October 12, 2021 | Triazoles

Chemistry Milestones Of 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wang, Z; Yu, Z; Kang, DW; Zhang, J; Tian, Y; Daelemans, D; De Clercq, E; Pannecouque, C; Zhan, P; Liu, XY or concate me.. Category: Triazoles

An article Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs WOS:000455855200001 published article about REVERSE-TRANSCRIPTASE INHIBITOR; COLORIMETRIC ASSAY; PATENT EVALUATION; DISCOVERY; STRATEGIES; GW678248 in [Wang, Zhao; Yu, Zhao; Kang, Dongwei; Zhang, Jian; Tian, Ye; Zhan, Peng; Liu, Xinyong] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China; [Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe] Katholieke Univ Leuven, Lab Virol & Chemotherapy, Rega Inst Med Res, Herestr 49 Postbus 1043 09-A097, B-3000 Leuven, Belgium in 2019.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

A novel series of acetamide-substituted derivatives and two prodrugs of doravirine were designed and synthesized as potent HIV-1 NNRTIs by employing the structure-based drug design strategy. In MT-4 cell-based assays using the MTT method, it was found that most of the new compounds exhibited moderate to excellent inhibitory potency against the wild-type (WT) HIV-1 strain with a minimum EC50 value of 54.8 nM. Among them, the two most potent compounds 8i (EC50 = 59.5 nM) and 8k (EC50 = 54.8 nM) displayed robust activity against WT HIV-1 with double-digit nanomolar EC50 values, being superior to lamivudine (3TC, EC50= 12.8 mu M) and comparable to doravirine (EC50= 13 nM). Besides, 8i and 8k shown moderate activity against the double RT mutant (K103N + Y181C) HIV-1 RES056 strain. The HIV-1 RT inhibition assay further validated the binding target. Molecular simulation of the representative compounds was employed to provide insight on their structure-activity relationships (SARs) and direct future design efforts. Finally, the aqueous solubility and chemical stability of the prodrugs 9 and 10 were investigated in detail.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Huang, HF; Shi, YM; Li, H; Li, HL; Pang, AM; Yang, J or concate me.. COA of Formula: C2H4N4

COA of Formula: C2H4N4. Recently I am researching about ENERGETIC MATERIALS; DERIVATIVES; PYRAZOLE; DESIGN; DETONATIONS; PERFORMANCE; INHIBITORS; CHEMISTRY; FRAMEWORK; FAMILY, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21602241, 21975066]; Open Research Fund Program of Science and Technology on Aerospace Chemical Power Laboratory [STACPL120181B04]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Huang, HF; Shi, YM; Li, H; Li, HL; Pang, AM; Yang, J. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Potassium 1,1,3,3-tetranitropropane-1,3-diide (K2TNP) was found to react readily with various (hetero)aryl amines (12 examples) to give corresponding N-(hetero)aryl-3,5-dinitropyrazoles in moderate to excellent yields. The reactions were performed at mild temperature, and most of the reactions completed in less than 4 h. Four potential energetic compounds show high enthalpy of formation, excellent thermal stability, and good sensitivity, with 3-(3,5-dinitropyrazol-1-yl)-1H-1,2,4-triazole (3j) being a potential 2,2′,4,4′,6,6′-hexanitrostibene (HNS) replacement.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Huang, HF; Shi, YM; Li, H; Li, HL; Pang, AM; Yang, J or concate me.. COA of Formula: C2H4N4

Some scientific research about 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Silva, EN; Silveira, JAG; Aragao, RM; Vieira, CF; Carvalho, FEL or concate me.. Product Details of 61-82-5

Product Details of 61-82-5. Silva, EN; Silveira, JAG; Aragao, RM; Vieira, CF; Carvalho, FEL in [Silva, Evandro Nascimento] Univ Estadual Ceara, Fac Educ Ciencias & Letras Sertao Cent, BR-63900000 Quixada, Ceara, Brazil; [Silveira, Joaquim A. G.; Vieira, Cinthya F.; Carvalho, Fabricio E. L.] Univ Fed Ceara, Dept Bioquim & Biol Mol, Lab Metab Plantas, Campus Pici,CP 6020, BR-60451970 Fortaleza, Ceara, Brazil; [Aragao, Rafael M.] UFRA, Campus Capanema, BR-68700030 Capanema, Para, Brazil published Photosynthesis impairment and oxidative stress in Jatropha curcas exposed to drought are partially dependent on decreased catalase activity in 2019.0, Cited 58.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Catalase (CAT) is a crucial enzyme to control the excess peroxisomal H2O2 produced during photorespiration. In many plant species, this enzymatic activity decreases in response to drought but its specific role in photosynthesis and redox metabolism is still poorly understood. In this study was tested the hypothesis that photosynthetic and oxidative changes induced by drought are dependent on CAT activity. For this, Jatropha curcas, a drought-tolerant species, was subjected to water deficit and CAT inhibition by a specific pharmacological inhibitor (3-AT), in order to decrease the activity of this enzyme to a similar level as compared to that exhibited by water deficit-treated plants. The CO2 assimilation and other photosynthetic-related parameters were decreased more intensively by drought as compared to plants exposed to 3-AT, whereas the photochemical efficiency of PSII remained unchanged in both conditions. Non-photochemical quenching was strongly increased in drought-treated plants, but only slightly increased in 3-AT treatment. Membrane integrity and lipid peroxidation were strongly increased in both treatments, while H2O2 content was increased only by drought imposition. Ascorbate peroxidase and superoxide dismutase activities were increased in both drought and 3-AT treatments, but glycolate oxidase was strongly increased only in drought-stressed plants. The obtained results evidence that CO2 assimilation and oxidative protection in leaves of Jatropha curcas plants exposed to water deficit are greatly dependent on drought-induced CAT activity deficiency.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Silva, EN; Silveira, JAG; Aragao, RM; Vieira, CF; Carvalho, FEL or concate me.. Product Details of 61-82-5

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Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M or concate me.

In 2019.0 ENVIRON SCI TECHNOL published article about CARBON-DIOXIDE CAPTURE; ACTIVATED CARBON; WATER-PURIFICATION; DYNAMIC PRINCIPLE; LIQUID WATER; CO2 CAPTURE; REGENERATION; KINETICS; SURFACE; EQUILIBRIUM in [Aumeier, Benedikt M.; Dang, Anh H. Q.; Ohs, Burkhard; Yuece, Sueleyman; Wessling, Matthias] Rhein Westfal TH Aachen, Aachener Verfahrenstech, Chem Proc Engn, Forckenbeckstr 51, D-52074 Aachen, Germany; [Wessling, Matthias] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany in 2019.0, Cited 67.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Recently, activated carbon adsorption for water treatment regained substantial attention due to the emerging task to remove trace organic compounds such as pesticides. In many applications, especially in decentralized water treatment, one major drawback of adsorbents is their limited recyclability due to inadequate logistics or uneconomical reactivation. In this lab-scale study, we present the temperature swing adsorption in the aqueous phase that allows the in situ regeneration of fixed-bed adsorbers, and prove its technical feasibility. Complying with circular water economy principles, we eliminated the pivotal need for regular replacement and consumables by employing only clean water instead of dedicated regeneration solutions. Adsorption of the herbicide amitrole in aqueous solution on granular activated carbon was exothermic (Delta H = -14.4 +/- 3.2 kJ mol(-1) for T = 20-94 degrees C) and followed the Freundlich model. The proposed method consisting of a short counterflow flush with liquid water at 125 degrees C effectively regenerated the adsorbent. Hence, we obtained a cyclic steady state operation with breakthrough after 122 +/- 14 bed volumes (at c(out)/c(in) = 0.2), cycle-average rejection of 90 +/- 1%, and water recovery of up to 78 +/- 4%. No thermal aging of adsorbent was observed over the investigated 17 cycles.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M or concate me.

Chemical Research in C2H4N4

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lauar, MR; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or concate me.

An article Catalase blockade reduces the pressor response to central cholinergic activation WOS:000498330200029 published article about NICOTINIC ACETYLCHOLINE-RECEPTORS; ENDOGENOUS HYDROGEN-PEROXIDE; CENTRAL ANGIOTENSIN-II; NITRIC-OXIDE; SMOOTH-MUSCLE; RAT-BRAIN; RELEASE; INHIBITION; VASOPRESSIN; EXPRESSION in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ UNESP, Dent Sch, Dept Physiol & Pathol, Araraquara, SP, Brazil in 2019.0, Cited 66.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O-2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv. In the present study, we investigated the effects of ATZ injected icv or intravenously (iv) on the pressor responses induced by icv injections of the cholinergic agonist carbachol, which similar to angiotensin II induces pressor responses that depend on sympathoexcitation and vasopressin release. In addition, the effects of H2O2 icv on the pressor responses to icv carbachol were also tested to compare with the effects of ATZ. Normotensive non-anesthetized male Holtzman rats (280-300 g, n = 8-9/group) with stainless steel cannulas implanted in the lateral ventricle were used. Previous injection of ATZ (5 nmol/1 mu l) or H2O2 (5 mu mol/1 mu l) icv similarly reduced the pressor responses induced by carbachol (4 nmol/1 mu l) injected icv (13 +/- 4 and 12 +/- 4 mmHg, respectively, vs. vehicle + carbachol: 30 +/- 5 mmHg). ATZ (3.6 mmol/kg of body weight) injected iv also reduced icv carbachol-induced pressor responses (21 +/- 2 mmHg). ATZ icv or iv and H2O2 icv injected alone produced no effect on baseline arterial pressure. The treatments also produced no significant change of heart rate. The results show that ATZ icv or iv reduced the pressor responses to icv carbachol, suggesting that endogenous H2O2 acting centrally inhibits the pressor mechanisms (sympathoactivation and/or vasopressin release) activated by central cholinergic stimulation.

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Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jin, MM; Chen, Y; Song, WX; Lian, H; Guo, HE; Dong, QC; Huang, JH; Su, JH or concate me.

In 2020.0 DYES PIGMENTS published article about LIGHT-EMITTING-DIODES; BIPOLAR HOST MATERIALS; HIGH-PERFORMANCE RED; HIGHLY EFFICIENT; PHOSPHORESCENT; BLUE; TRIPHENYLAMINE; ACCEPTOR; GREEN; ELECTRON in [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, MOE Key Lab Interface Sci & Engn Adv Mat, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, Res Ctr Adv Mat Sci & Technol, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Huang, Jinhai] Shanghai Taoe Chem Technol Co Ltd, Shanghai, Peoples R China in 2020.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

In this work, seven small molecular compounds named N,N-diphenyl-4-(2-phenylpyrimido [1,2-b]indazol-4-yl) aniline (1), N,N-diphenyl-4-(5-phenylpyrazolo [1,5-a]pyrimidin-7-yl)aniline (2), N,N-diphenyl-4-(5-phenyl[1,2,4]triazolo [1,5-a]pyrimidin-7-yl)aniline (3), 4,4′-(pyrimido [1,2-b]indazole-2,4-diyl)bis (N,N-diphenylaniline) (4), 4,4′-(pyrazolo [1,5-a]pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (5), 4,4′-([1,2,4]triazolo [1,5-a] pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (6), N,N-diphenyl-4-(4-phenylpyrimido [1,2-b]indazol-2-yl)aniline (7) with donor-acceptor (D-A) structure were designed and synthesized by employing triphenylamine (TPA) as donor and indazole, pyrazole and/or triazole as acceptor. Systematic study and analysis on thermal, photo physical, electrochemical properties of all compounds were performed. All compounds exhibit good thermal and morphological stabilities with decomposition temperatures (T-d) range from 270 to 462 degrees C, and glass transition temperatures (T-g) range from 78 to 127 degrees C. The investigation of photophysical properties of these compounds revealed that all these compounds are of high photoluminescence quantum yields (PLQY), particularly for compound 6, whose PLQY value was as high as 90.22%. To explore potential applications of these materials in organic light-emitting diodes (OLEDs), two devices with compounds 2 and 5 were fabricated. Both devices show excellent device performances with maximum current efficiency, maximum power efficiency and external quantum efficiency of 15.9 cd A(-1), 10.41 m W-1 and 8.4% for compound 2-based device and 10.1 cd A(-1), 5.81 m W-1 and 5.5% for compound 5-based device, respectively.

What kind of challenge would you like to see in a future of compound:C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Cardona, B; Rudel, RA or concate me.. HPLC of Formula: C2H4N4

I found the field of Cell Biology; Endocrinology & Metabolism very interesting. Saw the article US EPA’s regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects published in 2020.0. HPLC of Formula: C2H4N4, Reprint Addresses Rudel, RA (corresponding author), Silent Spring Inst, Newton, MA 02460 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Breast cancer risk from pesticides may be missed if effects on mammary gland are not assessed in toxicology studies required for registration. Using US EPA’s registration documents, we identified pesticides that cause mammary tumors or alter development, and evaluated how those findings were considered in risk assessment. Of 28 pesticides that produced mammary tumors, EPA’s risk assessment acknowledges those tumors for nine and dismisses the remaining cases. For five pesticides that alter mammary gland development, the implications for lactation and cancer risk are not assessed. Many of the mammary-active pesticides activate pathways related to endocrine disruption: altering steroid synthesis in H295R cells, activating nuclear receptors, or affecting xenobiotic metabolizing enzymes. Clearer guidelines based on breast cancer biology would strengthen assessment of mammary gland effects, including sensitive histology and hormone measures. Potential cancer risks from several common pesticides should be re-evaluated, including: malathion, triclopyr, atrazine, propylene oxide, and 3-iodo-2-propynyl butylcarbamate (IPBC).

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Cardona, B; Rudel, RA or concate me.. HPLC of Formula: C2H4N4

Discovery of C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Majeed, AA; Khalil, MMH; Fetoh, A; Aziz, AAA; Abu El-Reash, GM or concate me.

I found the field of Chemistry very interesting. Saw the article Divalent manganese, cobalt, copper and cadmium complexes of (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid: Preparation, characterization, computational and biological studies published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Abu El-Reash, GM (corresponding author), Mansoura Univ, Dept Chem, Fac Sci, POB 70, Mansoura, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In this work, (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H-1,2,4-triazol-3-amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E-a, A, Delta H*, Delta S* and Delta G*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS-antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF-7 (breast carcinoma) cancer cells.

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Discovery of C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA or concate me.

Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA in [Shvets, Elena H.; Pidvorotnia, Anastasiia, V; Kulyk, Olesia G.; Kolosov, Maksim A.] Kharkov Natl Univ, Sch Chem, UA-61022 Kharkiv, Ukraine; [Mazepa, Alexander, V] NAS Ukraine, AV Bogatsky Physicochem Inst, Odesa, Ukraine published A straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines in 2021.0, Cited 31.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

4,7-Dihydroazolo[1,5-a]pyrimidin-5-ylmethanesulfonamides are side-products of the three-component Biginelli-like reaction of aminoazoles, aldehydes andN,N-dialkyl-2-ketomethanesulfonamides. Herein, we report a straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines by a two-component condensation of aminoazoles andN,N-dialkyl(cinnamoyl)methanesulfonamides in DMF at reflux. The startingN,N-dialkyl-2-ketomethanesulfonamides can be obtained by either lithiation ofN,N-dialkylmethanesulfonamides and reaction with aldehydes followed by oxidation of the resulting alcohols or by Claisen condensation ofN,N-dialkylmethanesulfonamides with the corresponding esters. The chemical structures of all synthesized compounds are supported by(1)H and(13)C NMR-spectroscopy, mass spectrometry and elemental analysis.

Chemistry Milestones Of 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wen, D; Dong, Z; Ao, YY; Xie, KJ; Zhai, ML; Zhao, L or concate me.. Formula: C2H4N4

Formula: C2H4N4. Authors Wen, D; Dong, Z; Ao, YY; Xie, KJ; Zhai, ML; Zhao, L in ELSEVIER SCI LTD published article about in [Wen, Di; Dong, Zhen; Xie, Kangjun; Zhao, Long] Huazhong Univ Sci & Technol, Sch Elect & Elect Engn, State Key Lab Adv Electromagnet Engn & Technol, Wuhan 430074, Peoples R China; [Wen, Di; Xie, Kangjun] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China; [Ao, Yinyong] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Sichuan, Peoples R China; [Zhai, Maolin] Peking Univ, Beijing Natl Lab Mol Sci Radiochem & Radiat Chem, Coll Chem & Mol Engn,Key Lab Fundamental Sci, Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China in 2021.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Aminotriazole isomers with high nitrogen content show potential affinity for U(VI). Combining the advantages of both aminotriazole and cellulose, two n-aminotriazole isomers modified cellulose microspheres (n-ATARs, n = 3, 4) were newly prepared as adsorbents via radiation technology. Batch adsorption experiments showed that n-ATARs possessed good adsorption capacity of U(VI) in the order of 3-ATAR > 4-ATAR, and the adsorption process followed the Langmuir-Freundlich isotherm model and the pseudo-second-order kinetic model. Both n-ATARs exhibited good selectivity and reusability. Besides, 3-ATAR and 4-ATAR were more suitable for the extraction of trace amount of U(VI) from the contaminated groundwater and the simulated seawater, respectively. The effect of amino position on triazole ring on adsorption behavior of n-ATAR was studied and explained by DFT calculation. Finally, the adsorption mechanism of U(VI) onto n-ATARs was revealed to be inner-sphere complexation via different 1:1 or 1:2 coordination models by FTIR, MS, XPS analysis and DFT calculation.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wen, D; Dong, Z; Ao, YY; Xie, KJ; Zhai, ML; Zhao, L or concate me.. Formula: C2H4N4