October 13, 2021 | Triazoles

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Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Si, ZY; Hou, Z; Vikhe, YS; Thappeta, KRV; Marimuthu, K; De, PP; Ng, OT; Li, P; Zhu, YB; Pethe, K; Chan-Park, MB or concate me.

An article Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics WOS:000612551400104 published article about CHEMICAL-MODIFICATIONS; EFFLUX PUMPS; NANOPARTICLES; RESISTANCE; MODE; GENERATION; BACTERIA; DELIVERY; MICRO in [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ NTU, Sch Chem & Biomed Engn, Singapore 637459, Singapore; [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ, Ctr Antimicrobial Bioengn, Singapore 637459, Singapore; [Thappeta, Kishore Reddy Venkata] Nanyang Technol Univ, Singapore Ctr Environm & Life Sci SCELSE, Singapore 637551, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Tan Tock Seng Hosp, Dept Infect Dis, Singapore 308442, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Natl Ctr Infect Dis, Singapore 637459, Singapore; [De, Partha Pratim] Tan Tock Seng Hosp, Dept Lab Med, Singapore 308433, Singapore; [Ng, Oon Tek; Pethe, Kevin] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore; [Li, Peng] Northwestern Polytech Univ, Inst Flexible Elect, Xian 710072, Peoples R China; [Zhu, Yabin] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China; [Pethe, Kevin] Nanyang Technol Univ, Sch Biol Sci, Singapore 636921, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637459, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637459, Singapore in 2021.0, Cited 49.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with minimum inhibitory concentrations (MICs) of 8-32 mu g/mL against clinically relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clinically relevant antibiotics proved by decreasing the MICs of the ntibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1 mu g/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via intraperitoneal injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log(10) reduction of A. baumannii in murine intraperitoneal and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JJ; Sun, XQ; Chen, Y; Mi, YQ; Tan, WQ; Miao, Q; Li, Q; Dong, F; Guo, ZY or concate me.

Quality Control of 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry; Polymer Science very interesting. Saw the article Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities published in 2020.0, Reprint Addresses Guo, ZY (corresponding author), Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

In this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals’ scavenging activity, hydroxyl radicals’ scavenging activity, and DPPH radicals’ scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Galimberti, F; Moretto, A; Papa, E or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

Authors Galimberti, F; Moretto, A; Papa, E in PERGAMON-ELSEVIER SCIENCE LTD published article about DIFFERENT VALIDATION CRITERIA; REAL EXTERNAL PREDICTIVITY; CORRELATION-COEFFICIENT; IDENTIFICATION; ALTERNATIVES; EVALUATE; HAZARD in [Galimberti, Francesco; Moretto, Angelo] ASST Fatebenefratelli Sacco, Int Ctr Pesticides & Hlth Risk Prevent, ICPS, Milan, Italy; [Moretto, Angelo] Univ Milan, Dept Biomed & Clin Sci, Milan, Italy; [Papa, Ester] Univ Insubria, QSAR Res Unit Environm Chem & Ecotoxicol, Varese, Italy in 2020.0, Cited 45.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The EFSA ‘Guidance on tiered risk assessment for edge-of-field surface waters’ underscores the importance of in silico models to support the pesticide risk assessment. The aim of this work was to use in silico models starting from an available, structured and harmonized pesticide dataset that was developed for different purposes, in order to stimulate the use of QSAR models for risk assessment. The present work focuses on the development of a set of in silico models, developed to predict the aquatic toxicity of heterogeneous pesticides with incomplete/unknown toxic behavior in the water compartment. The generated models have good fitting performances (R-2 : 0.75-0.99), they are internally robust (Q(2) loo: 0.66-0.98) and can handle up to 30% of perturbation of the training set (Q(2) Imo: 0.64-0.98). The absence of chance correlation was guaranteed by low values of R-2 calculated on scrambled responses (R-2 Y-scr: 0.11-0.38). Different statistical parameters were used to quantify the external predictivity of the models (CCCext: 0.73-0.91, Q(2) ext-Fn: 0.53-0.96). The results indicate that all the best models are predictive when applied to chemicals not involved in the models development. In addition, all models have similar accuracy both in fitting and in prediction and this represents a good degree of generalization. These models may be useful to support the risk assessment procedure when experimental data for key species are missing or to create prioritization lists for the general a priori assessment of the potential toxicity of existing and new pesticides which fall in the applicability domain. (C) 2020 Elsevier Ltd. All rights reserved.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Galimberti, F; Moretto, A; Papa, E or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xie, SF; Huang, LQ; Zhong, L; Lai, BL; Yang, M; Chen, WB; Zhang, YQ; Dong, W or concate me.. Computed Properties of C2H4N4

An article Structures, Single-Molecule Magnets, and Fluorescent Properties of Four Dinuclear Lanthanide Complexes Based on 4-Azotriazolyl-3-hydroxy-2-naphthoic Acid WOS:000467351100062 published article about METAL-ORGANIC FRAMEWORKS; ION; ANISOTROPY; MAGNETIZATION; EXCHANGE; AXIALITY; BLOCKING; BEHAVIOR in [Xie, Shang-Fang; Huang, Li-Qian; Zhong, Li; Lai, Bi-Lin; Yang, Meng; Chen, Wen-Bin; Dong, Wen] Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou Key Lab Environm Funct Mat & Technol, Guangzhou 510006, Guangdong, Peoples R China; [Zhang, Yi-Quan] Nanjing Normal Univ, Sch Phys Sci & Technol, Jiangsu Key Lab NSLSCS, Nanjing 210023, Jiangsu, Peoples R China in 2019.0, Cited 67.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

Four isostructural dinuclear lanthanide complexes based on 4-azotriazolyl-3-hydroxy-2-naphthoic acid (H(3)ATNA) and 3-hydroxy-2-naphthoic acid (H(2)NA) ligands, {[Ln(2)(HATNA)(2)(HNA)(2)(H2O)(4)].6DMF} (Ln = Dy (1), Tb (2), Sm (3), Eu (4); DMF = N,N-dimethylformamide) have been prepared and characterized by X-ray diffraction crystallography, dc/ac magnetic characterization, and fluorescent spectrometry. The crystallographic data reveal dinuclear lanthanide cores of complexes 1-4, bridged by phenoxo and mu(1,3) carboxyl groups. Each nine-coordinated Ln(III) ion is located in a slightly distorted monocapped square antiprism. The ligand of H(3)ATNA displays a unique antenna effect in complex 4. Complexes 1-3 display only two ligand-centered fluorescent emissive peaks around 450 and 600 nm, and complex 4 shows four characteristic Eu(III)centered emission bands at 593, 618, 653, and 698 nm under excitation at 348 nm. Complex 1 exhibits single-molecule magnet behavior that is rationalized through ab initio calculations.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xie, SF; Huang, LQ; Zhong, L; Lai, BL; Yang, M; Chen, WB; Zhang, YQ; Dong, W or concate me.. Computed Properties of C2H4N4

An overview of features, applications of compound:1H-1,2,4-Triazol-5-amine

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Tkachenko, IG; Komykhov, SA; Gladkov, ES; Musatov, VI; Chebanov, VA; Desenko, SM or concate me.

Formula: C2H4N4. Authors Tkachenko, IG; Komykhov, SA; Gladkov, ES; Musatov, VI; Chebanov, VA; Desenko, SM in SPRINGER published article about in [Tkachenko, Irina G.; Komykhov, Sergey A.; Gladkov, Eugene S.; Musatov, Vladimir I.; Chebanov, Valentyn A.; Desenko, Sergey M.] Natl Acad Sci Ukraine, Inst Single Crystals, State Sci Inst, 60 Nauky Ave, UA-61072 Kharkov, Ukraine; [Tkachenko, Irina G.; Komykhov, Sergey A.; Gladkov, Eugene S.; Chebanov, Valentyn A.; Desenko, Sergey M.] Kharkov Natl Univ, 4 Svobody Sq, UA-61022 Kharkov, Ukraine; [Tkachenko, Irina G.] Minist Internal Affairs Ukraine, Kharkiv Forens Sci Ctr, 32 Kovtuna St, UA-61036 Kharkov, Ukraine in 2019.0, Cited 22.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Three-component reaction of 3-amino-1H-1,2,4-triazole or 5-amino-2H-1,2,3-triazole derivatives, acetaldehyde, and 1,3-dicarbonyl compounds (acetylacetone or -keto esters) in water under microwave irradiation leads to regioselective formation of 4,7-dihydro[1,2,4]-triazolo- and 4,7-dihydro[1,2,3]triazolo[1,5-a]pyrimidines. Using ethyl 4,4,4-trifluoro-3-oxobutanoate as 1,3-dicarbonyl compound under the same conditions allows to obtain the corresponding 5-hydroxy-4,5,6,7-tetrahydro derivatives, which fail to dehydrate in the reaction medium.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Tkachenko, IG; Komykhov, SA; Gladkov, ES; Musatov, VI; Chebanov, VA; Desenko, SM or concate me.

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Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Tkachenko, IG; Komykhov, SA; Gladkov, ES; Musatov, VI; Chebanov, VA; Desenko, SM or concate me.

Recommanded Product: 61-82-5. Authors Tkachenko, IG; Komykhov, SA; Gladkov, ES; Musatov, VI; Chebanov, VA; Desenko, SM in SPRINGER published article about in [Tkachenko, Irina G.; Komykhov, Sergey A.; Gladkov, Eugene S.; Musatov, Vladimir I.; Chebanov, Valentyn A.; Desenko, Sergey M.] Natl Acad Sci Ukraine, Inst Single Crystals, State Sci Inst, 60 Nauky Ave, UA-61072 Kharkov, Ukraine; [Tkachenko, Irina G.; Komykhov, Sergey A.; Gladkov, Eugene S.; Chebanov, Valentyn A.; Desenko, Sergey M.] Kharkov Natl Univ, 4 Svobody Sq, UA-61022 Kharkov, Ukraine; [Tkachenko, Irina G.] Minist Internal Affairs Ukraine, Kharkiv Forens Sci Ctr, 32 Kovtuna St, UA-61036 Kharkov, Ukraine in 2019.0, Cited 22.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

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Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Roner, MR; Carraher, CE; Miller, L; Mosca, F; Slawek, P; Haky, JE; Frank, J or concate me.

Safety of 1H-1,2,4-Triazol-5-amine. I found the field of Polymer Science very interesting. Saw the article Organotin Polymers as Antiviral Agents Including Inhibition of Zika and Vaccinia Viruses published in 2020.0, Reprint Addresses Roner, MR (corresponding author), Univ Texas Arlington, Dept Biol, Arlington, TX 76010 USA.; Carraher, CE (corresponding author), Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is the initial report of complete inhibition of the Zika virus by simple drugs. The ability to inhibit vaccinia virus is also reported. The inhibition of the vaccinia virus is shown by a number of organotin drugs including those also derived from lamivudine and camphoric acid and additional drugs derived from 3-amino-1,2,4-triazole, dicumarol, 4,6-diaminopyridine, alpha-cyano-4-hydroxcinnamic acid, and a variety of organotin polyethers including water soluble polymers derived from poly(ethylene glycol). All the drugs described in these studies are rapidly (< 30 s) synthesized using commercially available reactants at room temperature employing the interfacial reaction system that is employed industrially so that scale up to kilograms is relatively straight forward. Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Roner, MR; Carraher, CE; Miller, L; Mosca, F; Slawek, P; Haky, JE; Frank, J or concate me.

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Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mafuwe, PT; Moyo, M; Mugadza, T; Shumba, M; Nyoni, S or concate me.

An article Cobalt oxide nanoparticles anchored polyaniline-appended cobalt tetracarboxy phthalocyanine, modified glassy carbon electrode for facile electrocatalysis of amitrole WOS:000455274100030 published article about REDUCED GRAPHENE OXIDE; GOLD NANOPARTICLES; NANOCOMPOSITES; OXIDATION; BEHAVIOR; TETRAAMINOPHTHALOCYANINE; NANOSHEETS; REDUCTION; NANOTUBES; OXYGEN in [Mafuwe, Peter T.; Moyo, Mambo; Mugadza, Tawanda; Shumba, Munyaradzi] Midlands State Univ, Dept Chem Technol, Sensors Lab, P Bag 9055,Senga Rd, Gweru, Zimbabwe; [Nyoni, Steven] Chinhoyi Univ Technol, Dept Chem, Chinhoyi, Zimbabwe in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Cobalt oxide nanoparticles were anchored on polyaniline-appended cobalt phthalocyanine and used to modify glassy carbon electrodes for enhanced electrocatalytic oxidation of amitrole. The modified electrodes were characterised by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. Cyclic voltammetry, linear sweep voltammetry, chronoamperometry and differential pulse voltammetry were used to evaluate the electrocatalytic behaviour of the designed sensors. Catalytic rate constant of 6.26×10(5)M(-1)s(-1) and apparent electron transfer rate constant of 8.84×10(-3)cms(-1) were observed on CoTCPc-PANI-Co3O4NP-GCE. The adsorption equilibrium constant and Gibbs energy were 4.8×10(1)M(-1) and -12.1kJmol(-1), respectively, confirming substrate adsorption during a spontaneous reaction on the surface of the modified electrode. The limit of detection and limit of quantification were 6.61×10(-8)M and 2×10(-7)M, respectively, for the electrocatalytic detection of amitrole and only suffered 4% signal loss after repetitive ten runs in 1mM amitrole.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mafuwe, PT; Moyo, M; Mugadza, T; Shumba, M; Nyoni, S or concate me.

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Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Akrami, S; Karami, B; Farahi, M or concate me.

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article A novel protocol for catalyst-free synthesis of fused six-member rings to triazole and pyrazole published in 2020.0. Product Details of 61-82-5, Reprint Addresses Karami, B (corresponding author), Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Herein, an effectual, quick and novel method is described for the synthesis of new triazolo[1,5-a]pyrimidine, triazolo[5,1-b][1,3] thiazine and pyrazolo[1,5-a]pyrimidine derivatives. This series of fused six-member rings to triazole and pyrazole was prepared via the catalyst-free reaction of dialkyl acetylenedicarboxylates and 3-substituted 1H-1,2,4-triazole or 3-amino-1H-pyrazole-4-carbonitrile. The structures of the prepared products were deduced from their Fourier-transform infrared, elemental analysis and proton and carbon-13 nuclear magnetic resonance spectral data. Graphical abstract A novel and green method is described for the synthesis of new triazolo[1,5-a]pyrimidine, triazolo[5,1-b][1,3] thiazine and pyrazolo[1,5-a]pyrimidine derivatives. [GRAPHICS] .

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Akrami, S; Karami, B; Farahi, M or concate me.

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Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Gol, RM; Khatri, TT; Barot, VM or concate me.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. In 2019.0 CHEM HETEROCYCL COM+ published article about DESIGN; INHIBITOR; POTENT; 5-AMINOPYRAZOLE; ANAGLIPTIN; DINACICLIB; ESSRAMYCIN; PYRAZOLE in [Gol, Ravindra M.; Barot, Vijaykumar M.] Smt SM Panchal Sci Coll, Dept Chem, Talod 383215, Gujarat, India; [Khatri, Taslimahemad T.] Govt Sci Coll, Dept Chem, Chikhli 396521, Gujarat, India in 2019.0, Cited 50.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Efficient and regioselective on-water synthesis of variously substituted 5-amino-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitriles and 5-amino-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles using 1,8-diazabicyclo[5.4.0]undec-7-ene as catalyst has been demonstrated. The reaction of 2-benzylidenemalononitriles and 3-aryl-1H-pyrazol-5-amines or 1H-1,2,4-triazol-5-amine allows to obtain the respective pyrazolo[1,5-a]pyrimidines and [1,2,4]triazolo[1,5-a]pyrimidines in high yields up to 93%. Main advantages of the developed synthetic protocol are application of water as environmentally friendly solvent, short reaction times, simple workup procedure that often does not require further purification of products, and broad substrate scope.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Gol, RM; Khatri, TT; Barot, VM or concate me.