Month: October 2022

On March 5, 1990, Ito, Suketaka; Kakehi, Akikazu; Yamazaki, Akihiro published an article.COA of Formula: C9H9N3 The title of the article was Thermolysis of α-azidoacetophenone phenylsulfonylhydrazones. A new preparative route to 4-aryl-1H-1,2,3-triazoles. And the article contained the following:

Thermolysis of α-azidoacetophenone phenylsulfonylhydrazones 4-R(C6H4C(CH2N3):NNHSO2Ph (R = H, Br, Cl, NO2, Me, Ph, PhN:N) gave 4-aryl-1H-1,2,3-triazoles I in good yields. The reaction proceeds probably via the elimination of benzenesulfinic acid from 4-aryl-2-phenylsulfonyltriazolines formed intermediately. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to azidoacetophenone phenylsulfonylhydrazone thermolysis, cyclization azidoacetophenone phenylsulfonylhydrazone, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 13, 2020, Ren, Ming-Tian; Li, Min; Wang, An-Jing; Gao, Jie; Zhang, Xiang-Xiang; Shu, Wen-Ming published an article.Application of 5301-96-2 The title of the article was Iodine-Mediated Condensation-Cyclization of α-Azido Ketones with p-Toluenesulfonyl Hydrazide for Synthesis of 4-Aryl-NH-1,2,3-Triazoles. And the article contained the following:

A mol. iodine mediated condensation-cyclization reaction for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed from readily available α-azido acetophenones and p-toluenesulfonyl hydrazide. This reaction provides a metal-free strategy for the sequential formation of C-N and N-N bonds in mild condition. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to azido acetophenone toluenesulfonyl hydrazide iodine condensation cyclization tandem, aryl triazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On October 1, 2021, Huang, Chun; Geng, Xiao; Zhao, Peng; Zhou, You; Yu, Xiao-Xiao; Wang, Li-Sheng; Wu, Yan-Dong; Wu, An-Xin published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Direct Synthesis of 4-Aryl-1,2,3-triazoles via I2-Promoted Cyclization under Metal- and Azide-Free Conditions. And the article contained the following:

Authors herein report an iodine-mediated formal [2 + 2 + 1] cyclization of Me ketones, p-toluenesulfonyl hydrazines, and 1-aminopyridinium iodide for preparation of 4-aryl-NH-1,2,3-triazoles under metal- and azide-free conditions. Notably, this is achieved using p-toluenesulfonyl hydrazines and 1-aminopyridinium iodide as azide surrogates, providing a novel route to NH-1,2,3-triazoles. Furthermore, this approach provides rapid and practical access to potent inhibitors of indoleamine 2,3-dioxygenase (IDO). The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to aryl triazole preparation, methyl ketone para toluenesulfonyl hydrazine aminopyridinium iodide cyclization iodine, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 6, 2016, Zhu, Li-Li; Xu, Xiao-Qi; Shi, Jin-Wei; Chen, Bai-Ling; Chen, Zili published an article.Category: triazoles The title of the article was N2-Selective Iodofunctionalization of Olefins with NH-1,2,3-Triazoles to provide N2-Alkyl-Substituted 1,2,3-Triazoles. And the article contained the following:

A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazole through N-iodosuccinimide (NIS) mediated iodofuctionalization reaction of the alkene group with bi-, mono-, and unsubstituted NH-1,2,3-triazoles. The favored N-1 type hydrogen bond between the iodonium ion intermediate and 1,2,3-triazole was supposed to be generated, which gave the desired N2-alkyl triazole with a high N2-selectivity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to crystal mol structure iodoglyoside methoxyphenyl triazole, alkyl triazole preparation, iodination olefin triazole, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 25, 2017, Bhagat, Ujjawal Kumar; Kamaluddin; Peddinti, Rama Krishna published an article.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was DABCO-mediated aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to cycloalkenones. Regioselective synthesis of disubstituted 1,2,3-triazoles. And the article contained the following:

Aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to 2-cycloalken-1-ones was studied in the presence of DABCO as organic base. The reactions were carried out in acetonitrile at room temperature to provide 2,4-disubstituted 2H-1,2,3-triazoles I [R = H, Me; Ar = C6H5, 4-MeC6H4, 2-MeO-1-naphthyl, etc.; n = 1] as major adducts and 1,4-disubstituted 1H-1,2,3-triazoles II [n = 0] as minor adducts. Though the reaction times are longer (4-8 days), the two regioisomers were separated by using column chromatog. and the adducts were obtained in very good to excellent combined chem. yields. The electron-rich and electron-poor substituents on aryl moiety of 4-aryl-triazoles could tolerate the reaction conditions to afford the title adducts. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to disubstituted triazole regioselective preparation, aryl triazole cycloalkenone aza michael addition dabco mediated, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 14, 2020, Li, Tao; Chen, Bai-Ling; Zhu, Li-Li; Chen, Zili published an article.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Gold catalyzed cascade reaction of 2-Alkynyl arylazides with 1,2,3-Triazoles to provide N1- and N2-Indol-3-yl 1,2,3-Triazole derivatives. And the article contained the following:

A new method was developed to prepare N1 and N2-indol-3-yl 1,2,3-trizole products through gold catalyzed cascade reaction of o-alkynyl arylazides with 1,2,3-triazoles, in which, the in-situ generated α-imino gold carbene intermediate was intercepted by various types of triazole compounds N1-selective nucleophilic attack was favored to give moderate to high N1/N2 selectivity. In addition, indol-3-yl pyrazole compounds were also prepared by using the similar method. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to indolyl triazole pyrazole preparation, alkynyl arylazide triazole gold catalyst regioselective cascade cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sharma, Pankaj; Kumar, Niggula P.; Senwar, Kishna R.; Forero-Doria, Oscar; Nachtigall, Fabiane M.; Santos, Leonardo S.; Shankaraiah, Nagula published an article in 2017, the title of the article was Effect of sulfamic acid on 1,3-dipolar cycloaddition reaction: mechanistic studies and synthesis of 4-aryl-NH-1,2,3-triazoles from nitroolefins.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

A facile and new metal-free 1,3-dipolar cycloaddition reaction for the synthesis of 4-aryl-NH-1,2,3-triazoles, e.g., I from nitroolefins, e.g., 3-nitro-2-phenyl-2H-1-benzopyran and NaN3 employing NH2SO3H has been developed. Sulfamic acid proved to be an efficient additive in this transformation by inhibiting the formation of triaryl benzene. Mechanistic aspects and key intermediates associated with this transformation have also been characterized by online monitoring of the reaction using electrospray ionization tandem mass spectrometry method (ESI-MS/MS). The protocol emphasizes broad substrate scope for many functionalities, simple reaction conditions such as stability to open air, less reaction time, easy work-up, eco-friendly and with good to excellent yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole aryl preparation green chem, nitroolefn sodium azide dipolar cycloaddition reaction sulfamic acid catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 6, 2019, Li, Xiaoxiao; Zhao, Zhigang; Reheman, Xijiaaiti published a patent.Category: triazoles The title of the patent was Method for regioselectively synthesizing 2-allyl-1,2,3-triazole derivatives. And the patent contained the following:

The invention provides a method for regioselectively synthesizing N2-allyl-1,2,3-triazole derivatives of formula I [R1 is aryl, benzyl or alkyl; the protecting group PG is p-toluenesulfonyl or acetyl; R2 is an aryl, benzyl, alkyl, heterocyclic substituent or hydrogen] via NIS mediated allylation of allenamides with mono- and unsubstituted triazole and 1,2,3-benzotriazole. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to allenyl sulfonamide triazole iodosuccinimide mediator regioselective allylation, iodo triazolyl propenamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Re He Man, Xi Jia Ai Ti; Liu, Yong Chun; Li, Xiao Xiao; Zhao, Zhi Gang published an article in 2019, the title of the article was Highly N2-selective allylation of NH-1,2,3-triazoles with allenamides mediated by N-iodosuccinimide.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

A new method was developed to synthesize N2-allyl-substituted 1,2,3-triazoles via NIS mediated allylation of allenamides with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. All the N2-allyl-substituted 1,2,3-triazoles has relative stability. The ionic pair composed of a σ-complex and the conjugate base of the imide and the hydrogen bond between the conjugate base and NH-1,2,3-triazole were found to be generated, which selectively gave the desired N2-allylation products. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to allenyl sulfonamide triazole iodosuccinimide mediator regioselective allylation, iodo triazolyl propenamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tanaka, Y.; Velen, S. R.; Miller, S. I. published an article in 1973, the title of the article was Syntheses and properties of 1,2,3-triazoles.HPLC of Formula: 5301-96-2 And the article contains the following content:

Activated acetylenes reacted with N3- in DMF to give the corresponding 1,2,3-triazoles. E.g., p-O2NC6H4CCH gave 56% product after 10 hr at 120°. (Ethynylcarbonyl)triazoles underwent addition reactions with amines. The triazoles had pKs 4.95-9.45 in 1:1 EtOH-H2O at 25°. Their uv and ir spectra are discussed. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to triazole, cycloaddition alkyne azide, addition triazole amine, uv triazole, ir triazole, acidity triazole substituent effect, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics