October 15, 2021 | Triazoles

Top Picks: new discover of C2H4N4

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xiong, CT; Li, XQ; He, HZ; Xue, B; Wang, Y; Li, JQ; Zhu, ZW or concate me.

Xiong, CT; Li, XQ; He, HZ; Xue, B; Wang, Y; Li, JQ; Zhu, ZW in [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Natl Engn Res Ctr Novel Equipment Polymer Proc, Guangzhou 510640, Peoples R China; [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Key Lab Polymer Proc Engn, Minist Educ, Guangzhou, Peoples R China; [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Guangdong Prov Key Lab Tech & Equipment Macromol, Guangzhou, Peoples R China; [Li, Xiaoqing] Guangzhou Automobile Grp Component Co Ltd, Guangzhou, Peoples R China published A thermally reversible healingEPDMbased elastomer with higher tensile properties and damping properties in 2021.0, Cited 34.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Due to the disadvantages of lower tensile strength and fracture toughness, the widely application of Ethylene-propylene-diene-monomer rubber (EPDM) has been limited. In this study, a thermally reversible healing EPDM based elastomer with H-bonding and Zn-based-bonding dynamic cross-link network was prepared. The influence of mole ratio of ATA/MAH on tensile strength and fracture energy of mEPDM(0)-xATA was investigated. The results showed that increasing the content of ATA brings about a gradual improvement in tensile strength of the mEPDM(0)-xATA. Especially when the mole ratio of ATA/MAH is 1, the fracture energy of mEPDM(0)-ATA is dramatically enhanced to 33.9 MJ/m(3), which is best among the ratios studied in our research. After curing, the effect of ZnCl(2)content on tensile strength and fracture energy of mEPDM-ATA-nZn was also studied. Meanwhile, the uniaxial cyclic loading-unloading tensile test was used to study the viscous damping properties of mEPDM-ATA-0.4Zn, which showed reversible repair properties after heat treatment. The results of dynamic rheological measurement showed that the damping properties were improved.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xiong, CT; Li, XQ; He, HZ; Xue, B; Wang, Y; Li, JQ; Zhu, ZW or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zaharani, L; Khaligh, NG; Mihankhah, T; Johan, MR or concate me.. Recommanded Product: 61-82-5

Recommanded Product: 61-82-5. I found the field of Chemistry very interesting. Saw the article 1H,4H-Piperazine-diium Dichlorosulfonate: Structure Elucidation and its Dual Solvent-Catalyst Activity for the Synthesis of New Dihydro-[1,2,4]triazolo[1,5-a]pyrimidine Scaffolds published in 2020.0, Reprint Addresses Khaligh, NG (corresponding author), Univ Malaya, Inst Postgrad Studies, Nanotechnol & Catalysis Res Ctr, Kuala Lumpur 50603, Malaysia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

A new ionic liquid containing a 1H,4H-piperazine-diium ring and chlorosulfonate as a 1,4-dicationic core and counter ion, respectively, was designed and synthesised. The structure elucidation of this ionic liquid was conducted by 1D and 2D NMR, FT-IR, Raman, and mass spectrum analysis. The physical properties of this ionic liquid were determined and reported. Furthermore, the dual solvent-catalyst activity of piperazine-1,4-diium dichlorosulfonate was investigated for the synthesis of new dihydro[1,2,4]triazolo[1,5-a]pyrimidines through a one-pot three-component reaction. The ionic liquid was retrieved and reused several times without reducing its catalytic efficiency.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zaharani, L; Khaligh, NG; Mihankhah, T; Johan, MR or concate me.. Recommanded Product: 61-82-5

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Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yu, L; Xiong, SS; Lin, YH; Li, LY; Peng, JJ; Liu, W; Huang, XX; Wang, H; Li, J or concate me.

Recently I am researching about XENON ADSORPTION; SEPARATION, Saw an article supported by the Shenzhen Polytechnic. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yu, L; Xiong, SS; Lin, YH; Li, LY; Peng, JJ; Liu, W; Huang, XX; Wang, H; Li, J. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Recommanded Product: 61-82-5

Two ultramicroporous metal-organic frameworks, Zn(ox)(0.5)(trz) and Zn(ox)(0.5)(atrz) (ox = oxalate, trz = triazolate, and atrz = 3-aminotriazolate), have been synthesized and tested for the adsorptive separation of Xe and Kr. We demonstrate that the Xe/Kr adsorption selectivity relates to the pore size as well as the structure flexibility of the adsorbents.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yu, L; Xiong, SS; Lin, YH; Li, LY; Peng, JJ; Liu, W; Huang, XX; Wang, H; Li, J or concate me.

Extracurricular laboratory: Synthetic route of C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

An article Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy WOS:000526392600030 published article about GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; CANCER-CELLS; CATALASE; GENERATION; ENZYME; NANOMATERIALS; MECHANISMS; OXIDATION in [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; You, Yawen; Deng, Qingqing] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; [Li, Wei; Zhang, Lu] Univ Chinese Acad Sci, Beijing 100039, Peoples R China in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

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Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Redenti, S; Marcovich, I; De Vita, T; Perez, C; De Zorzi, R; Demitri, N; Perez, DI; Bottegoni, G; Bisignano, P; Bissaro, M; Moro, S; Martinez, A; Storici, P; Spalluto, G; Cavalli, A; Federico, S or concate me.

Recently I am researching about PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; PROTEIN-KINASES; PHOSPHORYLATION; MODEL; CK1; TAU, Saw an article supported by the MIURMinistry of Education, Universities and Research (MIUR) [PRIN2010W4779]; UniTS (FRA2013); MEIC [SAF2012_37979_CO3_01, SAF2016-76693-R]. Formula: C2H4N4. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Redenti, S; Marcovich, I; De Vita, T; Perez, C; De Zorzi, R; Demitri, N; Perez, DI; Bottegoni, G; Bisignano, P; Bissaro, M; Moro, S; Martinez, A; Storici, P; Spalluto, G; Cavalli, A; Federico, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Glycogen synthase kinase 3 beta (GSK-3 beta) and casein kinase 1 delta (CK-1 delta) are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson’s disease. An inhibitor able to target these two kinases was developed by docking-based design. Compound 12, 3-(7-amino-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)-2-cyanoacrylamide, showed combined inhibitory activity against GSK-3 beta and CK-1 delta [IC50(GSK-3 beta)=0.17 mu m; IC50(CK-1 delta)=0.68 mu m]. In particular, classical ATP competition was observed against CK-1 delta, and a co-crystal of compound 12 inside GSK-3 beta confirmed a covalent interaction between the cyanoacrylamide warhead and Cys199, which could help in the development of more potent covalent inhibitors of GSK-3 beta. Preliminary studies on in vitro models of Parkinson’s disease revealed that compound 12 is not cytotoxic and shows neuroprotective activity. These results encourage further investigations to validate GSK-3 beta/CK-1 delta inhibition as a possible new strategy to treat neuroinflammatory/degenerative diseases.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Hulin, M; Leroux, C; Mathieu, A; Gouzy, A; Berthet, A; Boivin, A; Bonicelli, B; Chubilleau, C; Hulin, A; Garziandia, EL; Mamy, L; Millet, M; Pernot, P; Quivet, E; Scelo, AL; Merlo, M; Ruelle, B; Bedos, C or concate me.. Computed Properties of C2H4N4

I found the field of Environmental Sciences & Ecology very interesting. Saw the article Monitoring of pesticides in ambient air: Prioritization of substances published in 2021.0. Computed Properties of C2H4N4, Reprint Addresses Hulin, M (corresponding author), ANSES, Risk Assessment Dept, 14 Rue Pierre & Marie Curie, F-94701 Maisons Alfort, France.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Despite the richness of data collected on pesticide concentrations in ambient air in France, knowledge on this topic remains partial and heterogeneous in the absence of specific regulations. The population exposure remains thus difficult to estimate; therefore it was necessary to define modalities for implementing national monitoring of pesticides in ambient air in metropolitan France and in the overseas territories. The objective of this work was to identify which active substances (a.s.) have to be monitored in priority. As part of a collective expertise, a group of multidisciplinary experts has developed a method to rank active substances authorised as plant protection products, biocides and antiparasitic agents, which were available on the French market in 2015. A 3-steps approach has been developed. The first step consisted of a theoretical approach based on a hierarchy of substances according to four criteria: (a) national uses, (b) emission potential to the air, (c) persistence in the air, and (d) chronic toxicity. The three first criteria give information on their potential to be present in the atmosphere, and the fourth criterion allows to consider their potential of hazard. The second step was an observational approach based on existing database on pesticide air measurements in France. In the third step, both approaches were combined using decision trees to select priority pesticides. Among the 1316 a.s. first identified from the EU Pesticides database, 90 were selected, among which 43 required metrological and/or analytical development. The experts recommended confirming the relevance of performing a longer term monitoring of these a.s. after a one-year exploratory campaign. The proposed method is reproduceable, transparent, easy to update (e.g. in the light of a change in product authorization), and can be adapted to other agricultural and geographical conditions, and objectives (e.g. monitoring of the ecotoxicological effects of pesticides). (C) 2020 Published by Elsevier B.V.

Extracurricular laboratory: Synthetic route of C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S or concate me.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S in [Zorn, Kimberley M.; Foil, Daniel H.; Lane, Thomas R.; Ekins, Sean] Collaborat Pharmaceut Inc, Raleigh, NC 27606 USA; [Russo, Daniel P.] Rutgers State Univ, Ctr Computat & Integrat Biol, Camden, NJ 08102 USA; [Hillwalker, Wendy; Feifarek, David J.; Jones, Frank; Klaren, William D.; Brinkman, Ashley M.] SC Johnson & Son Inc, Global Prod Safety, Racine, WI 53404 USA published Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction in 2020.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The U.S. Environmental Protection Agency (EPA) periodically releases in vitro data across a variety of targets, including the estrogen receptor (ER). In 2015, the EPA used these data to construct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrine disruption testing. However, mathematical models require in vitro data prior to predicting estrogenic activity, but machine learning methods are capable of prospective prediction from the molecular structure alone. The current study describes the generation and evaluation of Bayesian machine learning models grouped by the EPA’s ER agonist pathway model using multiple data types with proprietary software, Assay Central. External predictions with three test sets of in vitro and in vivo reference chemicals with agonist activity classifications were compared to previous mathematical model publications. Training data sets were subjected to additional machine learning algorithms and compared with rank normalized scores of internal five-fold cross-validation statistics. External predictions were found to be comparable or superior to previous studies published by the EPA. When assessing six additional algorithms for the training data sets, Assay Central performed similarly at a reduced computational cost. This study demonstrates that machine learning can prioritize chemicals for future in vitro and in vivo testing of ER agonism.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Category: Triazoles

In 2020.0 PROT MET PHYS CHEM+ published article about VOLATILE; STEEL in [Goncharova, O. A.; Kuznetsov, D. S.; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 17.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (potentiometric anode polarization and electrochemical impedance spectroscopy), and corrosion (periodic moisture condensation test) methods, the properties of adsorption films formed on the AMg6 aluminum alloy surface by the chamber method in vapors of some amines of heterocyclic compounds, carboxylic acids, and their salts are studied. It is established that the use of the studied compounds in the chamber processing of the alloy increases-though not effectively enough-its corrosion resistance in a humid atmosphere. The most promising inhibitors are carboxylic acids themselves; the optimum temperature for surface treatment with them is 140 degrees C. One-hour treatment of steel with pairs of oleic, neodecanoic acid, and carboxylic acid A at this temperature gives rise to the formation of nanoscale adsorption films on the AMg6 alloy, which slightly hydrophilize the surface, but possess a protective aftereffect. Apparently, further improvement of chamber protection methods of the AMg6 alloy should consist in the selection of synergists for chamber corrosion inhibitors of the carboxylate type.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Category: Triazoles

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Halawa, AH; Eskandrani, AA; Elgammal, WE; Hassan, SM; Hassan, AH; Ebrahim, HY; Mehany, ABM; El-Agrody, AM; Okasha, RM or concate me.. Computed Properties of C2H4N4

An article Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors WOS:000502786800074 published article about CARBONIC-ANHYDRASE INHIBITORS; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITIES; DERIVATIVES; PYRAZOLE; ANTICANCER; DOCKING; COMPLEXES; RELEASE in [Halawa, Ahmed H.; Elgammal, Walid E.; Hassan, Saber M.; Hassan, Ahmed H.; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Cairo 11284, Egypt; [Eskandrani, Areej A.; Okasha, Rawda M.] Taibah Univ, Fac Sci, Chem Dept, Medina 30002, Saudi Arabia; [Hassan, Ahmed H.] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia; [Ebrahim, Hassan Y.] Helwan Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11795, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11284, Egypt in 2019.0, Cited 65.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellular signal-regulated kinases (ERK1/2) are focal serine/threonine kinases in the MAP kinase module with numerous cytosolic and nuclear mitogenic effector proteins. Subsequently, hampering the ERK kinase activity by small molecule inhibitors is a robust strategy to control the malignancies with aberrant MAP kinase signaling cascades. Consequently, new heterocyclic compounds, containing a sulfonamide moiety, were rationally designed, aided by the molecular docking of the starting reactant 1-(4-((4-methylpiperidin-1-yl)sulfonyl)phenyl)ethan-1-one (3) at the ATP binding pocket of the ERK kinase domain, which was relying on the molecular extension tactic. The identities of the synthesized compounds (4-33) were proven by their spectral data and elemental analysis. The target compounds exhibited pronounced anti-proliferative activities against the MCF-7, HepG-2, and HCT-116 cancerous cell lines with potencies reaching a 2.96 mu M for the most active compound (22). Moreover, compounds 5, 9, 10b, 22, and 28 displayed a significant G2/M phase arrest and induction of the apoptosis, which was confirmed by the cell cycle analysis and the flow cytometry. Thus, the molecular extension of a small fragment bounded at the ERK kinase domain is a valid tactic for the rational synthesis of the ERK inhibitors to control various human malignancies.

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HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Glorian, J; Han, KT; Braun, S; Baschung, B or concate me.

An article Heat of Formation of Triazole-Based Salts: Prediction and Experimental Validation WOS:000591762100001 published article about ACCURATE THERMOCHEMICAL PROPERTIES; ENERGETIC MATERIALS APPLICATIONS; NITROGEN-RICH SALTS; SENSITIVITY; PRECURSORS; FAMILY in [Glorian, Julien; Han, Kyung-Tae; Braun, Silke; Baschung, Barbara] French German Res Inst St Louis, Propellant & Energet Mat PEM Grp, 5 Rue Gen Cassagnou, F-68300 St Louis, France in 2021.0, Cited 43.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

This work contributes to the growing interest in predictions linked with energetic salts. A reliable method to accurately compute the heat of formation of triazole-based salts was investigated. Calculations were based on Born-Haber energy cycles: gas-phase enthalpy of ions and lattice enthalpy were calculated separately. Ten triazole-based salts were synthesized and fully characterized. Their heat of combustion was measured by bomb calorimeter. Gas-phase heat of formation of cations and anions were computed at four different levels of theory: B3LYP 6-31G(d,p), CBS-4M, CBS-QB3, and G4. Ionic volumes were calculated at the B3LYP 6-31G(d,p) level with and without corrections. Lattice enthalpy estimations, based on calculated ionic volumes, were performed with the help of Jenkins and Gutowski methods. Combinations of the obtained results (gas-phase enthalpy of ions and lattice enthalpy) were used in the Born-Haber approach to predict solid phase enthalpy of formation of studied energetic salts. Direct comparison with experimental measurements enabled the identification of the most reliable path for energetic salt standard enthalpy of formation prediction.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Glorian, J; Han, KT; Braun, S; Baschung, B or concate me.