Day: November 3, 2021

COA of Formula: C2H4N4. I found the field of Chemistry very interesting. Saw the article A Stable Zn-Based Metal-Organic Framework as an Efficient Catalyst for Carbon Dioxide Cycloaddition and Alcoholysis at Mild Conditions published in 2020.0, Reprint Addresses Wang, J (corresponding author), Nanchang Univ, Minist Educ, Key Lab Poyang Environm & Resource Utilizat, Nanchang 330031, Jiangxi, Peoples R China.; Wang, J (corresponding author), Nanchang Univ, Sch Resource Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.; Deng, SG (corresponding author), Arizona State Univ, Sch Engn Matter Transport & Energy, 551 E Tyler Mall, Tempe, AZ 85287 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Developing highly efficient heterogeneous catalysts for cycloaddition of CO2 and epoxides to produce cyclic carbonates is promising but challenging. In this work, a novel three-dimensional metal organic framework (MOF) with cylinder pore systems and unsaturated Zn sites has been demonstrated as potent candidate in CO2 fixation at mild and solvent-free conditions. The Zn(atz)(bdc)(0.5), where atz = aminotriazole and H(2)bdc = terephthalic, exhibits microporous nature that can regulate the catalytic interaction of active centers and substrates. The structure stability has been systematically investigated and proven to be sufficient for practical application. Furthermore, the cooperative effects of porosity, CO2 binding affinity, activation centers, and synergism with co-catalyst have been deeply investigated. Moreover, high propylene epoxide conversion (97%) and selectivity (> 99%) have been achieved at mild conditions (60 degrees C and 1 MPa) with excellent cycle stability. Owing to the well-defined pore system, an obvious substrates selectivity has been clearly observed. A possible catalytic mechanism has been proposed and verified by DFT calculations. Furthermore, the prepared Zn-MOF can also be used as an efficient heterogeneous catalyst for the reaction of epoxides with alcohols to produce beta-alkoxy alcohol. [GRAPHICS] .

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Luo, ZQ; Wang, J; He, YQ; Ao, Q; Deng, Q; Zeng, ZL; Wang, HM; Deng, SG or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 61-82-5. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5 published in 2019.0, Reprint Addresses IJzerman, AP (corresponding author), Leiden Univ, Div Drug Discovery & Safety, Leiden Acad Ctr Drug Res, POB 9502, NL-2300 RA Leiden, Netherlands.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved in many inflammatory diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)clinical evidence suggests that dual CCR2/CCR5 inhibition might be more effective in the treatment of such multifactorial diseases. In this regard, the highly conserved intracellular binding site in chemokine receptors provides a new avenue for the design of multitarget ligands. In this study, we synthesized and evaluated the biological activity of a series of triazolopyrimidinone derivatives in CCR2 and CCR5. Radioligand binding assays first showed that they bind to the intracellular site of CCR2, and in combination with functional assays on CCR5, we explored structure-affinity/activity relationships in both receptors. Although most compounds were CCR2-selective, 39 and 43 inhibited beta-arrestin recruitment in CCR5 with high potency. Moreover, these compounds displayed an insurmountable mechanism of inhibition in both receptors, which holds promise for improved efficacy in inflammatory diseases.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zacarias, NVO; van Veldhoven, JPD; den Hollander, LS; Dogan, B; Openy, J; Hsiao, YY; Lenselink, EB; Heitman, LH; IJzerman, AP or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. Recently I am researching about ONE-POT SYNTHESIS; EFFICIENT CATALYST; SULFURIC-ACID; SOLID ACID; 3-COMPONENT; GREEN; BENZIMIDAZOQUINAZOLINONE; PHTHALAZINE; SULFATE; SYSTEMS, Saw an article supported by the University of Guilan Research Council. Published in ELSEVIER in AMSTERDAM ,Authors: Safari, N; Shirini, F; Tajik, H. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C-4(H-DABCO)(2)][HSO4](4) is easily prepared and characterized using FT-IR, H-1 NMR,C-13 NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method. (C) 2019 Elsevier B.V. All rights reserved.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Safari, N; Shirini, F; Tajik, H or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ALPHA-DIIMINE NICKEL; POLYOLEFIN THERMOPLASTIC ELASTOMERS; ETHYLENE-PROPYLENE COPOLYMERS; CHAIN-WALKING; LIVING POLYMERIZATION; METALLOCENE CATALYSTS; POLAR MONOMERS; PALLADIUM; OLEFINS; POLYPROPYLENE, Saw an article supported by the Alexander von Humboldt FoundationAlexander von Humboldt Foundation. Published in WILEY in HOBOKEN ,Authors: Jandaghian, MH; Ahmadjo, S; Mortzavi, SMM; Ahmadi, M. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Formula: C2H4N4

The reactive co-polymer approach is one of the most promising techniques for the synthesis of functional polyolefins. Following this concept, 1-hexene and p-methylstyrene are co-polymerized in the presence of a generic Brookhart-type catalyst. The microstructures of the co-polymers imply the tendency of p-methylstyrene co-monomers to place at the end of the structural branches formed by the chain walking reaction. The molar masses of the co-polymers decrease, not only at higher levels of co-monomer but surprisingly by decreasing reaction temperature. A mechanism consisting of a highly stable eta(3) metal-benzyl intermediate, which is quantitatively approved by density functional theory calculations, can delicately justify all the aforementioned observations. A series of the produced co-polymers is selectively functionalized by maleic anhydride at the benzylic position of p-methylstyrene, under very mild reaction conditions. Such a reactive intermediate opens the path for the introduction of different types of functionalities in polyolefins. Namely, the grafted co-polymers were further functionalized by a triazole ring, which provides a transient supramolecular network through intermolecular hydrogen bonding.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Jandaghian, MH; Ahmadjo, S; Mortzavi, SMM; Ahmadi, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Recently I am researching about ZINC-FINGER PROTEIN; GIBBERELLIN BIOSYNTHETIC GENES; STABILIZE TISSUE BOUNDARIES; SCARECROW-LIKE 3; DNA-BINDING; SHORT-ROOT; ARABIDOPSIS; EXPRESSION; DELLA; RICE, Saw an article supported by the . Published in MDPI in BASEL ,Authors: Aoyanagi, T; Ikeya, S; Kobayashi, A; Kozaki, A. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

INDETERMINATE DOMAIN (IDD) family proteins are plant-specific transcription factors. SomeArabidopsisIDD (AtIDD) proteins regulate the expression ofSCARECROW(SCR) by interacting with GRAS family transcription factors SHORT-ROOT (SHR) and SCR, which are involved in root tissue formation. Some AtIDD proteins regulate genes involved in the synthesis (GA3ox1) or signaling (SCL3) of gibberellic acid (GA) by interacting with DELLA proteins, a subfamily of the GRAS family. We analyzed the DNA binding properties and protein-protein interactions of select AtIDD proteins. We also investigated the transcriptional activity of the combination of AtIDD and GRAS proteins (AtIDD proteins combined with SHR and SCR or with REPRESSOR ofga1-3(RGA)) on the promoters ofSCR,SCL3, andGA3ox1by conducting a transient assay usingArabidopsisculture cells. Our results showed that theSCRpromoter could be activated by the IDD and RGA complexes and that theSCL3andGA3ox1promoters could be activated by the IDD, SHR, and SCR complexes, indicating the possibility that these complexes regulate and consequently coordinate the expression of genes involved in GA synthesis (GA3ox1), GA signaling (SCL3), and root formation (SCR).

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Aoyanagi, T; Ikeya, S; Kobayashi, A; Kozaki, A or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 CHINESE CHEM LETT published article about AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; MOLECULAR HYBRIDIZATION; EFFICIENT SYNTHESIS; DESIGN in [Yuan, Shuo; Wang, Sixi; Zhao, Min; Zhang, Danqing; Chen, Jinjie; Li, Jian-Xin; Zhang, Jingya; Song, Yihui; Wang, Jinyi; Yu, Bin; Liu, Hongmin] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Unorthodox synthesis, biological activity and DFT studies of novel and multifunctionalized naphthoxocine derivatives WOS:000486203200030 published article about CHROMONE-3-CARBOXYLIC ACID; REGIOSELECTIVE ACCESS; REARRANGEMENT; (+)-LAURENCIN; CYCLIZATIONS; ANNULATION; FRAMEWORK; ETHERS in [Abozeid, Mohamed Ahmed; El-Sawi, Aya Atef; Elmorsy, Mohamed Ramadan; Abdel-Rahman, Abdel-Rahman Hassan; El-Desoky, El-Sayed Ibrahim] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt; [Abdelmoteleb, Mohamed] Univ Nebraska, Dept Food Sci & Technol, FARRP, Lincoln, NE 68583 USA; [Abdelmoteleb, Mohamed] Mansoura Univ, Fac Sci, Dept Bot, Mansoura 35516, Egypt in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

A new promising protocol has been developed for the synthesis of scarce oxocine derivatives 3a-e and 6 through addition of amine-based nucleophiles such as hydroxylamine hydrochloride, primary amine and hydrazide to chromonylidene benzothiazol-2-ylacetonitrile 2 in refluxing dioxane under metal free reaction conditions in moderate to good yields. Other nitrogen nucleophiles such as piperidine, hydrazine and thiosemicarbazide failed to afford the corresponding oxocinols, and instead pyridine derivatives 7, 8 and 10 were obtained exclusively. Predictive study for the biological activities using PASS (prediction of activity spectra for biologically active substances) online software showed optimistic activities for oxocinols 3a-e in the treatment of cancer, influenza A and microbial infections. Additionally, DFT studies of oxocine derivatives 3a-e and 6 indicated the presence of required thermodynamics parameters for the application in dye-sensitized solar cells (DSSCs).

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Abozeid, MA; El-Sawi, AA; Elmorsy, MR; Abdelmoteleb, M; Abdel-Rahman, ARH; El-Desoky, ESI or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Cell Biology; Endocrinology & Metabolism very interesting. Saw the article US EPA’s regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects published in 2020.0. Safety of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Rudel, RA (corresponding author), Silent Spring Inst, Newton, MA 02460 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Breast cancer risk from pesticides may be missed if effects on mammary gland are not assessed in toxicology studies required for registration. Using US EPA’s registration documents, we identified pesticides that cause mammary tumors or alter development, and evaluated how those findings were considered in risk assessment. Of 28 pesticides that produced mammary tumors, EPA’s risk assessment acknowledges those tumors for nine and dismisses the remaining cases. For five pesticides that alter mammary gland development, the implications for lactation and cancer risk are not assessed. Many of the mammary-active pesticides activate pathways related to endocrine disruption: altering steroid synthesis in H295R cells, activating nuclear receptors, or affecting xenobiotic metabolizing enzymes. Clearer guidelines based on breast cancer biology would strengthen assessment of mammary gland effects, including sensitive histology and hormone measures. Potential cancer risks from several common pesticides should be re-evaluated, including: malathion, triclopyr, atrazine, propylene oxide, and 3-iodo-2-propynyl butylcarbamate (IPBC).

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Cardona, B; Rudel, RA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. Recently I am researching about GOLD NANOPARTICLES; NANOPOROUS CARBON; POROUS CARBON; SULFUR; SENSOR, Saw an article supported by the Young Foundation [QN2017408]; Top Talent of Hebei Province Educational Bureau [BJ2018208]; Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [B2017101018, B2017101022]; science and technology projects of Chengde High-tech Industrial Development Zone [HZLC2018005]; Chengde Technology Research and Development Program [201608B003]; major bidding project of Hebei Normal University for Nationalities [ZD2018003]. Published in ELSEVIER in AMSTERDAM ,Authors: Zhou, SH; Xu, HB; Liu, JY; Wei, YJ; Ma, XH; Han, ZM; Chen, HL. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

N-doped carbon nanopipe-arrayed mesoporous carbon (N-CMK-5) with double-pore system, large surface area (992 m(2)/g), and high nitrogen amount (5.2 at.%) was synthesized by a simplified template route. In this route, mesoporous silica was directly used instead of using time-consuming aluminosilicate as a template and the carbonization process occurred in a nitrogen atmosphere instead of a vacuum. Furthermore, CMK-3, N-doped CMK-3, and CMK-5 ordered mesopomus carbons (OMCs) were compared with the as-prepared N-doped CMK-5 (N-CMK-5) to investigate the effect of microstructure on the electrochemical activity of OMCs. N-CMK-5 exhibited higher electrochemical activity than the other OMCs because it has more exposed defective sites and nitrogen active species. The developed N-CMK-5-based electrochemical sensor showed good practical application for the electrochemical detection of pesticide amitrole in real water sample. This work contributes a simplified route to synthesize tubular N-CMK-5 carbon and provides valuable information on the design of high-performance carbon electrode materials.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Liu, JY; Wei, YJ; Ma, XH; Han, ZM; Chen, HL or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics