Day: August 26, 2021

Synthetic Route of 6523-49-5, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, molecular formula is C8H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

N’ – [5 -(3 -Chloro-propoxy)-2-cyano-4-methyoxy-phenyl] -N,N-dimethyl- formamidine (WO03055491, 580 mgs)5 4-(l,2,4-triazolyl)aniline (314 mgs) and AcOH(4 mL) were heated to 90 for 1 hr before cooling. The oil was concentrated and the resultant slurry dissolved in MeOH, sonicated and the resultant white powder filtered and dried to produce the title compound (765 mg). 1H NMR delta 9.65 (s, IH), 9.25 (s, IH), 8.5 (s, IH), 8.23 (s, IH), 8.02 (d, 2H, J9Hz ), 7.89 (s, IH), 7.87 (d, 2H, J=9), 7.24 (s, IH), 4.28 (t, 2H, J=6), 3.95 (s, 3H), 3.83(t, 2H, J6Hz), 2.27 (q, 2H, J6Hz); LC-MS rt 2.13 m/z 411 ES+.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 4-(1,2,4-Triazol-1-yl)aniline.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 7411-23-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

SEM-Cl (808.41 mg, 4.85 mmol, 858.18 mL, 1 eq) was added to a dichloromethane solution (10 mL) of acompound WX073-1 (1.1g, 4.85mmol, 1 eq) and triethylamine (727.00 mg, 7.18mmol, 1 mL, 1.48 eq), and the resultingmixture was reacted 25C for 1 hour. The reaction solution was spin-dried to obtain the target compound WX073-2. ESIm/z: [M-TMS+O]-=300.1.

I am very proud of our efforts over the past few months and hope to 3,5-Dibromo-1H-1,2,4-triazole help many people in the next few years.

Reference:
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.1455-77-2, name is 3,5-Diamino-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 1455-77-2

To a solution of 135.6 g (1.965 mol) of sodium nitrite in158.2 mL of water at -10 to -5 °C, we added a solution of 20 g(0.202 mol) of DAT in 423.7 mL 1.2 mol/L sulfuric acid for1.5 h. The reaction mixture was heated up to 60 °C and stirredfor another 1 h, then cooled the reaction mixture to roomtemperature. 67.2 mL 6 mol/L sulfuric acid and 11.85 g (0.121mol) aminosulfuric acid were added to reaction system andstirred for another 0.5 h, extracted with 322.5 × 3 mL of trioctylamineand 265.5 mL toluene, dried with magnesiumsulfate overnight. The magnesium sulfate was filtered and thefiltrate reacted with excess ammonia to obtain the yellow solid,dried in vacuum to give 25.1 g of 3,5-dinitro-1,2,4-triazoleammonium (AA DNT).

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 3,5-Diamino-1,2,4-triazole ,and how the biochemistry of the body works.

Reference:
Article; Li, Ya-Nan; Liu, Ning; Su, Peng-Fei; Wang, Ying-Lei; Ge, Zhong-Xue; Li, Hui; Wang, Bo-Zhou; Asian Journal of Chemistry; vol. 26; 21; (2014); p. 7151 – 7156;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 956317-36-5, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 5-methyl-2-{2H-1,2,3-triazol-2-yl)benzoic acid (4.00 g, 19.7 mmol) in CH2CI2 (90 mL) cooled at 0 C was added DMF (76 mu, 0.98 mmol) and oxalyl chloride (2.15 mL, 24.6 mmol). The reaction was allowed to warm to ambient temperature and stirred for 3.5 h. The solution was concentrated in vacuo to provide 5-methyl-2-(2H-1,2,3- triazol-2-yl)benzoyl chloride as a yellow-orange oil which gave a mass ion (ES+) of 218.2. NMR 6 (ppm) (CDC13): 7.89 (2 H, s), 7.76 (1 H, d, J= 8.2 Hz), 7.59-7.60 (1 H, m), 7.48-7.50 (1 H, m), 2.48 (3 H, s).

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2013/62857; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1455-77-2, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

To a stirred solution of IH- 1 ,2,4-triazole-3,5-diamine (1.0 g, 10.1 mmol), methyl 3-oxobutanoate (1.17 g, 10.1 mmol), and 2,4-dichlorobenzaldehyde (1.35 g, 10.1 mmol) in THF (30 mL) and heptane (8 mL) was added piperidine (30 mg, 0.3 mmol) and the reaction was heated to 70 °C for 2 days. The reaction was concentrated to afford crude methyl 2-amino-7-(2,4-dichlororhohenyl)-5-methyl-4,7-dihydro-[1,2,4]- triazolo[1,5-alpha]pyrimidine-6-carboxylate as a light yellow solid. [00202] HPLC Phenomenex LUNA C-18 4.6 x 50 mm, 0 to 100percent B over 4 minutes, 1 minutes hold time, A = 90percent water, 10percent methanol, 0.1percent TFA, B = 10percent water, 90percent methanol, 0.1percent TFA, RT = 3.03 min, 97percent homogeneity index.[00203] To a stirred solution of crude methyl 2-amino-7-(2,4-dichlorophenyl)-5- methyl-4,7-dihydro-[1,2,4]-triazolo[1,5-fl]pyrimidine-6-carboxylate (10.1 mmol) in CH2Cl2 (100 mL) was added DDQ (2.75 g, 12.1 mmol). The reaction was kept at room temperature for 1 h and was quenched by satd aq NaHCO3 solution. The organic layer was washed with satd aq NaHCO3 and brine prior to drying over anhydrousMgSO4. Filtration, concentration under reduced pressure and purification by silica gel chromatography afforded methyl 2-amino-7-(2,4-dichlorophenyl)-5-methyl-[ 1,2,4]- triazolo[1,5-fir]pyrimidine-6-carboxylate (2.0 g, 56percent) as a light yellow solid. [00204] 1H NMR (400 MHz, CDCl3) delta 7.59 (d, J= 1.8 Hz, 1H), 7.43 (dd, J= 1.8, 7.9 Hz, 1H), 7.29 (d, J= 7.9 Hz, 1H), 4.72 (s, 2H), 3.64 (s, 3H), 2.77 (s, 3H). [00205] HPLC Phenomenex LUNA C-18 4.6 x 50 mm, 0 to 100percent B over 4 minutes, 1 minutes hold time, A = 90percent water, 10percent methanol, 0.1percent TFA, B = 10percent water, 90percent methanol, 0.1percent TFA, RT = 2.85 min, 100percent homogeneity index. [00206] LCMS: Anal. Calcd. for C14H11Cl2N5O2 351.03; found: 352.11 (M+H)+.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 3,5-Diamino-1,2,4-triazole.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/71752; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 1001401-62-2, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 24: N-[(1S,2R)-2-Aminocyclopentyl]-2-(2H-l,2,3-triazol-2-yl)benzamide hydrochloride To a solution of ieri-butyl N-[(i ?,2S)-2-aminocyclopentyl] carbamate (CAS number 721395-15-9; 250 mg, 1.248 mmol) in dry DCM (4 ml) was added 2-(2H- 1,2,3 -triazol-2- yl)benzoic acid (CAS number 1001401-62-2; 283 mg, 1.498 mmol), aza-HOBt (289 mg, 1.872 mmol), triethylamine (0.522 ml, 3.74 mmol) and EDC (359 mg, 1.872 mmol). The reaction was stirred at room temperature for 18 hours then diluted with DCM (20 ml) and washed with HCl (aq, 1M, 20 ml), water (10 ml), saturated sodium bicarbonate solution (20 ml) and brine (10 ml). The organic s were filtered through a hydrophobic frit and concentrated in vacuo to afford a residue which was purified by column chromatography (silica, 10-100% ethyl acetate / petrol) to afford a solid. This Boc-protected intermediate was dissolved in hydrogen chloride in 1,4-dioxane (4 M, 10 ml) and stirred at room temperature for 2 hours. The resulting mixture was concentrated in vacuo thenazeotropically distilled with toluene to afford the title compound.1H NMR (400 MHz, DMSO-d6): delta ppm 1.48 – 1.69 (m, 1 H), 1.61 – 1.84 (m, 3 H), 1.85 – 1.97 (m, 1 H), 1.96 – 2.13 (m, 1 H), 3.52 – 3.67 (m, 1 H), 4.19 – 4.37 (m, 1 H), 7.50 – 7.62 (m, 1 H), 7.61 – 7.71 (m, 1 H), 7.70 – 7.78 (m, 1 H), 7.81 – 7.85 (m, 1 H), 7.93 (br. s., 3 H), 8.08 (s, 2 H), 8.32 – 8.48 (m, 1 H)MS ES+: 272

In the meantime we’ve collected together some recent articles in this area about 2-(2H-1,2,3-Triazol-2-yl)benzoic acid to whet your appetite. Happy reading!

Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Phenyl-1H-1,2,4-triazol-3-amine

3-Phenyl-1,2,4-triazol-5-amine (12, 3.20 g, 20 mmol) was dissolved in cold DMF (8 mL). Carbondisulphide (1.2 mL, 20 mmol) was added drop-wise, followed by 10 N KOH solution (2 mL, 20 mmol).The reaction mixture was stirred for 1 h on an ice-bath. Iodomethane (1.25 mL, 20 mmol) was added,and stirring was continued for 10 min. Subsequently, the ice-bath was removed and the reactionmixture was stirred for 2 h. Cold water (15 mL) was added to the mixture, the yellow precipitate wasfiltered, washed with water, dried and recrystalized from EtOH. Yield 80 mg, 32%; mp 207-209 C(EtOH). 1H-NMR (300 MHz, DMSO-d6): 2.63 (3H, s, SMe), 7.47-7.57 (3H, m, H-30, H-40 and H-50),8.03 (2H, dd, J = 6.8, 3.0 Hz, H-20 and H-60), 8.64 (2H, s, NH2). 13C-NMR (75 MHz, DMSO-d6): 18.8,126.6 (2C), 128.8 (2C), 129.1, 130.6, 157.5, 158.8, 199.5. Combustion elemental analysis calculated forC10H10N4S2: C, 47.98; H, 4.03; N, 22.38. Found: C, 48.06; H, 4.12; N, 22.14.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5-Phenyl-1H-1,2,4-triazol-3-amine ,and how the biochemistry of the body works.

Reference:
Article; Junaid, Ahmad; Lim, Felicia Phei Lin; Zhou, Yvonne Peijun; Chui, Wai Keung; Dolzhenko, Anton V.; Molecules; vol. 24; 8; (2019);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 252742-72-6, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 252742-72-6, name is 3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one, molecular formula is C3H4ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of Example 87D (0.05 g, 0.126 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.132 ml, 0.757 mmol) in Nu,Nu-dimethylformamide (1 mL) was treated with Example 637A (0.020 g, 0.151 mmol) and the reaction was stirred at room temperature for 3 hours. Additional N-ethyl-N- isopropylpropan-2-amine (0.05 mL) and additional Example 637A (0.010 g, 0.076 mmol) were added and the mixture was stirred 3 hours longer. The reaction mixture was directly purified by reverse phase HPLC on a Phenomenex Luna C8(2) 5 um IotaOmicronthetaAlpha AXIA column (30 mm x 75 mm) eluting with a gradient of 10-70percent acetonitrile in 0.1 percent ammonium acetate/water to afford the title compound. lH NMR (500 MHz, DMSO-d6) delta ppm 2.44 – 2.52 (m, 2H), 2.64 (t, J = 5.8 Hz, 2H), 3.14 (q, J = 2.7 Hz, 2H), 3.40 (s, 2H), 3.73 (s, 3H), 6.19 (d, J = 2.1 Hz, 1H), 6.44 – 6.51 (m, 1H), 7.02 (d, J = 4.9 Hz, 1H), 7.14 – 7.32 (m, 3H), 8.18 (d, J = 4.9 Hz, 1H), 1 1.24 (s, 1H), 1 1.30 – 1 1.39 (m, 1H), 1 1.77 (d, J = 2.2 Hz, 1H). MS (ESI+) m/z 421.1(M+H)+.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one is helpful to your research.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; TONG, Yunsong; BRUNCKO, Milan; CLARK, Richard F.; CURTIN, Michael L.; FLORJANCIC, Alan S.; FREY, Robin R.; GONG, Jianchun; HANSEN, Todd M.; JI, Zhiqin; LAI, Chunqiu; MASTRACCHIO, Anthony; MICHAELIDES, Michael; MIYASHIRO, Juliem; RISI, Roberto M.; SONG, Xiaohong; TAO, Zhi-fu; WOODS, Keith W.; ZHU, Guidong; PENNING, Thomas; SOUERS, Andrew; GOSWAMI, Rajeev; IQUTURI, Omprakash Reddy; DABBEERU, Madhu Babu; WO2014/139328; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 5-Bromo-1H-1,2,4-triazole

To a 250 mL reaction flask was added 3-bromo-lH-l,2,4-triazole (5 g, 33.8 mmol), copper(I) iodide (0.644 g, 3.38 mmol) and cesium carbonate (11.01 g, 33.8 mmol). The flask was evacuated/backfilled with N2, then DMSO (33.8 ml) and l-iodo-4-(trifluoromethoxy)benzene (4.87 g, 16.90 mmol) were added. The reaction mixture was heated to 100 °C for 20 h. The reaction was cooled to room temperature, diluted with EtOAc and filtered through a plug of Celite. The Celite was further washed with EtOAc. Water was added to the combined organics, and the layers were separated. The aqueous phase was neutralized to pH 7, and further extracted with EtOAc. The combined organics were concentrated in vacuo.Purification via flash chromatography (silica/EtO Ac/Hex) yielded 3-bromo-l-(4- (trifluoromethoxy)phenyl)-lH-l,2,4-triazole as an off white solid (3.78 g, 12.27 mmol,72.6percent): mp 69-70 °C; ]H NMR (400 MHz, CDC13) delta 8.44 (s, 1H), 7.70 (d, / = 8.9 Hz, 2H), 7.38 (d, J = 8.5 Hz, 2H); 19F NMR (376 MHz, CDC13) delta -58.04; EIMS m/z 307.

If you are hungry for even more, make sure to check my other article about 7343-33-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DOW AGROSCIENCES LLC; CROUSE, Gary D.; DEMETER, David A.; SPARKS, Thomas C.; WANG, Nick X.; DENT, William Hunter; DEAMICIS, Carl; NIYAZ, Noormohamed M.; BAUM, Erich W.; FISCHER, Lindsey Gayle; GIAMPIETRO, Natalie Christine; WO2013/9791; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 288-36-8

A) to the reactor were added successively 1mol difluorophenyl chloride, 1.2mol triazole, 0.15molCuI, 1.5mol potassium carbonate and 0.8LDMF (N, N- dimethylformamide), heated to 80 stirred 10 hours, TLC (thin layer chromatography) to detect the reaction was complete; the filtrate was filtered, concentrated under reduced pressure recovery DMF, the residue is recrystallized from ethyl acetate-white solid, that is the first product in a yield of 73% ;

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1H-1,2,3-Triazole, in my other articles.

Reference:
Patent; Liu, Ke; (7 pag.)CN105777740; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics