Day: January 4, 2023

Two cobalt complexes derived from 1H-1,2,3-triazole-4,5-dicarboxylic acid: Syntheses, structures and magnetic properties was written by Li, Ling;Zou, Ji-Yong;Gu, Zhen;You, Sheng-Yong;Chen, Yan-Hua;Xia, Jun;Cui, Jian-Zhong. And the article was included in Inorganic Chemistry Communications in 2016.Formula: C4H3N3O4 This article mentions the following:

Two cobalt(II) homometallic complexes, [Co₂(HTDA)₂(H₂O)₆·2H₂O] (1) and {[Co₃(TDA)₂(H₂O)₈]·H₂O}_n (2) (H₃TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid) were synthesized and structurally characterized. Single-crystal x-ray crystallog. study reveals that they crystallize in trigonal space group orthorhombic Pna2₁, resp. In 1, two Co^2 + cations are bonded by two HTDA^2 – ligands to generate a binuclear Co^II unit, which can further be extended to a 3-dimensional supermol. structure via the hydrogen bonds. At variance with 1, the nearest Co^2 + cations of 2 are connected via TDA^3 – ligands to form a 1-dimensional coordination polymer and can be further linked to each other to result in a 3-dimensional supermol. framework through the hydrogen bonding interactions as well. The magnetic properties of them were studied. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Formula: C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Formula: C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zinc (II) Chloride as Phase Transfer Catalyst and as Catalyst of Cycloaddition Azide Ion to Heterocumulenes and Terminal Alkynes in Organic Solvents was written by Vorona, Svetlana V.;Zevatskii, Yuri E.;Myznikov, Leonid V.. And the article was included in ChemistrySelect in 2019.Related Products of 40594-98-7 This article mentions the following:

The system of NaN₃-ZnCl₂ in organic solvents was effective for azide ion cycloaddition to heterocumulenes and terminal alkynes. The reaction proceeded readily in the case of heterocumulenes, so these transformations fall into the category of click reactions. The study on the reaction mechanism showed that role of zinc salt consists in transferring azide ion to the organic phase and decreasing the energy barrier of nucleophilic addition of azide ion to the unsaturated substrate. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Related Products of 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRelated Products of 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Resistance to dicyclanil and imidacloprid in the sheep blowfly, Lucilia cuprina, in Australia was written by Kotze, Andrew C.;Bagnall, Neil H.;Ruffell, Angela P.;George, Sarah D.;Rolls, Nicholas M.. And the article was included in Pest Management Science in 2022.Recommanded Product: 1614-12-6 This article mentions the following:

The sheep blowfly, Lucila cuprina, is a myiasis-causing parasite responsible for significant production losses and welfare issues for the Australian sheep industry. Control relies largely on the use of insecticides. The pyrimidine compound, dicyclanil, is the predominant control chem., although other insecticides also are used, including imidacloprid, ivermectin, cyromazine and spinosad. We investigated in vitro resistance patterns and mechanisms in field-collected blowfly strains. The Walgett 2019 strain showed significant levels of resistance to both dicyclanil and imidacloprid, with resistance factors at the IC50 of 26- and 17-fold, resp., in in vitro bioassays. Co-treatment with the cytochrome P 450 inhibitor, aminobenzotriazole, resulted in significant levels of synergism for dicyclanil and imidacloprid (synergism ratios of 7.2- and 6.1-fold, resp.), implicating cytochrome P 450 in resistance to both insecticides. Cyp12d1 transcription levels were increased up to 40-fold throughout the larval life stages in the resistant strain compared to a reference susceptible strain, whereas transcription levels of some other cyp genes (6g1, 4d1, 28d1) did not differ between the strains. Similar resistance levels also were observed in flies collected from the same property in two subsequent years. This study indicates that in vitro resistance to both dicyclanil and imidacloprid in this field-collected blowfly strain is likely mediated by cytochrome P 450, with Cyp12d1 implicated as the enzyme responsible; however, it remains possible that another P 450 also may be involved. A common resistance mechanism for the two drugs has important implications for drug rotation strategies designed to prolong the useful life of flystrike control chems. 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Recommanded Product: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Effective route for synthesis of novel aromatic pyridine derivates with polyamino polycarboxyl units was written by Gu, GuoLiang;Zhou, TaiYan. And the article was included in Journal of the Chemical Society of Pakistan in 2017.Computed Properties of C5H7N3O2 This article mentions the following:

A series of novel aromatic mols. with polyamino polycarboxyl were designed, synthesized and characterized in detail based on elemental anal., IR, mass, proton NMR spectroscopy. The synthetic route was optimized. The yield of second synthesis step over 91 % as a result of the catalyst (LiBr) used. Due to the fascinating structure with multiple N and O donor atoms, it may be potential applications in organic light emitting diodes (OLED). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Computed Properties of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Computed Properties of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction of 3-nitro- and 3-bromo-3-nitroacrylates with sodium azide was written by Anisimova, N. A.;Berestovitskaya, V. M.;Berkova, G. A.;Makarova, N. G.. And the article was included in Russian Journal of Organic Chemistry in 2007.Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate This article mentions the following:

Reactions of 3-nitro- and 3-bromo-3-nitroacrylates with NaN₃ proceed as 1,3-dipolar cycloaddition and lead to the formation of triazole- and nitrotriazolecarboxylates, and also of azido- and azidonitropropenoates. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats was written by Parrish, Karen E.;Mao, Jialin;Chen, Jacob;Jaochico, Allan;Ly, Justin;Ho, Quynh;Mukadam, Sophie;Wright, Matthew. And the article was included in Biopharmaceutics & Drug Disposition in 2016.Related Products of 1614-12-6 This article mentions the following:

1-Aminobenzotriazole (ABT) is a non-isoform specific, time-dependent inhibitor of cytochrome P 450 (CYP) enzymes used extensively in preclin. studies to determine the relative contribution of oxidative metabolism Although ABT has been widely used, the extent and duration of its inhibitory effect is not well understood. The purpose of this study is to characterize ABT inhibition of CYP in rats at both the hepatic and intestinal levels. In vivo studies using midazolam (p.o. and i.v.), as a probe for CYP activity, demonstrated that CYP inhibition was not complete even at the highest dose (300 mg/kg). Addnl. in vivo studies demonstrated that even at 26 h following ABT administration, there was significant CYP inhibition remaining. In vitro studies, conducted in both rat liver microsomes and rat hepatocytes, confirm that ABT is a time-dependent inhibitor of rat CYP orthologs. However, in rat liver microsomes, there was more than 15% CYP activity remaining following a 60 min preincubation at 2 mM ABT and 5-10% of CYP activity was remaining in rat hepatocytes suspended in rat plasma following a 60 min preincubation at 2 mM ABT. 1-Aminobenzotriazole is a useful tool in elucidating the oxidative component of metabolism in preclin. species; however, conclusions made from the preclin. use of ABT should not operate under the assumption that CYP enzymic activity is completely inhibited. Copyright © 2016 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Related Products of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Related Products of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Assembly of a Complex Branched Oligosaccharide by Combining Fluorous-Supported Synthesis and Stereoselective Glycosylation using Anomeric Sulfonium Ions was written by Huang, Wei;Gao, Qi;Boons, Geert-Jan. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

There is an urgent need to develop reliable strategies for the rapid assembly of complex oligosaccharides. This paper presents a set of strategically selected orthogonal protecting groups, glycosyl donors modified by a (S)-phenylthiomethylbenzyl ether at C-2, and a glycosyl acceptor containing a fluorous tag, which makes it possible to rapidly prepare complex branched oligosaccharides of biol. importance. The C-2 auxiliary controlled the 1,2-cis anomeric selectivity of the various galactosylation. The orthogonal protecting groups, 2-naphthylmethyl ether (Nap) and levulinic ester (Lev), made it possible to generate glycosyl acceptors and allowed the installation of a crowded branching point. After the glycosylation, the chiral auxiliary could be removed using acidic conditions, which was compatible with the presence of the orthogonal protecting groups Lev and Nap, thereby allowing the efficient installation of 1,2-linked glycosides. The light fluorous tag made it possible to purify the compounds by a simple filtration method using silica gel modified by fluorocarbons. The set of building blocks was successfully employed for the preparation of the carbohydrate moiety of the GPI anchor of Trypanosoma brucei, which is a parasite that causes sleeping sickness in humans and similar diseases in domestic animals. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Salicylic acid biosynthesis inhibitors increase chilling injury to maize (Zea mays L.) seedlings was written by Wang, Yang;Wen, Tingting;Huang, Yutao;Guan, Yajing;Hu, Jin. And the article was included in Plant Growth Regulation in 2018.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Salicylic acid (SA) is involved in plant response to many abiotic stresses. This study investigated the potential role of SA in regulating chilling tolerance of maize (Zea mays L.) seedlings. The results showed that chilling stress induced transient accumulation of free SA in maize plants, and stimulated the enzymic activities of phenylalanine ammonia-lyase (PAL) and benzoic acid-2-hydroxylase. However, seedlings pretreated with SA biosynthesis inhibitors (i.e., 2-aminoindane-2-phosphonic acid or 1-aminobenzotriazole) accumulated significantly less free and bound SA and suffered more severe cold injury. Together, these results indicated that the chilling-induced SA accumulation in maize seedlings was mainly attributed to the PAL pathway. SA application also induced chilling tolerance of maize seedlings; whereas, inhibition of SA biosynthesis significantly increased membrane peroxidation, decreased antioxidant enzymes activities, and resulted in growth retardation. Exogenous SA treatments reversed the effects of the SA inhibitors on chilling tolerance, indicating the important endogenous role of SA in inducing chilling tolerance of maize plants. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI was written by Kohn, Elise C.;Felder, Christian C.;Jacobs, William;Holmes, Katherine A.;Day, Alan;Freer, Richard;Liotta, Lance A.. And the article was included in Cancer Research in 1994.Application of 4546-95-6 This article mentions the following:

Evidence is accumulating that calcium homeostasis and calcium-regulated events may be selectively important in generation and maintenance of the malignant phenotype. CAI, a carboxyamido-triazole with a halogenated benzophenone tail, is a novel inhibitor of receptor-operated calcium influx and arachidonic acid release which inhibits malignant proliferation, invasion, and metastasis. The focus of this investigation was structural anal. of CAI and to determine if the inhibition of calcium influx and arachidonic acid release by CAI and its antiproliferative activity were mediated through the same chem. domains. Four families of mol. modifications of the CAI parent were synthesized: (I) modification or substitution of the triazole ring; (II) removal of the substituted benzophenone tail; (III) dehalogenation or partial truncation of the benzophenone moiety; and (IV) removal of the triazole and altered substitutions of the benzophenone tail. Compounds were tested for the inhibition of calcium influx and arachidonic acid release and inhibition of proliferation and colony formation in soft agar using the malignant CHO line transfected with the m5 muscarinic receptor and the A2058 human melanoma cell line. Only CAI and Group I compounds inhibited stimulated calcium influx, arachidonic acid release, and proliferation. Linear regression anal. of the relationship of the 50% inhibitory concentration values for all compounds in inhibition of calcium influx and arachidonate release was statistically significant (r² = 0.993). Similarly, a linear relationship was demonstrated between inhibition of calcium influx and inhibition of tumor cell proliferation (r² = 0.971). Groups II-IV had minimal or no signal or growth inhibitory activity. This investigation provides the first evidence for a coordinate link between calcium influx, calcium-mediated arachidonic acid release, and malignant proliferation and metastasis and constitutes the initial anal. of structurally important domains of the CAI mol. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeApplication of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Highly functionalized 3,4,5-trisubstituted 1,2,4-triazoles for future use as ligands in coordination polymers was written by Laessig, Daniel;Lincke, Joerg;Krautscheid, Harald. And the article was included in Tetrahedron Letters in 2010.Formula: C9H7N3O2 This article mentions the following:

An optimized synthesis of 3,4,5-trisubstituted 1,2,4-triazoles, which can be used as linkers for metal organic frameworks (MOFs), is described. The substituents in 3- and 5-position of the triazole have a significant impact on the torsion angles between the aromatic rings and therefore influence on solubility and coordination behavior of these ligands. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Formula: C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeFormula: C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics