Day: January 6, 2022

An article Bronsted acid-promoted ‘on-water’ C(sp(3))-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction WOS:000510956700009 published article about AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; MOLECULAR HYBRIDIZATION; EFFICIENT SYNTHESIS; DESIGN in [Yuan, Shuo; Wang, Sixi; Zhao, Min; Zhang, Danqing; Chen, Jinjie; Li, Jian-Xin; Zhang, Jingya; Song, Yihui; Wang, Jinyi; Yu, Bin; Liu, Hongmin] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China in 2020.0, Cited 33.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or send Email.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN HEALTH-RISK; ORGANOCHLORINE PESTICIDES; TRACE DETERMINATION; POLAR PESTICIDES; HPLC-DAD; PHARMACEUTICALS; RIVER; SPE, Saw an article supported by the Zhejiang Medical Technology and Education Project [2014KYA188]. Published in OXFORD UNIV PRESS INC in CARY ,Authors: Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Recommanded Product: 1H-1,2,4-Triazol-5-amine

A rapid and efficient method based on solid phase extraction and liquid chromatography-tandem mass spectrometry was validated, allowing the determination of the endocrine-disrupting herbicides (acetochlor, alachlor, amitrole and atrazine), fungicides (carbendazim, triadimefon, penconazole and propiconazole), and insecticides (carbaryl and carbofuran) in drinking water. Low method detection limits (0.01-0.64 ng/L) and method quantification limits (0.03-2.13 ng/L) were obtained with satisfactory recoveries and precision for the endocrine-disrupting pesticides. The method was applied for real drinking water samples collected in the area of the city of Hangzhou (Zhejiang, China); the results showed that carbendazim, atrazine and acetochlor were detected in the drinking water samples and acetochlor was the most detected analyte.

Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN or send Email.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines WOS:000571559800001 published article about FAST-ATOM-BOMBARDMENT; BIGINELLI; 3-AMINO-1,2,4-TRIAZOLE; ANTICANCER in [Shvets, Elena H.; Pidvorotnia, Anastasiia, V; Kulyk, Olesia G.; Kolosov, Maksim A.] Kharkov Natl Univ, Sch Chem, UA-61022 Kharkiv, Ukraine; [Mazepa, Alexander, V] NAS Ukraine, AV Bogatsky Physicochem Inst, Odesa, Ukraine in 2021.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

4,7-Dihydroazolo[1,5-a]pyrimidin-5-ylmethanesulfonamides are side-products of the three-component Biginelli-like reaction of aminoazoles, aldehydes andN,N-dialkyl-2-ketomethanesulfonamides. Herein, we report a straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines by a two-component condensation of aminoazoles andN,N-dialkyl(cinnamoyl)methanesulfonamides in DMF at reflux. The startingN,N-dialkyl-2-ketomethanesulfonamides can be obtained by either lithiation ofN,N-dialkylmethanesulfonamides and reaction with aldehydes followed by oxidation of the resulting alcohols or by Claisen condensation ofN,N-dialkylmethanesulfonamides with the corresponding esters. The chemical structures of all synthesized compounds are supported by(1)H and(13)C NMR-spectroscopy, mass spectrometry and elemental analysis.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ye, YJ; Nikovics, K; To, A; Lepiniec, L; Fedosejevs, ET; Van Doren, SR; Baud, S; Thelen, JJ in [Ye, Yajin; Fedosejevs, Eric T.; Van Doren, Steven R.; Thelen, Jay J.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Biochem, 1201 E Rollins, Columbia, MO 65211 USA; [Nikovics, Krisztina; To, Alexandra; Lepiniec, Loic; Baud, Sebastien] Univ Paris Saclay, AgroParisTech, Inst Jean Pierre Bourgin, INRAE,CNRS, F-78000 Versailles, France published Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants in 2020.0, Cited 60.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully understood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains. We report here the identification of a gene family encoding for three small plastidial proteins of the envelope membrane that interact with the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechanism restraining FAS in the light. Light enhances the interaction between carboxyltransferase interactors (CTIs) and alpha-CT, which in turn attenuates carbon flux into FAS. Knockouts for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in leaves, more than 4-fold higher than in wild-type plants. Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regulates CTI1 expression by direct binding to its promoter. This study reveals that in addition to light-dependent activation, envelope docking of ACCase permits fine-tuning of fatty acid supply during the plant life cycle.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about LIGHT-EMITTING-DIODES; CELL-CYCLE ARREST; QUINAZOLINE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ONE-POT; DESIGN; DOCKING; HETEROCYCLES; INHIBITORS, Saw an article supported by the . Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Fares, IMZ; Mekky, AEM; Elwahy, AHM; Abdelhamid, IA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. HPLC of Formula: C2H4N4

A novel series of bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8-ones) and bis(tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolinones) containing amide linkages were regionselectively prepared via a three-component reaction of bis(aldehydes) with dimedone and 3-amino-1,2,4-triazole (or 2-aminobenzimidazole) under conventional heating as well as under microwave irradiation.

HPLC of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, S; Shen, DD; Zhao, LJ; Yuan, XH; Cheng, JL; Yu, B; Zheng, YC; Liu, HM in [Yu, Bin; Zheng, Yichao; Liu, Hongmin] Zhengzhou Univ, Key Lab Technol Drug Preparat, Minist Educ China, Zhengzhou 450001, Peoples R China; Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China published Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors in 2020, Cited 47. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Targeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degraders have been identified, some of which have advanced into clinical trials. In this work, a focused library of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4. WS-722 inactivated BRD4 (BD1/BD2), BRD2 (BD1 BD2) and BRD3 (BD1/BD2) broadly with the IC50 values less than 5 mu mol/L. Besides, WS-722 inhibited growth of THP-1 cells with an IC50 value of 3.86 mu mol/L. Like (+)-JQ1, WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability. Docking studies showed that WS-722 occupied the central acetyl-lysine (Kac) binding cavity and formed a hydrogen bond with Asn140. In THP-1 cells, WS-722 showed target engagement to BRD4. Cellular effects of WS-722 on THP-1 cells were also examined, showing that WS-722 could block c-MYC expression, induce G0/G1 phase arrest and p21 up-regulation, and promote differentiation of THP-1 cells. BRD4 inhibition by WS-722 resulted in cell apoptosis and up-regulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines. The [1,2,4]triazolo[1,5-a] pyrimidine is a new template for the development of new BRD4 inhibitors. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, S; Shen, DD; Zhao, LJ; Yuan, XH; Cheng, JL; Yu, B; Zheng, YC; Liu, HM or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Microwave Assisted Three Component One-pot Synthesis of Bis(aminoazolo[1,5-a]pyrimidines) and Bis(aminoazino[1,2-a]benzimidazoles) Bearing Thiazole Moiety published in 2019.0. Computed Properties of C2H4N4, Reprint Addresses Mekky, AEM (corresponding author), Cairo Univ, Chem Dept, Fac Sci, Giza 12613, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Novel bis[(thiazol-2-yl)acetonitrile] derivatives were prepared in good yields by the cyclocondensation of bis(bromoacetyl) derivatives with two equivalents of 2-cyanothioacetamide in dioxane at reflux. The bis[(thiazol-2-yl)acetonitrile] derivatives were taken as synthetic precursors for the synthesis of novel bis(aminoazolo[1,5-a]pyrimidines), bearing thiazole moiety. The target molecules were prepared by the three component one pot reaction of bis[(thiazol-2-yl)acetonitrile] derivatives, dimethylformamide-dimethylacetal and several of 3-aminopyrazoles in pyridine under microwave irradiation at 140 degrees C for 2 h. Using the same protocol, novel bis(aminotriazolo[1,5-a]pyrimidines), bis(aminopyrimido[1,2-a]benzimidazoles) and bis(aminopyrido [1,2-a]benzimidazoles), incorporating thiazole moieties, were prepared by using the appropriate heterocyclic amine or 2-(1H-benzoimidazol-2-yl)acetonitrile instead of 3-aminopyrazoles. The structure of the newly prepared thiazoles was confirmed via considering their elemental analyses and spectral data.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Zeng, RL; Deng, JY; Dang, LM; Yu, XL in NATURE RESEARCH published article about PREDICTION; MOLECULES in [Zeng, Ruolan; Deng, Jiyong; Dang, Limin; Yu, Xinliang] Hunan Inst Engn, Hunan Prov Key Lab Environm Catalysis & Waste Reg, Coll Mat & Chem Engn, Xiangtan 411104, Hunan, Peoples R China in 2021, Cited 23. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A three-descriptor quantitative structure-activity/toxicity relationship (QSAR/QSTR) model was developed for the skin permeability of a sufficiently large data set consisting of 274 compounds, by applying support vector machine (SVM) together with genetic algorithm. The optimal SVM model possesses the coefficient of determination R-2 of 0.946 and root mean square (rms) error of 0.253 for the training set of 139 compounds; and a R-2 of 0.872 and rms of 0.302 for the test set of 135 compounds. Compared with other models reported in the literature, our SVM model shows better statistical performance in a model that deals with more samples in the test set. Therefore, applying a SVM algorithm to develop a nonlinear QSAR model for skin permeability was achieved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zeng, RL; Deng, JY; Dang, LM; Yu, XL or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Structures, Single-Molecule Magnets, and Fluorescent Properties of Four Dinuclear Lanthanide Complexes Based on 4-Azotriazolyl-3-hydroxy-2-naphthoic Acid published in 2019.0. Recommanded Product: 61-82-5, Reprint Addresses Chen, WB; Dong, W (corresponding author), Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou Key Lab Environm Funct Mat & Technol, Guangzhou 510006, Guangdong, Peoples R China.; Zhang, YQ (corresponding author), Nanjing Normal Univ, Sch Phys Sci & Technol, Jiangsu Key Lab NSLSCS, Nanjing 210023, Jiangsu, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Four isostructural dinuclear lanthanide complexes based on 4-azotriazolyl-3-hydroxy-2-naphthoic acid (H(3)ATNA) and 3-hydroxy-2-naphthoic acid (H(2)NA) ligands, {[Ln(2)(HATNA)(2)(HNA)(2)(H2O)(4)].6DMF} (Ln = Dy (1), Tb (2), Sm (3), Eu (4); DMF = N,N-dimethylformamide) have been prepared and characterized by X-ray diffraction crystallography, dc/ac magnetic characterization, and fluorescent spectrometry. The crystallographic data reveal dinuclear lanthanide cores of complexes 1-4, bridged by phenoxo and mu(1,3) carboxyl groups. Each nine-coordinated Ln(III) ion is located in a slightly distorted monocapped square antiprism. The ligand of H(3)ATNA displays a unique antenna effect in complex 4. Complexes 1-3 display only two ligand-centered fluorescent emissive peaks around 450 and 600 nm, and complex 4 shows four characteristic Eu(III)centered emission bands at 593, 618, 653, and 698 nm under excitation at 348 nm. Complex 1 exhibits single-molecule magnet behavior that is rationalized through ab initio calculations.

Recommanded Product: 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Baklykov, AV; Rusinov, GL; Rusinov, VL; Charushin, VN; Kopchuk, DS; Zyryanov, GV; Artem’ev, GA in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Baklykov, A. V.; Rusinov, G. L.; Rusinov, V. L.; Charushin, V. N.; Kopchuk, D. S.; Zyryanov, G. V.; Artem’ev, G. A.] Russian Acad Sci, Postovskii Inst Organ Synth, Ural Branch, Ul S Kovalevskoi Akad Skaya 22-20, Ekaterinburg 620990, Russia; [Baklykov, A. V.; Rusinov, G. L.; Rusinov, V. L.; Charushin, V. N.; Kopchuk, D. S.; Zyryanov, G. V.] Yeltsin Ural Fed Univ, Ul Mira 19, Ekaterinburg 620002, Russia in 2019.0, Cited 7.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one, an intermediate product in the synthesis of the antiviral drug Triazid (R), was obtained for the first time by condensation of 3H-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl2 in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics