Related Products of 16681-70-2, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 21-3 (0.2g, 0.36mMol), HOBT (0.05g, 0.4mMol), and 1H-1,2,3- triazole-4-carboxylic acid (0.05g, 0.4mMol) in anhydrous DMF (2mL) was added DIEA (0.18mL,1. ImMoI) followed by EDC (0.08g, 0.4mMol). The solution was heated in the microwave reactor for 12 minutes at 800C. The solution was then treated with 0.5mL of acetic acid and was heated to 800C in the microwave reactor for and additional 10 minutes. Upon cooling to room temperature, the solution was passed through a syringe filter and purified on a Cl 8 reverse phase HPLC to yield 21-4 as the HCl salt. Mass (M+l) calculated: observed: LC/MS (M+l) calculated: 554.6; observed: 554.3.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 16681-70-2.
Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics