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Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Aver’yanov, AA; Pasechnik, TD; Lapikova, VP; Romanova, TS; Babosha, AV; Baker, CJ or concate me.

Computed Properties of C2H4N4. In 2019.0 RUSS J PLANT PHYSL+ published article about SALICYLIC-ACID; RICE BLAST; INVOLVEMENT; RESISTANCE; REDUCTION; RADICALS; MEDIATE in [Aver’yanov, A. A.; Pasechnik, T. D.; Lapikova, V. P.; Romanova, T. S.] All Russia Res Inst Phytopathol, Vyazemskii 143050, Moscow Oblast, Russia; [Babosha, A. V.] Russian Acad Sci, Tsitsin Main Bot Garden, Moscow 127276, Russia; [Baker, C. J.] ARS, USDA, Beltsville, MD 20705 USA in 2019.0, Cited 21.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The study is aimed at the induction of systemic disease resistance by a local oxidative burst caused by inhibition of plant antioxidant enzymes. A possible involvement of ROS was ascertained. Inhibitors of superoxide dismutase and catalase, respectively, diethyldithiocarbamate (DDC) and aminotriazole (AT) were applied to the fist (local) true leaf of cucumber seedlings (Cucumis sativus L.). When the second and third (systemic) leaves developed, they were inoculated with spores of the virulent fungus Cladosporium cucumerinum Ell. et Arth. causing cucurbit scab. The inhibitors at concentrations nontoxic to leaves or spores greatly reduced the disease symptoms on the systemic leaves. The inhibition of both enzymes was confirmed, and increased superoxide production was found in the chemically treated local leaf. In case of a treatment with water, diffusates of the healthy systemic leaves stimulated spore germination, and those of infected systemic leaves were ineffective. Treatment of the local leaf with any compound systemically suppressed the aforementioned stimulation in the healthy counterpart and provided fungitoxicity in the infected one. Both antifungal effects were abolished by diffusate boiling, suggesting protein involvement. Meanwhile, the effects were insensitive to antioxidants and, apparently, independent of reactive oxygen. DDC and AT did not promote salicylic acid accumulation in infected systemic leaves; presumably, the disease control did not represent systemic acquired resistance. It is suggested that both inhibitors induce some kind of systemic resistance through the local oxidative burst caused by inhibition of antioxidant enzymes. The systemic implementation of the resistance may include antifungal effects.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Dogra, S; Kar, AK; Girdhar, K; Daniel, PV; Chatterjee, S; Choubey, A; Ghosh, S; Patnaik, S; Ghosh, D; Mondal, P or concate me.

Recently I am researching about INSULIN-RESISTANCE; LIPID-METABOLISM; LIVER; SREBP-1C; LIPOGENESIS; PATHOGENESIS; EXPRESSION; METFORMIN; PROMOTER; PATHWAY, Saw an article supported by the IIT Mandi, Department of Biotechnology, India [BT/PR22214/NNT/28/1267/2017]; Science & Engineering Research Board grant, India [ECR/2015/000165]; UGC, IndiaUniversity Grants Commission, India. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Dogra, S; Kar, AK; Girdhar, K; Daniel, PV; Chatterjee, S; Choubey, A; Ghosh, S; Patnaik, S; Ghosh, D; Mondal, P. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-lc within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities. (C) 2019 Elsevier Inc. All rights reserved.

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Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wang, S; Zhao, LJ; Shi, XJ; Ding, LN; Yang, LL; Wang, ZZ; Shen, DD; Tang, K; Li, XJ; Mamun, MAA; Li, HJ; Yu, B; Zheng, YC; Wang, SM; Liu, HM or concate me.

Product Details of 61-82-5. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction published in 2019.0, Reprint Addresses Yu, B; Zheng, YC; Wang, SM; Liu, HM (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China.; Yu, B; Zheng, YC; Wang, SM; Liu, HM (corresponding author), Zhengzhou Univ, Inst Drug Discovery & Dev, Zhengzhou 450001, Henan, Peoples R China.; Wang, SM (corresponding author), Univ Michigan, Dept Internal Med, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA.; Wang, SM (corresponding author), Univ Michigan, Dept Pharmacol, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA.; Wang, SM (corresponding author), Univ Michigan, Dept Med Chem, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA.; Yu, B; Zheng, YC; Liu, HM (corresponding author), Coinnovat Ctr Henan Prov New Drug R&D Preclin Saf, Zhengzhou 450001, Henan, Peoples R China.; Yu, B; Zheng, YC; Liu, HM (corresponding author), Zhengzhou Univ, Minist Educ China, Key Lab Adv Technol Drug Preparat Technol, Zhengzhou 450001, Henan, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

The cullin-RING ubiquitin ligases (CRLs) are responsible for about 20% of cellular protein degradation and regulate diverse cellular processes, and the dysfunction of CRLs is implicated in human diseases. Targeting the CRLs has become an emerging strategy for the treatment of human diseases. Herein, we describe the discovery of a hit compound from our in-house library and further structure-based optimizations, which have enabled the identification of new triazolo[1,5-a]pyrimidine-based inhibitors targeting the DCN1-UBC12 interaction. Compound WS-383 blocks the DCN1-UBC12 interaction (IC50 = 11 nM) reversibly and shows selectivity over selected kinases. WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells. WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27, and NRF2. Collectively, targeting the DCN1-UBC12 interaction would be a viable strategy for selective neddylation inhibition of Cul3/1 and may be of therapeutic potential for disease treatment in which Cul3/1 is dysregulated.

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SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Eggert, S; Gruebl, T; Rajender, R; Rupp, C; Sander, B; Heesch, A; Zimmermann, M; Hoepfner, S; Zentgraf, H; Kins, S or concate me.

Recently I am researching about APP; TRANSPORT; SIGNALS; UBIQUITINATION; DEGRADATION; TRAFFICKING; MEMBRANE; INTERNALIZATION; LOCALIZATION; COMPONENTS, Saw an article supported by the Projekt DEAL; AFI (Alzheimer Forschung Initative e.V.); BioComp (Forschungsinitiative Rheinland-Pfalz); TU Nachwuchsring; DFG (Deutsche Forschungsgemeinschaft)German Research Foundation (DFG). SDS of cas: 61-82-5. Published in SPRINGER BASEL AG in BASEL ,Authors: Eggert, S; Gruebl, T; Rajender, R; Rupp, C; Sander, B; Heesch, A; Zimmermann, M; Hoepfner, S; Zentgraf, H; Kins, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Endocytosis of the amyloid precursor protein (APP) is critical for generation of beta-amyloid, aggregating in Alzheimer’s disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also termed BaSS) motif remains controversial. Here, we show that APP lacking the YTSI motif (Delta YTSI) displays reduced localization to early endosomes and decreased internalization rates, similar to APP Delta NPTY. Additionally, we show that the YTSI-binding protein, PAT1a interacts with the Rab5 activator RME-6, as shown by several independent assays. Interestingly, knockdown of RME-6 decreased APP endocytosis, whereas overexpression increased the same. Similarly, APP Delta NPTY endocytosis was affected by PAT1a and RME-6 overexpression, whereas APP Delta YTSI internalization remained unchanged. Moreover, we could show that RME-6 mediated increase of APP endocytosis can be diminished upon knocking down PAT1a. Together, our data identify RME-6 as a novel player in APP endocytosis, involving the YTSI-binding protein PAT1a.

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Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mabkhot, YN; Kaal, NA; Alterary, S; Mubarak, MS; Alsayari, A; Bin Muhsinah, A or concate me.

Authors Mabkhot, YN; Kaal, NA; Alterary, S; Mubarak, MS; Alsayari, A; Bin Muhsinah, A in WILEY published article about ANTIOXIDANT ACTIVITIES; ESSENTIAL OIL in [Mabkhot, Yahia Nasser] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia; [Kaal, Nahed Ahmed; Alterary, Seham] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Mubarak, Mohammad S.] Univ Jordan, Dept Chem, Amman 11942, Jordan; [Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha, Saudi Arabia in 2019.0, Cited 25.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5-(2-bromo-acetyl)-substituted-thiophene derivative has been used as a synthon for synthesis of new thiophene-containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zong, N; Wang, HQ; Li, ZX; Ma, L; Xie, L; Pang, JL; Fan, YL; Zhao, J or concate me.. SDS of cas: 61-82-5

SDS of cas: 61-82-5. In 2020.0 PLANT MOL BIOL published article about ROOT-GROWTH MAINTENANCE; SNRK2 PROTEIN-KINASES; LOW WATER POTENTIALS; ABSCISIC-ACID; GENE-EXPRESSION; SIGNAL-TRANSDUCTION; STRESS TOLERANCE; OSMOTIC-STRESS; ARABIDOPSIS GROWTH; BZIP FACTOR in [Zong, Na; Wang, Hanqian; Li, Zaoxia; Ma, Li; Xie, Li; Pang, Junling; Fan, Yunliu; Zhao, Jun] Chinese Acad Agr Sci, Fac Maize Funct Genom, Biotechnol Res Inst, Natl Key Facil Crop Gene Resources & Genet Improv, 12 Zhongguancun South St, Beijing 100081, Peoples R China in 2020.0, Cited 85.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Key message NCP1, a NINJA family protein lacking EAR motif, acts as a negative regulator of ABA signaling by interacting with and inhibiting the activity of transcriptional activator ABP9. The phytohormone abscisic acid plays a pivotal role in regulating plant responses to a variety of abiotic stresses including drought and salinity. Maize ABP9 is an ABRE-binding bZIP transcription activator that enhances plant tolerance to multiple stresses by positively regulating ABA signaling, but the molecular mechanism by which ABP9 is regulated in mediating ABA responses remains unknown. Here, we report the identification of an ABP9-interacting protein, named ABP Nine Complex Protein 1 (NCP1) and its functional characterization. NCP1 belongs to the recently identified NINJA family proteins, but lacks the conserved EAR motif, which is a hallmark of this class of transcriptional repressors. In vitro and in vivo assays confirmed that NCP1 physically interacts with ABP9 and that they are co-localized in the nucleus. In addition, NCP1 and ABP9 are similarly induced with similar patterns by ABA treatment and osmotic stress. Interestingly, NCP1 over-expressing Arabidopsis plants exhibited a reduced sensitivity to ABA and decreased drought tolerance. Transient assay in maize protoplasts showed that NCP1 inhibits the activity of ABP9 in activating ABRE-mediated reporter gene expression, a notion further supported by genetic analysis of drought and ABA responses in the transgenic plants over-expressing both ABP9 and NCP1. These data together suggest that NCP1 is a novel negative regulator of ABA signaling via interacting with and inhibiting the activity of ABP9.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zong, N; Wang, HQ; Li, ZX; Ma, L; Xie, L; Pang, JL; Fan, YL; Zhao, J or concate me.. SDS of cas: 61-82-5

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Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lee, YR; Do, XH; Cho, KY; Jeong, K; Baek, KY or concate me.

In 2020.0 ACS APPL NANO MATER published article about METAL-ORGANIC FRAMEWORKS; HIGHLY EFFICIENT; CAPTURE; REMOVAL; MOFS; SORBENTS; HYDROGEN; ZR in [Lee, Yu Ri; Do, Xuan Huy; Baek, Kyung-Youl] Korea Inst Sci & Technol, Mat Architecturing Res Ctr, Seoul 02792, South Korea; [Do, Xuan Huy; Baek, Kyung-Youl] Korea Univ Sci & Technol, KIST Sch, Div Nano & Informat Technol, Seoul 02792, South Korea; [Cho, Kie Yong] Pukyong Natl Univ, Dept Ind Chem, Busan 608739, South Korea; [Jeong, Keunhong] Korea Mil Acad, Nucl & WMD Protect Res Ctr, Dept Chem, Seoul 01805, South Korea; [Baek, Kyung-Youl] Korea Res Inst Chem Technol, Ctr Convergent Chem Proc, Daejeon 34114, South Korea in 2020.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

The efficient removal of radioactive iodine (I-2) has drawn worldwide attention because of the severe effects of radiotoxicity on the environment and human health. As a result, efficient porous materials for the capture and safe storage of radioactive iodine are required. In this work, nanoscale zeolitic imidazolate framework-8 (ZIF-8) and its amino-functionalized ZIF-8 derivatives with 3-amino-1,2,4-triazole (Atz), denoted as ZIF8-A, were prepared via postsynthetic modification, and their performance for I-2 removal from n-hexane was investigated. The abundant amine functionalities in the ZIF8-A structure including the primary and secondary amine groups (-NH2 and -NH) and triazole-ring (-C=N-NH-) not only serve as effective adsorption sites but also form strong interactions with I-2 via electron transfer from the nitrogen atom of the ligand to I-2. The adsorption isotherms and the kinetics were well fitted by the Langmuir model and the pseudo-second-order kinetic model, respectively, suggesting a monolayer chemisorption process. ZIF8-A61 achieved an adsorption capacity of more than 870% compared to the pristine ZIF-8. Based on the experimental and computational results, a plausible mechanism for the adsorption of I-2 on ZIF8-A nanocrystals is proposed by considering the host-guest interactions, specifically, those between the amine functional groups and I-2. In addition, the reusability and structural stability of the adsorbents were investigated.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lee, YR; Do, XH; Cho, KY; Jeong, K; Baek, KY or concate me.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Nahan, K; Sussman, EM; Oktem, B; Schultheis, L; Wickramasekara, S or concate me.. Formula: C2H4N4

Formula: C2H4N4. I found the field of Chemistry very interesting. Saw the article Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast published in 2020.0, Reprint Addresses Wickramasekara, S (corresponding author), US FDA, DBCMS, OSEL, CDRH, 10903 New Hampshire Ave,Bldg 64,Rm 3064, Silver Spring, MD 20993 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

The use of additive-manufactured components in medical applications, specifically medical devices (e.g., orthopedic casts), has increased in recent years. Such devices may be fabricated at the point of care using consumer-grade additive manufacturing. Limited studies have been conducted to evaluate the extractable substances of these devices. Chemical characterization followed by toxicological risk assessment is one means of evaluating safety of devices. This study was designed to determine the extractables profile of additive-manufactured materials according to filament grade and post-processing method. Feedstocks for additive manufacturing were tested as filament and manufactured casts, while the cast from consumer-grade filament (CGF) was post-processed. Samples were extracted using three solvents of varying polarities. Extracts were analyzed by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) techniques. In GC/MS analysis, isopropanol extracts generated fewer compound identifications for USP Class VI filament (USPF)-based casts (3) compared with the respective filament (17) while hexane generated the most compound identifications for the finished cast manufactured from CGF. CGF was found to have the highest number of nonvolatile extractables for isopropanol (15) and hexane (34) by positive ion LC/MS. Additionally, CGF produced more non-polar extractables in hexane than the USPF. A known polymer byproduct and potential genotoxicant, styrene acrylonitrile (SAN) trimer, was one of the compounds identified in both GC/MS and LC/MS at quantities ranging from 19 to 270 mu g g(-1). Overall these results suggested that the extractables profile was affected by the filament material, printing procedure, and post-processing method.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Nahan, K; Sussman, EM; Oktem, B; Schultheis, L; Wickramasekara, S or concate me.. Formula: C2H4N4

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Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jahanshahi, P; Mamaghani, M or concate me.

In 2020.0 REACT KINET MECH CAT published article about ONE-POT SYNTHESIS; SOLVENT-FREE; HETEROGENEOUS CATALYST; GAMMA-FE2O3 NANOCRYSTALLITES; NAPHTHOPYRAN DERIVATIVES; 3-COMPONENT CONDENSATION; FACILE SYNTHESIS; GREEN CHEMISTRY; AQUEOUS-MEDIUM; NANOPARTICLES in [Jahanshahi, Parivash; Mamaghani, Manouchehr] Univ Guilan, Dept Chem, Fac Sci, POB 41335-1914, Rasht, Iran in 2020.0, Cited 78.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

A highly efficient and straightforward one-pot three-component synthesis of functionalized 2-amino-4H-chromenes and indole-substituted 3-amino-1H-benzo[f]chromenes have been developed by 3-amino-1,2,4-triazole supported on hydroxyapatite-encapsulated-gamma-Fe2O3(gamma-Fe2O3@HAp@CPTMS@AT) as the new magnetically recyclable heterogeneous basic nanocatalyst. The wide range of valuable 4H-chromene and 1H-chromene structures having different substituents were efficiently synthesized using one-pot tandem Knoevenagel cyclocondensation reaction of aromatic aldehydes, active methylene nitriles (malononitrile and 3-cyanoacetylindole) and diverse phenolic nucleophiles (resorcinol, alpha-naphthol and beta-naphthol) in the presence of nano gamma-Fe2O3@HAp@CPTMS@AT in EtOH. The structure and morphology of the synthesized nanocatalyst were characterized by using various techniques such as FT-IR, FESEM, EDS, XRD, TGA-DTA and VSM. The catalytic activity of nano gamma-Fe2O3@HAp@CPTMS@AT was evaluated and the results indicated its applicability as a novel, highly efficient, green, recyclable and promising heterogeneous basic nanocatalyst for the synthesis of 4H-chromene and 1H-chromene derivatives.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jahanshahi, P; Mamaghani, M or concate me.

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Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB or concate me.

Quality Control of 1H-1,2,4-Triazol-5-amine. Recently I am researching about BLOOD-BRAIN-BARRIER; IN-VITRO; CELL-MIGRATION; VASCULAR DEVELOPMENT; MODEL; THALIDOMIDE; DISRUPTION; CHEMICALS; NETWORK; CYTOTOXICITY, Saw an article supported by the Chemical Safety for Sustainability (CSS)National Research Program, Virtual Tissue Models project of the U.S. Environmental Protection Agency [CSS 5.3]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in formation of the blood-brain barrier. Typical high-throughput screening (HTS) assays investigate single biochemical or single cell responses following chemical insult. As the NVU comprises multiple cell types interacting at various stages of development, a methodology combining high-throughput results across pertinent cell-based assays is needed to investigate potential chemical-induced disruption to the development of this complex cell system. To this end, we implemented a novel method for screening putative NVU disruptors across diverse assay platforms to predict chemical perturbation of the developing NVU. HTS assay results measuring chemical-induced perturbations to cellular key events across angiogenic and neurogenic outcomes in vitro were combined to create a cell-based prioritization of NVU hazard. Chemicals were grouped according to similar modes of action to train a logistic regression literature model on a training set of 38 chemicals. This model utilizes the chemical-specific pairwise mutual information score for PubMed MeSH annotations to represent a quantitative measure of previously published results. Taken together, this study presents a methodology to investigate NVU developmental hazard using cell-based HTS assays and literature evidence to prioritize screening of putative NVU disruptors towards a knowledge-driven characterization of neurovascular developmental toxicity. The results from these screening efforts demonstrate that chemicals representing a range of putative vascular disrupting compound (pVDC) scores can also produce effects on neurogenic outcomes and characterizes possible modes of action for disrupting the developing NVU.