Day: November 4, 2021

Recommanded Product: 61-82-5. In 2021.0 BIOORG MED CHEM LETT published article about FRUITING BODY; ACID; DERIVATIVES; CINNAMOMEA; APOPTOSIS; CELLS; EXTRACT in [Li, Bin; Kuang, Yi; Yi, Yang; Qiao, Xue; Liang, Lei; Ye, Min] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China; [Li, Bin] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Minist Educ,Key Lab Bioact Subst & Resources Util, Beijing 100193, Peoples R China in 2021.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7. Chemical structures of the new compounds were elucidated by NMR and MS analyses. Furthermore, cytotoxicities of the triterpenoid derivatives were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7). As a result, 1a, 1g, and 4a exhibited potent cytotoxic activities against HL60, U251, and SW480 with IC50 values of 0.7 +/- 0.9, 2.9 +/- 1.3, and 2.2 +/- 0.6 mu M, respectively. Molecular docking indicates that 1a, 1g, and 4a have strong binding affinity with DNA topoisomerase II alpha (-9.3, -7.9, and -7.4 kcal/mol, respectively), and that they could be potent topoisomerase II alpha inhibitors.

Welcome to talk about 61-82-5, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or send Email.. Recommanded Product: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Liu, XT; Xing, SS; Xu, YT; Chen, RQ; Lin, C; Guo, LQ in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liu, Xiaotao; Xing, Shanshan; Guo, Liangqia] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China; [Xu, Yuanteng; Lin, Chang] Fujian Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Fuzhou 350005, Peoples R China; [Chen, Ruiqing] Fujian Med Univ, Affiliated Hosp 1, Cent Lab, Fuzhou 350005, Peoples R China in 2021.0, Cited 40.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Graphitic carbon nitride (g-C3N4) has been shown as a promising visible-light photosensitizer for photodynamic therapy (PDT) application. Nevertheless, its therapeutic efficiency is limited by the low efficiency of visible-light utilization. To overcome this issue, 3-amino-1,2,4-triazole-derived graphitic carbon nitride nanosheets (g-C3N5 NSs) are prepared for PDT application. The addition of nitrogen-rich triazole group into the g-C3N4 motif significantly makes the light absorption of g-C3N5 NSs red-shift with the band gap down to 1.95 eV, corresponding to a absorption edge at a wavelength of 636 nm. g-C3N5 NSs generate superoxide anion radicals (O-2(center dot-)) and singlet oxygen (O-1(2)) under the irradiation of a low-intensity white light emitting diode. Owing to the high efficiency of visible-light utilization, g-C3N5 NSs show about 9.5 fold photocatalytic activity of g-C3N4 NSs. In vitro anticancer studies based on the results of CCK-8 assay, Calcein-AM/PI cell-survival assay and photo-induced intracellular ROS level analysis in living HeLa cells demonstrate the potential of g-C3N5 NSs as a low-toxic and biocompatible high-efficient photosensitizer for PDT. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics WOS:000612551400104 published article about CHEMICAL-MODIFICATIONS; EFFLUX PUMPS; NANOPARTICLES; RESISTANCE; MODE; GENERATION; BACTERIA; DELIVERY; MICRO in [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ NTU, Sch Chem & Biomed Engn, Singapore 637459, Singapore; [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ, Ctr Antimicrobial Bioengn, Singapore 637459, Singapore; [Thappeta, Kishore Reddy Venkata] Nanyang Technol Univ, Singapore Ctr Environm & Life Sci SCELSE, Singapore 637551, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Tan Tock Seng Hosp, Dept Infect Dis, Singapore 308442, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Natl Ctr Infect Dis, Singapore 637459, Singapore; [De, Partha Pratim] Tan Tock Seng Hosp, Dept Lab Med, Singapore 308433, Singapore; [Ng, Oon Tek; Pethe, Kevin] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore; [Li, Peng] Northwestern Polytech Univ, Inst Flexible Elect, Xian 710072, Peoples R China; [Zhu, Yabin] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China; [Pethe, Kevin] Nanyang Technol Univ, Sch Biol Sci, Singapore 636921, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637459, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637459, Singapore in 2021.0, Cited 49.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with minimum inhibitory concentrations (MICs) of 8-32 mu g/mL against clinically relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clinically relevant antibiotics proved by decreasing the MICs of the ntibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1 mu g/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via intraperitoneal injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log(10) reduction of A. baumannii in murine intraperitoneal and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition WOS:000534662900001 published article about TRANSFER-RNA-BINDING; UNCHARGED TRANSFER-RNA; PROTEIN-KINASE; FACTOR 1A; SACCHAROMYCES-CEREVISIAE; STRUCTURAL BASIS; FULL ACTIVATION; INITIATION; ACID; RIBOSOME in [Ramesh, Rashmi; Sattlegger, Evelyn] Massey Univ, Sch Nat & Computat Sci, Albany Highway,Gate 4,Bldg 11, Auckland 0632, New Zealand; Linkoping Univ, Dept Biomed & Clin Sci BKV, Inst Clin & Expt Biol, Cellbiol Floor 12, S-58185 Linkoping, Sweden in 2020.0, Cited 59.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The signalling pathway governing general control nonderepressible (Gcn)2 kinase allows cells to cope with amino acid shortage. Under starvation, Gcn2 phosphorylates the translation initiation factor eukaryotic translation initiation factor (eIF)2 alpha, triggering downstream events that ultimately allow cells to cope with starvation. Under nutrient-replete conditions, the translation elongation factor eEF1A binds Gcn2 to contribute to keeping Gcn2 inactive. Here, we aimed to map the regions in eEF1A involved in binding and/or regulating Gcn2. We find that eEF1A amino acids 1-221 and 222-315, containing most of domains I and II, respectively, bind Gcn2 in vitro. Overexpression of eEF1A lacking or containing domain III impairs eIF2 alpha phosphorylation. While the latter reduces growth under starvation similarly to eEF1A lacking domain I, the former enhances growth in a Gcn2-dependent manner. Our studies suggest that domain II is required for Gcn2 inhibition and that eEF1A lacking domain III mainly affects the Gcn2 response pathway downstream of Gcn2.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. Yu, L; Xiong, SS; Lin, YH; Li, LY; Peng, JJ; Liu, W; Huang, XX; Wang, H; Li, J in [Yu, Liang; Lin, Yuhan; Liu, Wei; Huang, Xiaoxi; Wang, Hao; Li, Jing] Shenzhen Polytech, Hoffmann Inst Adv Mat, Shenzhen 518055, Guangdong, Peoples R China; [Xiong, Shunshun] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Sichuan, Peoples R China; [Li, Liangying; Li, Jing] Rutgers State Univ, Dept Chem & Chem Biol, 123 Bevier Rd, Piscataway, NJ 08854 USA; [Li, Liangying] Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China; [Peng, Junjie] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China published Tuning the Channel Size and Structure Flexibility of Metal-Organic Frameworks for the Selective Adsorption of Noble Gases in 2019.0, Cited 19.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Two ultramicroporous metal-organic frameworks, Zn(ox)(0.5)(trz) and Zn(ox)(0.5)(atrz) (ox = oxalate, trz = triazolate, and atrz = 3-aminotriazolate), have been synthesized and tested for the adsorptive separation of Xe and Kr. We demonstrate that the Xe/Kr adsorption selectivity relates to the pore size as well as the structure flexibility of the adsorbents.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Yu, L; Xiong, SS; Lin, YH; Li, LY; Peng, JJ; Liu, W; Huang, XX; Wang, H; Li, J or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. Mityuk, AP; Hrebonkin, A; Lebed, PS; Grabchuk, GP; Volochnyuk, DM; Ryabukhin, SV in [Mityuk, Andrey P.; Hrebonkin, Andrii; Lebed, Pavlo S.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.] Enamine Ltd, 78 Chervonotkatska Str, Kiev, Ukraine; [Lebed, Pavlo S.; Grabchuk, Galyna P.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.] Taras Shevchenko Natl Univ Kyiv, 60 Volodymyrska Str, Kiev, Ukraine; [Volochnyuk, Dmitriy M.] Natl Acad Sci Ukraine, Inst Organ Chem, 5 Murmanska Str, Kiev, Ukraine published Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines in 2021.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the procedure compared to previously known methods are shown. The scope and limitations of the method are determined. The impact of the structural features on regioselectivity are discussed. The preparativeness, scalability, and application scope of the elaborated protocol are demonstrated by the synthesis of five heteroannelated 3-cyanopyridines in quantities up to 100 grams.

Welcome to talk about 61-82-5, If you have any questions, you can contact Mityuk, AP; Hrebonkin, A; Lebed, PS; Grabchuk, GP; Volochnyuk, DM; Ryabukhin, SV or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer WOS:000504428300058 published article about HISTONE H2AX; BRCT DOMAINS; S-PHASE; DNA; PROTEIN; REPAIR; MDC1; LOCALIZATION; LIGASE; REGION in [Krieger, Kimiko L.; Hu, Wen-Feng; Ripperger, Tyler; Woods, Nicholas T.] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA; [Hu, Wen-Feng] Univ Nebraska Med Ctr, Coll Med, Dept Emergency Med, Omaha, NE 68198 USA; [Ripperger, Tyler] Univ Arizona, Dept Immunobiol, Coll Med, Tucson, AZ 85724 USA in 2019.0, Cited 43.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Deleterious mutations in Breast Cancer 1 (BRCA1) are associated with an increased risk of breast and ovarian cancer. Mutations in the tandem BRCA1 C-terminal (tBRCT) protein domain disrupt critical protein interactions required for the faithful repair of DNA through homologous recombination, which contributes to oncogenesis. Our studies have identified RICTOR, PRR5, and SIN1 subunits of the mammalian target of rapamycin complex 2 (mTORC2) as interacting partners with the tBRCT domain of BRCA1 leading to the disruption of the mTORC2 complex. However, the interplay between mTORC2 signaling and BRCA1 function in the DNA damage response (DDR) remains to be determined. In this study, we used protein interaction assays to determine the binary interactions between the tBRCT domain and mTORC2 subunits, evaluated the impact of mTOR inhibition on the transcriptional function of the tBRCT, evaluated the impact of mTOR signaling on BRCA1 recruitment to DNA damage-induced foci and determined the breast cancer cell line response to mTOR inhibition dependent upon BRCA1 expression and mutation. This study determined that PRR5, RICTOR, and SIN1 could each independently interact with the BRCA1 tBRCT. Inhibition of mTORC1, but not mTORC1/2, increases BRCA1 transcriptional activation activity. Treatment with pan-mTOR inhibitor PP242 diminishes DNA damage-induced gamma H2AX and BRCA1 foci formation. Breast cancer cells lacking expression of functional BRCA1 are more sensitive to mTOR inhibitors. These data suggest that mTOR signaling is required for BRCA1 response to DNA damage and breast cancer cells lacking BRCA1 are more sensitive to pan-mTOR inhibition. This work suggests chemotherapeutic strategies using mTOR inhibitors could be tailored for patients that lack functional BRCA1.

Welcome to talk about 61-82-5, If you have any questions, you can contact Krieger, KL; Hu, WF; Ripperger, T; Woods, NT or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair WOS:000529988600001 published article about TRANSPLANTATION; SURVIVAL; HEART; GENE; MITOCHONDRIA; METABOLISM; ACTIVATION; INFARCTION; EFFICACY; HOMOLOG in [Zhang, Dong-Yang; Xu, Rong-Jian; Jiao, Wen-Jie] Qingdao Univ, Affiliated Hosp, Dept Thorac Surg, Qingdao 266000, Peoples R China; [Zhang, Dong-Yang; Gao, Tong; Sun, Lu; Zhang, Chun-Feng; Bai, Long; Chen, Wei; Liu, Kai-Yu; Zhou, Yang; Jiao, Xuan; Zhang, Gui-Huan; Tian, Hai] Harbin Med Univ, Affiliated Hosp 2, Future Med Lab, Harbin, Peoples R China; [Gao, Tong; Sun, Lu; Zhang, Chun-Feng; Bai, Long; Chen, Wei; Liu, Kai-Yu; Zhou, Yang; Jiao, Xuan; Zhang, Gui-Huan; Tian, Hai] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiovasc Surg, Harbin 150086, Peoples R China; [Guo, Rui-Lin; Li, Jing-Xuan; Gao, Ying] Harbin Med Univ, Clin Coll 2, Harbin, Peoples R China in 2020.0, Cited 37.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Sirtuin 3 (SIRT3) is a deacetylase important for antioxidant protection, cell longevity, and aging. We hypothesized that SIRT3 improve oxidative resistance of aged cells and improve cell therapy in aged patients. In vitro, the proliferation and oxidative resistance of human mesenchymal stem cells (hMSCs) significantly declined with age. The expression and activity of antioxidant enzymes, including catalase (CAT) and manganese superoxide dismutase (MnSOD), increased after transfection of SIRT3 in hMSCs from older donors (O-hMSCs). The protein level of Forkhead box O3a (FOXO3a) in nucleus increased after SIRT3 overexpression. The antioxidant capacity of O-hMSCs increased after SIRT3 overexpression. 3-Amino-1,2,4-triazole (3-AT, CAT inhibitor) or diethyldithiocarbamate (DETC, SOD inhibitor) that was used to inhibit CAT or SOD activity significantly blocked the antioxidant function of SIRT3. When two inhibitors were used together, the antioxidant function of SIRT3 almost disappeared. Following myocardial infarction and intramyocardial injections of O-hMSCs in rats in vivo, the survival rate of O-hMSCs increased by SIRT3 transfection. The cardiac function of rats was improved after SIRT3-overexpressed O-hMSC transplantation. The infarct size, collagen content, and expression levels of matrix metalloproteinase 2 (MMP2) and MMP9 decreased. Besides, the protein level of vascular endothelial growth factor A and vascular density increased after cell transplantation with SIRT3-modified O-hMSCs. These results indicate that damage resistance of hMSCs decline with age and SIRT3 might protect O-hMSCs against oxidative damage by activating CAT and MnSOD through transferring FOXO3a into nucleus. Meanwhile, the therapeutic effect of aged hMSC transplantation can be improved by SIRT3 overexpression.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, DY; Gao, T; Xu, RJ; Sun, L; Zhang, CF; Bai, L; Chen, W; Liu, KY; Zhou, Y; Jiao, X; Zhang, GH; Guo, RL; Li, JX; Gao, Y; Jiao, WJ; Tian, H or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. Pogaku, V; Krishnan, R; Basavoju, S in [Pogaku, Vinay; Basavoju, Srinivas] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India; [Krishnan, R.] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, India published Synthesis and biological evaluation of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidines as potent antidiabetic, anticancer and antioxidant agents in 2021.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A series of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives 4a-p were synthesized and well characterized by using IR, H-1,C-13 NMR and mass spectral data. Finally, the structure of the compound 4l was solved unambiguously by single-crystal X-ray diffraction (SXRD) which confirms all the structures 4a-p. The in vitro alpha-glucosidase inhibition, anticancer (A549 and MCF-7 cell lines) and antioxidant studies of the title compounds 4a-pwere screened. Among all the compounds, 4g, 4h and 4n exhibited significant alpha-glucosidase inhibition activity with the IC(50)values 20.12 +/- 0.19 mu M, 21.55 +/- 0.46 mu M and 24.92 +/- 0.98 mu M. Similarly, the compounds 4h, 4d and 4e showed potent anticancer activity against A549 (human lung carcinoma) cell line with IC(50)values 3.64 mu M, 4.73 mu M and 4.56 mu M, respectively, whereas the compounds 4c and 4 o displayed potent anticancer activity against human breast cancer (MCF-7) cell line with IC50 values of 2.66 mu M and 2.11 mu M. In addition, the antioxidant activity revealed that the compounds 4e and 4h exhibited potent antioxidant activity (IC50: 4.25 mu M and 5.40 mu M). To determine the safety profile of the most active compounds4c,4d,4e,4g,4h,4n and 4o were tested against non-cancer HEK293 cell line (human embryonic kidney 293), results in the lower toxicity of these compounds. [GRAPHICS] .

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Pogaku, V; Krishnan, R; Basavoju, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. Authors Cen, HY; Chen, ZY in ELSEVIER published article about in [Cen, Hongyu; Chen, Zhenyu] Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China in 2021.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Functionalized graphene oxide (FGO) were synthesized and investigated as corrosion inhibitors of carbon steel in this research. The inhibition behavior of FGO in CO2-saturated NaCl solution was studied via weight loss, surface characterizations, and electrochemical measurements. Results confirm that FGO could protect metal effectively and the inhibition efficiency showed the extreme effect as the increase of FGO concentration, reaching a maximum of 83.4% at 20 mg/L. FGO can adsorb on carbon steel via the functionalized groups and form the hydrophobic cover layer on the metal surface by the lamellar nanoparticles.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics