Werbel, Leslie M. published the artcilePotential antimalarial substances. XIV. [[(Dialkylamino)alkyl]amino]pyrimido[1,2-a]benzimidazoles, 2,3,-dihydro-1H-cyclopenta[4,5]pyrimido[1,2-a]benzimidazoles, and s-triazolo[1,5-a]pyrimidines as potential antimalarial agents, Formula: C6H5ClN4, the main research area is pyrimido benzimidazoles; benzimidazoles pyrimido; cyclopentapyrimidobenzimidazoles; triazolo pyrimidines; pyrimidines triazolo.
The structure of the product of the reaction of 2-aminobenzimidazole with ethyl acetoacetate was established by NMR spectroscopy as 2-methylpyr imido[1,2-a]benzimidazol-4-ol (I). 7(and 8)-Chloro-2-methylpyrimido[1,2-a]benzimidazol-4-ol (II and III), 2-(trifluoromethyl)pyrimido[1,2-a]benzimidazol-4-ol, 2,7,8-trimethylpyrimido[1,2-a]benzimidazol-4-ol, 2-benzyl-1,2,3,4-tetrahydropyrido-[4′,3′:4,5]pyrimido[1,2-a]benzimidazol-12-ol, 1,2,3,4-tetrahydro-benzimidazo[2,1-b]quinazolin-12-ol, and 2,3-dihydro-1H-cyclopenta[4,5]pyrimido[1,2-a]benzimidazol-11-ol (IV) were prepared in a similar manner. Chlorination of I, II, III, IV, and 5-methyl-s-triazolo[1,5-a]pyrimidin-7-ol with POCl3 afforded the corresponding chloroheterocycles, which were condensed with the appropriate N,N-dialkylalkylenediamine or Na,Na-diethyl-6-methoxytoluene-α,3-diamine to give various 4-[[(dialkylamino)-alkyl]amino]-2-methylpyrimido[1,2-a]benzimidazoles, 11-[[(dialkylamino)alkyl]amino]-2,3-dihydro-1H-cyclopenta[4,5]pyrimido[1,2-a] benzimidazoles and 7-[[(dialkylamino)alkyl]-amino]-5-methyl-s-triazolo[1,5-a]pyrimidines. None of these compounds displayed significant antimalarial activity against Plasmodium berghei in the mouse.
Journal of Heterocyclic Chemistry published new progress about Drugs. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Formula: C6H5ClN4.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics