Day: December 6, 2022

Xu, Jun published the artcileSynthesis and antifungal activity of N-[3-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-2-hydroxypropyl]aminoacetic acid and its derivatives, Related Products of triazoles, the publication is Zhongguo Yaowu Huaxue Zazhi (1998), 8(3), 182-187, database is CAplus.

N-[3-(1H-1,2,4-Triazole-1-yl)-2-(2,4-difluorophenyl)-2-hydroxypropyl]aminoacetic acid and its 9 derivatives were designed and synthesized and evaluated for antifungal activities in vitro. The results of preliminary antifungal tests showed that some compounds exhibited potent activities against dermophytes, but lower activities against systematic pathogenic fungi except Cladosporium carrioni. The activities of compounds (5e) and (5h) were markedly superior to fluconazole, but less potent than those of ketoconazole in vitro.

Zhongguo Yaowu Huaxue Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C7H5Cl2NO, Related Products of triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Lu, Meiheng published the artcileThermochemistry and Initial Decomposition Pathways of Triazole Energetic Materials, Quality Control of 84406-63-3, the publication is Journal of Physical Chemistry A (2020), 124(15), 2951-2960, database is CAplus and MEDLINE.

A thorough investigation of the initial decomposition pathways of triazoles and their nitro-substituted derivatives has been conducted using the MP2 method for optimization and DLPNO-CCSD(T) method for energy. Different initial thermolysis mechanisms are proposed for 1,2,4-triazole and 1,2,3-triazole, the two kinds of triazoles. The higher energy barrier of the primary decomposition path of 1,2,4-triazole (H-transfer path, ~52 kcal/mol) compared with that of 1,2,3-triazole (ring-open path, ~45 kcal/mol) shows that 1,2,4-triazole is more stable, consistent with exptl. observations. For nitro-substituted triazoles, more dissociation channels associated with the nitro group have been obtained and found to be competitive with the primary decomposition paths of the triazole skeleton in some cases. Besides, the effect of the nitro group on the decomposition pattern of the triazole skeleton has been explored, and it has been found that the electron-withdrawing nitro group has an opposite effect on the primary dissociation channels of 1,2,4-triazole derivatives and 1,2,3-triazole derivatives

Journal of Physical Chemistry A published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Quality Control of 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Lu, Meiheng published the artcileThermochemistry and Initial Decomposition Pathways of Triazole Energetic Materials, Recommanded Product: 5-Nitro-1H-1,2,3-triazole, the publication is Journal of Physical Chemistry A (2020), 124(15), 2951-2960, database is CAplus and MEDLINE.

A thorough investigation of the initial decomposition pathways of triazoles and their nitro-substituted derivatives has been conducted using the MP2 method for optimization and DLPNO-CCSD(T) method for energy. Different initial thermolysis mechanisms are proposed for 1,2,4-triazole and 1,2,3-triazole, the two kinds of triazoles. The higher energy barrier of the primary decomposition path of 1,2,4-triazole (H-transfer path, ~52 kcal/mol) compared with that of 1,2,3-triazole (ring-open path, ~45 kcal/mol) shows that 1,2,4-triazole is more stable, consistent with exptl. observations. For nitro-substituted triazoles, more dissociation channels associated with the nitro group have been obtained and found to be competitive with the primary decomposition paths of the triazole skeleton in some cases. Besides, the effect of the nitro group on the decomposition pattern of the triazole skeleton has been explored, and it has been found that the electron-withdrawing nitro group has an opposite effect on the primary dissociation channels of 1,2,4-triazole derivatives and 1,2,3-triazole derivatives

Journal of Physical Chemistry A published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Recommanded Product: 5-Nitro-1H-1,2,3-triazole.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Xu, Zhimin published the artcileTriphenylphosphine-assisted dehydroxylative Csp³-N bond formation via electrochemical oxidation, Related Products of triazoles, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(100), 15089-15092, database is CAplus and MEDLINE.

A dehydroxylative Csp³-N coupling reaction assisted by triphenylphosphine has been developed through electrochem. oxidation The reaction proceeds via anodic oxidation of triphenylphosphine to generate its corresponding radical cation, followed by reacting with hydroxyl groups to form alkoxy triphenylphosphonium ions, which are trapped by azoles or amides to construct C-N bonds. This method provides an efficient electrochem. strategy of activating hydroxyl groups to form C-N bonds under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C10H14O2, Related Products of triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Shao, Xiaoqing published the artcileDecarboxylative C_sp³-N Bond Formation by Electrochemical Oxidation of Amino Acids, Formula: C2H2N4O2, the publication is Organic Letters (2019), 21(22), 9262-9267, database is CAplus and MEDLINE.

Decarboxylative C_sp3-N coupling reactions have been developed through electrochem. oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are trapped by azoles or amides to construct C-N bonds. This method avoids the preactivation of carboxylic acids and the use of expensive transition-metals and external chem. oxidants.

Organic Letters published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C13H19Br2ClN2O, Formula: C2H2N4O2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Wei, Ning published the artcileSynthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-butyl-N-substituted benzylamino)-2-propanol, COA of Formula: C12H13F2N3O4S, the publication is Dier Junyi Daxue Xuebao (2009), 30(9), 1052-1057, database is CAplus.

To study the antifungal activity of triazole alcs. by introducing N-Bu and substituted benzyl as side chain, fourteen title compounds were synthesized and characterized by ¹H NMR, IR, and LC-MS. The MICs of the compounds were determined by in vitro test using 8 clin. pathogenic fungi. The title compounds exhibited potent antifungal activities against nearly all fungi tested (except for Aspergillus fumigatus), especially for the deep infection ones. Three compounds showed a 16-fold activity (with a MIC₈₀ value of 0.015 6 μg/mL) as that of fluconazole against Microsporum gypseum. Two compounds showed a 128-fold activity (with a MIC₈₀ value of 0.003 9 μg/mL) as that of fluconazole against Candida albicans, and their activities were higher than those of other pos. controls.

Dier Junyi Daxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C4H4N2O2, COA of Formula: C12H13F2N3O4S.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Lu, Xiao-juan published the artcileSynthesis of 1-(H-1,2,4-triazole-1-yl)-2-(2,4-difluoro-phenyl)-3-(N-cyclopropyl-N-substituted amino)-2-propanols and its antifungal activity, Synthetic Route of 86386-77-8, the publication is Dier Junyi Daxue Xuebao (2008), 29(11), 1380-1383, database is CAplus.

A method for the synthesis of the title compounds is reported here. The above-mentioned products were characterized by NMR, MS, and element anal. The MICs of the compounds were determined by in vitro tests involving eight fungal strains, such as Trichophyton rubrum, Aspergillus fumigatus, Candida tropicalis, Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Microsporum canis. These compounds exhibited potent antifungal activity against the test systems. Some compounds had MIC₈₀ values less than 0.125 μg/mL^-1 against Candida albicans, showing an activity 4 times higher than that of fluconazole. Thus, the title compounds with cyclopropyl and alky substituents have antifungal activity and the antifungal activity decreases as the alkyl side chains gets longer.

Dier Junyi Daxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Synthetic Route of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Ning, Xiaowen published the artcileGreen and yellow pyridazine-based phosphorescent Iridium(III) complexes for high-efficiency and low-cost organic light-emitting diodes, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Dyes and Pigments (2019), 206-212, database is CAplus.

Despite efficient electroluminescence performance, the high fabrication cost due to the utilization of noble metals impedes the commercialization of phosphorescent organic light-emitting diodes (PHOLEDs) based on iridium(III) complexes. In this paper, we designed and synthesized a series of green and yellow phosphorescent iridium(III) complexes with 3-(2,4-difluorophenyl)-6-methylpyridazine as the cyclometalating ligand to fabricate high-performance and low-cost PHOLEDs. By the introduction of a pyridazine moiety to enhance the coordination bond between iridium(III) ion and cyclometalating ligands, these iridium(III) complexes were obtained in high yields and exhibit good thermal stabilities and volatilities, which are beneficial to reduce the device manufacturing cost. Besides, high photoluminescence quantum yields (PLQYs) and short phosphorescent lifetimes of these pyridazine-based iridium(III) complexes endow their PHOLEDs with excellent device performance, which can be promising for practical applications. Particularly, the green emitter (fpdz)₂Irpic exhibited a high PLQY of 0.89 in solid doped thin-film; PHOLED based on (fpdz)₂Irpic achieved an outstanding maximum external quantum efficiency (EQE_max) of 28.7% with ultralow efficiency roll-off of 2% at the high luminance of 1000 cd m^-2, which was superior to the com. green phosphor bis(phenylpyridineyl)iridium(acetylacetonate) [(ppy)₂Ir(acac), EQE_max = 24.2%].

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Ke, Xuefeng published the artcileSynthesis and antifungal activities of novel triazole derivatives with dithiocarbamates side chain, Safety of 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is Yaoxue Fuwu Yu Yanjiu (2016), 16(1), 11-14, 55, database is CAplus.

The title compounds were synthesized and their chem. structures were identified by ¹H-NMR and ¹³C-NMR. The in vitro antifungal activities of the synthesized compounds were evaluated. Ten prepared compounds had certain antifungal activity, and the in vitro antifungal activity of some compounds was superior to that of the control drugs.

Yaoxue Fuwu Yu Yanjiu published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Safety of 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Tao, Peng published the artcileHighly efficient blue phosphorescent iridium(III) complexes with various ancillary ligands for partially solution-processed organic light-emitting diodes, Formula: C8H5F3N4, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2017), 5(36), 9306-9314, database is CAplus.

One homoleptic facial and five novel highly efficient blue heteroleptic iridium(III) complexes were designed and synthesized by selecting 2-(4-fluoro-3-(trifluoromethyl)phenyl)pyridine as cyclometalated ligands and 2,4-pentanedione, 2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine, picolinic acid, 2-(1H-imidazol-2-yl)pyridine and 2-(1H-tetrazol-5-yl)pyridine as ancillary ligands, resp. The alternation of ancillary ligands could finely tune the photophys. properties of the phenylpyridine-based complexes, particularly with respect to emission wavelength, photoluminescence quantum yield (Φ_PL), full width at half maximum (FWHM), etc. The phosphors designed not only exhibit excellent solubility in commonly used solvents with robust chem. stability but also show bright emissions in the pure blue region with very high absolute Φ_PL up to 0.98 in solution and relatively narrow FWHMs up to 52 nm. Furthermore, based on these highly efficient blue phosphors, high-performance partially solution-processed blue organic light-emitting diodes have been successfully fabricated. The electroluminescence peak, 1931 Commission Internationale de L’Eclairage coordinate and FWHM of the device based on Ir4 are all superior to the device based on FIrpic. In addition, the maximum efficiencies of the device based on Ir4 (21.15 cd A^-1, 12.07 lm W^-1) are also higher than those of the device based on FIrpic (18.89 cd A^-1, 11.26 lm W^-1) under the same conditions.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C13H19Br2ClN2O, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics