Day: January 4, 2023

Tricyclic nitrogen-rich explosives with a planar backbone: bis(1,2,4-triazolyl)-1,2,3-triazoles as potential stable green gas generants was written by Gu, Hao;Cheng, Guangbin;Yang, Hongwei. And the article was included in New Journal of Chemistry in 2021.Synthetic Route of C4H3N3O4 This article mentions the following:

Two tricyclic nitrogen-rich compounds, 4,5-bis(5-nitro-1H-1,2,4-triazol-3-yl)-2H-1,2,3-triazole (4) and 4,5-bis(5-nitramino-1,2,4-triazole-3-yl)-2H-1,2,3-triazole (5), were obtained based on the combination of two different triazole heterocycles. The metal-free energetic salts (6-16) were synthesized with pos. heat of formation and good thermal stability. Among these salts, dicarbohydrazide salt 9 and triaminoguanidine salt 16 exhibit the relevant high detonation velocities (9: D = 8720 m s^-1 and 16: D = 8748 m s^-1) which are comparable to that of RDX (8795 m s^-1). Besides, the impact and friction sensitivities of compounds 4-16 (IS: 28-40 J, FS: 324-360 N) indicate that they have low sensitivities to mech. stimulations. The planar structure of crystal 4·3H₂O was confirmed by single crystal X-ray anal. In order to evaluate their gas production capacities, constant-volume combustion experiments were conducted on 9 and 16 with high gas production volume (≥ 840 dm³ kg^-1). The maximum gas-production pressures of 9 (P_max = 16.20 MPa) and 16 (P_max = 11.21 MPa) are much higher than that of commonly used gas generant guanidine nitrate (GN: P_max = 4.20 MPa). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A Method for Assessing Greener Alternatives between Chemical Products Following the 12 Principles of Green Chemistry was written by DeVierno Kreuder, Ashley;House-Knight, Tamara;Whitford, Jeffrey;Ponnusamy, Ettigounder;Miller, Patrick;Jesse, Nick;Rodenborn, Ryan;Sayag, Shlomo;Gebel, Malka;Aped, Inbal;Sharfstein, Israel;Manaster, Efrat;Ergaz, Itzhak;Harris, Angela;Nelowet Grice, Lisa. And the article was included in ACS Sustainable Chemistry & Engineering in 2017.Product Details of 1614-12-6 This article mentions the following:

Companies are interested in improving chems. to reduce environmental impacts, aka green chem. The 12 principles of green chem. outline a framework for identifying a greener chem. or process, spanning aspects in health hazard, ecol. risk, and resource efficiency across a product lifecycle. However, that framework does not detail how to measure performance. Collecting the data required, beyond simple health hazard ratings is resource intensive. This paper describes an approach for establishing green chem. metrics (GCM), to evaluate chems. and chem. processes against the 12 principles, using readily available data, such as the data compiled in compliance with the Globally Harmonized System of Classification and Labeling of Chems. (GHS). Using the GCM, chems. or processes can be ranked by a hierarchy of metrics: (1) scores for each of the 12 principles; (2) 3 category rankings between new and improved chems./processes (Improved Resource Use, Increased Energy Efficiency, and Reduced Human and Environmental Hazards); and (3) a summary comparison ranking. The GCM approach is unique in that it is robust and flexible enough to encompass a diverse product portfolio, inexpensive to implement with on-hand data, based on generally accepted industry practices, and allows meaningful communications about chem. sustainability options. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction between 1,2,3-triazole-4,5-dicarboxylic acid and the silver(I) cation was written by Capitan, F.;Salinas, F.;Alonso, E. J.. And the article was included in Boletin de la Sociedad Quimica del Peru in 1973.Category: triazoles This article mentions the following:

1,2,3-Triazole-4,5-dicarboxylic acid reacts with Ag(I) in aqueous HNO3 to give the mono-Ag salt, which has solubility product 1.45 × 10-9. The reaction was useful for determining Ag(I) by potentiometric (σ = ±0.0924) and conductometric (σ = ±0.0332) methods in the absence of Pb(II) and Hg(II), which interfere by forming white precipitates under the reaction conditions. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Category: triazoles).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Nucleoside analogues for the treatment of animal trypanosomiasis was written by Mabille, Dorien;Ilbeigi, Kayhan;Hendrickx, Sarah;Ungogo, Marzuq A.;Hulpia, Fabian;Lin, Cai;Maes, Louis;de Koning, Harry P.;Van Calenbergh, Serge;Caljon, Guy. And the article was included in International Journal of Parasitology: Drugs and Drug Resistance in 2022.Related Products of 1614-12-6 This article mentions the following:

Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleosides for the treatment of AT. Promising hits were identified with excellent in vitro activity across all important animal trypanosome species. Compound 7, an inosine analog, and our previously described lead compound, 3′-deoxytubercidin (8), showed broad spectrum anti-AT activity, metabolic stability in the target host species and absence of toxicity, but with variable efficacy ranging from limited activity to full cure in mouse models of Trypanosoma congolense and T. vivax infection. Several compounds show promise against T. evansi (surra) and T. equiperdum (dourine). Given the preferred target product profile for a broad-spectrum compound against AT, this study emphasizes the need to include T. vivax in the screening cascade given its divergent susceptibility profile and provides a basis for lead optimization towards such broad spectrum anti-AT compound In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Related Products of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Related Products of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A naturally occurring isoform-specific probe for highly selective and sensitive detection of human cytochrome P450 3A5 was written by Wu, Jing-Jing;Cao, Yun-Feng;Feng, Liang;He, Yu-Qi;Hong, James Y.;Dou, Tong-Yi;Wang, Ping;Hao, Da-Cheng;Ge, Guang-Bo;Yang, Ling. And the article was included in Journal of Medicinal Chemistry in 2017.Safety of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Cytochrome P 450 (CYP) 3A5 characterized with polymorphic and extensive expression in multiple tissues is the most important P 450 enzyme among the minor CYP3A isoforms. However, a selective and sensitive probe for CYP3A5 remains unavailable. In this study, we identified and characterized a naturally occurring lignan 12 (schisantherin E) as an isoform-specific probe for selective detection of CYP3A5 activity in complex biol. samples. With thorough characterization including LC-MS and NMR, we found that 12 can be metabolized by CYP3A5 to generate a major metabolite 2-O-demethylated 12. Meanwhile, both reaction phenotyping and chem. inhibition experiments further revealed that CYP3A5 selectively catalyzed the 2-O-demethylation of 12. Specifically, the interactions between the Phe210 residue of CYP3A5 and Me benzoate of 12 might play key roles in 12-O-demethylation, which was revealed by docking simulation and site-directed mutagenesis studies. These findings are beneficial for exploring the role of CYP3A5 in drug metabolism and pathol. process. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Safety of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Safety of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Two complexes based on 1H-1,2,3-triazole-4,5-dicarboxylic acid: hydrothermal synthesis, crystal structures and spectral properties was written by Tong, Xiao-Lan;Xin, Jian-Hua;Guo, Wei-Hua;Zhu, Xia-Ping. And the article was included in Journal of Coordination Chemistry in 2011.Product Details of 4546-95-6 This article mentions the following:

[Zn₃(tda)₂(bipy)₂(H₂O)₂·4H₂O]_n (1) and [Co₂(Htda)₂(H₂O)₆·5H₂O] (2) were synthesized and characterized structurally by x-ray diffraction, where H₃tda = 1H-1,2,3-triazole-4, 5-dicarboxylic acid and 2,2′-bipy = 2,2′-bipyridine. Their solid-state structures were characterized by elemental anal. and IR spectroscopy. The mol. unit of 1 consists of two crystallog. unique Zn(II) ions assuming different coordination geometries, the tda^3- exhibits a hexadentate binding mode chelating three Zn(II) ions; neighboring Zn-Zn distances through tda^3- bridges are 5.910(6), 5.888(5), and 6.279(3) Å, resp. In 2, two neighboring Co(II) ions are bridged by two Htda^2- ligands, forming a binuclear structure, with Co-Co distance of 4.091 Å and is further linked to generate a 3-dimensional structure via hydrogen bonds. Fluorescent of 1 was investigated. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Product Details of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Product Details of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An improved water-soluble/stereospecific biotransformation of aporphine alkaloids in Stephania epigaea to 4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana was written by Cai, Le;Dong, Jian-Wei;Zhao, Li-Xing;Zhou, Hao;Xing, Yun;Li, Ying;Li, Zhen-Jie;Duan, Wei-He;Li, Xue-Jiao;Ding, Zhong-Tao. And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2016.Name: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Aporphine alkaloids were transformed into the corresponding stereospecific 4R-hydroxyaporphine alkaloids through the solid-state fermentation of Stephania epigaea with Clonostachys rogersoniana. This process was validated by both solid- and liquid-state fermentations with aporphine alkaloids as substrates. Cytochrome P 450 enzymes were confirmed to participate in the catalysis of this biotransformation. 4R-Hydroxyaporphine alkaloids exhibit the same levels of acetylcholinesterase (AChE) inhibitory and cytotoxic activities as aporphine alkaloids and are considerably more water soluble than aporphine alkaloids, indicating their potential as water-soluble AChE inhibitors and antitumor agents. This paper suggests that C. rogersoniana fermentation can facilitate a novel biotransformation of aporphine alkaloids in S. epigaea to 4R-hydroxyaporphine alkaloids. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Name: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Name: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

3D geometrically frustrated magnets assembled by transition metal ion and 1,2,3-triazole-4,5-dicarboxylate as triangular nodes was written by Zhang, Wei-Xiong;Xue, Wei;Lin, Jian-Bin;Zheng, Yan-Zhen;Chen, Xiao-Ming. And the article was included in CrystEngComm in 2008.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

Three new chiral metal-organic frameworks, (H₂NMe₂)[M(tzdc)]·0.5H₂O [M=Co(II) (1), Mn(II) (2)] and (NH₄)[Mn(tzdc)]·2.6H₂O (3) (tzdc^3- = 1,2,3-triazole-4,5-dicarboxylate), have been solvothermally synthesized. In the frameworks of 1-3, the ratio of metal and tzdc^3- is 1: 1. Each metal ion is chelated by three tzdc^3- ligands, and each tzdc^3- connects three metal ions, resulting in three-dimensional, 3-connected anionic frameworks, 1 and 2 are isomorphous, and both crystallize in the cubic space group P2₁3. With the template of H₂NMe₂⁺ cations, the frameworks of 1 and 2 have a well-known, porous (10,3)-a network. In contrast, 3 can be obtained by replacing the H₂NMe₂⁺ with smaller NH₄⁺ cations, which leads to a significant topol. change to a unique uniform etd (8,3) network as well as the change of the space group to P6₁. Magnetic studies show dominated antiferromagnetic interactions in 1-3 with θ = -46.8(1), -22.3(1) and -25.8(1) K for 1, 2 and 3, resp. Due to the triangular arrangement of the metal centers, geometrically spin-frustrated magnetism is a characteristic behavior of 1-3. For 1, spin-glassy behavior with a freezing temperature T_f of 2.4 K was distinctly observed, and an empirical factor f = |θ|/T_f ≈ 20 > 10 indicates strong spin-frustration effect. For both 2 and 3, no obvious long-range magnetic ordering and/or spin-glassy behavior was observed down to 2.0 K, which might indicate the f values in them being also larger than 10. By contrast, the observed spin-glassy behavior above 2.0 K in 1 is probably due to the stronger magnetic anisotropy of Co(II) ion and the stronger antiferromagnetic interactions in 1. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors was written by Ai, Teng;Wilson, Daniel J.;More, Swati S.;Xie, Jiashu;Chen, Liqiang. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid This article mentions the following:

Derived from the previously reported human sirtuin 2 (SIRT2) inhibitors that were based on a 5-aminonaphthalen-1-yloxy nicotinamide core structure, 5-((3-amidobenzyl)oxy)nicotinamides offered excellent activity against SIRT2 and high isoenzyme selectivity over SIRT1 and SIRT3. Selected compounds also exhibited generally favorable in vitro absorption, distribution, metabolism, and excretion properties. Kinetic studies revealed that a representative SIRT2 inhibitor acted competitively against both NAD⁺ and the peptide substrate, an inhibitory modality that was supported by the computational study. More importantly, two selected compounds I and II exhibited significant protection against α-synuclein aggregation-induced cytotoxicity in SH-SY5Y cells. Therefore, 5-((3-amidobenzyl)oxy)nicotinamides represent a new class of SIRT2 inhibitors that are attractive candidates for further lead optimization in the continued effort to explore selective inhibition of SIRT2 as a potential therapy for Parkinson’s disease. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Recommanded Product: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Recommanded Product: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors was written by Yoetz-Kopelman, Tal;Porat-Ophir, Carmit;Shacham-Diamand, Yosi;Freeman, Amihay. And the article was included in Sensors and Actuators, B: Chemical in 2016.Name: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

A fast and cost-effective whole-cell electrochem. biosensor aiming at early-stage screening of potential inhibitors of cytochrome P 450 is proposed and its feasibility demonstrated. Sensing is performed by monitoring the decrease in the electrochem. signal generated by the oxidation of the product of the enzymic reaction of cytochrome P 450 BM3 expressed in E. coli cells. The system is self-maintained and does not require enzyme purification or external addition of NADPH or other cofactors. Measurements were performed simultaneously at eight chips at low pos. potential of 100 mV vs. Ag/AgCl under continuous stirring. Kinetic anal. of aniline determination by the whole-cell system was performed and the concentration of aniline for the inhibition studies was selected accordingly. Three known inhibitors – imidazole, metyrapone and 1-aminobenzotriazole (ABT) – were tested and their inhibition profiles characterized. Imidazole was found to be the most potent inhibitor of the three. To the best of our knowledge, the system developed enables for the first time rapid and cheap cytochrome P 450 inhibitors detection by a disposable whole-cell electrochem. chip, combined with the advantages of a whole-cell system, without neither enzyme purification nor NADPH addition Furthermore, the system developed also provides capability of performing aniline detection e.g. for environmental monitoring, by means of electrochem. biosensing. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Name: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Name: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics