Day: October 13, 2021

In 2020.0 J BIOL INORG CHEM published article about OXYGEN SPECIES ROS; DNA-BINDING; LIGAND; CYTOTOXICITY; POTENT; SPECTROSCOPY; HETEROCYCLES; TRANSFERRIN; DERIVATIVES; RESISTANCE in [Fandzloch, Marzena] PAS, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Fandzloch, Marzena; Jezierska, Julia] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland; [Dobrzanska, Liliana; Wisniewska, Joanna; Lakomska, Iwona] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Lwowska 1, PL-87100 Torun, Poland in 2020.0, Cited 80.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Six novel ruthenium(III) complexes of general formula [RuCl3(L)(3)] (1,3,5) and [RuCl3(H2O)(L)(2)] (2,4,6), where L stands for three different triazolopyrimidine-derived ligands, are reported. The compounds have been structurally characterized (IR, EPR, SCXRD), and their magnetic moments have been determined. The single-crystal X-ray diffraction study revealed a slightly distorted octahedral geometry of the Ru(III) complexes with mer configuration in 1 and 5, and fac configuration in 3. In 2 and 4, three chloride ions are in mer configuration and the two triazolopyrimidines are oriented trans mutually with the water molecule playing the role of the sixth ligand. All complexes have been thoroughly screened for their in vitro cytotoxicity against human breast cancer cell line MCF-7, human cervical cancer cell line HeLa, and L929 murine fibroblast cells, uncovering among others that the most lipophilic complexes 5 and 6, containing the bulky ligand dptp (5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine), display high cytotoxic activity against MCF-7, and HeLa cells. Moreover, it was also revealed that during the interaction of the complexes 1-6 with the cancer MCF-7 cell line, reactive oxygen species are released intracellularly, which could indicate that they are involved in cell apoptosis. Furthermore, extensive studies have been carried out to reveal the mechanism by which complexes 1-6 interact with DNA, albumin, and apotransferrin. The biological studies were complemented by detailed kinetic studies of the hydrolysis of the complexes in the pH range 5-8, to determine the stability of the complexes in solution. Graphic abstract Six novel ruthenium(III) complexes with triazolopyrimidine derivatives demonstrated the potential for use as anticancer agents by maintaining the toxic effect on MCF-7 and HeLa cells.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Fandzloch, M; Dobrzanska, L; Jedrzejewski, T; Jezierska, J; Wisniewska, J; Lakomska, I or concate me.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Pore-size tuning in pillared-layer metal-organic framework with self-penetrated rob net for selective gas adsorption and efficient dyes adsorption in aqueous solution WOS:000474310000008 published article about COORDINATION POLYMERS; CRYSTAL-STRUCTURES; UNITS; SEPARATION; CH4; CO2; PERFORMANCE; STABILITY; TOPOLOGY; LIGANDS in [Liu, Jie; Wei, Yuhui; Bao, Fenlin; Li, Guixiang; Liu, Huiyan; Wang, Haiying] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China in 2019.0, Cited 45.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Two metal-organic frameworks, [Zn-2(atrz)(2)(bpdc)]center dot 0.5H(2)O (1) and [Zn-2(mtrz)(2)(azdc)]center dot DMA center dot CH3OH center dot H2O (2), with 3-substitued 1,2,4-triazole (Hatrz = 3-amino-1,2,4-triazole, Hmtrz = 3-methyl-1,2,4-triazole) have been constructed. Both MOFs possess 3D self-penetrated frameworks featuring Zn-triazolate layers pillared by dicarboxylate ligands (H(2)bdc = 1,4-benzenedicarboxylate, H(2)azdc = azobenzene-4,4′-dicarboxylate). In particular, 2 exhibits a rare rob network with the dimeric Zn-triazolate as the 6-connected nodes, which resulted from the synergistic effects of both 3-substitued group of triazolate and size-alterable dicarboxylate pillar on the final frameworks. Detailed structural analysis of 1 and 2 and its comparison with commonly observed pcu net in pillared-layer structure has been presented. Pore-size tuning and functionalities have also been achieved related to diverse molecular length of pillars. 2 with long pillar displays suitable pore size, and consequently, demonstrates selective CO2 uptake and efficient dyes adsorption in aqueous solution based on size-exclusion effect. (C) 2019 Elsevier Ltd. All rights reserved.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Novel bio-based core-shell organic-inorganic nanohybrid from embedding aspartic acid-guanine ionic liquid on the hydroxylated nano silica surface (nano [(Asp-Gua) IL@PEG-SiO2]): A versatile nanostructure for the synthesis of bis(2,3-dihydroquinazolin-4(1H)-one) derivatives and tricarboxamides under green media WOS:000523757900016 published article about MULTICOMPONENT REACTIONS; CATALYTIC APPLICATIONS; DESIGN; ANTICANCER; NANOCOMPOSITE in [Nikoofar, Kobra; Shahriyari, Fatemeh] Alzahra Univ, Fac Phys & Chem, Dept Chem, Tehran, Iran in 2020.0, Cited 47.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A new multi-layered nano structure has been prepared using hydroxylated nano silica (as core) and novel guaninium aspartate ionic liquid (as shell) (nano [(Asp-Gua) IL@PEG-SiO2]). It characterized by FT-IR, H-1 NMR, FESEM, EDAX, XRD, TGA/ DTG, and BET analysis. This bio-based organic-inorganic hybrid catalyzed synthesis of peptide-like tricarboxamides though the pseudo five-component condensation of aromatic aldehydes, aromatic amines, tert-butyl isocyanide, and Meldrum’s acid under green solventless conditions at room temperature successfully. Its efficacy affirmed in the preparation of bis (2,3-dihydroquinazolin-4(1H)-one) derivatives via one-pot pseudo five-component reaction of aldehydes, amines, and isatoic anhydride in 70 degrees C aqueous media. The protocol contains several advantages such as relatively short reaction times, simple work-up procedure, economic and environmentally-friend because of performing the two class of MCRs under green media, utilizing wide-range of substrates, and reusability and recoverability of the core-shell nano-promoter for 3 runs without significant activity loss. (C) 2020 Published by Elsevier Ltd.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Nikoofar, K; Shahriyari, F or concate me.. Computed Properties of C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking published in 2020.0. HPLC of Formula: C2H4N4, Reprint Addresses George, RF (corresponding author), Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11562, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

A series of 1,2,4-triazolo [1,5-a]pyrimidine derivatives was designed, synthesized and screened for their antibacterial and antifungal activities as well as their safety profile. Compounds 2b, 3a, 6b, 8b, 8c, 8h, 9a,b, 10b, 11a,b and 12a,b showed high activity against Gram-positive and Gram-negative bacteria with MIC values ranging from 0.25 to 2.0 mu g/mL. Many compounds were safe with no cytotoxicity against human embryonic kidney and red blood cells at concentration up to 32 mu g/mL. Moreover, compound 9a showed the highest inhibitory activity against DNA Gyrase with IC50 = 0.68 mu M compared to ciprofloxacin IC50 = 0.85 mu M. Molecular docking at DNA Gyrase active site revealed binding mode and docking scores comparable to that of ciprofloxacin confirming their antibacterial activity via DNA Gyrase inhibition.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Abd El-Aleam, RH; George, RF; Hassan, GS; Abdel-Rahman, HM or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J ENVIRON CHEM ENG published article about CARBON-PASTE ELECTRODE; ELECTROCATALYTIC OXIDATION; OXIDE NANOPARTICLES; SENSOR; NANOCOMPOSITE; WO3; FABRICATION; BEHAVIOR; PHTHALOCYANINE; PHOTOCATALYST in [Ilager, Davalasab; Shetti, Nagaraj P.] KLE Inst Technol, Ctr Electrochem Sci & Mat, Dept Chem, Hubballi 580027, Karnataka, India; [Seo, Hyngtak; Kalanur, Shankara S.] Ajou Univ, Dept Mat Sci & Engn, Suwon 16499, South Korea in 2020.0, Cited 70.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

The increasing health risk associated with the exposure to mutagenic, teratogenic and carcinogenic herbicide the environment has encouraged a significant interest towards the development of rapid and cheaper detection technologies for the accurate quantification. The present work involves the exploitation of catalytic oxidation herbicide, amitrole (AMT) at iron doped tungsten oxide (Fe-WO3) nanoparticles and cationic surfactant cetyltrimethylammonium bromide (CTAB) based carbon paste electrode for the sensitive quantification. The working electrode assembly of Fe-WO3/CTAB causes the catalytic oxidation via faster electron transfer compared to bare electrode. Furthermore, the physiochemical properties and thermodynamic properties of AMT were explored. Under the optimized conditions, the modified sensor exhibits good linear detection range (5.0 x 10(-8) M to 8.0 x 10(-5) M), lower limit of detection (0.82 nM) and limit of quantification (2.82 nM) by square wave voltammetric (SWV) technique. Hence, developed senor showed an intensification of peak current of AMT with significant sensitivity, selectivity and reproducibility for AMT analysis and received acceptable results indicates the application of sensors for the analysis of AMT in water as well as soil samples.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ilager, D; Seo, H; Shetti, NP; Kalanur, SS or concate me.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,4-Triazol-5-amine. Zhang, JJ; Mi, YQ; Sun, XQ; Chen, Y; Miao, Q; Tan, WQ; Li, Q; Dong, F; Guo, ZY in [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Miao, Qin; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Miao, Qin; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China published Improved Antioxidant and Antifungal Activity of Chitosan Derivatives Bearing Urea Groups in 2020.0, Cited 38.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Eight novel chitosan derivatives bearing urea groups are designed and synthesized. Fourier transform infrared spectroscopy, H-1 nuclear magnetic resonance spectrometer, and elemental analysis are performed to confirm the structural characteristics of chitosan derivatives. The antioxidant activities, including superoxide radicals’ scavenging activity, 1,1-diphenyl-2-picrylhydrazyl radicals’ scavenging activity, and hydroxyl radical’ scavenging activity, of the derivatives are explored within different concentrations in the reaction system. In vitro fungicidal activity of these compounds is further tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, F. oxysporum f. sp. cucumebrium Owen, and Botrytis cinerea, respectively, particularly compounds exhibit significant control effect at 1.0 mg mL(-1). The experimental results indicate that the products bearing urea groups show enhanced antifungal property and antioxidant activity compared with pristine chitosan. Meanwhile, their bioactivities follow some regularity on the whole, that is, they are related to the electron-withdrawing property of the different substituted groups of urea. Derivatives with stronger electron-withdrawing property will have higher biological activities. L929 cells are used to carry out cytotoxicity test of chitosan and chitosan derivatives by Cell Counting Kit-8 assay. The results indicate that some of the samples show low cytotoxicity. This research will be helpful to broaden the application of chitosan in materials.

Name: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JJ; Mi, YQ; Sun, XQ; Chen, Y; Miao, Q; Tan, WQ; Li, Q; Dong, F; Guo, ZY or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Highly efficient photocatalytic activity and mechanism of novel Er3+ and Tb3+ co-doped BiOBr/ g-C3N5 towards sulfamethoxazole degradation WOS:000677845500002 published article about VISIBLE-LIGHT; HETEROJUNCTION; NANOSHEETS; OXIDATION; COMPOSITE; REMOVAL; GREEN; BIOI in [Wei, Wei; Gong, Haoyang; Sheng, Lin; Wu, Houfan; Zhu, Shuguang] Anhui Jianzhu Univ, Sch Environm & Energy Engn, Hefei 230601, Peoples R China; [Wei, Wei; Gong, Haoyang; Sheng, Lin; Wu, Houfan; Zhu, Shuguang] Anhui Prov Key Lab Environm Pollut Control & Reso, Hefei 230601, Peoples R China; [Wei, Wei; Gong, Haoyang; Sheng, Lin; Wu, Houfan; Zhu, Shuguang] Key Lab Water Pollut Control & Wastewater Reuse A, Hefei 230601, Peoples R China; [Feng, Li; Li, Xuhao; You, Weihong] Guangdong Univ Technol, Sch Civil & Transportat Engn, Guangzhou 510006, Guangdong, Peoples R China in 2021.0, Cited 63.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Bismuth oxyhalides (BiOX (X = Cl, Br, I) are considered to be an important p-type semiconductors in the photocatalysis applications. In particular, tetragonal BiOBr is considered as a stable photocatalyst due to its resilient absorption in the visible region with an band gap energy of 2.8 eV. In the meantime, lanthanide ions (with 3+ oxidation state) implies as conversion catalyst gained huge impact and remain a serious topic in materials chemistry. Here we synthesized upconversion photocatalyst mainly consists of BiOBr with the Er 3+ and Tb 3+ ions along with low band gap g-C3N5 for the improved photocatalytic performances. The synthesized Er3+/ Tb3+@BiOBr-g-C3N5 heterojunction was systematically characterized by XRD, and FT-IR for the confirmation of the composite and their morphology were analysed with FESEM and HR-TEM analysis which revealed that the sheets of g-C3N5 were decorated by Er3+/Tb3+ loaded BiOBr microspheres. The XPS analysis confirmed the suitable oxidation state of all the individual elements existing in the composite. As the UV-DRS analysis showed that the band gap of the Er3+/Tb3+ BiOBr-gC3N5 heterojunction was narrowed to 2.64 eV. To evaluate the photocatalytic efficiency of the synthesized g-C3N5, Er3+/Tb3+@BiOBr and Er3+/Tb3+@BiOBr-gC3N5 heterojunction under the simulated visible light irradiation source towards the aqueous sulfamethoxazole degradation. The Er3+/Tb3+@BiOBr-gC3N5 heterojunction shows maximum degradation efficiency of 94.2% after 60 min of visible light irradiation whereas the pure g-C3N5 provided about 43.8% and Er3+/Tb3+@BiOBr implies 55.2% degradation efficiency. The plausible degradation mechanism of pollutant removal was proposed.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wei, W; Gong, HY; Sheng, L; Wu, HF; Zhu, SG; Feng, L; Li, XH; You, WH or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ATP CONTENT; HISTONE CROTONYLATION; OXIDATIVE STRESS; GENE-EXPRESSION; IN-VITRO; IDENTIFICATION; DYSFUNCTION; TEMPERATURE; METABOLISM; FERTILITY, Saw an article supported by the National Nature Science Foundation Project of ChinaNational Natural Science Foundation of China (NSFC) [31101714, 81901562, 31372307]. Formula: C2H4N4. Published in SPRINGER HEIDELBERG in HEIDELBERG ,Authors: Luo, YX; Zhuan, QR; Li, J; Du, XZ; Huang, ZY; Hou, YP; Fu, XW. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Type 1 diabetes (T1D) results in decreased oocyte quality and compromised early embryonic development. Procyanidin B2 (PB2) is a natural compound extracted from grape seeds and has strong antioxidant activity in vivo. This study evaluated the effect of PB2 on oocyte maturation in diabetic mice. Diabetic mice were induced by streptozotocin (STZ) injection. PB2 was supplemented in the in vitro maturation medium, and the ratio of germinal vesicle breakdown (GVBD) and polar body extrusion (PBE), reactive oxygen species (ROS) levels, mitochondrial function, developmental ability, as well as crotonylation at H4K5 were determined in oocytes. PB2 can promote the extrusion of PBE (88.34% vs. 75.02%,P < 0.05); reduce the generation of ROS (1.12 vs. 1.96,P < 0.05); and improve the level of mitochondrial membrane potential (0.87 vs. 0.79 Delta phi m,P < 0.05), ATP level (1.31 vs. 0.71 pmol,P < 0.05), and mitochondria temperature (618.25 vs. 697.39 pixels,P < 0.05). The addition of PB2 also improved the level of oocyte crotonylation at H4K5 (crH4K5) (47.26 vs. 59.68 pixels,P < 0.05) and increased the blastocyst rate (61.51% vs. 36.07%,P < 0.05) after parthenogenetic activation. Our results are the first to reveal a role for PB2 in promoting the viability of oocytes by regulating the mitochondrial function. Moreover, we uncover that PB2 can improve the level of crH4K5, which provides a new strategy to combat the decline in oocyte quality of diabetic. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Luo, YX; Zhuan, QR; Li, J; Du, XZ; Huang, ZY; Hou, YP; Fu, XW or concate me.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. In 2019.0 BRAIN RES BULL published article about NICOTINIC ACETYLCHOLINE-RECEPTORS; ENDOGENOUS HYDROGEN-PEROXIDE; CENTRAL ANGIOTENSIN-II; NITRIC-OXIDE; SMOOTH-MUSCLE; RAT-BRAIN; RELEASE; INHIBITION; VASOPRESSIN; EXPRESSION in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ UNESP, Dent Sch, Dept Physiol & Pathol, Araraquara, SP, Brazil in 2019.0, Cited 66.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O-2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv. In the present study, we investigated the effects of ATZ injected icv or intravenously (iv) on the pressor responses induced by icv injections of the cholinergic agonist carbachol, which similar to angiotensin II induces pressor responses that depend on sympathoexcitation and vasopressin release. In addition, the effects of H2O2 icv on the pressor responses to icv carbachol were also tested to compare with the effects of ATZ. Normotensive non-anesthetized male Holtzman rats (280-300 g, n = 8-9/group) with stainless steel cannulas implanted in the lateral ventricle were used. Previous injection of ATZ (5 nmol/1 mu l) or H2O2 (5 mu mol/1 mu l) icv similarly reduced the pressor responses induced by carbachol (4 nmol/1 mu l) injected icv (13 +/- 4 and 12 +/- 4 mmHg, respectively, vs. vehicle + carbachol: 30 +/- 5 mmHg). ATZ (3.6 mmol/kg of body weight) injected iv also reduced icv carbachol-induced pressor responses (21 +/- 2 mmHg). ATZ icv or iv and H2O2 icv injected alone produced no effect on baseline arterial pressure. The treatments also produced no significant change of heart rate. The results show that ATZ icv or iv reduced the pressor responses to icv carbachol, suggesting that endogenous H2O2 acting centrally inhibits the pressor mechanisms (sympathoactivation and/or vasopressin release) activated by central cholinergic stimulation.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lauar, MR; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or concate me.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article beta-N-methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development WOS:000463920200006 published article about AMYOTROPHIC-LATERAL-SCLEROSIS; 2-AMINO-3-(METHYLAMINO)-PROPANOIC ACID BMAA; INDUCED OXIDATIVE STRESS; CYANOBACTERIAL NEUROTOXIN; AMINO-ACIDS; UNLIKELY CAUSE; BRAIN; RELEASE; ALS; EXPOSURE in [van Onselen, Rianita; Downing, Tim G.] Nelson Mandela Univ, Dept Biochem & Microbiol, POB 77000, ZA-6031 Port Elizabeth, South Africa in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

The naturally produced, nonprotein amino acid beta-N-methylamino-l-alanine (BMAA) has been proposed as a significant contributor to sporadic neurodegenerative disease development worldwide. However, the existing hypothesized mechanisms of toxicity do not adequately explain the role of BMAA in neurodegenerative disease development. There is evidence for BMAA-induced enzyme inhibition, but the effect of BMAA on human stress response enzymes has received little attention, despite the well-described role of oxidative stress in neurodegenerative disease development. The aim of this study was therefore to investigate the effect of BMAA on human catalase activity and compare it to the known inhibitor 3-amino-1,2,4-triazole. BMAA inhibited human erythrocyte catalase in a cell-free exposure to the same extent as the known inhibitor. Based on enzyme kinetics, the inhibition appears to be noncompetitive, possibly as a result of BMAA binding in the nicotinamide adenine dinucleotide phosphate (NADPH) binding site. BMAA-induced catalase inhibition was also observed in a human cell line culture. We therefore propose that BMAA-induced enzyme inhibition, specifically catalase inhibition, is a mechanism of toxicity that may contribute to the neurotoxicity of BMAA, further supporting the role of BMAA in neurodegenerative disease development.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact van Onselen, R; Downing, TG or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics