 54g of sodium triazole monohydrate and 500ml of dry DMF under nitrogen atmosphere. The reaction mass was cooled to 25 C. (2,2′-[5-Bromomethyl)-l,3-phenylene]di(2-methylpropio-nitrile was added to the reaction mass over a period of 2hr. The reaction mass was maintained at this temperature until the completion of reaction. The reaction mass was transferred into 3 L flask containing 1.6L of water and stirred for 30min. Reaction mass was extracted with toluene (2 x 300ml and 1 x 100ml). Toluene layers were combined and washed with water (2 x 200ml). Toluene layer was treated with activated carbon (5g) and filtered. Toluene was distilled off from the filtrate under vacuum to get 98g of crude anastrozole.

I am very proud of our efforts over the past few months and hope to Sodium 1,2,4-triazol-1-ide help many people in the next few years.

Reference:
Patent; NATCO PHARMA LIMITED; PULLA REDDY, Muddasani; SAMBASIVA RAO, Talasila; VENKAIAH CHOWDARY, Nannapaneni; WO2007/39919; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics