Day: October 26, 2022

On December 1, 2017, Kang, Taewon; Kim, Hongsik; Lee, Dongwhan published an article.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Triazoliptycenes: A Twist on Iptycene Chemistry for Regioselective Cross-Coupling To Build Nonstacking Fluorophores. And the article contained the following:

Triazoliptycene fluorophores have been designed and synthesized, in which a three-dimensional propeller-like iptycene motif is employed to suppress intermol. π-π stacking in the solid state. Key to the success of this modular synthesis is a stereoelectronic bias imposed by the iptycene scaffold, which assists the desired regioselectivity in the C-N cross-coupling step as the last-stage structure diversification from a common precursor. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to crystal mol structure triazoliptycene fluorophore, triazoliptycene modular preparation regioselective coupling nonstacking fluorophore, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On November 7, 2014, Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published an article.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles. And the article contained the following:

A p-TsOH-mediated 1,3-dipolar cycloaddition of nitroolefins and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed. p-TsOH was discovered as a vital additive in this type of 1,3-dipolar cycloaddition This novel cycloaddition reaction is a good method for the rapid synthesis of valuable 4-aryl-NH-1,2,3-triazoles in high yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to aryltriazole preparation toluenesulfonic acid mediated dipolar cycloaddition, dipolar cycloaddition nitroolefin sodium azide aryltriazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On November 7, 2014, Liu, Zhenquan; Zhu, Daqian; Luo, Bingling; Zhang, Naiyuan; Liu, Qi; Hu, Yumin; Pi, Rongbiao; Huang, Peng; Wen, Shijun published an article.Category: triazoles The title of the article was Mild Cu(I)-Catalyzed Cascade Reaction of Cyclic Diaryliodoniums, Sodium Azide, and Alkynes: Efficient Synthesis of Triazolophenanthridines. And the article contained the following:

Linear iodoniums are widely used as arylating reagents. However, cyclic diaryl iodoniums are ignored despite their potential to initiate dual arylations, atom and step economically. In our current work, a three-component cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes has been successfully achieved under mild conditions, catalyzed by cheap copper species. The regioselectivity associated with unsym. iodoniums was enhanced by installing two methyls ortho and para to the IIII center. The reaction enables a rapid access to a variety of complex mols., triazolophenanthridine derivatives I [R1 = H, OMe, Me, etc.; R2 = H, OMe, Me, etc.; R3 = ph, 4-Me-ph, 4-F-ph, etc.]. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to cyclic diaryliodonium sodium azide alkyne, tandem azidation azide alkyne cycloaddition ullmann coupling copper catalyst, triazolophenanthridine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 15, 2010, Zhang, Wensheng; Kuang, Chunxiang; Yang, Qing published an article.Application of 5301-96-2 The title of the article was Palladium-catalyzed one-pot synthesis of 4-aryl-1H-1,2,3-triazoles from anti-3-aryl-2,3-dibromopropanoic acids and sodium azide. And the article contained the following:

4-Aryl-1H-1,2,3-triazoles were synthesized from anti-3-aryl-2,3-dibromopropanoates and NaN3 by a 1-pot method using DMF as solvent in the presence of tris(dibenzylideneacetone)dipalladium(0) [Pd2(dba)3] and Xantphos. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to bromopropanoate sodium azide heterocyclization palladium catalyst, brominated cinnamate sodium azide heterocyclization palladium catalyst, triazole aryl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 16, 2015, Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles [Erratum to document cited in CA161:682131]. And the article contained the following:

On page 5730, structure 4a in Scheme 2 was published incorrectly, and subsequent text corresponding to this Structure is also incorrect; the correct structure, name, and text are given. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to erratum aryltriazole preparation toluenesulfonic acid mediated dipolar cycloaddition, dipolar cycloaddition nitroolefin sodium azide aryltriazole preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 16, 2015, Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles [Erratum to document cited in CA161:682131]. And the article contained the following:

On page 5730, structure 4a in Scheme 2 was published incorrectly, and subsequent text corresponding to this Structure is also incorrect; the correct structure, name, and text are given. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to erratum aryltriazole preparation toluenesulfonic acid mediated dipolar cycloaddition, dipolar cycloaddition nitroolefin sodium azide aryltriazole preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 1, 2014, He, Yun; Sun, Erxiao; Zhao, Yi; Hai, Li; Wu, Yong published an article.Formula: C9H9N3 The title of the article was The one-pot synthesis of 4-aryl-1H-1,2,3-triazoles without azides and metal catalization. And the article contained the following:

In this study, a new methodol. for the one-pot synthesis of 4-aryl-1H-1,2,3-triazoles, e.g., I (R = H, Me, Cl, F, NO2, CN), from arylglyoxaldoxime semicarbazones is presented. 4-Aryl-1,2,3-triazoles were obtained in moderate to good yields via sodium dithionite and O2, which are all efficient, safe and inexpensive reagents. This reaction is more suitable for large-scale syntheses than those using hydrazoic acid, sodium azide, or organic azides. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to arylglyoxaldoxime semicarbazone oxidative heterocyclization sodium dithionite oxygen, aryl triazole preparation, dithionite oxygen oxidative heterocyclization mediator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On June 16, 2022, Fang, Wenkui; Li, Guanqun; Cai, Yuting; Pan, Xiang; Zhu, Wenhao; Wang, Yang; Wang, Zengquan published a patent.Electric Literature of 2092807-41-3 The title of the patent was Preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. And the patent contained the following:

A triazolo pyrazine compound, wherein the triazolo pyrazine compound is a compound as represented by formula I as follows, or a stereoisomer, a geometrical isomer, a tautomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof, wherein W is selected from a substituted or unsubstituted aryl or heteroaryl, X is C or N, and R is H or any substituent group. When the triazolo pyrazine compound provided by the invention is used as a Tyk2 specific inhibitor, a more targeted drug can be provided for autoimmune inflammatory diseases driven by an IL-23/Th17 axis, and the compound can be used for treating rheumatoid arthritis, psoriasis, ankylosing spondylitis, sicca syndrome, lupus erythematosus, inflammatory bowel disease, Behcet’s disease, severe COVID-19 pneumonia and other diseases more safely and effectively. The experimental process involved the reaction of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine(cas: 2092807-41-3).Electric Literature of 2092807-41-3

The Article related to triazolopyrazine compound preparation tyk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 2092807-41-3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 2, 2021, Fang, Wenkui; Li, Guanqun; Cai, Yuting; Pan, Xiang; Zhu, Wenhao; Wang, Yang; Wang, Zengquan published a patent.Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine The title of the patent was Preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. And the patent contained the following:

The present invention relates to the preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. In particular, the triazole pyrazine compound I (wherein, W = (un)substituted aryl or heteroaryl; X = C or N; R = H or any substituent group such as halogen, cyanide, amino, alkyl, alkoxy, cyanoalkyl etc) or its stereoisomers, geometric isomers, tautomers, hydrates, solvates and pharmaceutically acceptable salts or prodrugs were prepared The inventive compound can be used as a Tyk2 specific inhibitor which can provide a more targeted medicament for an autoimmune inflammatory disease driven by an IL-23/Th17 axis and diseases such as rheumatoid arthritis, psoriasis, compulsive spondylitis, Sjogren’s syndrome, lupus erythematosus, inflammatory bowel disease, Behcet’s disease, Covid-19 severe pneumonia can be safely and effectively treated. The experimental process involved the reaction of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine(cas: 2092807-41-3).Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine

The Article related to triazolopyrazine compound preparation tyk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Si-Yuan; Guan, Zhen-Yu; Xue, Jing; Zhang, Guang-Yi; Guan, Xiao-Yu; Deng, Qing-Hai published an article in 2020, the title of the article was Practical copper-catalyzed chloronitration of alkenes with TMSCl and guanidine nitrate.Application of 5301-96-2 And the article contains the following content:

A novel and practical chloronitration of alkenes in the presence of easily available TMSCl and guanidine nitrate was developed by using cheap copper sulfate pentahydrate as the catalyst. A variety of vic-chloronitro compounds were directly synthesized in good to excellent yields on up to 100 mmol scale under mild reaction conditions, and the resulting products could be smoothly transformed into the corresponding nitroalkenes and diverse nitro compounds bearing a vicinal nucleophilic “C”, “N” or “S” unit. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to nitroalkene preparation, alkene guanidine nitrate chloronitration, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics