Day: December 6, 2022

Liu, Yi published the artcileRapid visual identification of nitroaromatics compounds by aggregation-induced enhanced emission fluorescent assays with a Cd(II)-H₃BTT complex, Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarbonitrile, the publication is Sensors and Actuators, B: Chemical (2019), 126623, database is CAplus.

A new type of aggregation induced enhance emission (AIEE) active Cd(II) complex based on novel nitrogen-rich polycyclic ligand 4,5-bis(tetrazol-5-yl)-2H-1,2,3-triazole (H₃BTT) and its metal organic gel (MOG) had been synthesized for the first time. The colloid of Cd(II)-H₃BTT complex showed obvious AIEE characteristics in binary solvent system of DMF and ethanol, and displayed high sensitivity and selectivity for PA sensing over other nitroaroms. like DNB, TNB and TNT, where the limit of detection had been found as low as 9.3 × 10^-7 M. Further, visual colorimetric recognition in colloidal state sensor and coated filter paper were all accomplished by spiking PA in tap water and river water. Interestingly, after being ripened, this colloid could be converted into stable MOG with the AIEE performance inherited, which also shown good fluorescence recognition ability and excellent reusability for the visual colorimetric PA detection. And this regenerated colloid from the MOG storage for a period of time kept the same detection ability for PA as fresh colloid. Finally, the recognition mechanism of PA was confirmed as the counterion-displacement assays by FTIR and UV experiments This novel Cd(II)-H₃BTT complex provided a new insight into the design and synthesis of AIEE naked eyes recognized sensor for nitroaroms. with a simple and cheap preparation process, high sensitivity and stable storage.

Sensors and Actuators, B: Chemical published new progress about 53817-16-6. 53817-16-6 belongs to triazoles, auxiliary class Triazoles, name is 1H-1,2,3-Triazole-4,5-dicarbonitrile, and the molecular formula is C4HN5, Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarbonitrile.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Wang, Shudong published the artcileSynthesis and evaluation of some substituted heterocyclic fluconazole analogues as antifungal agents, COA of Formula: C12H13F2N3O4S, the publication is Asian Journal of Chemistry (2014), 26(8), 2362-2364, database is CAplus.

A new series of fluconazole analogs I [R = 2-CH₃, 3,5-(NO₂)₂, 4-tert-Bu, etc.] were designed, synthesized and evaluated as antifungal agents. Most of the synthesized compounds showed moderate activity against eight human pathogenic fungi in vitro. Compounds I (R = 2-CH₃, 4-n-Pr) showed the best antifungal activity against Candida albicans with the value of MIC₈₀ = 0.5 μg/mL for both.

Asian Journal of Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C4H6O3, COA of Formula: C12H13F2N3O4S.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Ma, Chunlin published the artcileSyntheses, characterizations and crystal structures of new triorgano-tin or -germanium complexes with 1H-5-mercapto-1,2,3-triazolato, Category: triazoles, the publication is Polyhedron (2004), 23(11), 1981-1986, database is CAplus.

Triorganotin and triorganogermanium(IV) complexes with 1H-5-mercapto-1,2,3-triazolato, R₃MSC₂H₂N₃ [M = Sn, R = CH₃, (1); C₂H₅, (2); Bu, (3); C₆H₅, (4); M = Ge, R = CH₃, (5); C₂H₅, (6); Bu, (7); C₆H₅, (8)], were synthesized. All the complexes 1–8 were characterized by elemental, IR and ¹H NMR analyses. Among them complexes 4 and 8 also were characterized by x-ray crystallog. diffraction analyses, which revealed that the Sn and Ge atom environments are distorted tetrahedral coordination polyhedrons, coordinated to three Ph groups and to one S atom of the ligand. The packing of complexes 4 and 8 is stabilized into a 1-dimensional infinite chain by intermol. N-H···N H bonds.

Polyhedron published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Category: triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Jiang, Yongwei published the artcileSynthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents, COA of Formula: C12H13F2N3O4S, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4471-4475, database is CAplus and MEDLINE.

On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one derivatives I (R = 4-F, 2-F, 4-Cl, 3-Cl, 2,4-Cl₂, 3-Br, 2-Br, 4-MeO, 3-MeO, 4-OCF₃, 4-Me, 3-Me, 2-Me, 3,4-Me₂, 2,4-Me₂, 4-nPr, 4-Bu, 4-pentyl, 4-hexyl, 4-tBu, 4-iPr) and II (R = 4-F, 3-F, 2-F, 4-Cl, 3,4-Cl₂, 4-Br, 3-Br, 4-Me, 2,3-Me₂, 4-MeO, 3,4-(MeO)₂,2,4-(MeO)₂, 4-NO₂, 3-NO₂, 2-NO₂, 3-CN) were synthesized as fluconazole analogs. Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent antifungal activities against C. albicans than reference drug fluconazole. Flexible mol. docking was used to analyze the structure-activity relationships (SARs) of the target compounds The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.

Bioorganic & Medicinal Chemistry Letters published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, COA of Formula: C12H13F2N3O4S.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Dan, Zhi Gang published the artcileDesign and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14α-demethylase (CYP51), Quality Control of 86386-77-8, the publication is Chinese Chemical Letters (2009), 20(8), 935-938, database is CAplus.

A series of triazoles I (R = NCCH₂, MeOC₆H₄, PhC(O)OC₆H₄CH₂, etc.) have been designed and synthesized as potential inhibitors of lanosterol 14α-demethylase (CYP51) and antifungal agents. Their structures were confirmed by MS and ¹H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. All title compounds exhibited some antifungal activity.

Chinese Chemical Letters published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Chai, Xiaoyun published the artcileDesign, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, HPLC of Formula: 86386-77-8, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(6), 1811-1814, database is CAplus and MEDLINE.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols, e.g., I, as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

Bioorganic & Medicinal Chemistry Letters published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, HPLC of Formula: 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Chai, Xiaoyun published the artcileNew azoles with antifungal activity: Design, synthesis, and molecular docking, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(2), 686-689, database is CAplus and MEDLINE.

In order to search for many target compounds with excellent activities, a series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluoro-phenyl)-3-[(4-substituted phenyl)-piperazin-1-yl]-propan-2-ols were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum. Moreover, a mol. model for the binding between I and the active site of CACYP51 was provided based on the computational docking results.

Bioorganic & Medicinal Chemistry Letters published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Chai, Xiaoyun published the artcileDesign, synthesis and molecular docking studies of novel triazole as antifungal agent, Application In Synthesis of 86386-77-8, the publication is European Journal of Medicinal Chemistry (2011), 46(7), 3167-3176, database is CAplus and MEDLINE.

In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted trifluoromethyl phenyl)-piperazin-1-yl]-propan-2-ols I [R = alkyl, aryl, arylalkenyl, heteroaryl(alkenyl)] were designed, synthesized and evaluated as antifungal agents. The MIC₈₀ values indicate that the compounds I [R = arylalkenyl, heteroaryl(alkenyl)] showed higher antifungal activities against Candida albicans than I [R = alkyl, aryl]. Moreover, the mol. model for the binding between compound I [R = Me, CH:CHPh] and the active site of CACYP51 was provided based on the computational docking results, and the structure-activity relationship was analyzed.

European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Application In Synthesis of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Chai, Xiaoyun published the artcileDesign, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase, Name: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is European Journal of Medicinal Chemistry (2009), 44(5), 1913-1920, database is CAplus and MEDLINE.

Based on the results of computational docking to the active site of the cytochrome P 450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols I (R = H, 2-F, 2,4-Cl₂, 4-MeO₂C, PhO₂C, etc.) as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. The MIC₈₀ values indicate that compounds I (R = H, 2-F, 4-Me, etc.) exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole, while I (R = COOR¹, R¹ = Me, Et, iso-Pr, COOAr, etc.; Ar = Ph, 3-O₂NC₆H₄, 4-ClC₆H₄, 2-MeO₂CC₆H₄, etc.) showed no activity or only moderate activity against all fungi tested. Noticeably, the MIC value of I (R = H, 2-F, 4-Cl) is 64 times lower than that of fluconazole against Microsporum gypseum in vitro. And I (R = H, 2-F, CO₂Et) showed 128 times higher activity (with the MIC₈₀ value of 0.0039 μg/mL) than that of fluconazole against Candida albicans and also showed higher activity than that of the other pos. controls. Computational docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. In addition, the activity of the compounds would be enhanced when the side chains were shorter.

European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Name: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Wu, Jin-Ting published the artcileNitrogen-Rich Amino-triazolium Salts Based on Binary 4,5-Dicyano-1,2,3-triazolate (C₄N₅^–) Anion, Synthetic Route of 53817-16-6, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2016), 642(5), 409-413, database is CAplus.

A series of amino-triazolium salts based on 4,5-dicyano-1,2,3-triazolate (C₄N₅^–) anion were synthesized for first time by means of facile deprotonation reactions. The ionic compounds were characterized by single-crystal X-ray diffraction, vibrational spectroscopy, and elemental anal. The thermal stability of the salts was assessed by differential scanning calorimetry, which showed good thermal stabilities up to above 180 °C. The heats of formation of these salts were computed using the methods of isodesmic reactions. In addition, the sensitivities of the studied salts toward impact and friction were determined, and all salts were found to be neither impact (> 40 J) nor friction sensitive (> 360 N).

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 53817-16-6. 53817-16-6 belongs to triazoles, auxiliary class Triazoles, name is 1H-1,2,3-Triazole-4,5-dicarbonitrile, and the molecular formula is C17H14F3N3O2S, Synthetic Route of 53817-16-6.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics