Day: January 18, 2022

Torra, J; Rojano-Delgado, AM; Menendez, J; Salas, M; de Prado, R in [Torra, Joel] Univ Lleida, Dept Hortofructicultura Bot & Jardineria, Agrotecnio, Alcalde Rovira Roure 191, Lleida 25198, Spain; [Rojano-Delgado, Antonia Maria; de Prado, Rafael] Univ Cordoba, Dept Agr Chem & Soil Sci, Campus Rabanales, Cordoba 14014, Spain; [Menendez, Julio] Escuela Politecn Super, Dept Ciencias Agroforestales, Campus Univ La Rabida, Huelva 21071, Spain; [Salas, Marisa] Corteva Agrisci, Crop Protect, F-782808 Guyancourt, France published Cytochrome P450 metabolism-based herbicide resistance to imazamox and 2,4-D in Papaver rhoeas in 2021.0, Cited 35.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Papaver rhoeas biotypes displaying multiple herbicide resistance to ALS inhibitors and synthetic auxin herbicides (SAH) are spreading across Europe. In Spain, enhanced metabolism to imazamox was confirmed in one population, while cytochrome-P450 (P450) based metabolism to 2,4-D in another two. The objectives of this research were to further confirm the presence of P450 mediated enhanced metabolism and, if so, to confirm whether a putative common P450 is responsible of metabolizing both 2,4-D and imazamox. Metabolism studies were undertaken in five P. rhoeas populations with contrasted HR profiles (herbicide susceptible, only HR to ALS inhibitors, only HR to SAH, or multiple HR to both), and moreover, three different P450 inhibitors were used. The presence of enhanced metabolism to these SoA was confirmed in three more HR P. rhoeas populations. This study provides the first direct evidence that imazamox metabolism in these biotypes is P450-mediated, also in one population without an altered target site. Additionally, it was further confirmed that enhanced metabolism of 2,4-D in biotypes only HR to SAH or multiple HR to ALS inhibitors and SAH involves P450 as well. No metabolism was detected using the three inhibitors in all the herbicide-metabolizing P. rhoeas biotypes, suggesting that a common metabolic system involving P450s is responsible of degrading herbicides affecting both SoAs. Thus, selection pressure with either SAH or imidazolinone ALS inhibitors can select not only for resistance to each of them, but it can also confer cross-resistance between them in P. rhoeas.

Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Dual-functionalized ZIF-8 as an efficient acid-base bifunctional catalyst for the one-pot tandem reaction WOS:000589899500008 published article about METAL-ORGANIC FRAMEWORK; DEACETALIZATION; CONDENSATION; HYDROGEN; SITES in [Lee, Yu-Ri; Do, Xuan Huy; Hwang, Seung Sang; Baek, Kyung-Youl] Korea Inst Sci & Technol, Mat Architecturing Res Ctr, Seoul 02792, South Korea; [Do, Xuan Huy; Baek, Kyung-Youl] Korea Univ Sci & Technol, KIST Sch, Div Nano Informat Technol, Seoul 02792, South Korea; [Baek, Kyung-Youl] Korea Res Inst Chem Technol, Ctr Convergent Chem Proc, 141 Gajeong Ro, Daejeon 34114, South Korea in 2021.0, Cited 29.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

An acid-base bifunctional zeolitic imidazolate framework catalyst (ZIF8-A61-SO3H) with amine and sulfonic acid groups was successfully prepared through simple two step post-synthetic modification: preparation of aminefunctionalized ZIF-8 with amine contents of 61% (ZIF8-A61) by the ligand exchange of 2-mIM with 3-amino1,2,4-triazole (Atz), followed by the sulfonic acid functionalization by the ring-opening reaction of 1,3-propanesultone with -NH2 groups in ZIF8-A61. Amine-functionalized ZIF8-A materials with difference amine contents (15%, 34%, and 61%, respectively) were also prepared by controlling the synthesis time. All obtained ZIF catalysts evaluated as a heterogeneous catalyst for one-pot deacetalization-Knoevenagel condensation tandem reaction. Compared with ZIF-8 and amine-functionalized ZIF-8 catalysts, ZIF8-A61-SO3H catalyst showed good catalytic performance with 100% conversion of the reactant and 98% selectivity of the final Knoevenagel product. An enhanced catalytic activity can be attributed to the co-existence of site-isolated acid-base groups on the ZIF8-A61-SO3H catalyst in close proximity. The heterogeneous nature of the catalytic system was confirmed by a hot-filtering test and the catalyst also exhibited reusable in the five repeated cycles. A plausible catalytic mechanism of deacetalization-Knoevenagel condensation reaction over ZIF8-A61-SO3H was also proposed.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis of highly functionalised 5-membered ring fused pyrimidine derivatives using an isocyanide-based one-pot, three component reaction WOS:000527104200003 published article about MULTICOMPONENT REACTIONS; HETEROCYCLIC-SYSTEMS; CONSTRUCTION; UGI; ADDITIONS; ANALOGS; AMINES in [Mohlala, Reagan L.; Coyanis, E. Mabel] MINTEK, Adv Mat Div, Private Bag X3015, ZA-2125 Randburg, South Africa; [Mohlala, Reagan L.; Fernandes, Manuel A.; Bode, Moira L.] Univ Witwatersrand, Sch Chem, Mol Sci Inst, PO Wits, ZA-2050 Johannesburg, South Africa in 2020.0, Cited 60.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A one-pot reaction of the zwitterion formed from an isocyanide and an acetylenedicarboxylate with different five-membered rings containing both an acidic proton and a suitable nucleophile resulted in the preparation of novel 5-membered ring fused pyrimidine derivatives in yields ranging from 18 to 87%. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Mohlala, RL; Coyanis, EM; Fernandes, MA; Bode, ML or send Email.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives WOS:000469518100013 published article about 2-MERCAPTOTHIAZOLINE; ANTICANCER; 4-THIAZOLINE-2-THIONES; 2-THIAZOLINE-2-THIOL; ADSORPTION; HISTORY; BINDING; POTENT; DRUGS in [Mabkhot, Yahia N.] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha 61441, Saudi Arabia; [Algarni, H.] King Khalid Univ, Dept Phys, Fac Sci, POB 9004, Abha 61441, Saudi Arabia; [Algarni, H.] King Khalid Univ, RCAMS, POB 9004, Abha 61441, Saudi Arabia; [Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha 61441, Saudi Arabia; [Kheder, Nabila A.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt; [Almarhoon, Zainab M.; Al-aizari, Faiz A.] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Al-aizari, Faiz A.] AL Baydha Univ, Fac Sci, Dept Chem, Albaydah 38018, Yemen in 2019.0, Cited 58.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing H-1-NMR, C-13-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Antiglycation Activity of Triazole Schiff’s Bases Against Fructose-mediated Glycation: In Vitro and In Silico Study published in 2020.0, Reprint Addresses Choudhary, MI (corresponding author), Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objectives: Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triamle-4-Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity. Methods: In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of triazole Schiff’s bases. The active compounds were subjected to cytotoxicity analysis by MTT assay on mouse fibroblast (3T3) cell line. Molecular docking and simulation studies were carried out to evaluate the interactions and stability of compounds with HSA. Anti-hyperglycemic and antioxidant activities of selected non-cytotoxic compounds were evaluated by in vitro a-glucosidase inhibition, and DPPH free radical scavenging assays, respectively. Results: Compound 1 (IC50 =47.30 +/- 0.38 mu M) from 4H-1,2,4-triazole-4-Schiff’s bases has exhibited antiglycation activity comparable to standard rutin (IC50 =54.5 +/- 0.05 mu M) along with a stable RMSD profile in MD simulation studies. Compound 1 also exhibited a potent a-glucosidase inhibitory activity, and moderate antioxidant property. Other derivatives showed a weak antiglycation activity with IC50 values between 248.1-637.7 mu M. Compounds with potential antiglycation profile were found to be non-cytotoxic in a cellular assay. Conclusion: The study identifies triazole Schiff s bases active against fructose-mediated glycation of HSA, thus indicates their potential against late diabetic complications due to production of advancedend products (AGEs).

Welcome to talk about 61-82-5, If you have any questions, you can contact Shaikh, M; Siddiqui, S; Zafar, H; Naqeeb, U; Subzwari, F; Imad, R; Khan, KM; Choudhary, MI or send Email.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics