Day: January 12, 2022

Recently I am researching about IRON-OXIDE NANOPARTICLES; FUNCTIONALIZED FE3O4 NANOPARTICLES; ONE-POT SYNTHESIS; SURFACE FUNCTIONALIZATION; MULTICOMPONENT REACTIONS; DERIVATIVES; CATALYST; 3-COMPONENT; GREEN, Saw an article supported by the Research Council of the Payame Noor University (PNU) in Iran. Quality Control of 1H-1,2,4-Triazol-5-amine. Published in SPRINGER in DORDRECHT ,Authors: Basirat, N. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Supported 3-(3-sulfamic acid imidazolium trifluoroacetate)propyl triethoxysilane on magnetic nanoparticles as a novel nanocatalyst was synthesized and characterized by FT-IR, XRD, TGA, SEM, TEM and VSM techniques. The catalytic activity of the magnetic catalyst was studied through one-pot synthesis of triazole quinazolinones and fused pyrimidine derivatives via one-pot multi-component reactions under thermal conditions. This catalyst demonstrated excellent catalytic properties with high percentage in short reaction times, low cost and easily separated using an external magnet and reusable without significant loss of its catalytic efficiency. [GRAPHICS] .

Welcome to talk about 61-82-5, If you have any questions, you can contact Basirat, N or send Email.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; AUTOPHAGY; APOPTOSIS; ROS; DESIGN in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Name: 1H-1,2,4-Triazol-5-amine

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, S; Ma, XB; Yuan, XH; Yu, B; Xu, YC; Liu, HM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Ratiometric Fluorescent Mapping of pH and Glutathione Dictates Intracellular Transport Pathways of Micellar Nanoparticles published in 2020.0. Product Details of 61-82-5, Reprint Addresses Liu, GH; Hu, JM (corresponding author), Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Visualization of intracellular transport pathways is crucial to investigate the internalization mechanism and understand the intracellular behavior of nanomaterials. Herein, we rationalized the design of micellar nanopartides (NPs for ratiometric fluorescent mapping of intracellular pH and glutathione (GSH), two essential parameters for maintaining normal cellular functions. Specifically, pH-sensitive naphthalimide-based probe (NPI) and pH-inert rhodamine B (RhB) were covalently labeled to double hydrophilic block copolymers (DHBCs) using the thiolactone chemistry, enabling the covalent attachment of NPI and RhB to one molecule with a redox-responsive disulfide linkage. The dually labeled DHBCs exhibited blue/orange dual emissions in acidic pH, which was further converted into green/orange dual emissions in neutral pH because of the deprotonation of NPI moieties and the sole green emission in the presence of GSH at neutral pH because of the decreased Forster resonance energy transfer efficiency between an NPI donor and an RhB acceptor as a result of GSH-mediated cleavage of disulfide bonds. These remarkable ratiometric fluorescence changes allowed for not only the simultaneous mapping of the intracellular pH and GSH but also the intracellular transport pathways of internalized NPs.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Ding, ZX; Liu, GH; Hu, JM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 61-82-5. I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article An efficient green synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives via Strecker reaction under controlled microwave heating published in 2019.0, Reprint Addresses Abdel-Hameed, AM (corresponding author), Menia Univ, Fac Sci, Chem Dept, Al Minya 61519, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

A highly efficient multi-component one-pot synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about VOLATILE; STEEL in [Goncharova, O. A.; Kuznetsov, D. S.; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 17.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (potentiometric anode polarization and electrochemical impedance spectroscopy), and corrosion (periodic moisture condensation test) methods, the properties of adsorption films formed on the AMg6 aluminum alloy surface by the chamber method in vapors of some amines of heterocyclic compounds, carboxylic acids, and their salts are studied. It is established that the use of the studied compounds in the chamber processing of the alloy increases-though not effectively enough-its corrosion resistance in a humid atmosphere. The most promising inhibitors are carboxylic acids themselves; the optimum temperature for surface treatment with them is 140 degrees C. One-hour treatment of steel with pairs of oleic, neodecanoic acid, and carboxylic acid A at this temperature gives rise to the formation of nanoscale adsorption films on the AMg6 alloy, which slightly hydrophilize the surface, but possess a protective aftereffect. Apparently, further improvement of chamber protection methods of the AMg6 alloy should consist in the selection of synergists for chamber corrosion inhibitors of the carboxylate type.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A P/N-containing flame retardant constructed by phosphaphenanthrene, phosphonate, and triazole and its flame retardant mechanism in reducing fire hazards of epoxy resin WOS:000511274000001 published article about THERMAL-DEGRADATION; PERFORMANCE; COMPOUND; STABILITY; NITROGEN; BEHAVIOR in [Cheng, Jianwen; Duan, Huajun; Wang, Jun; Zhang, Qianqian] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Sch Mech & Elect Engn, Wuhan 430070, Peoples R China; [Yang, Shuang; Wang, Jun; Ding, Guoping; Hu, Yefa] Wuhan Univ Technol, Inst Adv Mat Mfg Equipment & Technol, Wuhan, Peoples R China; [Huo, Siqi] Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia in 2020.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

A P/N-containing flame retardant (PPT) constructed by phosphaphenanthrene, phosphonate, and triazole groups was successfully synthesized and used as a reactive co-curing agent for epoxy resin (EP). The curing behavior, thermal property, combustion behavior, and flame retardant mechanism of EP thermosets were comprehensively investigated. According to the analysis of DSC and TGA, PPT accelerated the crosslinking reaction and enhanced the charring ability for EP thermosets at high temperature. The results of combustion test indicated that PPT endowed epoxy thermoset with outstanding flame retardancy. When the phosphorus content was 0.71 wt%, EP/DDS/PPT-2 achieved a LOI value of 33.2% and passed V-0 rating in UL-94 test, and its peak heat release rate and total heat release were decreased by 63.7 and 30.5%, respectively, relative to EP/DDS. Moreover, the FIGRA of EP/DDS/PPT-2 was reduced from 9.7 to 3.5 kW m(-2) s(-1), manifesting the significantly improved fire safety of EP thermoset. The flame retardant mechanism was summarized as two parts: (a) the barrier effect of continuous phosphorus-rich char layers in condensed phase, (b) the quenching effect of phosphorous radicals and diluting effect of nonflammable gases in gaseous phase.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J MOL STRUCT published article about CHLOROSULFONIC ACID; INFRARED SPECTRA; SULFONATION; CATALYST; AGENTS in [Shahnavaz, Zohreh; Khaligh, Nader Ghaffari; Zaharani, Lia; Johan, Mohd Rafie; Hamizi, Nor Aliya] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Inst Postgrad Studies, 3rd Floor,Block A, Kuala Lumpur 50603, Malaysia in 2020.0, Cited 35.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

In the present study, the chemical structure of 4,4′-trimethylene-N,N’-dipiperidinium chlorosulfonate is elucidated by 1D NMR, and 2D NMR, FTIR, Raman analyses, and Mass spectra. It was indicated that the chlorosulfonic acid could not act as a sulfonating agent in the reaction with secondary amines like TMDP due to due more steric hindrance of the sulfur atom by chlorine and oxygen atoms. Raman and FTIR spectra are demonstrated as two high-value optical techniques to the elucidation and identification of chemical structures that confirmed C3(v) symmetry for chlorosulfonate anion in the ionic liquid. Then, the solvent-catalyst activity of ionic liquid was demonstrated in the one-pot synthesis of a series of novel triazolo-pyrimidines under mild conditions. The ionic liquid was retrieved and reused several times without reducing its catalytic efficiency. (C) 2020 Elsevier B.V. All rights reserved.

HPLC of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; AUTOPHAGY; APOPTOSIS; ROS; DESIGN in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ACID-DERIVATIVES; TRIAZOLE, Saw an article supported by the Imam Khomeini International University, Iran. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Safari, F; Bayat, M; Nasri, S; Karami, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. HPLC of Formula: C2H4N4

Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products with potential anti-tumor activities. In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and Nmethyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Bronsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo [1,5-a] pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of our synthetic compounds on different cancer cells including human malignant melanoma cells (A375), prostate cancer cells (PC3 cells, LNCaP cells) and normal cells HDF (human dermal fibroblast). Notably, we found that compound 4b that contains a nitro group has the best antitumor activity on three different cancer cells. By using DAPI staining, we showed cancer cells death. Apoptosis induction was shown using quantitative real time PCR (qRT-PCR) by evaluating of Bax and Bcl2 mRNA levels. Finally, we demonstrated that 4b has epithelial-to-mesenchymal transition (EMT) inhibition effect on cancer cells (by induction of E-cadherin and reduction of vimentin mRNA expression levels as two potential EMT markers). So, 4b could be an anti-cancer promising drug. Although, in vivo experiments will be required to evaluate possible side effects.

Welcome to talk about 61-82-5, If you have any questions, you can contact Safari, F; Bayat, M; Nasri, S; Karami, S or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT in ELSEVIER SCIENCE BV published article about IONIC LIQUIDS; ENANTIOMERIC SEPARATION; BETA-CYCLODEXTRINS; ENANTIOSEPARATION; PERFORMANCE; COMPLEXES; MECHANISM; LIGAND; DRUGS; MODEL in [Liu, Jie; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Ma, Xiaofei; Li, Jingtang] China Pharmaceut Univ, Dept Analyt Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 39.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated. Molecular modeling was applied to demonstrate the chiral recognition mechanism of the LA-ATM, which well supported the experimental results. Furthermore, a mathematical equation built up based on the molecular mechanics calculations was used in predicting resolution of tested drugs using LA or LA-ATM mediated CE, the predicted result was well correlated with the experimental result. (C) 2019 Published by Elsevier B.V.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics