Name: 1H-1,2,4-Triazol-5-amine. Recently I am researching about ACETYLCHOLINESTERASE; INHIBITORS; PROTOCOL; NEURODEGENERATION; DISCOVERY; PEPTIDES; AGENTS; DRUGS; SITE, Saw an article supported by the University Grants Commission, IndiaUniversity Grants Commission, India; Ministry of AYUSHMinistry of AYUSH; University of DelhiUniversity of Delhi. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
2-(piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid beta aggregation inhibitors. Formation of synthesized compounds (P1-P9) was justified via H-1 NMR, C-13 NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated A beta aggregation and Cu(II)-mediated A beta aggregation. Also, docking study carried out was in concordance with in vitro results. The most potent molecule amongst the derivatives exhibited excellent anti-AChE activity (IC50=4.8 nM). Kinetic study of P3 suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds are capable of inhibiting self-induced beta-amyloid (A beta) aggregation with the highest inhibition percentage to be 81.65%. Potency of P1 and P3 to inhibit self-induced A beta(1-)(42) aggregation was ascertained by TEM analysis. Compounds were also evaluated for their A beta disaggregation, antioxidation, metal-chelation activity. (C) 2019 Elsevier Masson SAS. All rights reserved.
Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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