Day: October 17, 2022

《A fast and simple SPE-LC-MS/MS procedure for extraction and quantitative analysis of 1,2,4-triazole, N,N-dimethylsulfamide, and other small polar organic compounds in groundwater》 was written by Bollmann, Ulla E.; Badawi, Nora. Application of 288-36-8This research focused ontriazole dimethylsulfamide organic compound groundwater; ENVI-Carb; Hypercarb; LC-MS/MS; PMOCs; SPE; Solid phase extraction. The article conveys some information:

Small polar organic pollutants have been discovered to be great threats to the groundwater, as they often are highly mobile and persistent in the environment. 1,2,4-Triazole and N,N-dimethylsulfamide, two well-known examples of small polar compounds, are frequent pollutants of upper groundwater. Both are degradation products of several fungicides commonly or previously used in agriculture, but also in wood-preserving paints. A common trait in the anal. of these small polar compounds is the lack of sufficient pre-concentration methods to lower the limit of detection and enable quant. anal. at nano-scale concentrations To date, they are analyzed only by direct injection in HPLC-MS/MS, with detection limits just below the European threshold value for pesticides in groundwater of 0.1μg/L. Based on a comprehensive method development, a solid phase extraction method was developed. As known LC methods for anal. of 1,2,4-triazole are based on Thermo Fisher’s Hypercarb column, emphasis was placed on testing various carbon-based materials. The final, thoroughly validated extraction protocol is based on Supelco’s ENVI-Carb Plus cartridges. With extraction recoveries close to 100% for 1,2,4-triazole and N,N-dimethylsulfamide and quantification limits of around 0.003μg/L, the method enables extraction and quantification of polar pollutants at nano-scale concentration from groundwater samples. In addition, the method is very promising to be used for other small polar pollutants. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Kitamura, Kai; Itoh, Hiroaki; Sakurai, Kaori; Dan, Shingo; Inoue, Masayuki published 《Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase》.Journal of the American Chemical Society published the findings.SDS of cas: 510758-28-8 The information in the text is summarized as follows:

Yaku’amide B (1b) is a structurally unique tetradecapeptide bearing four b,b-dialkylated a,b-unsaturated amino acid residues. Growth-inhibitory profile of 1b against a panel of 39 human cancer cell lines is distinct from those of clin. used anticancer drugs, suggesting a novel mechanism of action. We achieved total syntheses of chem. probes based on 1b and elucidated the cellular target and mode of action of 1b. Fluorescent (3, 4) and biotinylated (5, 6) derivatives of 1b were prepared for cell imaging studies and pull-down assays, resp. In addition, the unnatural enantiomer of 1b (ent-1b) and its fluorescent probe (ent-3) were synthesized for control experiments Subcellular localization anal. using 3 and 4 showed that 1b selectively accumulates in the mitochondria of MCF-7 human breast cancer cells. Pull-down assays with 6 revealed FoF1-ATP synthase as the major target protein of 1b. Consistent with these findings, biochem. activity assays showed that 1b inhibits ATP production catalyzed by mitochondrial FoF1-ATP synthase. Remarkably, 1b was also found capable of enhancing the ATP hydrolytic activity of FoF1-ATP synthase. On the other hand, ent-1b inhibits ATP synthesis more weakly than 1b, and does not affect ATP hydrolysis, suggesting the stereospecific requirement for the characteristic multimodal functions of 1b. These findings corroborate that 1b causes growth arrest in MCF-7 cells by inhibiting ATP production and enhancing ATP hydrolysis, thereby depleting the cellular ATP pool. This study provides, for the first time, a structural basis for the design and development of anticancer agents exploiting the novel mode of action of 1b. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Chemically Triggered Synthesis, Remodeling, and Degradation of Soft Materials》 was published in Journal of the American Chemical Society in 2020. These research results belong to Sun, Xiaolong; Chwatko, Malgorzata; Lee, Doo-Hee; Bachman, James L.; Reuther, James F.; Lynd, Nathaniel A.; Anslyn, Eric V.. Application of 510758-28-8 The article mentions the following:

Polymer topol. dictates dynamic and mech. properties of materials. For most polymers, topol. is a static characteristic. In this article, we present a strategy to chem. trigger dynamic topol. changes in polymers in response to a specific chem. stimulus. Starting with a dimerized PEG and hydrophobic linear materials, a lightly crosslinked polymer, and a crosslinked hydrogel, transformations into an amphiphilic linear polymer, lightly crosslinked and linear random copolymers, a crosslinked polymer, and three different hydrogel matrixes were achieved via two controllable crosslinking reactions: reversible conjugate additions and thiol-disulfide exchange. Significantly, all the polymers, before or after topol. changes, can be triggered to degrade into thiol- or amine-terminated small mols. The controllable transformations of polymeric morphologies and their degradation herald a new generation of smart materials. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: triazolesIn 2016 ,《Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors》 appeared in European Journal of Medicinal Chemistry. The author of the article were Camarasa, Marta; Puig de la Bellacasa, Raimon; Gonzalez, Alex L.; Ondono, Raul; Estrada, Roger; Franco, Sandra; Badia, Roger; Este, Jose; Martinez, Miguel Angel; Teixido, Jordi; Clotet, Bonaventura; Borrell, Jose I.. The article conveys some information:

The design and selection of a combinatorial library of pyrido[2,3-d]pyrimidin-7(8H)-ones allowed the synthesis of 121 compounds, using known and new synthetic methodologies and the evaluation of the inhibitory activity against hepatitis C virus (HCV) genotype 1b replicon. Among these compounds, I and II presented very high activities [EC50 = 0.027 μM (CC50 = 5.3 μM) and EC50 = 0.034 μM (CC50 = 13.5 μM), resp.] and high selectivity indexes, 196 and 397. These values are similar to the EC50 reported for sofosbuvir (2) (0.048 μM) using a similar methodol. approach and the same virus subtype. Compounds I and II and were obtained through shorter synthetic itineraries than sofosbuvir and II was achiral contrary to sofosbuvir which presented 4 stereogenic centers. In-silico studies suggested that I and II inhibited NS5B polymerase through allosteric site binding. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Category: triazoles)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2015 ,《Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: Use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group》 appeared in Organic & Biomolecular Chemistry. The author of the article were ElMarrouni, Abdellatif; Heras, Montserrat. The article conveys some information:

The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic substitution reaction between 4-[4-(benzyloxy)benzyloxy]-2-(benzylsulfonyl)pyrimidine and the nucleophilic side chain of several Nα-Boc amino esters (Boc = tert-butoxycarbonyl), as the key step, followed by a series of standard protecting group transformations. P-Benzyloxybenzyloxy is efficiently removed under mild acid conditions to recover the 4(3H)-pyrimidinone system. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《CASPT2, CASSCF and non-adiabatic molecular dynamics (NAMD) studies on the low-lying electronic states of 1H-1,2,3-triazole photolysis》 was written by Gil, Eduarda Sangiogo; de Araujo, Bruno Bercini; Goncalves, Paulo F. B.. SDS of cas: 288-36-8This research focused ontriazole photolysis mechanism oscillator strength triplet state absorption spectra. The article conveys some information:

The photolysis mechanisms of 1H-1,2,3-triazole and 1H-1,2,3-benzotriazole were elucidated by employing multiconfigurational methods (CASSCF and CASPT2). The potential energy curves and crossing points for the low-lying excited states were analyzed. In addition to the static electronic structure calculations, non-adiabatic mol. dynamics (NAMD) was propagated at the CASSCF level using SHARC (Surface Hopping including ARbitrary Couplings) dynamics in order to verify the proposed static picture, thereby understanding the possible reaction paths and the time scale of the photo-induced events. The S1 state for 1H-1,2,3-triazole reached a conical intersection between the S0 and S1 surfaces on a time scale of 100 fs. The emerging picture of the reaction presented here is the rupture of the triazole ring in the S1 state and the relaxation through a conical intersection to the S0. On the S0 surface, the triazoles easily extrude N2 and then undergo the hetero-Wolff rearrangement forming ethanimine.1H-1,2,3-Triazole(cas: 288-36-8SDS of cas: 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties SDS of cas: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core》 was written by Wang, Yueliang; Xing, Li; Ji, Yinchun; Ye, Jiqing; Dai, Yang; Gu, Wangting; Ai, Jing; Song, Zilan. Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)This research focused ontyrosine kinase AXL kinase inhibitor pyrazine antiproliferative cancer; AXL Kinase; Cancer; Pyrazine. The article conveys some information:

Starting from the recently launched FLT3/AXL multi-targeted inhibitor Gilteritinib (5), we conducted a side-chain ring closure medicinal chem. approach leading to the identification of compound 15c as a highly potent AXL inhibitor in the biochem. and cellular anti-proliferative assays, with IC50 values of 1.2 and 0.3 nM, resp. Compared with the reference compound 5, our new discovered AXL inhibitor 15c is more potent in both assays. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2015,Konno, Hiroyuki; Abumi, Kanako; Sasaki, Yasuhiro; Yano, Shigekazu; Nosaka, Kazuto published 《Structure activity relationship study of burkholdine analogues toward simple antifungal agents》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:

Cyclic and linear lipopeptides, burkholdine analogs, were synthesized by conventional Fmoc-SPPS (Fmoc = tert-butoxycarabonyle) and cyclization with DIPC/HOBt in the solution phase. Synthesized peptides were evaluated for antifungal activities with MIC values against Saccharomyces cerevisiae and Aspergillus oryzae. As a result, the stereochem. of the amino acid residues and sequences of burkholdine analogs exerted a significant influence on antifungal activities. In addition, we found a linear burkholdine analog with moderate antifungal activities. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Physical Chemistry Chemical Physics included an article by Giannoulis, Angeliki; Yang, Yin; Gong, Yan-Jun; Tan, Xiaoli; Feintuch, Akiva; Carmieli, Raanan; Bahrenberg, Thorsten; Liu, Yangping; Su, Xun-Cheng; Goldfarb, Daniella. Formula: C12H22F6N6OP2. The article was titled 《DEER distance measurements on trityl/trityl and Gd(III)/trityl labelled proteins》. The information in the text is summarized as follows:

Triarylmethyl (TAM or trityl) radicals are becoming important for measuring distances in proteins and nucleic acids. Here, we report on a new trityl spin label CT02MA, which conjugates to a protein via a redox stable thioether bond. The performance of the new spin label was demonstrated in W-band double electron-electron resonance (DEER) distance measurements on doubly trityl-labeled mutants of IgG-binding protein 1 (GB1) and ubiquitin. For both doubly CT02MA-labeled proteins we measured, by applying chirped pump pulse(s), relatively narrow distance distributions, comparable to those obtained with the same protein mutants doubly labeled with BrPy-DO3MA-Gd(III). We noticed, however, that the sample contained some free CT02MA that was difficult to remove at the purification step. Dual labeling of ubiquitin with one CT02MA tag and one BrPy-DO3MA-Gd(III) tag was achieved as well and the trityl-Gd(III) distance distribution was measured, facilitated by the use of a dual mode cavity in combination with a chirped pump pulse. We also measured the Gd(III)-Gd(III) distance distribution in this sample, showing that the labeling procedure was not fully selective. Nevertheless, these measurements demonstrate the potential of the high sensitivity Gd(III)-trityl W-band DEER distance measurements in proteins, which can be further exploited by designing orthogonal Gd(III)/trityl labeling schemes. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《A Water-Soluble Perylene Bisimide Cyclophane as a Molecular Probe for the Recognition of Aromatic Alkaloids》 were Sapotta, Meike; Hofmann, Anja; Bialas, David; Wuerthner, Frank. And the article was published in Angewandte Chemie, International Edition in 2019. Product Details of 510758-28-8 The author mentioned the following in the article:

Herein, we report a water-soluble macrocyclic host based on perylene bisimide (PBI) chromophores that recognizes natural aromatic alkaloids in aqueous media by intercalating them into its hydrophobic cavity. The host-guest binding properties of our newly designed receptor with several alkaloids were studied by UV/Vis and fluorescence titration experiments as the optical properties of the chromophoric host change significantly upon complexation of guests. Structural information on the host-guest complexes was obtained by 1D and 2D NMR spectroscopy and mol. modeling. Our studies reveal a structure-binding property relationship for a series of structurally diverse aromatic alkaloids with the new receptor and higher binding affinity for the class of harmala alkaloids. To our knowledge, this is the first example of a chromophoric macrocyclic host employed as a mol. probe for the recognition of aromatic alkaloids. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics