Day: November 29, 2021

An article 4-Chlorothiazole-5-carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N-heterocyces Endowed with Anti-Tumor Activity WOS:000455256500032 published article about MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL-ACTIVITY; ANTIBACTERIAL ACTIVITY; DERIVATIVES; 1,2,4-TRIAZOLE; ANTIFUNGAL; RESISTANCE; INHIBITORS; PYRAZOLE; SYSTEMS in [El Azab, Islam H.; Gobouri, Adil A.; Altalhi, Tariq A.] Taif Univ, Fac Sci, Chem Dept, POB 888, At Taif 21974, Saudi Arabia in 2019.0, Cited 44.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In our approach to synthesize bioactive molecules, a series of novel N-heterocycles were synthesized and evaluated for their in vitro antitumor activity against a panel of three human cancer cell lines, namely, human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa), and human prostate cancer PC-3. The majority of the tested compounds exhibited significant cytotoxic activity toward the tested tumor cell lines. Analogues 33, 34, 31, 38, 21, 23, 22, and 20 exhibited considerable cytotoxic activities comparable with standard drug 5-fuorouracil. Compound 33 displayed superior cytotoxicity with IC50 value of 4.12 +/- 1.21 mu g/mL against HeLa tumor cell line.

Name: 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast WOS:000518866700047 published article about 3D; EMISSIONS; LEACHABLES; COMPONENTS; MIGRATION; PRINTERS; RELEASE; DEVICES; TISSUES; DESIGN in [Nahan, Keaton; Sussman, Erie M.; Wickramasekara, Samanthi] US FDA, Ctr Devices & Radiol Hlth, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA; [Schultheis, Lester] Univ Maryland, Fischell Dept Bioengn, Robert E Fischell Med Device Inst, 8278 Paint Branch Dr, College Pk, MD 20742 USA in 2020.0, Cited 48.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The use of additive-manufactured components in medical applications, specifically medical devices (e.g., orthopedic casts), has increased in recent years. Such devices may be fabricated at the point of care using consumer-grade additive manufacturing. Limited studies have been conducted to evaluate the extractable substances of these devices. Chemical characterization followed by toxicological risk assessment is one means of evaluating safety of devices. This study was designed to determine the extractables profile of additive-manufactured materials according to filament grade and post-processing method. Feedstocks for additive manufacturing were tested as filament and manufactured casts, while the cast from consumer-grade filament (CGF) was post-processed. Samples were extracted using three solvents of varying polarities. Extracts were analyzed by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) techniques. In GC/MS analysis, isopropanol extracts generated fewer compound identifications for USP Class VI filament (USPF)-based casts (3) compared with the respective filament (17) while hexane generated the most compound identifications for the finished cast manufactured from CGF. CGF was found to have the highest number of nonvolatile extractables for isopropanol (15) and hexane (34) by positive ion LC/MS. Additionally, CGF produced more non-polar extractables in hexane than the USPF. A known polymer byproduct and potential genotoxicant, styrene acrylonitrile (SAN) trimer, was one of the compounds identified in both GC/MS and LC/MS at quantities ranging from 19 to 270 mu g g(-1). Overall these results suggested that the extractables profile was affected by the filament material, printing procedure, and post-processing method.

HPLC of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. I found the field of Biochemistry & Molecular Biology; Plant Sciences very interesting. Saw the article The lotus NnFTIP1 and NnFT1 regulate flowering time in Arabidopsis published in 2021.0, Reprint Addresses Chen, Y; Song, SY (corresponding author), Zhejiang Univ, Inst Crop Sci, State Key Lab Rice Biol, Zhejiang Prov Key Lab Crop Genet Resources, Hangzhou 310058, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

In higher plants, floral signals are mainly collected and transduced to FLOWERING LOCUS T (FT) in Arabidopsis and its orthologues. The movement of FT from leaves to the shoot apical meristem (SAM) is partially mediated by FT-INTERACTING PROTEIN1 (FTIP1). Although the functions of OsFTIP1 in rice and DOFTIP1 in orchid in FT transport have also been investigated, the FTIP1 homologue in lotus (Nelumbo nucifera Gaertn.), a type of horticultural plant with high economic and cultural value, has not been isolated, and the mechanism of NnFT1 transport has not been explored. Here, we revealed that NnFTIP1 mediates the transport of NnFT1 in ectopic transgenic lines in Arabidopsis. Overexpression of NnFTIP1 in the ftip1-1 background rescued the late flowering phenotype of ftip1-1, indicating that NnFTIP1 has a conserved function as FTIP1. NnFTIP1 and NnFT1 share similar tissue expression patterns and subcellular localization. NnFTIP1 and NnFT1 interact both in vitro and in vivo. In addition, NnFTIP1 affects NnFT1 transport from leaves to the SAM. Furthermore, we found that NnUOF8, a MYB-like transcription factor, directly regulates the expression of NnFTIP1. Our results suggest that the functions of FTIP1 and FT are conserved during evolution in flowering plants.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, L; Zhang, F; Liu, FB; Shen, J; Wang, JX; Jiang, M; Zhang, DS; Yang, PF; Chen, Y; Song, SY or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis and biological evaluation of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidines as potent antidiabetic, anticancer and antioxidant agents WOS:000578392700001 published article about RAPID COLORIMETRIC ASSAY; GREEN SYNTHESIS; PYRAZOLE; DERIVATIVES; INHIBITORS; DISCOVERY; ANTITUMOR; SURVIVAL; DOCKING; DESIGN in [Pogaku, Vinay; Basavoju, Srinivas] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India; [Krishnan, R.] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, India in 2021.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

A series of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives 4a-p were synthesized and well characterized by using IR, H-1,C-13 NMR and mass spectral data. Finally, the structure of the compound 4l was solved unambiguously by single-crystal X-ray diffraction (SXRD) which confirms all the structures 4a-p. The in vitro alpha-glucosidase inhibition, anticancer (A549 and MCF-7 cell lines) and antioxidant studies of the title compounds 4a-pwere screened. Among all the compounds, 4g, 4h and 4n exhibited significant alpha-glucosidase inhibition activity with the IC(50)values 20.12 +/- 0.19 mu M, 21.55 +/- 0.46 mu M and 24.92 +/- 0.98 mu M. Similarly, the compounds 4h, 4d and 4e showed potent anticancer activity against A549 (human lung carcinoma) cell line with IC(50)values 3.64 mu M, 4.73 mu M and 4.56 mu M, respectively, whereas the compounds 4c and 4 o displayed potent anticancer activity against human breast cancer (MCF-7) cell line with IC50 values of 2.66 mu M and 2.11 mu M. In addition, the antioxidant activity revealed that the compounds 4e and 4h exhibited potent antioxidant activity (IC50: 4.25 mu M and 5.40 mu M). To determine the safety profile of the most active compounds4c,4d,4e,4g,4h,4n and 4o were tested against non-cancer HEK293 cell line (human embryonic kidney 293), results in the lower toxicity of these compounds. [GRAPHICS] .

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Pogaku, V; Krishnan, R; Basavoju, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities WOS:000663580300014 published article about FRUITING BODY; ACID; DERIVATIVES; CINNAMOMEA; APOPTOSIS; CELLS; EXTRACT in [Li, Bin; Kuang, Yi; Yi, Yang; Qiao, Xue; Liang, Lei; Ye, Min] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China; [Li, Bin] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Minist Educ,Key Lab Bioact Subst & Resources Util, Beijing 100193, Peoples R China in 2021.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7. Chemical structures of the new compounds were elucidated by NMR and MS analyses. Furthermore, cytotoxicities of the triterpenoid derivatives were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7). As a result, 1a, 1g, and 4a exhibited potent cytotoxic activities against HL60, U251, and SW480 with IC50 values of 0.7 +/- 0.9, 2.9 +/- 1.3, and 2.2 +/- 0.6 mu M, respectively. Molecular docking indicates that 1a, 1g, and 4a have strong binding affinity with DNA topoisomerase II alpha (-9.3, -7.9, and -7.4 kcal/mol, respectively), and that they could be potent topoisomerase II alpha inhibitors.

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A P/N-containing flame retardant constructed by phosphaphenanthrene, phosphonate, and triazole and its flame retardant mechanism in reducing fire hazards of epoxy resin WOS:000511274000001 published article about THERMAL-DEGRADATION; PERFORMANCE; COMPOUND; STABILITY; NITROGEN; BEHAVIOR in [Cheng, Jianwen; Duan, Huajun; Wang, Jun; Zhang, Qianqian] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Sch Mech & Elect Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Wang, Jun; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Inst Adv Mat Mfg Equipment & Technol, Wuhan, Peoples R China; [Huo, Siqi] Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia in 2020.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

A P/N-containing flame retardant (PPT) constructed by phosphaphenanthrene, phosphonate, and triazole groups was successfully synthesized and used as a reactive co-curing agent for epoxy resin (EP). The curing behavior, thermal property, combustion behavior, and flame retardant mechanism of EP thermosets were comprehensively investigated. According to the analysis of DSC and TGA, PPT accelerated the crosslinking reaction and enhanced the charring ability for EP thermosets at high temperature. The results of combustion test indicated that PPT endowed epoxy thermoset with outstanding flame retardancy. When the phosphorus content was 0.71 wt%, EP/DDS/PPT-2 achieved a LOI value of 33.2% and passed V-0 rating in UL-94 test, and its peak heat release rate and total heat release were decreased by 63.7 and 30.5%, respectively, relative to EP/DDS. Moreover, the FIGRA of EP/DDS/PPT-2 was reduced from 9.7 to 3.5 kW m(-2) s(-1), manifesting the significantly improved fire safety of EP thermoset. The flame retardant mechanism was summarized as two parts: (a) the barrier effect of continuous phosphorus-rich char layers in condensed phase, (b) the quenching effect of phosphorous radicals and diluting effect of nonflammable gases in gaseous phase.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about GENE-EXPRESSION; STRESS-RESPONSE; ARABIDOPSIS; CATALASE; TOLERANCE; BINDING; PLANTS; FAMILY; HOMEOSTASIS; CAT2, Saw an article supported by the . Category: Triazoles. Published in WILEY in HOBOKEN ,Authors: Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Drought stress often limits plant growth and global crop yields. Catalase (CAT)-mediated hydrogen peroxide (H2O2) scavenging plays an important role in the adaptation of plant stress responses, but the transcriptional regulation of the CAT gene in response to drought stress is not well understood. Here, we isolated an APETALA2/ETHYLENE-RESPONSIVE FACTOR (AP2/ERF) domain-containing transcription factor (TF), NtERF172, which was strongly induced by drought, abscisic acid (ABA) and H2O2, from tobacco (Nicotiana tabacum) by yeast one-hybrid screening. NtERF172 localized to the nucleus and acted as a transcriptional activator. Chromatin immunoprecipitation, yeast one-hybrid assays, electrophoretic mobility shift assays and transient expression analysis assays showed that NtERF172 directly bound to the promoter region of the NtCAT gene and positively regulated its expression. Transgenic plants overexpressing NtERF172 displayed enhanced tolerance to drought stress, whereas suppression of NtERF172 decreased drought tolerance. Under drought stress conditions, the NtERF172-overexpressed lines showed higher catalase activity and lower accumulation of H2O2 compared with wild-type (WT) plants, while the NtERF172-silenced plants showed the inverse correlation. Exogenous application of amino-1,2,4-triazole (3-AT), an irreversible CAT inhibitor, to the NtERF172-overexpression lines showed decreased catalase activity and drought tolerance, and increased levels of cellular H2O2. Knockdown of NtCAT in the NtERF172-overexpression lines displayed a more drought stress-sensitive phenotype than NtERF172-overexpression lines. We propose that NtERF172 acts as a positive factor in drought stress tolerance, at least in part through the regulation of CAT-mediated H2O2 homeostasis.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H4N4. Recently I am researching about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Fahim, AM; Shalaby, MA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Fahim, AM; Shalaby, MA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry; Energy & Fuels; Engineering very interesting. Saw the article Characterization and potential utilization of extracts and pyrolyzates from Jasminum nudiflorum Lindl. Bark published in 2021. Name: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Peng, WX (corresponding author), Henan Agr Univ, Henan Prov Engn Res Ctr Biomass Value Added Prod, Zhengzhou 450002, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Utilization of lignocellulosic biomass is increasingly important. Jasminum nudiflorum Lindl. (JNL) is a widely cultivated landscape plant in China. To evaluate the chemical components, pyrolysis characteristics as well as the potential values of JNL bark for utilization, the components were extracted using methanol, ethanol, and benzene/ethanol (2:1, v/v) and pyrolyzed from room temperature to 300 ?C, respectively. Many components were detected in the extracts and the pyrolyzates of JNL bark and their chemical properties were analyzed. The compounds identified in the extracts and the pyrolyzates of JNL bark included acids, aldehydes, alcohols, esters, ketones, aromatics, saccharides, olefins, and nitrogen-containing compounds. Some of the identified compounds, such as urs-12-en-28-al, 3-(acetyloxy)-, (3.beta.)-, 5-hydroxymethylfurfural, and vanillin, are widely used in the medical, energy, and food industries. The pyrolysis of JNL bark using thermogravimetric (TG) analyzer showed the highest reaction rate occurred at between 200 and 300 ?C where the maximum mass loss was observed. According to the Coats-Redfern method, the calculated apparent activation energy (E) and pre-exponential factor (A) of the pyrolysis process of JNL bark were 52.04 kJ mol- 1 and 3.14 ? 105 min-1, respectively. This research provides information on the components and pyrolysis characteristics of JNL bark, which shows great potential for application in medical, food, and chemical industries.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J AM CHEM SOC published article about GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; CANCER-CELLS; CATALASE; GENERATION; ENZYME; NANOMATERIALS; MECHANISMS; OXIDATION in [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; You, Yawen; Deng, Qingqing] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; [Li, Wei; Zhang, Lu] Univ Chinese Acad Sci, Beijing 100039, Peoples R China in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

Welcome to talk about 61-82-5, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics