Day: December 29, 2021

SDS of cas: 61-82-5. Recently I am researching about SOLVENT-FREE SYNTHESIS; CONVENIENT; TRIAZOLOQUINAZOLINONE; 3-COMPONENT; SYSTEMS, Saw an article supported by the National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21462041]. Published in SCIENCE PRESS in BEIJING ,Authors: Ma, HF; Li, WB; Ablajan, K. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Under the catalysis of solid acidic ion exchange resin Amberlyst-15, using ethanol as solvent, aromatic aldehyde, beta-ketoester, and 3-amino-1,2,4-triazole or 2-aminobenzo as starting materials, a series of triazolo[1,5-a]pyrimidine derivatives 5a similar to 5m and dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines 6a similar to 6g were synthesized by three-component one-pot reaction of imidazole derivatives. The method is simple and efficient, and has short reaction time, simple post-treatment and wide application range of the substrate. The catalyst can be recycled for 4 times without the significant decrease of catalytic activity. It conforms to the basic standard of green chemistry.

Welcome to talk about 61-82-5, If you have any questions, you can contact Ma, HF; Li, WB; Ablajan, K or send Email.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about GANCICLOVIR; INHIBITION; MUTATIONS, Saw an article supported by the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201100016I]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. HPLC of Formula: C2H4N4

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC50:<0.05M) against a normal laboratory HCMV strain (AD-169) in human foreskin fibroblast cells than Ganciclovir (EC50=0.32M), an anti-HCMV agent in clinical use. Additionally, the HCMV-resistant isolate (GDGr K-17) was tested for sensitivity to 1,3-oxazole derivatives with most antiviral potency against the strain AD169. A one of them (5-((2-hydroxyethyl)(methyl)amino)-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile) showed very high potency (EC50:<0.05; CC50: >150 mu M, and SI50=3125) towards the resistant isolate compared to standard drugs Cidofovir (EC50=0.10 mu M, CC50: >30 mu M and SI50: <4). But, in contrast to the primary assays, the antiviral activity of these compounds against both the normal strain and the resistant isolate of HCMV were considerably less than one of Cidofovir in secondary assay. These results provided evidence that derivatives of 1,3-oxazole could be useful for developing new anti-HCMV drugs. Welcome to talk about 61-82-5, If you have any questions, you can contact Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Safari, F; Bayat, M; Nasri, S; Karami, S in [Safari, Fatemeh] Univ Guilan, Fac Sci, Dept Biol, Rasht, Iran; [Bayat, Mohammad; Nasri, Shima; Karami, Solmaz] Imam Khomeini Int Univ, Fac Sci, Dept Chem, Qazvin, Iran published Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-alpha] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process in 2020.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products with potential anti-tumor activities. In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and Nmethyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Bronsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo [1,5-a] pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of our synthetic compounds on different cancer cells including human malignant melanoma cells (A375), prostate cancer cells (PC3 cells, LNCaP cells) and normal cells HDF (human dermal fibroblast). Notably, we found that compound 4b that contains a nitro group has the best antitumor activity on three different cancer cells. By using DAPI staining, we showed cancer cells death. Apoptosis induction was shown using quantitative real time PCR (qRT-PCR) by evaluating of Bax and Bcl2 mRNA levels. Finally, we demonstrated that 4b has epithelial-to-mesenchymal transition (EMT) inhibition effect on cancer cells (by induction of E-cadherin and reduction of vimentin mRNA expression levels as two potential EMT markers). So, 4b could be an anti-cancer promising drug. Although, in vivo experiments will be required to evaluate possible side effects.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. Authors Abdel-Kader, NS; Moustafa, H; El-Ansary, AL; Sherif, OE; Farghaly, AM in ROYAL SOC CHEMISTRY published article about in [Abdel-Kader, Nora S.; Moustafa, Hussein; El-Ansary, Aida L.; Sherif, Omaima E.] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt; [Farghaly, Aya M.] Cairo Univ, Ctr Environm Hazard Mitigat, Giza, Egypt in 2021.0, Cited 71.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

8-Acetyl-7-hydroxy-4-methyl coumarin and 3-amion-1,2,4-triazole were used to prepare a Schiff base (Sbat). The [Ag(Sbat)(NO3)]center dot H2O and [Cu(Sbat)(OH)(H2O)(2)]center dot 3H(2)O complexes were separated by the reaction of the Schiff base with Ag(i) and Cu(ii) metal ions. All the prepared compounds were subjected to elemental and spectral analyses (IR, UV-vis, H-1 NMR, and mass spectroscopy). Moreover, the complexes were also subjected to TG analysis, molar conductance measurements, magnetic moment analysis, and XRD measurements. The value of the molar conductance designates their non-electrolytic character. The local minimum structure, global properties and nonlinear optical parameters of the Schiff base were calculated at the B3LYP/6-31++(d,p) level of theory and those of its complexes were calculated at the B3LYP/GENECP level. The electronic spectra in the UV-visible region of the Schiff base (Sbat) and [Ag(Sbat)(NO3)]center dot H2O and [Cu(Sbat)(OH)(H2O)(2)]center dot 3H(2)O complexes in DMSO as a solvent were investigated experimentally and theoretically using the time dependent density functional theory (TD-DFT) method at the CAM-B3LYP/6-311++G(d,p) level of theory. The studied compounds were screened for their in vitro antibacterial activity against three Gram-positive (B. subtilis, S. aureus and S. faecalis) and three Gram-negative bacteria (E. coli, N. gonorrhoeae and P. auregenosa). An antifungal assay was performed against two fungal (C. albicans and A. flavus) species. The Ag-Sbat complex showed the highest antimicrobial activity. The cytotoxic activity of the Schiff base and its silver complex was tested in vitro against the MCF-7 (breast cancer) and HCT-116 (colon cancer) cell lines.

Welcome to talk about 61-82-5, If you have any questions, you can contact Abdel-Kader, NS; Moustafa, H; El-Ansary, AL; Sherif, OE; Farghaly, AM or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Monitoring of pesticides in ambient air: Prioritization of substances WOS:000588616700010 published article about CURRENTLY USED PESTICIDES; OZONE in [Hulin, Marion; Leroux, Carole; Mathieu, Aurelie; Merlo, Mathilde] ANSES, Risk Assessment Dept, 14 Rue Pierre & Marie Curie, F-94701 Maisons Alfort, France; [Gouzy, Aurelien; Garziandia, Eva Leoz] INERIS, Parc Technol ALATA BP2, F-60550 Verneuil En Halatte, France; [Berthet, Aurelie] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland; [Boivin, Arnaud; Scelo, Anne-Laure] ANSES, Regulated Prod Assessment Dept, 14 Rue Pierre & Marie Curie, F-94701 Maisons Alfort, France; [Bonicelli, Bernard; Ruelle, Bernadette] INRAE UMR ITAP, 361 Rue Jean Francois Breton, F-34196 Montpellier, France; [Chubilleau, Catherine] Ctr Hosp Niort, Serv Hyg Hosp, F-79000 Niort, France; [Hulin, Agnes] ATMO Nouvelle Aquitaine, F-17180 La Rochelle, Perigny, France; [Garziandia, Eva Leoz] LCSQA, F-60550 Verneuil En Halatte, France; [Mamy, Laure; Bedos, Carole] Univ Paris Saclay, UMR ECOSYS, AgroParisTech, INRAE, F-78850 Thiverval Grignon, France; [Millet, Maurice] Univ Strasbourg, EPEES UMR 7515 CNRS, 25 Rue Becquerel, F-67087 Strasbourg 2, France; [Pernot, Pierre] AirParif, 7 Rue Crillon, F-75005 Paris, France; [Quivet, Etienne] Aix Marseille Univ, LCE, CNRS, Marseille, France in 2021.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

Despite the richness of data collected on pesticide concentrations in ambient air in France, knowledge on this topic remains partial and heterogeneous in the absence of specific regulations. The population exposure remains thus difficult to estimate; therefore it was necessary to define modalities for implementing national monitoring of pesticides in ambient air in metropolitan France and in the overseas territories. The objective of this work was to identify which active substances (a.s.) have to be monitored in priority. As part of a collective expertise, a group of multidisciplinary experts has developed a method to rank active substances authorised as plant protection products, biocides and antiparasitic agents, which were available on the French market in 2015. A 3-steps approach has been developed. The first step consisted of a theoretical approach based on a hierarchy of substances according to four criteria: (a) national uses, (b) emission potential to the air, (c) persistence in the air, and (d) chronic toxicity. The three first criteria give information on their potential to be present in the atmosphere, and the fourth criterion allows to consider their potential of hazard. The second step was an observational approach based on existing database on pesticide air measurements in France. In the third step, both approaches were combined using decision trees to select priority pesticides. Among the 1316 a.s. first identified from the EU Pesticides database, 90 were selected, among which 43 required metrological and/or analytical development. The experts recommended confirming the relevance of performing a longer term monitoring of these a.s. after a one-year exploratory campaign. The proposed method is reproduceable, transparent, easy to update (e.g. in the light of a change in product authorization), and can be adapted to other agricultural and geographical conditions, and objectives (e.g. monitoring of the ecotoxicological effects of pesticides). (C) 2020 Published by Elsevier B.V.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics