Day: February 10, 2022

Formula: C2H4N4. Authors Kovygin, YA; Vandyshev, DY; Ledenyova, IV; Kosheleva, EA; Polikarchuk, VA; Kozaderov, OA; Shikhaliev, KS in SPRINGER published article about in [Kovygin, Yu A.; Vandyshev, D. Yu; Ledenyova, I., V; Kosheleva, E. A.; Polikarchuk, V. A.; Kozaderov, O. A.; Shikhaliev, Kh S.] Voronezh State Univ, 1 Univ Skaya Pl, Voronezh 394018, Russia in 2021.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A convenient method for the synthesis of 2-(2-R-5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the regioselective domino reaction of N-arylitaconimides with substituted 3-aminotriazoles was proposed. Presumably, the reaction pathway includes the conjugated aza-addition of the endo-nucleophilic center of triazole to imide, followed by the recyclization of the intermediate to triazolo[1,5-a]pyrimidine.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kovygin, YA; Vandyshev, DY; Ledenyova, IV; Kosheleva, EA; Polikarchuk, VA; Kozaderov, OA; Shikhaliev, KS or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase WOS:000552629800008 published article about GROWTH-FACTOR RECEPTOR-2; BIOLOGICAL EVALUATION; ANTICANCER EVALUATION; INHIBITORS; ANGIOGENESIS; RESISTANCE; MECHANISM; DISCOVERY; DESIGN in [Dawood, Dina H.] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Pharmaceut & Drug Ind Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt; [Nossier, Eman S.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, POB 11754, Cairo, Egypt; [Ali, Mamdouh M.; Mahmoud, Abeer E.] Natl Res Ctr, Biochem Dept, Genet Engn & Biotechnol Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt in 2020.0, Cited 50.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Based on the previous studies that revealed the valuable role of pyrazole scaffold in cancer management and VEGFR-2 inhibition, a new set of pyrazole conjugated with pyrazoline, triazolopyrimidine and pyrazolone moieties were synthesized and investigated for their anticancer efficiency against human breast cancer MCF-7. The anticancer screening revealed the significant sensitivity of breast carcinoma towards compounds 4b, 5c, 6c, 7b, 7c and 12c with IC50 values ranging from 16.50 – 26.73 mu M in comparison with tamoxifen (IC50 = 23.31 mu M). Moreover, the new analogues were further examined for their VEGFR-2 inhibitory activity, among the tested derivatives 5c, 6c, 7b, 7c and 12c displayed prominent inhibitory efficiency versus VEGFR-2 kinase with % inhibition ranging from 70 to 79%. Compounds 6c, 7c and 12c revealed inhibitory efficiency in nanomolar level with IC50 (913.51, 225.17 and 828.23 nM, respectively) comparing to sorafenib (IC50 = 186.54 nM). Flow cytometric analysis revealed that the promising compound 12c prompted pre-G1 apoptosis and cell growth cessation at G2/M phase and stimulated apoptosis via activation of caspase-3. Moreover, molecular docking study of the promising derivatives was performed to highlight their binding modes and interactions with the amino acid residues of VEGFR-2 enzyme.

Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples WOS:000580519700021 published article about INDUCED OXIDATIVE STRESS; HYDROGEN-PEROXIDE; SUPEROXIDE-DISMUTASE; C-ABL; CELLS; ANTIOXIDANT; EXPRESSION; GENE; DOXORUBICIN; GLUTATHIONE in [Grilo, Luis F.; Martins, Joao D.; Cavallaro, Chiara H.; Oliveira, Paulo J.; Pereira, Susana P.] CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, Cantanhede, Portugal; [Nathanielsz, Peter W.] Coll Agr & Nat Resources, Dept Anim Sci, Laramie, WY USA; [Pereira, Susana P.] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal in 2020.0, Cited 64.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways involving H2O2. Detoxification and control of H2O2 levels results mainly from catalase activity. The aim of this work was to develop a precise, simple, cost-effective microassay to measure catalase activity in small tissue samples and cell extracts. We developed a protocol that quantifies H2O2 decomposition by intrinsic catalase in biological samples. Catalase activity was calculated based on rate of decomposition of H2O2, following absorbance at 240 nm. We developed a multi-well spectroscopic approach, reducing sample quantity requirements and allowing simultaneous assessment of large number of samples. The protocol is sensitive across a wide range of catalase activity (11.5-7575 U). The assay presents a 95% confidence interval with an intra-assay coefficient of variation of 3.7%, an inter-assay coefficient of variation of 6.2% and good correlation with a commercial kit. The assay was established and validated for different biological samples, including sheep hepatic tissue and human tumor and non-tumor cell lines. This high-throughput method is robust, sensitive, time-saving and cost-effective, generating highly reproducible results with precision and good correlation with a commercial kit reinforcing the method’s validity for research and toxicological applications.

Welcome to talk about 61-82-5, If you have any questions, you can contact Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synergistic effect of Fe3O4 anchored N-doped rGO hybrid on mechanical, thermal and electromagnetic shielding properties of epoxy composites WOS:000467349000035 published article about REDUCED GRAPHENE; NANOCOMPOSITE; NANOPARTICLES; OXIDE in [Chhetri, Suman; Adak, Nitai Chandra; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Council Sci & Ind Res Cent Mech Engn Res Inst, Surface Engn & Tribol Div, Durgapur 713209, India; [Chhetri, Suman; Adak, Nitai Chandra; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India; [Srivastava, Suneel Kumar] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India in 2019.0, Cited 42.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Herein, Fe3O4 nano-particles are anchored over nitrogen doped reduced graphene oxide Fe3O4@N-rGO) structure to accommodate electric and magnetic components, so that it could match both the conduction and polarization loss to augment the attenuation of electromagnetic radiation. The formation of condensed heteroaromatic structure and decoration of Fe3O4 particles on r-GO structure are confirmed by photoelectron spectroscopy (XPS). high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD). The Fe3O4@N-rGO hybrid is subsequently dispersed in epoxy matrix, which result in significantly higher electrical conductivity (1.31 s/m) and electromagnetic interference (EMI) shielding efficiency (- 26 dB at 1 mm thickness). It was assumed that presence of electric-magnetic integrated Fe3O4@N-rGO hybrid in epoxy matrix significantly improved the interfacial polarization and anisotropy energy, which was reflected in absorption loss value of -27 dB. The composites also exhibited enhanced mechanical and thermo-mechanical properties coupled with improved thermal stability.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. I found the field of Chemistry very interesting. Saw the article 4-Chlorothiazole-5-carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N-heterocyces Endowed with Anti-Tumor Activity published in 2019.0, Reprint Addresses El Azab, IH (corresponding author), Taif Univ, Fac Sci, Chem Dept, POB 888, At Taif 21974, Saudi Arabia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

In our approach to synthesize bioactive molecules, a series of novel N-heterocycles were synthesized and evaluated for their in vitro antitumor activity against a panel of three human cancer cell lines, namely, human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa), and human prostate cancer PC-3. The majority of the tested compounds exhibited significant cytotoxic activity toward the tested tumor cell lines. Analogues 33, 34, 31, 38, 21, 23, 22, and 20 exhibited considerable cytotoxic activities comparable with standard drug 5-fuorouracil. Compound 33 displayed superior cytotoxicity with IC50 value of 4.12 +/- 1.21 mu g/mL against HeLa tumor cell line.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact El Azab, IH; Gobouri, AA; Altalhi, TA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis of Some Benzimidazole-based Heterocycles and their Application as Copper Corrosion Inhibitors WOS:000458310800002 published article about SODIUM-CHLORIDE SOLUTIONS; ACIDIC PICKLING SOLUTIONS; MILD-STEEL; ALUMINUM CORROSION; ANODIC-DISSOLUTION; BENZOTRIAZOLE; SERIES; DERIVATIVES; ADDITIONS in [Eldebss, Taha M. A.; Farag, Ahmad M.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt; [Shamy, Adel Y. M.] Egyptian Energy & Elect Minist, Cent Chem Labs, Cairo, Egypt in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

A series of new substituted benzimidazoles embedded with a variety of function groups has been synthesized from N-methyl-2-bromoacetylbenzimidazole. The synthesized compounds were fully characterized, and their structures were elucidated based on elemental analysis, spectral data, and alternative synthetic pathways, whenever possible. Some of benzimidazole derivatives were tested as corrosion inhibitors.

Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 DYES PIGMENTS published article about LIGHT-EMITTING-DIODES; BIPOLAR HOST MATERIALS; HIGH-PERFORMANCE RED; HIGHLY EFFICIENT; PHOSPHORESCENT; BLUE; TRIPHENYLAMINE; ACCEPTOR; GREEN; ELECTRON in [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, MOE Key Lab Interface Sci & Engn Adv Mat, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, Res Ctr Adv Mat Sci & Technol, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Huang, Jinhai] Shanghai Taoe Chem Technol Co Ltd, Shanghai, Peoples R China in 2020.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Name: 1H-1,2,4-Triazol-5-amine

In this work, seven small molecular compounds named N,N-diphenyl-4-(2-phenylpyrimido [1,2-b]indazol-4-yl) aniline (1), N,N-diphenyl-4-(5-phenylpyrazolo [1,5-a]pyrimidin-7-yl)aniline (2), N,N-diphenyl-4-(5-phenyl[1,2,4]triazolo [1,5-a]pyrimidin-7-yl)aniline (3), 4,4′-(pyrimido [1,2-b]indazole-2,4-diyl)bis (N,N-diphenylaniline) (4), 4,4′-(pyrazolo [1,5-a]pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (5), 4,4′-([1,2,4]triazolo [1,5-a] pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (6), N,N-diphenyl-4-(4-phenylpyrimido [1,2-b]indazol-2-yl)aniline (7) with donor-acceptor (D-A) structure were designed and synthesized by employing triphenylamine (TPA) as donor and indazole, pyrazole and/or triazole as acceptor. Systematic study and analysis on thermal, photo physical, electrochemical properties of all compounds were performed. All compounds exhibit good thermal and morphological stabilities with decomposition temperatures (T-d) range from 270 to 462 degrees C, and glass transition temperatures (T-g) range from 78 to 127 degrees C. The investigation of photophysical properties of these compounds revealed that all these compounds are of high photoluminescence quantum yields (PLQY), particularly for compound 6, whose PLQY value was as high as 90.22%. To explore potential applications of these materials in organic light-emitting diodes (OLEDs), two devices with compounds 2 and 5 were fabricated. Both devices show excellent device performances with maximum current efficiency, maximum power efficiency and external quantum efficiency of 15.9 cd A(-1), 10.41 m W-1 and 8.4% for compound 2-based device and 10.1 cd A(-1), 5.81 m W-1 and 5.5% for compound 5-based device, respectively.

Name: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jin, MM; Chen, Y; Song, WX; Lian, H; Guo, HE; Dong, QC; Huang, JH; Su, JH or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Preparation of C3N5 nanosheets with enhanced performance in photocatalytic methylene blue (MB) degradation and H-2-evolution from water splitting WOS:000564655700001 published article about GRAPHITIC CARBON NITRIDE; H-2 EVOLUTION; G-C3N4; PROTON in [Liu, Tianyu; Yang, Guojiang; Wang, Wei; Wang, Chongxi; Wang, Min; Sun, Xiaonan; Xu, Peng; Zhang, Jintao] Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Jiangsu, Peoples R China in 2020.0, Cited 35.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Ultrathin C3N5 nanosheets with enhanced photocatalytic methylene blue (MB) degradation and H-2-evolution performance were prepared from thermal treatment of 3-amino-1,2,4-triazole (3-AT) and NH4Cl followed with a protonate procedure. The characterization results revealed that the protonating process could contribute to the exfoliation of C3N5 with large surface area, the effective charge transfer capability and the modified band structure. The as-prepared C3N5 nanosheets exhibited enhanced properties in photocatalytic reactions such as MB photodegradation and H-2-evolution from water splitting. This study offered a feasible route to prepare highly-efficient two-dimensional photocatalyst, which could be applied potentially for implementation in wide range of energy generation and environmental applications.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Reproductive Biology; Toxicology very interesting. Saw the article A cross-platform approach to characterize and screen potential neurovascular unit toxicants published in 2020.0. HPLC of Formula: C2H4N4, Reprint Addresses Knudsen, TB (corresponding author), 109 TW Alexander Dr,D-143-02, Res Triangle Pk, NC 27711 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in formation of the blood-brain barrier. Typical high-throughput screening (HTS) assays investigate single biochemical or single cell responses following chemical insult. As the NVU comprises multiple cell types interacting at various stages of development, a methodology combining high-throughput results across pertinent cell-based assays is needed to investigate potential chemical-induced disruption to the development of this complex cell system. To this end, we implemented a novel method for screening putative NVU disruptors across diverse assay platforms to predict chemical perturbation of the developing NVU. HTS assay results measuring chemical-induced perturbations to cellular key events across angiogenic and neurogenic outcomes in vitro were combined to create a cell-based prioritization of NVU hazard. Chemicals were grouped according to similar modes of action to train a logistic regression literature model on a training set of 38 chemicals. This model utilizes the chemical-specific pairwise mutual information score for PubMed MeSH annotations to represent a quantitative measure of previously published results. Taken together, this study presents a methodology to investigate NVU developmental hazard using cell-based HTS assays and literature evidence to prioritize screening of putative NVU disruptors towards a knowledge-driven characterization of neurovascular developmental toxicity. The results from these screening efforts demonstrate that chemicals representing a range of putative vascular disrupting compound (pVDC) scores can also produce effects on neurogenic outcomes and characterizes possible modes of action for disrupting the developing NVU.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 CHEMISTRYSELECT published article about METAL-ORGANIC FRAMEWORKS in [Li, Zhuo; Lu, Ying; Zhang, Shan; Sun, Xiu-Wei; Dang, Tian-Yi; Zhang, Zhong; Tian, Hong-Rui; Liu, Shu-Xia] Northeast Normal Univ, Fac Chem, Minist Educ, Key Lab Polyoxometalate Sci, Changchun 130024, Jilin, Peoples R China in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Nowadays, the research of proton conductive materials has been extended from traditional sulfonated polymers to novel crystalline solid materials. It is important but still challenging to develop high-performance proton-conducting materials suitable for proton exchange membrane fuel cells (PEMFCs). Considering the features of molybdenum oxide and triazole in the construction of proton-conducting material, two triazole-modified molybdenum oxides, [MoO3(trz)(0.5)]1and [H(atrz)(4)[(atrz)(2)(gamma-Mo8O26)] . 2H(2)O2(trz=1,2,4-triazole, atrz=3-amino-1,2,4-triazole), were re-synthesized under optimized synthetic conditions, and their proton-conducting performances were investigated.1and2show high proton conductivities of 1.94×10(-2) S cm(-1)(85 degrees C, 95 % RH) and 1.3×10(-3) S cm(-1)(65 degrees C, 95 % RH), respectively.

Welcome to talk about 61-82-5, If you have any questions, you can contact Li, Z; Lu, Y; Zhang, S; Sun, XW; Dang, TY; Zhang, Z; Tian, HR; Liu, SX or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics