Month: February 2022

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Recently I am researching about OXYGEN SPECIES ROS; DNA-BINDING; LIGAND; CYTOTOXICITY; POTENT; SPECTROSCOPY; HETEROCYCLES; TRANSFERRIN; DERIVATIVES; RESISTANCE, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Fandzloch, M; Dobrzanska, L; Jedrzejewski, T; Jezierska, J; Wisniewska, J; Lakomska, I. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Six novel ruthenium(III) complexes of general formula [RuCl3(L)(3)] (1,3,5) and [RuCl3(H2O)(L)(2)] (2,4,6), where L stands for three different triazolopyrimidine-derived ligands, are reported. The compounds have been structurally characterized (IR, EPR, SCXRD), and their magnetic moments have been determined. The single-crystal X-ray diffraction study revealed a slightly distorted octahedral geometry of the Ru(III) complexes with mer configuration in 1 and 5, and fac configuration in 3. In 2 and 4, three chloride ions are in mer configuration and the two triazolopyrimidines are oriented trans mutually with the water molecule playing the role of the sixth ligand. All complexes have been thoroughly screened for their in vitro cytotoxicity against human breast cancer cell line MCF-7, human cervical cancer cell line HeLa, and L929 murine fibroblast cells, uncovering among others that the most lipophilic complexes 5 and 6, containing the bulky ligand dptp (5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine), display high cytotoxic activity against MCF-7, and HeLa cells. Moreover, it was also revealed that during the interaction of the complexes 1-6 with the cancer MCF-7 cell line, reactive oxygen species are released intracellularly, which could indicate that they are involved in cell apoptosis. Furthermore, extensive studies have been carried out to reveal the mechanism by which complexes 1-6 interact with DNA, albumin, and apotransferrin. The biological studies were complemented by detailed kinetic studies of the hydrolysis of the complexes in the pH range 5-8, to determine the stability of the complexes in solution. Graphic abstract Six novel ruthenium(III) complexes with triazolopyrimidine derivatives demonstrated the potential for use as anticancer agents by maintaining the toxic effect on MCF-7 and HeLa cells.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. In 2020.0 MOLECULES published article about HETEROCYCLES; DERIVATIVES; DESIGN in [El Azab, Islam H.] Taif Univ, Fac Sci, Chem Dept, POB 888, At Taif 2974, Saudi Arabia; [Elkanzi, Nadia A. A.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia in 2020.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In search of unprecedented tri and/or tetrapod pharmacophoric conjugates, a series of 32 new 4-ethyl-1H-benzo[b][1,4]diazepin-2(3H)-ones were synthesized and properly elucidated using MS, IR, NMR, and elemental analysis. In vitro investigation of 11 compounds of this series, using a panel of two human tumor cell lines namely; human breast adenocarcinoma (MCF-7), and human colorectal carcinoma (HCT-116), revealed promising cytotoxic activities. Among all synthesized compounds, analogue 9 displayed maximum cytotoxicity with IC50 values of 16.19 +/- 1.35 and 17.16 +/- 1.54 mu M against HCT-116 and MCF-7, respectively, compared to standard drug doxorubicin.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact El Azab, IH; Elkanzi, NAA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry very interesting. Saw the article Synthesis, biological evaluation, molecular docking and DFT calculations of novel benzenesulfonamide derivatives published in 2019.0, Reprint Addresses Fahim, AM (corresponding author), Natl Res Ctr, Dept Green Chem, POB 12622, Cairo, Egypt.; Shalaby, MA (corresponding author), Damietta Univ, Fac Sci, Dept Chem, New Damietta 34517, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Fahim, AM; Shalaby, MA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Facile Regioselective On-Water Synthesis of 4,7-Dihydropyrazolo[1,5-a]Pyrimidines and 4,7-Dihydro[1,2,4]Triazolo[1,5-a]Pyrimidines WOS:000467059700011 published article about DESIGN; INHIBITOR; POTENT; 5-AMINOPYRAZOLE; ANAGLIPTIN; DINACICLIB; ESSRAMYCIN; PYRAZOLE in [Gol, Ravindra M.; Barot, Vijaykumar M.] Smt SM Panchal Sci Coll, Dept Chem, Talod 383215, Gujarat, India; [Khatri, Taslimahemad T.] Govt Sci Coll, Dept Chem, Chikhli 396521, Gujarat, India in 2019.0, Cited 50.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Efficient and regioselective on-water synthesis of variously substituted 5-amino-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitriles and 5-amino-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles using 1,8-diazabicyclo[5.4.0]undec-7-ene as catalyst has been demonstrated. The reaction of 2-benzylidenemalononitriles and 3-aryl-1H-pyrazol-5-amines or 1H-1,2,4-triazol-5-amine allows to obtain the respective pyrazolo[1,5-a]pyrimidines and [1,2,4]triazolo[1,5-a]pyrimidines in high yields up to 93%. Main advantages of the developed synthetic protocol are application of water as environmentally friendly solvent, short reaction times, simple workup procedure that often does not require further purification of products, and broad substrate scope.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. Recently I am researching about RENEWABLE THERMOPLASTICS; TOUGHENING ELASTOMERS; MECHANICAL-PROPERTIES; HYDROXYPROPYL LIGNIN; MULTIPHASE MATERIALS; NETWORK; COPOLYMERS; BEHAVIOR; FILLERS; BLENDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21706082]; Science and Technology Program of Guangzhou [201707020025, 201804010140]; Guangdong Province Science FoundationNational Natural Science Foundation of Guangdong Province [2017B090903003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M622693]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Huang, JH; Liu, WF; Qiu, XQ. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

For the first time, the coordination-based energy sacrificial bonds have been constructed in the interface between lignin and polyolefin elastomer for preparing a new class of high performance thermoplastic elastomers (TPEs) with biomass lignin as the hard plastic phase. The coordination bonds not only promoted the dispersion of lignin, but also improved the interfacial interactions between lignin and polyolefin elastomer matrix, and also facilitated the orientation of chain segments during stretching. The synergistic coordination effect of lignin promoted higher energy dissipation, leading to simultaneously enhanced strength and toughness of lignin-based TPEs even with the lignin loading as high as 30 wt %. The lignin-based TPEs also exhibited excellent shape memory performance. Our strategy offers a promising methodology for the facile production of high performance but cost-effective TPE materials using biorenewable resources as plastic phase.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Huang, JH; Liu, WF; Qiu, XQ or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Catalase blockade reduces the pressor response to central cholinergic activation WOS:000498330200029 published article about NICOTINIC ACETYLCHOLINE-RECEPTORS; ENDOGENOUS HYDROGEN-PEROXIDE; CENTRAL ANGIOTENSIN-II; NITRIC-OXIDE; SMOOTH-MUSCLE; RAT-BRAIN; RELEASE; INHIBITION; VASOPRESSIN; EXPRESSION in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ UNESP, Dent Sch, Dept Physiol & Pathol, Araraquara, SP, Brazil in 2019.0, Cited 66.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O-2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv. In the present study, we investigated the effects of ATZ injected icv or intravenously (iv) on the pressor responses induced by icv injections of the cholinergic agonist carbachol, which similar to angiotensin II induces pressor responses that depend on sympathoexcitation and vasopressin release. In addition, the effects of H2O2 icv on the pressor responses to icv carbachol were also tested to compare with the effects of ATZ. Normotensive non-anesthetized male Holtzman rats (280-300 g, n = 8-9/group) with stainless steel cannulas implanted in the lateral ventricle were used. Previous injection of ATZ (5 nmol/1 mu l) or H2O2 (5 mu mol/1 mu l) icv similarly reduced the pressor responses induced by carbachol (4 nmol/1 mu l) injected icv (13 +/- 4 and 12 +/- 4 mmHg, respectively, vs. vehicle + carbachol: 30 +/- 5 mmHg). ATZ (3.6 mmol/kg of body weight) injected iv also reduced icv carbachol-induced pressor responses (21 +/- 2 mmHg). ATZ icv or iv and H2O2 icv injected alone produced no effect on baseline arterial pressure. The treatments also produced no significant change of heart rate. The results show that ATZ icv or iv reduced the pressor responses to icv carbachol, suggesting that endogenous H2O2 acting centrally inhibits the pressor mechanisms (sympathoactivation and/or vasopressin release) activated by central cholinergic stimulation.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. I found the field of Chemistry; Engineering very interesting. Saw the article Enhanced visible photocatalytic oxidation activity of perylene diimide/g-C3N4 n-n heterojunction via pi-pi interaction and interfacial charge separation published in 2020.0, Reprint Addresses Xu, J; Wang, ZP (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.; Zhu, YF (corresponding author), Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Herein, perylene diimide (PDI)/oxygen-doped g-C3N4 nanosheets (O-CN) n-n heterojunction photocatalyst was prepared by an in-situ electrostatic assembling. The pi-pi interaction between self-assembled PDI and O-CN could lead to the electron delocalization effect to facilitate the electron migration. Self-assembled PDI could broaden the visible response range of O-CN to produce more photogenerated carries. Moreover, the interlaced band structures of O-CN and self-assembled PDI could result in a built-in electric field to promote the interfacial charge separation. Besides, many active species (h(+), O-center dot(2-) and O-1(2) ) could be accumulated to improve the oxidation ability of PDI/O-CN. Therefore, PDI/O-CN exhibited enhanced visible photocatalytic oxidation activities towards disinfection, degradation and oxygen evolution. The optimum PDI/O-CN inactivated 96.6% of Staphylococcus aureus cells within 3 h, while O-CN only killed 62.2%. Additionally, the phenol degradation rate and evolved oxygen amount in 2 h of PDI/O-CN-40% were 3.6 and 1.8 times as high as those of O-CN, respectively.

Welcome to talk about 61-82-5, If you have any questions, you can contact Gao, QZ; Xu, J; Wang, ZP; Zhu, YF or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019.0 J MOL STRUCT published article about DENSITY-FUNCTIONAL THEORY; FALCIPARUM DIHYDROOROTATE DEHYDROGENASE; X-RAY-STRUCTURE; ELECTRONIC EXCITATIONS; ANTIMALARIAL ACTIVITY; CHLORIDE COMPLEXES; LEAD OPTIMIZATION; CHARGE-TRANSFER; EXCITED-STATES; TRIAZOLOPYRIMIDINE in [El Bakri, Youness; Sebhaoui, Jihad; Essassi, El Mokhtar] Univ Mohammed V Rabat, Fac Sci, Lab Chim Organ Heterocycl,URAC 21, Ctr Rech Sci Medicaments,Pole Competences Pharmac, Ave Ibn Battouta, Rabat 1014, Morocco; [El Bakri, Youness] Peoples Friendship Univ Russia, RUDN Univ, Dept Organ Chem, 6 Miklukho Maklayast, Moscow 117198, Russia; [Lai, Chin-Hung] Chung Shan Med Univ, Dept Med Appl Chem, Taichung 40241, Taiwan; [Lai, Chin-Hung] Chung Shan Med Univ Hosp, Dept Med Educ, Taichung 402, Taiwan; [Ben Ali, Abdelkader] Mohammed V Univ Rabat, Fac Sci, Ctr Sci Mat, Lab Chim Appl Mat, Ave Ibn Battouta, Rabat 1014, Morocco; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The current work reports the synthesis of two new triazolopyrimidine derivatives from 3-aminotriazole and ethyl 3-phenylglycidate. The two new compounds were characterized using IR spectra, UV-vis spectra, NMR (H-1 and C-13), thermal analyses (TGA and DTA) and finally the structure of one was confirmed by X-ray diffraction studies. Quantum chemical calculations were also conducted to corroborate experimental findings. (C) 2019 Elsevier B.V. All rights reserved.

HPLC of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A thermally reversible healingEPDMbased elastomer with higher tensile properties and damping properties WOS:000568417400001 published article about MOLECULAR-STRUCTURE; HYDROGEN-BOND; POLYMERS; PERFORMANCE; SEPARATION; RUBBER; TOUGH in [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Natl Engn Res Ctr Novel Equipment Polymer Proc, Guangzhou 510640, Peoples R China; [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Key Lab Polymer Proc Engn, Minist Educ, Guangzhou, Peoples R China; [Xiong, Chengtian; He, Hezhi; Xue, Bin; Wang, Yi; Li, Jiqian; Zhu, Zhiwen] South China Univ Technol, Sch Mech & Automot Engn, Guangdong Prov Key Lab Tech & Equipment Macromol, Guangzhou, Peoples R China; [Li, Xiaoqing] Guangzhou Automobile Grp Component Co Ltd, Guangzhou, Peoples R China in 2021.0, Cited 34.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Due to the disadvantages of lower tensile strength and fracture toughness, the widely application of Ethylene-propylene-diene-monomer rubber (EPDM) has been limited. In this study, a thermally reversible healing EPDM based elastomer with H-bonding and Zn-based-bonding dynamic cross-link network was prepared. The influence of mole ratio of ATA/MAH on tensile strength and fracture energy of mEPDM(0)-xATA was investigated. The results showed that increasing the content of ATA brings about a gradual improvement in tensile strength of the mEPDM(0)-xATA. Especially when the mole ratio of ATA/MAH is 1, the fracture energy of mEPDM(0)-ATA is dramatically enhanced to 33.9 MJ/m(3), which is best among the ratios studied in our research. After curing, the effect of ZnCl(2)content on tensile strength and fracture energy of mEPDM-ATA-nZn was also studied. Meanwhile, the uniaxial cyclic loading-unloading tensile test was used to study the viscous damping properties of mEPDM-ATA-0.4Zn, which showed reversible repair properties after heat treatment. The results of dynamic rheological measurement showed that the damping properties were improved.

Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry very interesting. Saw the article Preparation and characterization of a novel DABCO based tetra cationic ionic liquid as a reusable catalyst for the multi-component synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4] triazoloquinazolinone derivatives under solvent-free condition published in 2020.0, Reprint Addresses Shirini, F (corresponding author), Univ Guilan, Coll Sci, Dept Chem, Rasht 41335, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C-4(H-DABCO)(2)][HSO4](4) is easily prepared and characterized using FT-IR, H-1 NMR,C-13 NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method. (C) 2019 Elsevier B.V. All rights reserved.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics