Day: October 27, 2021

Authors Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY in WILEY published article about GENE-EXPRESSION; STRESS-RESPONSE; ARABIDOPSIS; CATALASE; TOLERANCE; BINDING; PLANTS; FAMILY; HOMEOSTASIS; CAT2 in [Zhao, Qiang; Liu, Xin] Qingdao Agr Univ, Coll Hort, Qingdao, Peoples R China; [Hu, Ri-Sheng; Li, Yang-Yang] Hunan Tobacco Res Inst, Changsha, Hunan, Peoples R China; [Liu, Dan] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao, Shandong, Peoples R China; [Xiang, Xiao-Hua] Haikou Cigar Res Inst, Haikou, Hainan, Peoples R China in 2020.0, Cited 66.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Drought stress often limits plant growth and global crop yields. Catalase (CAT)-mediated hydrogen peroxide (H2O2) scavenging plays an important role in the adaptation of plant stress responses, but the transcriptional regulation of the CAT gene in response to drought stress is not well understood. Here, we isolated an APETALA2/ETHYLENE-RESPONSIVE FACTOR (AP2/ERF) domain-containing transcription factor (TF), NtERF172, which was strongly induced by drought, abscisic acid (ABA) and H2O2, from tobacco (Nicotiana tabacum) by yeast one-hybrid screening. NtERF172 localized to the nucleus and acted as a transcriptional activator. Chromatin immunoprecipitation, yeast one-hybrid assays, electrophoretic mobility shift assays and transient expression analysis assays showed that NtERF172 directly bound to the promoter region of the NtCAT gene and positively regulated its expression. Transgenic plants overexpressing NtERF172 displayed enhanced tolerance to drought stress, whereas suppression of NtERF172 decreased drought tolerance. Under drought stress conditions, the NtERF172-overexpressed lines showed higher catalase activity and lower accumulation of H2O2 compared with wild-type (WT) plants, while the NtERF172-silenced plants showed the inverse correlation. Exogenous application of amino-1,2,4-triazole (3-AT), an irreversible CAT inhibitor, to the NtERF172-overexpression lines showed decreased catalase activity and drought tolerance, and increased levels of cellular H2O2. Knockdown of NtCAT in the NtERF172-overexpression lines displayed a more drought stress-sensitive phenotype than NtERF172-overexpression lines. We propose that NtERF172 acts as a positive factor in drought stress tolerance, at least in part through the regulation of CAT-mediated H2O2 homeostasis.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 J INORG ORGANOMET P published article about STRUCTURAL-CHARACTERIZATION; ANTICANCER; POLYESTERS; DIHALIDES; ABILITY; ABC/3TC in [Roner, Michael R.; Miller, Lindsey] Univ Texas Arlington, Dept Biol, Arlington, TX 76010 USA; [Carraher, Charles E., Jr.; Mosca, Francisca; Slawek, Paul; Haky, Jerome E.; Frank, Jessica] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA in 2020.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is the initial report of complete inhibition of the Zika virus by simple drugs. The ability to inhibit vaccinia virus is also reported. The inhibition of the vaccinia virus is shown by a number of organotin drugs including those also derived from lamivudine and camphoric acid and additional drugs derived from 3-amino-1,2,4-triazole, dicumarol, 4,6-diaminopyridine, alpha-cyano-4-hydroxcinnamic acid, and a variety of organotin polyethers including water soluble polymers derived from poly(ethylene glycol). All the drugs described in these studies are rapidly (< 30 s) synthesized using commercially available reactants at room temperature employing the interfacial reaction system that is employed industrially so that scale up to kilograms is relatively straight forward. Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Roner, MR; Carraher, CE; Miller, L; Mosca, F; Slawek, P; Haky, JE; Frank, J or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Ye, YJ; Nikovics, K; To, A; Lepiniec, L; Fedosejevs, ET; Van Doren, SR; Baud, S; Thelen, JJ in NATURE RESEARCH published article about CARRIER PROTEIN; ARABIDOPSIS; SPINACH; LIGHT; BIOSYNTHESIS; WRINKLED1; COENZYME; PHOSPHORYLATION; ACCUMULATION; GENES in [Ye, Yajin; Fedosejevs, Eric T.; Van Doren, Steven R.; Thelen, Jay J.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Biochem, 1201 E Rollins, Columbia, MO 65211 USA; [Nikovics, Krisztina; To, Alexandra; Lepiniec, Loic; Baud, Sebastien] Univ Paris Saclay, AgroParisTech, Inst Jean Pierre Bourgin, INRAE,CNRS, F-78000 Versailles, France in 2020.0, Cited 60.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully understood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains. We report here the identification of a gene family encoding for three small plastidial proteins of the envelope membrane that interact with the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechanism restraining FAS in the light. Light enhances the interaction between carboxyltransferase interactors (CTIs) and alpha-CT, which in turn attenuates carbon flux into FAS. Knockouts for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in leaves, more than 4-fold higher than in wild-type plants. Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regulates CTI1 expression by direct binding to its promoter. This study reveals that in addition to light-dependent activation, envelope docking of ACCase permits fine-tuning of fatty acid supply during the plant life cycle.

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ye, YJ; Nikovics, K; To, A; Lepiniec, L; Fedosejevs, ET; Van Doren, SR; Baud, S; Thelen, JJ or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis, Characterization, and DFT Calculations of Quinoline and Quinazoline Derivatives WOS:000579454600025 published article about DENSITY-FUNCTIONAL THERMOCHEMISTRY; BEARING BRIDGEHEAD NITROGEN; SPECTROSCOPIC CHARACTERIZATION; SMALL-MOLECULE; POTENT; OPTIMIZATION; INHIBITORS; AMETOCTRADIN; POLYMERASE; AGENTS in [Mohamed, H. S.] Beni Suef Univ, Res Inst Med & Aromat Plants, Bani Suwayf 62511, Egypt; [Abdel-Latif, M. K.; Ahmed, S. A.] Beni Suef Univ, Fac Sci, Dept Chem, Bani Suwayf 62511, Egypt in 2020.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Treatment of 3-methylcyclohexanone with ethyl formate in the presence of sodium methoxide afforded sodium (2-methyl-6-oxocyclohexylidene)methanolate which reacted with aminopyrazoles, aminotriazole, and aminotetrazole to produce fused quinazoline derivatives; its reactions with cyanothioacetamide, cyanoacetamide, and cyanoacetohydrazide gave tetrahydroquinoline-3-carbonitrile derivatives. The reactions of 8-methyl-2-sulfanyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile with alkylating agents led to the formation of thieno[2,3-b]quinoline derivatives. DFT computational studies of the synthesized compounds were carried out using B3LYP/6-311+G** and HF/6-311+G** approximations. The calculated HOMO and LUMO energies showed that charge transfer occurs in their molecules.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohamed, HS; Abdel-Latif, MK; Ahmed, SA or concate me.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Abd El-Aleam, RH; George, RF; Hassan, GS; Abdel-Rahman, HM in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about CATALYTIC INHIBITORS; DISCOVERY; DESIGN in [Abd El-Aleam, Rehab H.] Modern Univ Technol & Informat MTI, Fac Pharm, Pharmaceut Chem Dept, Cairo 11571, Egypt; [George, Riham F.; Hassan, Ghaneya S.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11562, Egypt; [Hassan, Ghaneya S.] Badr Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11829, Egypt; [Abdel-Rahman, Hamdy M.] Assiut Univ, Fac Pharm, Med Chem Dept, Assiut 71526, Egypt; [Abdel-Rahman, Hamdy M.] Nahda Univ, Fac Pharm, Pharmaceut Chem Dept, Bani Suwayf, Egypt in 2020.0, Cited 20.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A series of 1,2,4-triazolo [1,5-a]pyrimidine derivatives was designed, synthesized and screened for their antibacterial and antifungal activities as well as their safety profile. Compounds 2b, 3a, 6b, 8b, 8c, 8h, 9a,b, 10b, 11a,b and 12a,b showed high activity against Gram-positive and Gram-negative bacteria with MIC values ranging from 0.25 to 2.0 mu g/mL. Many compounds were safe with no cytotoxicity against human embryonic kidney and red blood cells at concentration up to 32 mu g/mL. Moreover, compound 9a showed the highest inhibitory activity against DNA Gyrase with IC50 = 0.68 mu M compared to ciprofloxacin IC50 = 0.85 mu M. Molecular docking at DNA Gyrase active site revealed binding mode and docking scores comparable to that of ciprofloxacin confirming their antibacterial activity via DNA Gyrase inhibition.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Abd El-Aleam, RH; George, RF; Hassan, GS; Abdel-Rahman, HM or concate me.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Ring Opening and Recyclization Reactions with Chromone-3-carbonitrile WOS:000461906200039 published article about BIOLOGICAL EVALUATION; CLOSURE REACTIONS; DERIVATIVES; AGENTS; REARRANGEMENT; HYDRAZONE; CHROMONES; ANALOGS; ACID; DCP in [Ibrahim, Magdy A.; El-Kazak, Azza M.] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt in 2019.0, Cited 32.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Chemical transformations of chromone-3-carbonitrile (1) with some substituted hydrazines, namely, thiosemicarbazide, S-methyl/benzyldithiocarbazate, 7-chloro-4-hydrazinoquinoline, and 3-hydrazino-5,6-diphenyl-1,2,4-triazine, led to substituted pyrazoles 2, 5-8. Ring opening of carbonitrile 1 followed by recyclization with 3-amino-1,2,4-triazole and 2-aminobenzimidazole gave triazolo[1,5-a]pyrimidine 9 and pyrimido[1,2-a]benzimidazole 10, respectively. Treatment of carbonitrile 1 with some heterocyclic amines produced 2-amino-3-substituted-chromones 11 and 12. The novel 3-hydroxychromeno[4,3-b]pyrazolo[4,3-e]pyridin-5(1H)-one (13) was efficiently synthesized from the ring conversion of carbonitrile 1 with cyanoacetohydrazide. A mixture of chromeno[2,3-b]naphthyridine 14 and chromeno[4,3-b]pyridine 15 was obtained from base catalyzed transformation of carbonitrile 1 with malononitrile dimer. A diversity of novel annulated chromeno[2,3-b]pyridines 16-22 was also synthesized. Chromeno[2,3-b]pyrrole-2-carboxylate 23 was obtained from the reaction of carbonitrile 1 with ethyl chloroacetate. Structures of the new synthesized products were deduced on the basis of their analytical and spectral data.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ibrahim, MA; El-Kazak, AM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Efficient and straightforward access to diverse and densely functionalized chromenes by 3-amino-1,2,4-triazole supported on hydroxyapatite-encapsulated-gamma-Fe2O3(gamma-Fe2O3@HAp@CPTMS@AT) as a new magnetic basic nanocatalyst WOS:000549705900001 published article about ONE-POT SYNTHESIS; SOLVENT-FREE; HETEROGENEOUS CATALYST; GAMMA-FE2O3 NANOCRYSTALLITES; NAPHTHOPYRAN DERIVATIVES; 3-COMPONENT CONDENSATION; FACILE SYNTHESIS; GREEN CHEMISTRY; AQUEOUS-MEDIUM; NANOPARTICLES in [Jahanshahi, Parivash; Mamaghani, Manouchehr] Univ Guilan, Dept Chem, Fac Sci, POB 41335-1914, Rasht, Iran in 2020.0, Cited 78.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A highly efficient and straightforward one-pot three-component synthesis of functionalized 2-amino-4H-chromenes and indole-substituted 3-amino-1H-benzo[f]chromenes have been developed by 3-amino-1,2,4-triazole supported on hydroxyapatite-encapsulated-gamma-Fe2O3(gamma-Fe2O3@HAp@CPTMS@AT) as the new magnetically recyclable heterogeneous basic nanocatalyst. The wide range of valuable 4H-chromene and 1H-chromene structures having different substituents were efficiently synthesized using one-pot tandem Knoevenagel cyclocondensation reaction of aromatic aldehydes, active methylene nitriles (malononitrile and 3-cyanoacetylindole) and diverse phenolic nucleophiles (resorcinol, alpha-naphthol and beta-naphthol) in the presence of nano gamma-Fe2O3@HAp@CPTMS@AT in EtOH. The structure and morphology of the synthesized nanocatalyst were characterized by using various techniques such as FT-IR, FESEM, EDS, XRD, TGA-DTA and VSM. The catalytic activity of nano gamma-Fe2O3@HAp@CPTMS@AT was evaluated and the results indicated its applicability as a novel, highly efficient, green, recyclable and promising heterogeneous basic nanocatalyst for the synthesis of 4H-chromene and 1H-chromene derivatives.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jahanshahi, P; Mamaghani, M or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. In 2020.0 PLANT PHYSIOL published article about ABIOTIC STRESS; ARABIDOPSIS; SUMO; PROTEINS; DROUGHT; CONJUGATION; BINDING; TOLERANCE; PATHWAYS; IDENTIFY in [Wang, Feige; Shi, Yaqiao; Han, Danlu; Wu, Yuanyuan; Ye, Weixian; Yang, Huanling; Lai, Jianbin; Yang, Chengwei] South China Normal Univ, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Peoples R China; [Liu, Yiyang; Li, Guowei; Cui, Feng; Wan, Shubo] Shandong Acad Agr Sci, Biotechnol Res Ctr, Jinan 250100, Peoples R China; [Liu, Yiyang; Li, Guowei; Cui, Feng; Wan, Shubo] Shandong Prov Key Lab Crop Genet Improvement Ecol, Jinan 250100, Peoples R China in 2020.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Heat stress (HS) has serious effects on plant development, resulting in heavy agricultural losses. A critical transcription factor network is involved in plant adaptation to high temperature. DEHYDRATION RESPONSIVE ELEMENT-BINDING PROTEIN2A (DREB2A) is a key transcription factor that functions in plant thermotolerance. The DREB2A protein is unstable under normal temperature and is degraded by the 26S proteasome; however, the mechanism by which DREB2A protein stability dramatically increases in response to HS remains poorly understood. In this study, we found that the DREB2A protein of Arabidopsis (Arabidopsis thaliana) is stabilized under high temperature by the posttranslational modification SUMOylation. Biochemical data indicated that DREB2A is SUMOylated at K163, a conserved residue adjacent to the negative regulatory domain during HS. SUMOylation of DREB2A suppresses its interaction with BPM2, a ubiquitin ligase component, consequently increasing DREB2A protein stability under high temperature. In addition, analysis of plant heat tolerance and marker gene expression indicated that DREB2A SUMOylation is essential for its function in the HS response. Collectively, our data reveal a role for SUMOylation in the maintenance of DREB2A stability under high temperature, thus improving our understanding of the regulatory mechanisms underlying HS response in plant cells. SUMOylation increases the protein stability of DREB2A, a key transcription factor in the response to heat stress in plant cells.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wang, FG; Liu, YY; Shi, YQ; Han, DL; Wu, YY; Ye, WX; Yang, HL; Li, GW; Cui, F; Wan, SB; Lai, JB; Yang, CW or concate me.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Computed Properties of C2H4N4. I found the field of Microbiology very interesting. Saw the article A pilin chaperone required for the expression of electrically conductive Geobacter sulfurreducens pili published in 2019.0, Reprint Addresses Zhou, SG (corresponding author), Fujian Agr & Forestry Univ, Coll Resources & Environm, Fujian Prov Key Lab Soil Environm Hlth & Regulat, Fuzhou, Fujian, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Mechanisms controlling the expression of the electrically conductive pili (e-pili) of Geobacter species are of interest because of the important role of e-pili in diverse biogeochemical processes, anaerobic digestion and electromicrobiological applications. We investigated the function of the protein, designated Spc (short pilin chaperone), encoded by the gene immediately downstream from the gene for PilA, the monomer that assembles into e-pili. Multiple lines of evidence suggest that Spc forms an oligomer that is associated with the inner membrane. Mutating the start codon of spc to prevent translation increased the transcript abundance of pilA but greatly diminished the abundance of PilA, and e-pili could no longer be detected. Cross-linking, protein capture and two-hybrid studies demonstrated that Spc and PilA interacted. Two sites in PilA for electrostatic interaction with Spc were identified. The results demonstrate that Spc is required for PilA stability prior to incorporation into e-pili, suggesting that Spc has a chaperone function that may be specific to the relatively short PilA monomers that assemble into e-pili. These results are important for identifying microorganisms likely to express e-pili from (meta)genomic data and for the construction of microbial strains expressing e-pili.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Computed Properties of C2H4N4. In 2019.0 CHEM HETEROCYCL COM+ published article about ONE-POT SYNTHESIS; BUILDING-BLOCKS; HYDRAZINE; COMPLEXES; EFFICIENT; DERIVATIVES; LIGAND; YLIDE in [Kudyakova, Yulia S.; Slepukhin, Pavel A.; Burgart, Yanina V.; Saloutin, Victor I.; Bazhin, Denis N.] Russian Acad Sci, Ural Branch, Postovsky Inst Organ Synth, 22 S Kovalevskoi,20 Akad Skaya St, Ekaterinburg 620990, Russia; [Onoprienko, Aleksandra Ya.; Slepukhin, Pavel A.; Burgart, Yanina V.; Saloutin, Victor I.; Bazhin, Denis N.] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia in 2019.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Five- and six-membered fluorine-containing azaheterocycles were synthesized based on available furan-3(2H)-ones, and the influence of the nature of the fluoroalkyl substituent on the direction of the chemical transformations by the action of N,N- and N,O-binucleophiles was revealed.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kudyakova, YS; Onoprienko, AY; Slepukhin, PA; Burgart, YV; Saloutin, VI; Bazhin, DN or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics