Day: October 13, 2022

Androvic, Ladislav; Woldrichova, Lucie; Jozefjakova, Klaudia; Pechar, Michal; Lynn, Geoffrey M.; Kankova, Dana; Malinova, Lenka; Laga, Richard published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability》.COA of Formula: C30H30N10 The article contains the following contents:

Myriad nanocarriers have been developed to improve the therapeutic index of low-mol.-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either “”grafting from”” or “”grafting onto”” approaches and characterized by quant. arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (~10-25 nm) for tumor uptake; those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-mol.-weight drugs-an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant-were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8COA of Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.COA of Formula: C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Peyman, Anusch; Uhlmann, Eugen; Wagner, Konrad; Augustin, Sascha; Breipohl, Gerhard; Will, David W.; Schaefer, Andrea; Wallmeier, Holger published their research in Angewandte Chemie, International Edition in English on December 6 ,1996. The article was titled 《Phosphonic ester nucleic acids (PHONAs): oligodeoxyribonucleotide analog with an achiral phosphonic acid ester backbone》.COA of Formula: C9H8N4O4S The article contains the following contents:

The preparation of polyamide nucleic acid analogs with an achiral and neg. charged backbone to which the nucleobases are attached through carboxymethylene linkers, is reported. The experimental part of the paper was very detailed, including the reaction process of 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5COA of Formula: C9H8N4O4S)

3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C9H8N4O4S

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Gan, Weiping; Cao, Xiaosong; Shi, Yi; Zou, Lei; Gao, Haifeng published 《Ligand effect in the synthesis of hyperbranched polymers via copper-catalyzed azide-alkyne cycloaddition polymerization (CuAACP)》.Journal of Polymer Science, Part A: Polymer Chemistry published the findings.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Copper-catalyzed azide-alkyne cycloaddition polymerization (CuAACP) of AB2 monomers demonstrated a chain-growth mechanism without any external ligand because of the complexation of in situ formed triazole groups with Cu catalysts. In this study, we explored the use of various ligands that affected the polymerization kinetics to tune the polymers’ mol. weights and the degree of branching (DB). Eight ligands were studied, including polyethylene glycol monomethyl ether (PEG350, Mn = 350), tris(benzyltriazolylmethyl)amine (TBTA), 2,6-bis(1-undecyl-1H-benzo[d]imidazol-2-yl)pyridine (Py(DBim)2), 2,2′-bipyridyl (bpy), 4,4′-di-n-nonyl-2,2′-bipyridine (dNbpy), N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDETA), N,N,N’,N”,N”-penta(n-butyl)diethylenetriamine (PBuDETA), and N,N,N’,N”,N”-pentabenzyldiethylenetriamine (PBnDETA). All ligands except PEG350 exhibited stronger coordination with Cu(I) than the polytriazole polymer, which freed the Cu catalyst from polymers and resulted in dominant step-growth polymerization with simultaneous chain-growth feature. Meanwhile, the use of PEG350 ligand retained the confined Cu in the polymer, demonstrating a chain-growth mechanism, but lower polymer mol. weights as compared with the no-external-ligand polymerization Results indicated that aliphatic substituent groups on ligands had little effect on the mol. weights and DB of the polymers, but rigid aromatic substituent groups decreased both values. By varying the ligand species and amounts, hyperbranched polymers with DB value ranging from 0.53 ([TBTA]0/[Cu]0 = 5) to 0.98 ([PMDETA]0/[Cu]0 = 2) have been achieved. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ismatullayevich, Muydinov Izzatillo; Erkinjonovich, Zaynabiddinov Anvar; Komiljonovich, Pzilov Mamurjon; Bakhtoyarovich, Kyrgyzov Fazliddin; Urinovich, Komilov Kamariddin; Nurillayevich, Rakhimov Rakhmatilla published their research in Natural Volatiles & Essential Oils in 2021. The article was titled 《Effects of new derivatives of 1, 2, 3 -triazoles on liver glycogene and some biochemical indicators in the blood of alloxan-induced diabetic rats》.Safety of 1H-1,2,3-Triazole The article contains the following contents:

Impacts of heterocyclic compounds new derivatives of 1, 2, 3 triazoles to the amount of glycogen in the liver homogenate, the amount of glucose in the blood plasma, activity of aspartate aminotransferase (Al AT) and alanine aminotransferase (As AT) of the healthy and alloxan induced diabetic rat were studied in vivo experiments New derivatives of 1, 2, 3 triazoles were administered to diabetes-induced animals once daily for 10 days through the per os method. It was determined that the amount of glycogen in their liver was almost close to the control (intact) level after pharmacotherapy of diabetes induced rats with new derivatives of 1,2,3-triazoles. New derivatives of 1,2,3-triazoles were found to be able to restore AsAT and AlAT activity, which play a key role in carbohydrate metabolism in animal liver homogenates in the diabetes-induced model. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Pollastri, Sara; Delaunay, Clara; Thepaut, Michel; Fieschi, Franck; Bernardi, Anna published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors》.Synthetic Route of C30H30N10 The author mentioned the following in the article:

The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The mols. described here are the first known glycomimetic ligands of L-SIGN. In the experiment, the researchers used many compounds, for example, Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2015 ,《A Novel Bio-Orthogonal Cross-Linker for Improved Protein/Protein Interaction Analysis》 appeared in Analytical Chemistry (Washington, DC, United States). The author of the article were Nury, Catherine; Redeker, Virginie; Dautrey, Sebastien; Romieu, Anthony; van der Rest, Guillaume; Renard, Pierre-Yves; Melki, Ronald; Chamot-Rooke, Julia. The article conveys some information:

The variety of protein crosslinkers developed in recent years illustrates the current requirement for efficient reagents optimized for mass spectrometry (MS) anal. To date, the most widely used strategy relies on com. crosslinkers that bear an isotopically labeled tag and N-hydroxysuccinimid-ester (NHS-ester) moieties. Moreover, an enrichment step using liquid chromatog. is usually performed after enzymic digestion of the crosslinked proteins. Unfortunately, this approach suffers from several limitations. First, it requires large amounts of proteins. Second, NHS-ester crosslinkers are poorly efficient because of their fast hydrolysis in water. Finally, data anal. is complicated because of uneven fragmentation of complex isotopic crosslinked peptide mixtures We therefore synthesized a new type of trifunctional crosslinker to overrule these limitations. This reagent, named NNP9, comprises a rigid core and bears two activated carbamate moieties and an azido group. NNP9 was used to establish intra- and intermol. crosslinks within creatine kinase, then to map the interaction surfaces between α-Synuclein (α-Syn), the aggregation of which leads to Parkinson’s disease, and the mol. chaperone Hsc70. We show that NNP9 crosslinking efficiency is significantly higher than that of NHS-ester com. crosslinkers. The number of crosslinked peptides identified was increased, and a high quality of MS/MS spectra leading to high sequence coverage was observed Our data demonstrate the potential of NNP9 for an efficient and straightforward characterization of protein-protein interfaces and illustrate the power of using different crosslinkers to map thoroughly the surface interfaces within protein complexes. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 56602-33-6In 2020 ,《Double-layered honeycomb architectures constructed via hierarchical self-assembly of hexagonal spin crossover cobalt(II) metallacycles》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Akiyoshi, Ryohei; Kuroiwa, Keita; Sakuragi, Mina; Yoshimoto, Soichiro; Ohtani, Ryo; Nakamura, Masaaki; Lindoy, Leonard F.; Hayami, Shinya. The article contains the following contents:

A hexagonal cobalt(II) metallacycle and its “”lipid packaged”” derivatives, [Co6(R-bisterpy)6]X12 (R = H, OC16H33, OC27H55; X = BF4, C12-Glu), have been synthesized and characterized. The compounds incorporating BF4- anions formed sphere-like aggregates while the compounds with C12-Glu lipid anions gave double-layered honeycomb architectures composed of hexagonal stacked tubular structures, which exhibit spin crossover behavior. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Related Products of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Related Products of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Phosphorus, Sulfur and Silicon and the Related Elements included an article by Xiong, Biquan; Wang, Gang; Zhou, Congshan; Liu, Yu; Li, Jiandong; Zhang, Pangliang; Tang, Kewen. Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V). The article was titled 《DCC-assisted direct esterification of phosphinic and phosphoric acids with O-nucleophiles》. The information in the text is summarized as follows:

A novel and efficient dicyclohexylcarbodiimide-promoted protocol for the selective and controllable esterification of P(O)OH compounds using O-nucleophiles (alcs. and phenols) as efficient esterification reagents is described. This method features a high efficiency and good functional-group tolerance, meaning a simple way to synthesize a broad spectrum of phosphinic and phosphoric acid esters from basic starting materials with moderate to excellent yields.((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Chemical Synthesis of Triazole-Derived Suppressors of Strigolactone Functions》 was written by Ito, Shisanku; Kikuzato, Ko; Nakamura, Hidemitsu; Asami, Tadao. HPLC of Formula: 288-36-8This research focused ontriazole preparation; Carotenoid cleavage dioxygenase; Cytochrome P450; Strigolactone; Strigolactone receptor; Triazole; α/β-Hydrolase. The article conveys some information:

The chem. synthetic methods for triazole derivatives, e.g., I that can suppress the function of SL by inhibiting SL biosynthesis pathway or SL perception sites such as D14 has been described. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties HPLC of Formula: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3-triazole moiety》 was written by Jiang, Yuqin; Li, Yanyan; Yang, Tingting; Shi, Xin; Suo, Huajun; Zhang, Weiwei; Xu, Guiqing; Li, Wei. Name: 1H-1,2,3-TriazoleThis research focused ontriazole copper Schiff base. The article conveys some information:

A new series of paeonol Schiff base derivatives containing a 1,2,3-triazole moiety were synthesized using the copper(I) catalyzed azide-alkynecycloaddn. (CuAAC) reaction and evaluated for their cytotoxicity in vitro against human cervical carcinoma HeLa cells, human lung cancer A549 cells, and human liver cancer HepG2 cells. Unfortunately, all the tested compounds showed poor activities toward the human cervical carcinoma HeLa cells and human liver cancer HepG2 cells. However, compounds (E)-2-(1-(((1-[2-fluorophenyl]-1H-1,2,3-triazol-4-yl)methyl)imino)ethyl)-5-methoxyphenol (4c) and (E)-2-(1-(((1-[3- chlorophenyl]-1H-1,2,3-triazol-4-yl)methyl)imino)ethyl)-5-methoxyphenol (4i) exhibited inhibitory activities toward human lung cancer A549 cells (IC50 = 45.1 μM for 4c and 78.9 μM for 4i) compared with that of paeonol, which indicated that such paeonol Schiff base derivatives containing a 1,2,3-triazole moiety could be further modified to obtain good cytotoxicity in vitro against human lung cancer A549 cells. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics