October 18, 2021 | Triazoles

Chemical Research in 1H-1,2,4-Triazol-5-amine

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact El Azab, IH; Elkanzi, NAA or concate me.

Computed Properties of C2H4N4. El Azab, IH; Elkanzi, NAA in [El Azab, Islam H.] Taif Univ, Fac Sci, Chem Dept, POB 888, At Taif 2974, Saudi Arabia; [Elkanzi, Nadia A. A.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia published An Efficient Synthetic Approach Towards Benzo[b]pyrano[2,3-e][1,4]diazepines, and Their Cytotoxic Activity in 2020.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In search of unprecedented tri and/or tetrapod pharmacophoric conjugates, a series of 32 new 4-ethyl-1H-benzo[b][1,4]diazepin-2(3H)-ones were synthesized and properly elucidated using MS, IR, NMR, and elemental analysis. In vitro investigation of 11 compounds of this series, using a panel of two human tumor cell lines namely; human breast adenocarcinoma (MCF-7), and human colorectal carcinoma (HCT-116), revealed promising cytotoxic activities. Among all synthesized compounds, analogue 9 displayed maximum cytotoxicity with IC50 values of 16.19 +/- 1.35 and 17.16 +/- 1.54 mu M against HCT-116 and MCF-7, respectively, compared to standard drug doxorubicin.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact El Azab, IH; Elkanzi, NAA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Discover the magic of the C2H4N4

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Althagafi, I; El-Metwaly, N; Farghaly, TA or concate me.

An article New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking WOS:000469518100100 published article about BIOLOGICAL EVALUATION; BIS-THIAZOLES; ANTI-HCV; INHIBITORS; DESIGN; IDENTIFICATION; POTENT; AGENTS; THIADIAZOLES; COMPLEXES in [Althagafi, Ismail; El-Metwaly, Nashwa; Farghaly, Thoraya A.] Umm Al Qura Univ, Fac Sci Appl, Dept Chem, Mecca 21514, Saudi Arabia; [El-Metwaly, Nashwa] Mansoura Univ, Dept Chem, Fac Sci, Mansoura 002050, Egypt; [Farghaly, Thoraya A.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt in 2019.0, Cited 41.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Based on the extensive biological activities of thiazole derivatives against different types of diseases, we are interested in the effective part of many natural compounds, so we synthesized a new series of compounds containing di-, tri- and tetrathiazole moieties. The formation of such derivatives proceeded via reaction of 2-bromo-1-(4-methyl-2-(methylamino)thiazol-5-yl)ethan-1-one with heterocyclic amines, o-aminothiophenol and thiosemicarbazone derivatives. The structure and mechanistic pathways for all products were discussed and proved based on spectral results, in addition to conformational studies. Our aim after the synthesis is to investigate their antimicrobial activity against various types of bacteria and fungi species. Preceeding such an investigation, a molecular docking study was carried out with selected conformers, as representative examples, against three pathogen-proteins. This preliminary stage could support the biological application. The potency of these compounds as antimicrobial agents has been evaluated. The results showed that derivatives which have di- and trithiazole rings displayed high activity that exceeds the used standard antibiotic.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Althagafi, I; El-Metwaly, N; Farghaly, TA or concate me.

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COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Voitekhovich, SV; Grigoriev, YV; Lyakhov, AS; Matulis, VE; Ivashkevich, LS; Bogomyakov, AS; Lavrenova, LG; Ivashkevich, OA or concate me.

Authors Voitekhovich, SV; Grigoriev, YV; Lyakhov, AS; Matulis, VE; Ivashkevich, LS; Bogomyakov, AS; Lavrenova, LG; Ivashkevich, OA in PERGAMON-ELSEVIER SCIENCE LTD published article about MAGNETIC-PROPERTIES; CRYSTAL-STRUCTURE; COORDINATION POLYMERS; CHAINS; LIGANDS; PROTON; THERMODYNAMICS; PERFORMANCE; TETRAZOLES; STRATEGY in [Voitekhovich, Sergei V.; Grigoriev, Yuri, V; Lyakhov, Alexander S.; Matulis, Vadim E.; Ivashkevich, Ludmila S.] Belarusian State Univ, Res Inst Phys Chem Problems, Leningradskaya 14, Minsk 220006, BELARUS; [Bogomyakov, Artem S.] Russian Acad Sci, Int Tomog Ctr, Siberian Branch, Inst Skaya 3a, Novosibirsk 630090, Russia; [Lavrenova, Ludmila G.] Russian Acad Sci, Nikolaev Inst Inorgan Chem, Siberian Branch, Acad Lavrentiev Ave 3, Novosibirsk 630090, Russia; [Ivashkevich, Oleg A.] Belarusian State Univ, Nezalezhnasti Ave 4, Minsk 220050, BELARUS in 2020.0, Cited 55.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

1-(1,2,4-Triazol-3-yl)-1H-tetrazole (trt) and 1-(1-tert-butyl-1,2,4-triazol-3-yl)-1H-tetrazole (btrt) were synthesized by heterocyclization of corresponding amines with triethyl orthoformate and sodium azide. The interaction of trt with copper(II) chloride in ethanol in the presence of hydrochloric acid was found to result in 10 coordination polymer [CuCl2(trt)(H2O)](n)center dot nH(2)O. N-tert-butylated ligand btrt reacts with the copper salt in ethanol giving 2D coordination polymer [CuCl2(btrt)](n). Tetrazole ring-opening reaction with the formation of [CuCl2(3-amino-1,2,4-triazolium)(2)][CuCl4]center dot 2H(2)O was observed in the interaction of trt with copper(II) chloride in aqueous hydrochloric acid. The temperature-dependent magnetic susceptibility measurements of [CuCl2(btrt)](n) revealed that the copper(II) ions were weakly ferromagnetically coupled showing a coupling constant J of 1.2 cm(-1). (C) 2019 Elsevier Ltd. All rights reserved.

Chemical Research in C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mei, J; Liu, WF; Huang, JH; Qiu, XQ or concate me.

An article Lignin-Reinforced Ethylene-Propylene-Diene Copolymer Elastomer via Hydrogen Bonding Interactions WOS:000464437200017 published article about CROSS-LINKING; RUBBER; EXTRACTION in [Mei, Jie; Liu, Weifeng; Huang, Jinhao; Qiu, Xueqing] South China Univ Technol, Sch Chem & Chem Engn, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China; [Qiu, Xueqing] South China Univ Technol, State Key Lab Pulp & Paper Engn, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China in 2019.0, Cited 27.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

It is still a great challenge to prepare lignin/polyolefin composites with good strength and toughness. Inspired by the energy sacrificial mechanism from biomaterials, dynamic hydrogen bonds (H-bonds) are incorporated into the lignin/ethylene-propylene-diene monomer (EPDM) composite system to improve the interfacial interactions between lignin and EPDM. Such H-bonding interactions are demonstrated to be able to simultaneously improve the modulus, strength, and toughness of lignin/EPDM composites without sacrificing the extensibility. This work provides a facile method for the high-valued utilization of lignin in the preparation of high-performance elastomer composites using bio-renewable resources as reinforcing agent.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mei, J; Liu, WF; Huang, JH; Qiu, XQ or concate me.

What kind of challenge would you like to see in a future of compound:1H-1,2,4-Triazol-5-amine

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or concate me.

COA of Formula: C2H4N4. Recently I am researching about AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; MOLECULAR HYBRIDIZATION; EFFICIENT SYNTHESIS; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773562, 81703326]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M630840, 2019T120641]; Scientific Program of Henan Province [182102310123]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Final Thoughts on Chemistry for C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Landin, EJB; Lovera, S; de Fabritiis, G; Kelm, S; Mercier, J; McMillan, D; Sessions, RB; Taylor, RJ; Sands, ZA; Joedicke, L; Crump, MP or concate me.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. In 2019.0 ANGEW CHEM INT EDIT published article about PROTEIN-COUPLED RECEPTOR; CRYSTAL-STRUCTURE; LIGAND-BINDING; A(2A) RECEPTOR; PATHWAYS; DYNAMICS in [Landin, Erik J. B.; Crump, Matthew P.] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Kelm, Sebastian; McMillan, David; Taylor, Richard J.; Joedicke, Lisa] UCB Celltech, 216 Bath Rd, Slough SL1 3WE, Berks, England; [Lovera, Silvia; Mercier, Joel; Sands, Zara A.] UCB Biopharma, 1 Chemin Foriest, B-1420 Braine Lalleud, Belgium; [de Fabritiis, Gianni] Acellera, Barcelona Biomed Res Pk PRBB,C Doctor Aiguader 88, Barcelona 08003, Spain; [de Fabritiis, Gianni] Passeig Lluis Co 23, ICREA, Barcelona 08010, Spain; [Sessions, Richard B.] Univ Bristol, Biomed Sci, Bristol BS8 1TD, Avon, England in 2019.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The widely expressed G-protein coupled receptors (GPCRs) are versatile signal transducer proteins that are attractive drug targets but structurally challenging to study. GPCRs undergo a number of conformational rearrangements when transitioning from the inactive to the active state but have so far been believed to adopt a fairly conserved inactive conformation. Using (FNMR)-F-19 spectroscopy and advanced molecular dynamics simulations we describe a novel inactive state of the adenosine 2A receptor which is stabilised by the aminotriazole antagonist Cmpd-1. We demonstrate that the ligand stabilises a unique conformation of helix V and present data on the putative binding mode of the compound involving contacts to the transmembrane bundle as well as the extracellular loop 2.

The Best Chemistry compound:61-82-5

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Antil, B; Ranjan, R; Gopinath, CS; Deka, S or concate me.

An article Directed holey and ordered g-C(3)N(4.5)nanosheets by a hard template nanocasting approach for sustainable visible-light hydrogen evolution with prominent quantum efficiency WOS:000546391600041 published article about GRAPHITIC CARBON NITRIDE; PHOTOCATALYTIC H-2 EVOLUTION; POLYMERIC PHOTOCATALYST; ELECTRON-TRANSFER; SURFACE-AREA; NANOSHEETS; WATER; NANOPARTICLES; G-C3N4; DOTS in [Antil, Bindu; Deka, Sasanka] Univ Delhi, Dept Chem, Nanochem Lab, North Campus, Delhi 110007, India; [Ranjan, Ravi; Gopinath, Chinnakonda S.] CSIR, Catalysis & Inorgan Chem Div, Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Ranjan, Ravi; Gopinath, Chinnakonda S.] CSIR, Acad Sci & Innovat Res AcSIR, Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India in 2020.0, Cited 47.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

It is desirable yet challenging to synthesize a highly ordered holey carbon nitride material with excess nitrogen atoms for a sustainable solar H(2)evolution. Herein, we report the development of directed highly ordered nitrogen-rich honeycomb-like mesoporous carbon nitride nanosheets by using a novel synthetic approach for this purpose. The unique formation route, surface structure and charge carrier dynamics of the two dimensional holey nanosheets are comprehensively monitored and confirmed by SAXS, HRTEM, AFM, BET, XPS and TRPL analyses. Non-stoichiometric high nitrogen content mesoporous nanosheets with the final stoichiometry of g-C(3)N(4.5)acquiring a high specific surface area (382 m(2)g(-1)), remarkable pore size (7.2 nm) and sheet thickness similar to 5-6 nm are realized in this first report. This elegant material possesses unique low band-gap energy (2.42 eV). Remarkably, the as-synthesized g-C(3)N(4.5)NSs exhibit a record high photocatalytic H(2)evolution rate of 8180 mu mol g(-1)h(-1)under the present light irradiation (420 <=lambda <= 510 nm) condition. The apparent quantum efficiency is found to be as high as 27.14% at 420 nm and retains its photocatalytic activity for longer consecutive catalytic cycles. Bigger pore size and pore volume, and thin walls leading to shortening of the path length of exciton pairs, efficient charge separation and the prolonged average life time of the charge carriers, and lone electron pairs associated with the excess nitrogen content are found to be the reasons behind the excellent visible light driven water splitting reaction. Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Antil, B; Ranjan, R; Gopinath, CS; Deka, S or concate me.

You Should Know Something about 1H-1,2,4-Triazol-5-amine

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Drokin, RA; Tiufiakov, DV; Voinkov, EK; Slepukhin, PA; Ulomsky, EN; Esaulkova, YL; Volobueva, AS; Lantseva, KS; Misyurina, MA; Zarubaev, VV; Rusinov, VL or concate me.

In 2021.0 CHEM HETEROCYCL COM+ published article about ETIOTROPIC THERAPY; INFLUENZA; PRECURSOR; ARVI in [Drokin, Roman A.; Tiufiakov, Dmitrii V.; Voinkov, Egor K.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia; [Slepukhin, Pavel A.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, 22-20 Sofyi Kovalevskoi St, Ekaterinburg 620108, Russia; [Esaulkova, Yana L.; Volobueva, Alexandrina S.; Misyurina, Mariya A.; Zarubaev, Vladimir V.] St Petersburg Pasteur Res Inst Epidemiol & Microb, 14 Mira St, St Petersburg 197101, Russia; [Lantseva, Kristina S.] St Petersburg State Univ, 7-9 Univ Embankment, St Petersburg 199034, Russia in 2021.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

An azo coupling reaction of alpha-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-c][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Downstream Synthetic Route Of C2H4N4

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mei, J; Liu, WF; Huang, JH; Qiu, XQ or concate me.

Chemical Properties and Facts of 1H-1,2,4-Triazol-5-amine

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP or concate me.

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 TOXICOL IN VITRO published article about INDUCED OXIDATIVE STRESS; HYDROGEN-PEROXIDE; SUPEROXIDE-DISMUTASE; C-ABL; CELLS; ANTIOXIDANT; EXPRESSION; GENE; DOXORUBICIN; GLUTATHIONE in [Grilo, Luis F.; Martins, Joao D.; Cavallaro, Chiara H.; Oliveira, Paulo J.; Pereira, Susana P.] CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, Cantanhede, Portugal; [Nathanielsz, Peter W.] Coll Agr & Nat Resources, Dept Anim Sci, Laramie, WY USA; [Pereira, Susana P.] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal in 2020.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways involving H2O2. Detoxification and control of H2O2 levels results mainly from catalase activity. The aim of this work was to develop a precise, simple, cost-effective microassay to measure catalase activity in small tissue samples and cell extracts. We developed a protocol that quantifies H2O2 decomposition by intrinsic catalase in biological samples. Catalase activity was calculated based on rate of decomposition of H2O2, following absorbance at 240 nm. We developed a multi-well spectroscopic approach, reducing sample quantity requirements and allowing simultaneous assessment of large number of samples. The protocol is sensitive across a wide range of catalase activity (11.5-7575 U). The assay presents a 95% confidence interval with an intra-assay coefficient of variation of 3.7%, an inter-assay coefficient of variation of 6.2% and good correlation with a commercial kit. The assay was established and validated for different biological samples, including sheep hepatic tissue and human tumor and non-tumor cell lines. This high-throughput method is robust, sensitive, time-saving and cost-effective, generating highly reproducible results with precision and good correlation with a commercial kit reinforcing the method’s validity for research and toxicological applications.