On January 26, 2017, Schwink, Lothar; Buning, Christian; Glombik, Heiner; Gossel, Matthias; Kadereit, Dieter; Halland, Nis; Lohmann, Matthias; Poeverlein, Christoph; Ritter, Kurt published a patent.Product Details of 1159811-32-1 The title of the patent was Preparation of substituted fused heterocycles as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders. And the patent contained the following:
The title compounds I [A = N or C; B = CO, N or CH; E = N or C; G = N or CR30 (wherein at least one of the groups A, B, E or G = N); R30 = H or (CR11R12)nR32; R11, R12 = (independently) H or alkyl; n = 0-3; R32 = alkyl, COOR13, CONR14R15, etc.; R13 = H or alkyl; R14, R15 = (independently) H, alkyl, cycloalkyl, etc.; or R14 and R15 form together with the N-atom to which they are attached, (un)substituted 4-6 membered heterocycle, optionally containing an addnl. heteroatom selected from the list O, S and NR18 (R18 = H or alkyl); R1a, R1b, R1c = (independently) H, F, Cl, Br, alkyl or CN; R2a, R2b, R2c = (independently) H, F, Cl, Br, alkyl or CN; Y = N or CH; Z = a bond, O, C(O), etc.; R3 = a bond or (CR7R71)p (wherein p = 0-4; R7, R71 = (independently) H or alkyl); R4 = alkyl, (un)substituted cycloalkyl, Ph, etc.] that are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders, were prepared For example, reacting 6-bromo-2-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridine with (R)-3-{[6-(cyclopropylmethoxy)pyridin-3-yl]oxy}pyrrolidin-2-one in the presence of N,N’-dimethylethane-1,2-diamine and cesium carbonate in 1,4-dioxane afforded the isoindolinone II. Exemplified compounds I were tested for their biol. activity using the cell line expressing human GPR119 (data given). The invention furthermore relates to the use of the compounds I as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them. The experimental process involved the reaction of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate(cas: 1159811-32-1).Product Details of 1159811-32-1
The Article related to fused heterocycle preparation gpr119 modulator antidiabetic antiobesity dyslipidemia, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 1159811-32-1
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics