The Article related to fused heterocycle preparation gpr119 diabetes obesity dyslipidemia, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 1159811-32-1
On October 8, 2015, Schwink, Lothar; Buning, Christian; Glombik, Heiner; Gossel, Matthias; Kadereit, Dieter; Halland, Nis; Lohmann, Matthias; Poeverlein, Christoph; Ritter, Kurt published a patent.HPLC of Formula: 1159811-32-1 The title of the patent was Preparation of fused heterocycles as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders. And the patent contained the following:
Disclosed are fused heterocyclic compounds of formula I as GPR119 modulators useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of I as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them. I [wherein R1a, R1b, R1c, R2a, R2b, and R2c are independently H, Cl, F, alkyl, etc.; R3 is a bond or (CR7R7′)p; R7R7′ wherein each R is independently H or alkyl; p is 0, 1, 2, 3, or 4; R4 is alkyl, cycloalkyl, Ph, etc.; R30 is H, alkyl, hydroxyalkyl, etc.; A and E are independently N or C; B is CO, N, or CH; G is N or (un)substituted C; Y is N or CH; Z is bond, O, C=O, etc.] or any stereoisomeric forms or physiol. acceptable salts thereof, are claimed and exemplified. For example, (R)-II was prepared by coupling dimethylamine with the corresponding acid. I were evaluated for GPR agonistic activity using a HTRF assay from which (R)-II was determined to exhibit an EC50 value of 0.126 μM. The experimental process involved the reaction of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate(cas: 1159811-32-1).HPLC of Formula: 1159811-32-1
The Article related to fused heterocycle preparation gpr119 diabetes obesity dyslipidemia, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 1159811-32-1
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics