Day: October 21, 2022

《Monopeptide-based powder gelators for instant phase-selective gelation of aprotic aromatics and for toxic dye removal》 was written by Li, Zhongyan; Luo, Ziqing; Zhou, Jialing; Ye, Zecong; Ou, Guang-chuan; Huo, Yanping; Yuan, Lin; Zeng, Huaqiang. Electric Literature of C12H22F6N6OP2 And the article was included in Langmuir in 2020. The article conveys some information:

Through a combinatorial screening of 35 possible phase-selective monopeptide-based organogelators readily made at low cost, we identified five of them with high gelling ability toward aprotic aromatic solvents in the powder form. The best of them (Fmoc-V-6) is able to instantly and phase-selectively gel benzene, toluene, and xylenes in the presence of water at room temperature at a gelator loading of 6% w/v. This enables the gelled aromatics to be separated by filtration and both aromatics and the gelling material to be recycled by distillation We also identified Fmoc-I-16 as the best gelator for benzyl alc., and the corresponding organogel efficiently removes toxic dye mols. by 82-99% from their highly concentrated aqueous solutions These efficient removals of toxic organic solvents and dyes from water suggest their promising applications in remediating contaminated water resources. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Electric Literature of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Electric Literature of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: triazolesIn 2020 ,《Graphite-like polyoxometalate-based metal-organic framework as an efficient anode for lithium ion batteries》 appeared in CrystEngComm. The author of the article were Yang, Xiya; Zhu, Peipei; Ma, Xiaoliang; Li, Wenjing; Tan, Zenglong; Sha, Jingquan. The article conveys some information:

A new polyoxometalate (POM) pillared metal-organic framework (POMOF), [Cu24(Trz)16(H2O)Cl4(HPMo12O40)] (Cu-POM, Trz = 1,2,3-triazole), was synthesized and characterized. Crystal anal. reveals that the Keggin POMs are inserted into copper-triazole layers with a graphite-like structure generating a POM-supported porous three-dimensional framework. Owing to the combination of the multi-electron redox property of POM units and the open porous framework, Cu-POM can be utilized as an anode material for lithium ion batteries (LIBs), and exhibits a reversible capacity of 525 mA h g-1 at a c.d. of 100 mA g-1 after 100 cycles. Moreover, to illustrate lithium storage, the impedance spectra of compound Cu-POM during the first and 100th charge process have also been studied. The study of Cu-POM in this work might guide the development of POM-based electrode materials for LIBs. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1H-1,2,3-TriazoleIn 2020 ,《Visible-Light Photoredox Catalyzed C-N Coupling of Quinoxaline-2(1H)-ones with Azoles without External Photosensitizer》 appeared in ChemCatChem. The author of the article were Sun, Mingli; Wang, Lei; Zhao, Lulu; Wang, Zhiming; Li, Pinhua. The article conveys some information:

A visible-light photoredox catalyzed C-N coupling of quinoxaline-2(1H)-ones with azoles in the absence of external photosensitizer was developed. The protocol employed com. available pyrazoles and triazoles as amination reagents and showed wide substrate scope, providing the corresponding C3-position amination products in good yields and high regioselectivity under ambient conditions. Investigations indicated that the starting materials and products can act as photosensitizers avoiding use of addnl. photocatalyst in an autocatalytic manner. In addition, 1O2 coexists with O2·- from mol. oxygen (3O2) via an energy transfer (ET) and single electron transfer (SET) process during the reaction. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Reference of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Reference of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kluge, R.; Schulz, M.; Liebsch, S. published an article on February 19 ,1996. The article was titled 《Diastereoselective Epoxidation of Olefins by Organo Sulfonic Peracids. II》, and you may find the article in Tetrahedron.Name: 3-Nitro-1-tosyl-1H-1,2,4-triazole The information in the text is summarized as follows:

The behavior of sulfonic peracids (generated in situ) toward olefins, allylic alcs., homoallylic alcs., and α,β-unsaturated ketones was studied. For example, 4-methylbenzenesulfonoperoxoic acid was generated in situ from 1-(4-methylphenylsulfonyl)-1H-imidazole and trimethyloxonium tetrafluoroborate. Epoxidation of α-pinene with 4-methylbenzenesulfonoperoxoic acid gave 2α,3α-epoxypinane. Generally, the epoxidation proceeds in a peracid-like manner with greater diastereoselectivity than those by common oxidants. In particular, the epoxidation of Δ4 3-ketosteroids gave 4α,5α-epoxides with good diastereoselectivity. Enhanced α-selectivity was also found in the epoxidation of a cholesterol derivative The results came from multiple reactions, including the reaction of 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5Name: 3-Nitro-1-tosyl-1H-1,2,4-triazole)

3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 3-Nitro-1-tosyl-1H-1,2,4-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Oh, Takahiro; Nagao, Masanori; Hoshino, Yu; Miura, Yoshiko published 《Self-Assembly of a Double Hydrophilic Block Glycopolymer and the Investigation of Its Mechanism》.Langmuir published the findings.COA of Formula: C30H30N10 The information in the text is summarized as follows:

We report the self-assembly of a double hydrophilic block glycopolymer (DHBG) via hydrogen bonding and coordinate bonding. This DHBG, composed of poly(ethylene)glycol (PEG) and glycopolymer, self-assembled into a well-defined structure. The DHBG was prepared through the controlled radical polymerization of trimethylsilyl-protected propargyl methacrylate using a PEG-based reversible addition-fragmentation chain transfer reagent, followed by sugar conjugation using click chem. The DHBG self-assembly capability was investigated by transmission electron microscopy and dynamic light scattering. Interestingly, the DHBG self-assembled into a spherical structure in aqueous solution Hydrogen bonding and coordinate bonding with Ca2+ were identified as the driving forces for self-assembly. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8COA of Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.COA of Formula: C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,ChemBioChem included an article by Xia, Shuai; Zhang, Yibin; Fang, Mingxi; Mikesell, Logan; Steenwinkel, Tessa E.; Wan, Shulin; Phillips, Tyler; Luck, Rudy L.; Werner, Thomas; Liu, Haiying. Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V). The article was titled 《A FRET-Based Near-Infrared Fluorescent Probe for Ratiometric Detection of Cysteine in Mitochondria》. The information in the text is summarized as follows:

We report a near-IR fluorescent probe A for the ratiometric detection of cysteine based on FRET from a coumarin donor to a near-IR rhodamine acceptor. Upon addition of cysteine, the coumarin fluorescence increased dramatically up to 18-fold and the fluorescence of the rhodamine acceptor decreased moderately by 45% under excitation of the coumarin unit. Probe A has been used to detect cysteine concentration changes in live cells ratiometrically and to visualize fluctuations in cysteine concentrations induced by oxidation stress through treatment with hydrogen peroxide or lipopolysaccharide (LPS). Finally, probe A was successfully applied for the in vivo imaging of Drosophila melanogaster larva to measure cysteine concentration changes. The experimental part of the paper was very detailed, including the reaction process of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zhang, Xi; Liu, Dong-yun; Shang, Hai; Jia, Yi; Xu, Xu-Dong; Tian, Yu; Guo, Peng published their research in RSC Advances in 2021. The article was titled 《Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation》.Product Details of 56602-33-6 The article contains the following contents:

Pandanus tectorius (L.) Parkins.(PTPs) is rich in caffeoylquinic acids and amino acids, especially some essential amino acids, such as valine, phenylalanine, and so forth. A series of novel amino acid ester-coupled caffeoylquinic acid derivatives have been designed and synthesized. Biol. evaluation suggested that some amino acid ester-coupled derivatives exhibited varying degrees of lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 6c, 6d, 6e and 6f exhibited comparable potential lipid-lowering effect with the pos. control simvastatin and chlorogenic acid. Further studies on the mechanism of 6c, 6d, 6e and 6f revealed that the lipid-lowering effects were related to their regulation of TG levels and mRNA levels of lipometabolic-modulating genes, and merit further investigation.((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Xuning; Zeng, Yaqiong; Tung, Ching-Wei; Lu, Ying-Rui; Baskaran, Sambath; Hung, Sung-Fu; Wang, Shifu; Xu, Cong-Qiao; Wang, Junhu; Chan, Ting-Shan; Chen, Hao Ming; Jiang, Jianchao; Yu, Qi; Huang, Yanqiang; Li, Jun; Zhang, Tao; Liu, Bin published an article in 2021. The article was titled 《Unveiling the In Situ Generation of a Monovalent Fe(I) Site in the Single-Fe-Atom Catalyst for Electrochemical CO2 Reduction》, and you may find the article in ACS Catalysis.Computed Properties of C2H3N3 The information in the text is summarized as follows:

Atomically dispersed single-atom catalysts are among the most attractive electrocatalysts for the CO2 reduction reaction (CRR). To elucidate the origin of the exceptional activity of atomically dispersed Fe-N-C catalyst in CRR, we have performed operando 57Fe Mössbauer spectroscopic studies on a model single-Fe-atom catalyst with a well-defined N coordination environment. Combining with operando X-ray absorption spectroscopy, the in situ-generated four pyrrolic nitrogen atom-coordinated low-spin Fe(I) (LS FeIN4) featuring monovalent iron is identified as the reactive center for the conversion of CO2 to CO. Furthermore, d. functional theory calculations reveal that the optimal binding strength of CO2 to the LS FeIN4 site, with strong orbital interactions between the singly occupied dz2 orbital of the Fe(I) site and the singly occupied π* orbital of [COOH] fragment, is the key factor for the excellent CRR performance. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Computed Properties of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Computed Properties of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: triazolesIn 2017 ,《A poly(propyleneimine) dendrimer-based polyplex-system for single-chain antibody-mediated targeted delivery and cellular uptake of siRNA》 appeared in Small. The author of the article were Tietze, Stefanie; Schau, Isabell; Michen, Susanne; Ennen, Franka; Janke, Andreas; Schackert, Gabriele; Aigner, Achim; Appelhans, Dietmar; Temme, Achim. The article conveys some information:

Therapeutics based on small interfering RNAs (siRNAs) offer a great potential to treat so far incurable diseases or metastatic cancer. However, the broad application of siRNAs using various nonviral carrier systems is hampered by unspecific toxic side effects, poor pharmacokinetics due to unwanted delivery of siRNA-loaded nanoparticles into nontarget organs, or rapid renal excretion. In order to overcome these obstacles, several targeting strategies using chem. linked antibodies and ligands have emerged. This study reports a new modular polyplex carrier system for targeted delivery of siRNA, which is based on transfection-disabled maltose-modified poly(propyleneimine)-dendrimers (mal-PPI) bioconjugated to single chain fragment variables (scFvs). To achieve targeted delivery into tumor cells expressing the epidermal growth factor receptor variant III (EGFRvIII), monobiotinylated anti-EGFRvIII scFv fused to a Propionibacterium shermanii transcarboxylase-derived biotinylation acceptor (P-BAP) is bioconjugated to mal-PPI through a novel coupling strategy solely based on biotin-neutravidin bridging. In contrast to polyplexes containing an unspecific control scFv-P-BAP, the generated EGFRvIII-specific polyplexes are able to exclusively deliver siRNA to tumor cells and tumors by receptor-mediated endocytosis. These results suggest that receptor-mediated uptake of otherwise noninternalized mal-PPI-based polyplexes is a promising avenue to improve siRNA therapy of cancer, and introduce a novel strategy for modular bioconjugation of protein ligands to nanoparticles. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Category: triazoles)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2022 ,《Targeted Molecular Construct for Bioorthogonal Theranostics of PD-L1-Expressing Cancer Cells》 appeared in JACS Au. The author of the article were Chow, Shiao Y.; Unciti-Broceta, Asier. The article conveys some information:

Mol. targeting of tumor-overexpressed oncoproteins can improve the selectivity and tolerability of anticancer therapies. The immunoinhibitory membrane protein programmed death ligand 1 (PD-L1) is highly expressed on certain tumor types, which masks malignant cells from T cell recognition and creates an optimal environment for the cancer to thrive and spread. We report here a ligand-tetrazine conjugate (LTzC) armed with a PD-L1 small mol. inhibitor to selectively target PD-L1-expressing cancer cells and inhibit PD-L1 function and conjugated to a tetrazine module and a lipoyl group to incorporate bioorthogonal reactivities and an oxidative stress enhancer into the construct. By pairing LTzC with an imaging probe, we have established a “”track-tag””ystem for selective labeling of PD-L1 both on and in living cells using click chem. We have further shown the specificity and versatility of LTzC by click-to-release activation of prodrugs and selective killing of PD-L1-expressing breast cancer cells, offering a new multimodal approach to “”track-treat”” malignant cells that are capable of evading the immune system. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics