Month: November 2022

On December 15, 2020, Liu, Yanli; Guo, Bingqian; Aguilera-Jimenez, Estrella; Chu, Vivian S.; Zhou, Jin; Wu, Zhong; Francis, Joshua M.; Yang, Xiaojun; Choi, Peter S.; Bailey, Swneke D.; Zhang, Xiaoyang published an article.Quality Control of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide The title of the article was Chromatin looping shapes KLF5-dependent transcriptional programs in human epithelial cancers. And the article contained the following:

Activation of transcription factors is a key driver event in cancer. We and others have recently reported that the Kruppel-like transcription factor KLF5 is activated in multiple epithelial cancer types including squamous cancer and gastrointestinal adenocarcinoma, yet the functional consequences and the underlying mechanisms of this activation remain largely unknown. Here we demonstrate that activation of KLF5 results in strongly selective KLF5 dependency for these cancer types. KLF5 bound lineage-specific regulatory elements and activated gene expression programs essential to cancer cells. HiChIP anal. revealed that multiple distal KLF5 binding events cluster and synergize to activate individual target genes. Immunoprecipitation-mass spectrometry assays showed that KLF5 interacts with other transcription factors such as TP63 and YAP1, as well as the CBP/EP300 acetyltransferase complex. Furthermore, KLF5 guided the CBP/EP300 complex to increase acetylation of H3K27, which in turn enhanced recruitment of the bromodomain protein BRD4 to chromatin. The 3D chromatin architecture aggregated KLF5-dependent BRD4 binding to activate Polymerase II (POL2) elongation at KLF5-target genes, which conferred a transcriptional vulnerability to proteolysis-targeting chimera (PROTAC)-induced degradation of BRD4. Our study demonstrates that KLF5 plays an essential role in multiple epithelial cancers by activating cancer-related genes through 3D chromatin loops, providing an evidence-based rationale for targeting the KLF5 pathway. The experimental process involved the reaction of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide(cas: 1949837-12-0).Quality Control of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

The Article related to epithelial cancer chromatin looping shape klf5 transcription, Mammalian Pathological Biochemistry: Oncology and other aspects.Quality Control of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On December 18, 2018, Chung, Chan-I.; Zhang, Qiang; Shu, Xiaokun published an article.Recommanded Product: 1949837-12-0 The title of the article was Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach. And the article contained the following:

Protein-protein interactions (PPIs) mediate signal transduction in cells. Small mols. that regulate PPIs are important tools for biol. and biomedicine. Dynamic imaging of small mol. induced PPIs characterizes and verifies these mols. in living cells. It is thus important to develop cellular assays for dynamic visualization of small mol. induced protein-protein association and dissociation in living cells. Here we have applied a fluorophore phase transition based principle and designed a PPI assay named SPPIER (separation of phases-based protein interaction reporter). SPPIER utilizes the green fluorescent protein (GFP) and is thus genetically encoded. Upon small mol. induced PPI, SPPIER rapidly forms highly fluorescent GFP droplets in living cells. SPPIER detects immunomodulatory drug (IMiD) induced PPI between cereblon and the transcription factor Ikaros. It also detects IMiD analog (e.g., CC-885) induced PPI between cereblon and GSPT1. Furthermore, SPPIER can visualize bifunctional mols. (e.g. PROTAC)-induced PPI between an E3 ubiquitin ligase and a target protein. Lastly, SPPIER can be modified to image small mol. induced protein-protein dissociation, such as nutlin-induced dissociation between HDM2 and p53. The intense brightness and rapid kinetics of SPPIER enable robust and dynamic visualization of PPIs in living cells. The experimental process involved the reaction of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide(cas: 1949837-12-0).Recommanded Product: 1949837-12-0

The Article related to fluorescent imaging protein interaction small mol induced, Biochemical Methods: Spectral and Related Methods and other aspects.Recommanded Product: 1949837-12-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 26, 2017, Schwink, Lothar; Buning, Christian; Glombik, Heiner; Gossel, Matthias; Kadereit, Dieter; Halland, Nis; Lohmann, Matthias; Poeverlein, Christoph; Ritter, Kurt published a patent.Product Details of 1159811-32-1 The title of the patent was Preparation of substituted fused heterocycles as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders. And the patent contained the following:

The title compounds I [A = N or C; B = CO, N or CH; E = N or C; G = N or CR30 (wherein at least one of the groups A, B, E or G = N); R30 = H or (CR11R12)nR32; R11, R12 = (independently) H or alkyl; n = 0-3; R32 = alkyl, COOR13, CONR14R15, etc.; R13 = H or alkyl; R14, R15 = (independently) H, alkyl, cycloalkyl, etc.; or R14 and R15 form together with the N-atom to which they are attached, (un)substituted 4-6 membered heterocycle, optionally containing an addnl. heteroatom selected from the list O, S and NR18 (R18 = H or alkyl); R1a, R1b, R1c = (independently) H, F, Cl, Br, alkyl or CN; R2a, R2b, R2c = (independently) H, F, Cl, Br, alkyl or CN; Y = N or CH; Z = a bond, O, C(O), etc.; R3 = a bond or (CR7R71)p (wherein p = 0-4; R7, R71 = (independently) H or alkyl); R4 = alkyl, (un)substituted cycloalkyl, Ph, etc.] that are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders, were prepared For example, reacting 6-bromo-2-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridine with (R)-3-{[6-(cyclopropylmethoxy)pyridin-3-yl]oxy}pyrrolidin-2-one in the presence of N,N’-dimethylethane-1,2-diamine and cesium carbonate in 1,4-dioxane afforded the isoindolinone II. Exemplified compounds I were tested for their biol. activity using the cell line expressing human GPR119 (data given). The invention furthermore relates to the use of the compounds I as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them. The experimental process involved the reaction of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate(cas: 1159811-32-1).Product Details of 1159811-32-1

The Article related to fused heterocycle preparation gpr119 modulator antidiabetic antiobesity dyslipidemia, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 1159811-32-1

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Chen, Xingkuan; Fang, Xinqiang; Chi, Yonggui Robin published an article in 2013, the title of the article was cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity.Product Details of 1469801-67-9 And the article contains the following content:

The first successful generation of cis-homoenolate equivalent from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products, e.g., I and II. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Product Details of 1469801-67-9

The Article related to enal imine cyclization heterocyclic carbene, cyclic ketone stereoselective preparation, heterocyclic carbene stereoselective cyclization catalyst, Heterocyclic Compounds (One Hetero Atom): Ethylene Oxides and other aspects.Product Details of 1469801-67-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On December 31, 2018, Lee, Dong-Hwan; Hasanuzzaman, M.; Kwon, Daeho; Choi, Hye-Young; Kim, So Myoung; Kim, Dong Jin; Kang, Dong Ju; Hwang, Tae-Ho; Kim, Hyung-Hoi; Shin, Ho Jung; Shin, Jae-Gook; Oh, Sangtae; Lee, Seokjoon; Kim, So Won published an article.Recommanded Product: 5301-96-2 The title of the article was 10-Phenyltriazoyl Artemisinin is a Novel P-glycoprotein Inhibitor that Suppresses the Overexpression and Function of P-glycoprotein. And the article contained the following:

The effect of drugs on ATP-binding cassette transporters, especially permeability-glycoprotein (P-gp), is an important consideration during new anti-cancer drug development. In this context, the effects of a newly synthesized artemisinin derivative, 10-(4-phenyl-1H-1,2,3- triazol)-artemisinin (5a), were evaluated on P-gp expression and function. Reverse transcript polymerase chain reaction and immunoblotting techniques were used to determine the effect of 5a on P-gp expression in LS174T cells. In addition, the ability of 5a to work as either a substrate or an inhibitor of P-gp was investigated through different methods. The results revealed that 5a acts as a novel P-gp inhibitor that dually suppresses the overexpression and function of P-glycoprotein. Co-treatment of LS174T cell line, human colon adenocarcinoma cell line, with 5a and paclitaxel recovered the anticancer effect of paclitaxel by controlling the acquired drug resistance pathway. The overexpression of P-gp induced by rifampin and paclitaxel in a colorectal cell line was suppressed by 5a which could be a novel inhibitory substrate inhibiting the transport of paclitaxel by P-gp. The results revealed that 5a can be classified as a type B P-gp inhibitor (with both substrate and inhibitor activities) with an addnl. function of suppressing P-gp overexpression. The results might be clin. useful in the development of anticancer drugs against cancers with multidrug resistance. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 5301-96-2

The Article related to glycoprotein inhibitor anticancer agent colon adenocarcinoma, artemisinin, immunoblotting techniques, p-glycoprotein, paclitaxel, rifampin, triazolyl artemisinin., Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tome, A. C. published an article in 2004, the title of the article was Product class 13: 1,2,3-triazoles.Computed Properties of 5301-96-2 And the article contains the following content:

A review. Methods to prepare 1,2,3-triazoles are reviewed including cyclization, aromatization, ring transformation and substituent modification. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to review triazole preparation cyclization aromatization ring transformation, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.Related Products of 5301-96-2 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Related Products of 5301-96-2

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Related Products of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.COA of Formula: C9H9N3 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 3, 2019, Yang, Yong-Zheng; Song, Ren-Jie; Li, Jin-Heng published an article.HPLC of Formula: 5301-96-2 The title of the article was Intermolecular Anodic Oxidative Cross-Dehydrogenative C(sp3)-N Bond-Coupling Reactions of Xanthenes with Azoles. And the article contained the following:

A new anode strategy for accessing xanthen-9-azoles via an electrochem. C(sp3)-H/N-H cross-coupling of xanthenes with azoles is described. This reaction proceeds efficiently with a broad scope of both xanthenes and N-H-free azoles under metal- and addnl. oxidant-free conditions and represents a new access to direct incorporation of important N-heterocycle units into the resulting xanthenes. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to xanthenazole preparation electrochem cross coupling xanthene azole, intermol anodic oxidative cross dehydrogenative coupling, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 7, 1998, Bolkan, Steven A.; Dunn, Steve published a patent.Synthetic Route of 5301-96-2 The title of the patent was Aqueous metal cleaner having an anticorrosion system. And the patent contained the following:

The title composition is composed of an alk. metal salt, a surfactant, and a corrosion inhibitor with a pH ∼7.5 to <10, preferably silicate free, of a combination of a triazole compound and an alkali metal borate. The use of 1,2,3-benzotriazole (Cobratec) and borax prevent discoloration of steel in addition to providing an anticorrosive effect at mild pH levels. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to aqueous cleaning composition corrosion inhibitor, borate alkali triazole corrosion inhibitor, mild alk aqueous cleaner copper, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics