Day: November 10, 2021

Authors Suzuki, S; Hasegawa, A; Uebori, M; Shinomiya, M; Yoshida, Y; Ookubo, K; Takino, M; Hasegawa, H; Takazawa, M; Takemine, S in WILEY published article about in [Suzuki, Shigeru; Uebori, Michiko; Takazawa, Mari] Chubu Univ, Grad Sch Biosci & Biotechnol, 1200 Matsumoto, Kasugai, Aichi 4878501, Japan; [Hasegawa, Atsuko] Kanagawa Environm Res Ctr, Environm Conservat Div, 1-3-39,Shinomiya, Hiratsuka, Kanagawa 2540014, Japan; [Shinomiya, Miho] Saitama Prefectural Univ, Sch Hlth & Social Serv, 820 Sannomiya, Koshigaya 3438540, Japan; [Yoshida, Yasuko] Sumica Chem Anal Serv Ltd, Environm Hlth & Safety Div, Bunkyo Ku, Sumitomo Fudosan Hongo Bldg 9F,22-5,Hongo 3 Chome, Tokyo 1130033, Japan; [Ookubo, Kaori] Saga Prefectural Inst Publ Hlth & Pharmaceut Res, Phys & Chem Res & Investigate Div, 1-20 Hacchonawatemachi, Saga 8490925, Japan; [Takino, Masahiko] Agilent Technol Japan Ltd, Chromatog & Mass Spectrometry Div, 9-1 Takakura Machi, Hachioji, Tokyo 1920033, Japan; [Hasegawa, Hitomi] Nagoya City Environm Sci Res Inst, Water Qual Div, Minami Ku, 5-16-8 Toyoda, Nagoya, Aichi 4570841, Japan; [Takazawa, Mari] Publ Works Res Inst, Water Environm Res Grp, 1-6 Minamihara, Tsukuba, Ibaraki, Japan; [Takemine, Shusuke] Ctr Environm Sci Saitama, Chem Subst Team, 914 Oaza Kamitanadare,Kisai Machi, Kazo, Saitama 3470115, Japan in 2021.0, Cited 41.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Despite the increasing detection of emerging substances in the environment, the identity of most are left unknown due to the lack of efficient identification methods. We developed a non-target analysis method for identifying unknown substances in the environment by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) with a product ion and neutral loss database (PNDB). The present analysis describes an elucidation method with elemental compositions of the molecules, product ions, and corresponding neutral losses of the unknown substance: (1) with the molecular formula, possible molecular structures are retrieved from two chemical structure databases (PubChem and ChemSpider); then (2) with the elemental compositions of product ions and neutral losses, possible partial structures are retrieved from the PNDB; and finally, (3) molecular structures that match the possible partial structures are listed in order of number of hits. A molecular structure with a higher number of hits is more similar to the structure of the analyzed substance. The performance of the non-target method was evaluated by simulated analysis of 150 LC/HRMS spectra registered in MassBank. First, all substances of the same mass data (41/41) and 68% (39/57) of the mass data of the same substances not registered in the PNDB were elucidated. It was demonstrated that 14% (7/52) and 31% (16/52) of the substances with no mass spectral data registered in the PNDB were obtained at the first and within the fifth place, respectively. Owing to the fact that 10 of the total hits occurred in product ions and neutral losses, almost 50% of the substances evaluated with this method were placed at the top 4 positions in the similarity ranking. Importantly, the proposed method is effective for analyzing mass spectral data that has not been registered in the PNDB and thus is expected to be used for a variety of non-target analyses.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Suzuki, S; Hasegawa, A; Uebori, M; Shinomiya, M; Yoshida, Y; Ookubo, K; Takino, M; Hasegawa, H; Takazawa, M; Takemine, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article The wood decay fungus Cerrena unicolor adjusts its metabolism to grow on various types of wood and light conditions WOS:000457746300026 published article about CELLOBIOSE DEHYDROGENASE; PHENOTYPE MICROARRAYS; BROWN-ROT; DEGRADATION; LACCASE; DIVERSITY; MECHANISMS; ENZYMES in [Pawlik, Anna; Ruminowicz-Stefaniuk, Marta; Janusz, Grzegorz] Marie Curie Sklodowska Univ, Dept Biochem, Lublin, Poland; [Frac, Magdalena] Polish Acad Sci, Inst Agrophys, Lublin, Poland; [Mazur, Andrzej; Wielbo, Jerzy] Marie Curie Sklodowska Univ, Dept Genet & Microbiol, Lublin, Poland in 2019.0, Cited 47.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Cerrena unicolor is a wood-degrading basidiomycete with ecological and biotechnological importance. Comprehensive Biolog-based analysis was performed to assess the metabolic capabilities and sensitivity to chemicals of C. unicolor FCL139 growing in various sawdust substrates and light conditions. The metabolic preferences of the fungus towards utilization of specific substrates were shown to be correlated with the sawdust medium applied for fungus growth and the light conditions. The highest catabolic activity of C. unicolor was observed after fungus precultivation on birch and ash sawdust media. The fungus growing in the dark showed the highest metabolic activity which was indicated by capacity to utilize a broad spectrum of compounds and the decomposition of 74/95 of the carbon sources. In all the culture light conditions, p-hydroxyphenylacetic acid was the most readily metabolized compound. The greatest tolerance to chemicals was also observed during C. unicolor growth in darkness. The fungus was the most sensitive to nitrogen compounds and antibiotics, but more resistant to chelators. Comparative analysis of C. unicolor and selected wood-decay fungi from different taxonomic and ecological groups revealed average catabolic activity of the fungus. However, C. unicolor showed outstanding capabilities to catabolize salicin and arbutin. The obtained picture of C. unicolor metabolism showed that the fungus abilities to decompose woody plant material are influenced by various environmental factors.

Welcome to talk about 61-82-5, If you have any questions, you can contact Pawlik, A; Ruminowicz-Stefaniuk, M; Frac, M; Mazur, A; Wielbo, J; Janusz, G or send Email.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Authors Xu, XQ; Wu, P; Li, CY; Zhao, KY; Wang, CR; Deng, RP; Zhang, JL in AMER CHEMICAL SOC published article about in [Xu, Xiaoqing; Zhao, Keyong; Wang, Chiran; Deng, Renpan; Zhang, Jinli] Shihezi Univ, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Sch Chem & Chem Engn, Shihezi 832003, Peoples R China; [Wu, Peng] Soochow Univ, Sch Chem & Environm Engn, Suzhou 215123, Jiangsu, Peoples R China; [Li, Changyong] Univ Bremen, Ctr Appl Space Technol & Micrograv ZARM, D-28359 Bremen, Germany in 2021.0, Cited 59.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In this work, amine-functionalized ZIF8 (i.e., ZIF8-A) was dispersed in n-heptanol (ZIF8-A/n-heptanol) to remove SO2. The effects of ZIF8-A proportion, SO2 concentration, and absorption and desorption temperatures on the removal of SO2 were systematically investigated. The experimental results showed that the activity of ZIF8-A on SO2 removal was enhanced after being dispersed in n-heptanol. The SO2 saturation capacity increased with increasing proportion of ZIF8-A and SO(2)concentration. The optimal temperatures for SO2 absorption and desorption were found to be 25 and 120 degrees C, respectively. Under the optimal experimental conditions (25 degrees C and 4% SO2), the SO2 saturation capacity was 589 mg/g. Five continuous absorption-desorption cycles suggested a good regeneration performance. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, ultraviolet analyses, and computational simulation indicated that SO2 mainly interacted with ZIF8-A via hydrogen bonds besides physical absorption. The simulation results further indicated that the enhanced SO2 adsorption performance of ZIF8-A when dispersed in n-heptanol was due to the lower self-diffusion coefficient and higher isosteric heat of SO2 molecules in ZIF8-A/nheptanol.

Welcome to talk about 61-82-5, If you have any questions, you can contact Xu, XQ; Wu, P; Li, CY; Zhao, KY; Wang, CR; Deng, RP; Zhang, JL or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H4N4. In 2020.0 J MATER CHEM A published article about METAL-ORGANIC FRAMEWORK; FLUORESCENT-PROBE; IONIC LIQUIDS; ANILINE; LUMINESCENT; BENZOTHIADIAZOLE; ADSORPTION; MOLECULES; REMOVAL; CAPTURE in [Tang, Yuanzhe; Huang, Hongliang; Peng, Ben; Chang, Yanjiao; Li, Yang; Zhong, Chongli] Tiangong Univ, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China; [Tang, Yuanzhe; Huang, Hongliang; Peng, Ben; Chang, Yanjiao; Li, Yang; Zhong, Chongli] Tiangong Univ, Sch Chem & Chem Engn, Tianjin 300387, Peoples R China; [Zhong, Chongli] Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China in 2020.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Primary aromatic amines (PAAs), as a class of persistent and highly toxic organic pollutants, have been posing a great threat to human health and the environment. Therefore, the design and preparation of a highly sensitive and selective luminescent probe to detect PAAs among various amines are important but challenging. In this work, by introducing electron-deficient monomer 4,4 ‘-(benzo[c][1,2,5]thiadiazole-4,7-diyl)dibenzaldehyde (BTDD) with an aggregation-caused quenching behavior into the 2D framework, fluorescent ultrathin covalent triazine framework (F-CTF) nanosheets were constructed. Compared with the aggregated BTDD monomer, the obtained F-CTF-3 nanosheet shows much higher fluorescence quantum yield due to the BTDD fragment being well dispersed in the 2D framework. The F-CTF-3 nanosheet exhibits high stability, high porosity, and high fluorescence performance and has a rich electron-deficient unit in the pore channel, making it an ideal platform for sensing electron-rich PAA molecules. In fact, the F-CTF-3 nanosheet shows high sensitivity and selectivity for PAA detection by fluorescence quenching, among various amines, covering some classic aliphatic amines, heterocyclic amines, secondary aromatic amines and tertiary aromatic amines. To the best of our knowledge, it is the first reported fluorescent sensor for selective sensing of PAAs among various amines. Moreover, F-CTF-3 exhibits unprecedented low detection limits of 11.7 and 1.47 nM toward phenylamine (PA) andp-phenylenediamine (PDA), respectively, surpassing all the reported fluorescent sensors. The combination of experimental analysis and density functional theory (DFT) calculations demonstrates that the unique PAA detection performance of F-CTF-3 can be attributed to the static quenching process, which is confirmed by the formation of a ground-state fluorescence-quenched complex on account of the hydrogen bonding interactions between F-CTF-3 and PAAs. This work not only provides a thiadiazole-based 2D fluorescent organic framework nanosheet, but also an excellent fluorescent sensor with unexpected sensitivity and selectivity for PAA detection.

COA of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity WOS:000472294100001 published article about THYROPEROXIDASE INHIBITION; MECHANISM in [Price, Roger J.; Lake, Brian G.] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England; [Burch, Rachel] Brunel Univ, Res Support & Dev Off, Uxbridge, Middx, England; [Chatham, Lynsey R.; Higgins, Larry G.] CXR Biosci Ltd, Concept Life Sci, Dundee, Scotland; [Currie, Richard A.] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell, Berks, England in 2020.0, Cited 16.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

1. A number of chemicals have been shown to produce disruption of the thyroid gland, resulting in reduced thyroid hormone synthesis, by a mechanism involving inhibition of thyroid peroxidase (TPO) activity (EC 1.11.1.8). 2. An assay was developed for rat thyroid gland microsomal TPO activity, employing L-tyrosine as the physiological substrate, with analysis of the formation of the 3-iodo-L-tyrosine (3MIT) metabolite by ultra-performance liquid chromatography-mass spectrometry-mass spectrometry. 3. Formation of 3MIT was linear with respect to both rat thyroid gland microsomal protein concentration and incubation time, whereas only small quantities of 3,5-diodo-L-tyrosine were formed. 4. Studies were performed with nine known TPO inhibitors. The most potent inhibitors were 3-amino-1,2,4-triazole, ethylene thiourea, methimazole and 6-propyl-2-thiouracil which had IC50 values (i.e. concentration to produce a 50% inhibition of enzyme activity) of 0.059, 0.791, 1.07 and 1.96 mu M, respectively, whereas the least potent inhibitor was sodium perchlorate which had an IC50 value of 13,800 mu M. 5. For five inhibitors, where literature data were available, the observed IC50 values obtained in this study employing rat thyroid gland microsomes and L-tyrosine as substrate were similar to those previously reported using the spectrophotometric guaiacol oxidation assay.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Divalent manganese, cobalt, copper and cadmium complexes of (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid: Preparation, characterization, computational and biological studies WOS:000578430900001 published article about METAL-COMPLEXES; CU(II) COMPLEXES; ANTIOXIDANT; NI(II); CO(II); HYDRAZIDE; SPECTRA; CD(II); MODELS; ZN(II) in [Majeed, Abdulnasir A.; Khalil, Mostafa M. H.; Abdel Aziz, Ayman A.] Ain Shams Univ, Dept Chem, Fac Sci, Cairo, Egypt; [Fetoh, Ahmed; Abu El-Reash, G. M.] Mansoura Univ, Dept Chem, Fac Sci, POB 70, Mansoura, Egypt in 2021.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

In this work, (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H-1,2,4-triazol-3-amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E-a, A, Delta H*, Delta S* and Delta G*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS-antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF-7 (breast carcinoma) cancer cells.

Welcome to talk about 61-82-5, If you have any questions, you can contact Majeed, AA; Khalil, MMH; Fetoh, A; Aziz, AAA; Abu El-Reash, GM or send Email.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. I found the field of Chemistry very interesting. Saw the article Synthesis and properties of gem-dinitro energetic salts based on 1,2,4-oxadiazole with low impact sensitivity published in 2021.0, Reprint Addresses Chen, FX (corresponding author), Beijing Inst Technol, Sch Chem Sc Chem Engn, Liangxiang Campus,8 Liangxiang East Rd, Beijing 102488, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Eight energetic salts with a gem-dinitro group based on 1,2,4-oxadiazole were developed. All of the structures were confirmed by infrared (IR) spectroscopy, H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS), and single-crystal X-ray diffraction was used to determine the structures of the pivotal intermediate 3-(chlorodinitromethyl)-5-methyl-1,2,4-oxadiazole (3), the potassium salt (4) and the hydrazinium salt (7). All of them are insensitive to impact (>40 J) and have higher energy levels than trinitrotoluene (TNT).

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Lu, T; He, YN; Song, J; Hou, ZW; Yin, HQ; Fan, GJ; Chen, FX or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about GRAPHITIC CARBON-NITRIDE; HYDROGEN EVOLUTION; EFFICIENCY; NANOSHEETS; TEMPLATES; NANOTUBES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21475043, 21675051, 21874042]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wang, HY; Li, MX; Lu, QJ; Cen, YM; Zhang, YY; Yao, SZ. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. COA of Formula: C2H4N4

Three-dimensional graphite carbon nitride (3D-CN) has received tremendous research interest due to its unique structural features, fascinating physicochemical properties, widespread potential applications. Most syntheses of 3D-CN mainly focus on developing g-C3N4 (2.7 eV) using and hard-templating strategies. Nevertheless, the excellent photo catalytic activity of 3D-CN is related to its small band gap, which is relevant to its structure and the nitrogen (N) content. Meanwhile, it is still a challenge to prepare N-rich CN with special structure and a small band gap using a simple and green strategy. Herein, a novel, mesoporous rod-like and N-rich graphite carbon nitride (RN-g-C3N5) is fabricated by a facile and green KBr-guided approach using 3-amino-1,2,4-triazole. The KBr acting as a guider can be easily removed by water. Surprisingly, the mesoporous rod-like structure makes for the usage of visible light and the enhancement of surface area of RN-g-C3N5. More importantly, the special structure and high N content result in a narrow band gap (1.90 eV). Therefore, RN-g-C3N5 displays notably superior photocatalytic performance. Meanwhile, the RN-g-C3N5 with excellent photocatalytic performance has great prospects in environmental remediation.

COA of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J APPL POLYM SCI published article about THERMAL-DEGRADATION; PERFORMANCE; COMPOUND; STABILITY; NITROGEN; BEHAVIOR in [Cheng, Jianwen; Duan, Huajun; Wang, Jun; Zhang, Qianqian] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Sch Mech & Elect Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Wang, Jun; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Inst Adv Mat Mfg Equipment & Technol, Wuhan, Peoples R China; [Huo, Siqi] Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia in 2020.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

A P/N-containing flame retardant (PPT) constructed by phosphaphenanthrene, phosphonate, and triazole groups was successfully synthesized and used as a reactive co-curing agent for epoxy resin (EP). The curing behavior, thermal property, combustion behavior, and flame retardant mechanism of EP thermosets were comprehensively investigated. According to the analysis of DSC and TGA, PPT accelerated the crosslinking reaction and enhanced the charring ability for EP thermosets at high temperature. The results of combustion test indicated that PPT endowed epoxy thermoset with outstanding flame retardancy. When the phosphorus content was 0.71 wt%, EP/DDS/PPT-2 achieved a LOI value of 33.2% and passed V-0 rating in UL-94 test, and its peak heat release rate and total heat release were decreased by 63.7 and 30.5%, respectively, relative to EP/DDS. Moreover, the FIGRA of EP/DDS/PPT-2 was reduced from 9.7 to 3.5 kW m(-2) s(-1), manifesting the significantly improved fire safety of EP thermoset. The flame retardant mechanism was summarized as two parts: (a) the barrier effect of continuous phosphorus-rich char layers in condensed phase, (b) the quenching effect of phosphorous radicals and diluting effect of nonflammable gases in gaseous phase.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking WOS:000505596300067 published article about CATALYTIC INHIBITORS; DISCOVERY; DESIGN in [Abd El-Aleam, Rehab H.] Modern Univ Technol & Informat MTI, Fac Pharm, Pharmaceut Chem Dept, Cairo 11571, Egypt; [George, Riham F.; Hassan, Ghaneya S.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11562, Egypt; [Hassan, Ghaneya S.] Badr Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11829, Egypt; [Abdel-Rahman, Hamdy M.] Assiut Univ, Fac Pharm, Med Chem Dept, Assiut 71526, Egypt; [Abdel-Rahman, Hamdy M.] Nahda Univ, Fac Pharm, Pharmaceut Chem Dept, Bani Suwayf, Egypt in 2020.0, Cited 20.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

A series of 1,2,4-triazolo [1,5-a]pyrimidine derivatives was designed, synthesized and screened for their antibacterial and antifungal activities as well as their safety profile. Compounds 2b, 3a, 6b, 8b, 8c, 8h, 9a,b, 10b, 11a,b and 12a,b showed high activity against Gram-positive and Gram-negative bacteria with MIC values ranging from 0.25 to 2.0 mu g/mL. Many compounds were safe with no cytotoxicity against human embryonic kidney and red blood cells at concentration up to 32 mu g/mL. Moreover, compound 9a showed the highest inhibitory activity against DNA Gyrase with IC50 = 0.68 mu M compared to ciprofloxacin IC50 = 0.85 mu M. Molecular docking at DNA Gyrase active site revealed binding mode and docking scores comparable to that of ciprofloxacin confirming their antibacterial activity via DNA Gyrase inhibition.

Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics