Day: October 26, 2022

Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On October 6, 2017, Zhang, Lingling; Yi, Hong; Wang, Jue; Lei, Aiwen published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Visible-Light Mediated Oxidative C-H/N-H Cross-Coupling between Tetrahydrofuran and Azoles Using Air. And the article contained the following:

THF is a privileged structural moiety in many important organic compounds In this work, a simple and mild catalytic oxidative amination of THF mediated by visible-light catalysis was developed. The C(sp3)-H bond of THF was activated using mol. oxygen as a benign oxidant. Besides, a variety of azoles could be tolerated, providing a green route for N-substituted azoles, e.g., I. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole thf oxidative cross coupling amination light blue led, thf azole hybrid preparation, visible light oxidative amination mediator, methyltriphenyl acridinium perchlorate oxidative cross coupling amination photocatalyst and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yan, Wuming; Liao, Tao; Tuguldur, Odbadrakh; Zhong, Cheng; Petersen, Jeffrey L.; Shi, Xiaodong published an article in 2011, the title of the article was Mitsunobu Reaction of 1,2,3-NH-Triazoles: A Regio- and Stereoselective Approach to Functionalized Triazole Derivatives.Synthetic Route of 5301-96-2 And the article contains the following content:

Mitsunobu reactions of primary, secondary, benzylic and allylic alcs. with 1,2,3-triazoles and 1,2,3-benzotriazole gave the N2-alkylated triazoles and benzotriazoles in most cases as the major regioisomers; N-alkylation reactions also occurred with high stereoselectivities when either trans-2-methyl-1-cycloalkanols or nonracemic alcs. were used as electrophiles. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to alkyl allylic benzylic triazole regioselective stereoselective preparation, regioselective mitsunobu reaction triazole benzotriazole alc, stereoselective regioselective mitsunobu reaction benzotriazole nonracemic alc methylcycloalkanol and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 5, 2021, Hazarika, Roktopol; Garg, Anirban; Chetia, Swadhin; Phukan, Parmita; Kulshrestha, Akshay; Kumar, Arvind; Bordoloi, Ankur; Kalita, Amlan Jyoti; Guha, Ankur Kanti; Sarma, Diganta published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Magnetically separable ZnFe2O4 nanoparticles: a low cost and sustainable catalyst for propargyl amine and NH-triazole synthesis. And the article contained the following:

The multicomponent reaction (MCR) strategy for the construction of important mol. scaffolds is in trending nowadays and among them, A3-coupling stands in a significant position. Aldehyde, amine and alkynes are coupled in this particular reaction via C-H activation process. Herein, zinc ferrite nanoparticles are reported as magnetically separable heterogeneous catalyst for A3-coupling reaction with attractive attributes like excellent productivity, selectivity and better reusability. Moreover, the catalyst can also be effectively applied for the synthesis of various NH-triazoles in quant. yields. A plausible mechanism has been proposed for the synthesis of NH-triazoles followed by validation with computational study. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole preparation, magnetically separable zinc ferrite nanoparticle preparation multicomponent catalyst, aldehyde amine alkyne coupling zinc ferrite, nitromethane aldehyde sodium azide coupling zinc ferrite, propargyl amine preparation and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On February 23, 2017, Qian, Yimin; Dong, Hanqing; Wang, Jing; Berlin, Michael; Siu, Kam; Crew, Andrew P.; Crews, Craig M. published a patent.Application of 1949837-12-0 The title of the patent was Preparation of bifunctional PROTAC compounds and methods for the enhanced degradation of targeted bromodomain-containing proteins. And the patent contained the following:

The invention is related to compounds UTM-L-PTM [UTM = a small mol. E3 ubiquitin ligase binding moiety that binds an E3 ubiquitin ligase selected from the group consisting of VHL, IAP, Cereblon, and MDM2; PTM = a small mol. bromodomain and extra-terminal domain (BET)-containing protein targeting moiety; and L = a bond or a chem. linking moiety connecting UTM and PTM], e.g., I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate or polymorph thereof which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by the bifunctional compounds of the invention. In particular, the invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds that exhibited a broad range of pharmacol. activities consistent with the degradation/inhibition of targeted polypeptides were prepared Thus, I was prepared and displayed proteolytic modulatory activity ( BRD4 degradation DC50 in the range of 10-100 nM and cMyc Imax = 100%). The experimental process involved the reaction of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide(cas: 1949837-12-0).Application of 1949837-12-0

The Article related to chimeric mol preparation targeted bromodomain containing protein degradation ubiquitination, protac modulator preparation targeted ubiquitination brd4 degradation inhibition, von hippel lindau ligand preparation brd4 protac degradation inhibition and other aspects.Application of 1949837-12-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 20, 2021, Wang, Tao; Tang, Zongyuan; Luo, Han; Tian, Yi; Xu, Mingchuan; Lu, Qixing; Li, Baosheng published an article.HPLC of Formula: 5301-96-2 The title of the article was Access to (Z)-β-Substituted Enamides from N1-H-1,2,3-Triazoles. And the article contained the following:

A direct ring-opening/nucleophilic substitution reaction of N1-H-1,2,3-triazoles was described. Divergent (Z)-β-halogen- or sulfonyl-substituted enamides were stereospecifically synthesized in a tunable manner. This strategy might not only enable a new ring-opening method of N1-H-1,2,3-triazoles under non-metal catalysis and mild reaction conditions but also offer a good opportunity to reliably access versatile (Z)-β-substituted enamides that could be used as synthetic precursors for further synthetic transformations. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to acyl halide triazole tandem diastereoselective ring opening nucleophilic substitition, halovinyl amide preparation, sulfonate acyl chloride triazole multicomponent tandem ring opening substitition, amido vinylsulfonate preparation diastereoselective and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Park, Gab-Man; Park, Hyun; Oh, Sangtae; Lee, Seokjoon published an article in 2017, the title of the article was Antimalarial activity of C-10 substituted triazolyl artemisinin.Computed Properties of 5301-96-2 And the article contains the following content:

Synthesis of C-10 substituted triazolyl artemisinins I [R = Ph, 4-MeC6H4, 3-ClC6H4, etc.], II and III [R = 4-Ph, 5-Ph, 5-(4-MeC6H4), 5-(3-ClC6H4), etc.] by the Huisgen cycloaddition reaction between dihydroartemisinins and variously substituted 1,2,3-triazoles was described. The antimalarial activities of 32 novel artemisinin derivatives I , II and III were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin I [R = 3-ClC6H4], II [R = 3-ClC6H4] and III [R = 5-(3-ClC6H4), 4-(3-ClC6H4)] showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to substituted triazolyl artemisinin preparation regioselective diastereoselective antimalarial human, dihydroartemisinin triazole huisgen cycloaddition, antimalarial activity, artemisinin, dihydroartemisinin, substituted triazolyl artemisinin, synthesis and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ni, Qijian; Song, Xiaoxiao; Xiong, Jiawen; Raabe, Gerhard; Enders, Dieter published an article in 2015, the title of the article was Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction.Electric Literature of 1469801-67-9 And the article contains the following content:

An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with α-chloroaldehydes has been developed. This new protocol provides a facile approach for the asym. synthesis of benzothiazolo-pyrimidinones and a pyrrolo[1,2-a]indolone in moderate to good yields (34-78%) and excellent stereoselectivities (87-99% ee, up to >20 : 1 d.r.). The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Electric Literature of 1469801-67-9

The Article related to regioselective stereoselective benzothiazolopyrimidinone preparation tandem reaction, nitrogen heterocyclic carbene catalyzed mannich lactamization domino reaction, domino reaction benzothiazolylimine alpha chloroaldehyde benzothiazolopyrimidinone pyrroloindolone preparation and other aspects.Electric Literature of 1469801-67-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 19, 2018, Bhagat, Ujjawal Kumar; Peddinti, Rama Krishna published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Asymmetric Organocatalytic Approach to 2,4-Disubstituted 1,2,3-Triazoles by N2-Selective Aza-Michael Addition. And the article contained the following:

Cycloalkenones (2-cyclohexen-1-one, 4,4-dimethyl-2-cyclohexen-1-one, 2-cyclopenten-1-one) underwent regio- and enantioselective aza-Michael reactions with aryl-1,2,3-triazoles in the presence of a nonracemic cinchonine-derived thiourea to yield nonracemic (oxocycloalkyl)aryltriazoles I [R = Ph, 3-MeOC6H4, 4-MeOC6H4, 4-MeC6H4, 4-i-PrC6H4, 2-ClC6H4, 4-ClC6H4, 2-O2NC6H4, 3-O2NC6H4, 2-BrC6H4, 4-BrC6H4, 2,5-(MeO)2C6H3, 3,4-(MeO)2C6H3, 2,3-Cl2C63, 2,4,5-(MeO)3C6H2, 2-methoxy-1-naphthyl; X = CH2, CMe2, bond] in 58-75% yields and in 44->99% ee (with 0-25% yields of regioisomeric products derived from N1-addition). The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to oxocycloalkyl aryltriazole regioselective enantioselective preparation, regioselective enantioselective aza michael addition aryltriazole cycloalkenone cinchonine thiourea, cinchonine thiourea catalyst regioselective enantioselective michael addition aryltriazole cycloalkenone and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On March 18, 2015, Goodman, C. Guy; Walker, Morgan M.; Johnson, Jeffrey S. published an article.Safety of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate The title of the article was Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation [Erratum to document cited in CA162:137454]. And the article contained the following:

Some of the catalyst identifiers (A-G) used in the Supporting Information did not match those shown in the paper; the Supporting Information has been updated. The authors were made aware of several relevant publication involving enantioconvergent proline-catalyzed aldol reactions of chiral racemic electrophiles and provide the relevant citation information. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Safety of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

The Article related to erratum butyrolactone gamma derivative enantioconvergent annulation synthesis, halo keto ester kinetic resolution asym homoenolate reaction erratum, alkenal annulation halo keto ester hetereocyclic carbene catalyst erratum, regioselective annulation halo keto ester alkenal erratum and other aspects.Safety of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics