Day: January 4, 2023

Structural stabilization of a metal-organic framework for gas sorption investigation was written by Gao, Qiang;Zhao, Xiao-Lin;Chang, Ze;Xu, Jian;Bu, Xian-He. And the article was included in Dalton Transactions in 2016.Recommanded Product: 157069-48-2 This article mentions the following:

By inserting a ligand into a reported metal-organic framework (Co-MOF1), the reformed aggregation of triangle grids, [Co₃(μ₃-O)(cpt)₃tpt·NO₃] (Co-MOF1-tpt) (Hcpt = 4-(4′-carboxyphenyl)-1,2,4-triazole, tpt = tri(4-pyridyl)-1,3,5-triazine), shows enhanced stability. In addition, owing to its structural characteristic, the Co-MOF1-tpt also reveals a certain CO₂ storage ability and CO₂/CH₄ adsorption selectivity as expected. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Recommanded Product: 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Recommanded Product: 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor was written by Kung, Daniel W.;Coffey, Steven B.;Jones, Ryan M.;Cabral, Shawn;Jiao, Wenhua;Fichtner, Michael;Carpino, Philip A.;Rose, Colin R.;Hank, Richard F.;Lopaze, Michael G.;Swartz, Roger;Chen, Hou;Hendsch, Zachary;Posner, Bruce;Wielis, Christopher F.;Manning, Brian;Dubins, Jeffrey;Stock, Ingrid A.;Varma, Sam;Campbell, Mary;DeBartola, Demetria;Kosa-Maines, Rachel;Steyn, Stefanus J.;McClure, Kim F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Synthetic Route of C9H7N3O This article mentions the following:

The discovery of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor is described. The characterization and redressing of the issues associated with these compounds is detailed. An efficient three-step synthesis and a binding assay were relied upon as the primary means of rapidly improving potency and ADMET properties for this class of inverse agonist compounds Compound 10n bearing distributed polarity in the form of an imidazo-thiazole acetamide and a Ph triazole is a unit lower in log P and has significantly improved binding affinity compared to the hit mol. 10a, providing support for further optimization of this series of compounds In the experiment, the researchers used many compounds, for example, 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3Synthetic Route of C9H7N3O).

4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C9H7N3O

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice was written by Oda, Shingo;Shirai, Yuji;Akai, Sho;Nakajima, Akira;Tsuneyama, Koichi;Yokoi, Tsuyoshi. And the article was included in Journal of Applied Toxicology in 2017.Reference of 1614-12-6 This article mentions the following:

The acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs are potentially chem. reactive and are suggested to be implicated in toxicity, including hepatotoxicity, nephrotoxicity and drug hypersensitivity reactions. However, it remains unknown whether AG formation is related to toxicity in vivo. In this study, we sought to determine whether AG is involved in the pathogenesis of liver injury using a mouse model of diclofenac (DIC)-induced liver injury. Mice that were administered DIC alone exhibited significantly increased plasma alanine aminotransferase levels, whereas mice that were pretreated with the UDP-glucuronosyltransferase inhibitor (-)-borneol (BOR) exhibited suppressed alanine aminotransferase levels at 3 and 6 h after DIC administration although not significant at 12 h. The plasma DIC-AG concentrations were significantly lower in BOR- and DIC-treated mice than in mice treated with DIC alone. The mRNA expression levels of chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2 and the neutrophil marker CD11b were reduced in the livers of mice that had been pretreated with BOR compared to those that had been administered DIC alone, whereas mRNA expression of the macrophage marker F4/80 was not altered. An immunohistochem. anal. at 12 h samples revealed that the numbers of myeloperoxidase- and lymphocyte antigen 6 complex-pos. cells that infiltrated the liver were significantly reduced in BOR- and DIC-treated mice compared to mice that were treated with DIC alone. These results indicate that DIC-AG is partly involved in the pathogenesis of DIC-induced acute liver injury in mice by activating innate immunity and neutrophils. Copyright © 2016 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Reference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of ¹⁸F-difluoromethylarenes using arylboronic acids, ethyl bromofluoroacetate and [¹⁸F]fluoride was written by Sap, Jeroen B. I.;Wilson, Thomas C.;Kee, Choon Wee;Straathof, Natan J. W.;am Ende, Christopher W.;Mukherjee, Paramita;Zhang, Lei;Genicot, Christophe;Gouverneur, Veronique. And the article was included in Chemical Science in 2019.HPLC of Formula: 179056-04-3 This article mentions the following:

Herein, the radiosynthesis of ¹⁸F-difluoromethylarenes RCHF¹⁸F (R = 4-C₂H₅, 4-OC₆H₅, 3,5-CH₃, etc.) via the assembly of three components, a boron reagent, Et bromofluoroacetate, and cyclotron-produced non-carrier added [¹⁸F]fluoride was reported. The two key steps are a copper-catalyzed cross-coupling reaction, and a Mn-mediated ¹⁸F-fluorodecarboxylation. In the experiment, the researchers used many compounds, for example, 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3HPLC of Formula: 179056-04-3).

4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.HPLC of Formula: 179056-04-3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Biodegradation of bisphenol a by Sphingobium sp. YC-JY1 and the essential role of cytochrome P450 monooxygenase was written by Jia, Yang;Eltoukhy, Adel;Wang, Junhuan;Li, Xianjun;Hlaing, Thet Su;Aung, Mar Mar;Nwe, May Thet;Lamraoui, Imane;Yan, Yanchun. And the article was included in International Journal of Molecular Sciences in 2020.Name: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30°C and 6.5, resp. The biodegradation pathway was proposed based on the identification of the metabolites. The addition of cytochrome P 450 (CYP) inhibitor 1-aminobenzotriazole significantly decreased the degradation of BPA by Sphingobium sp. YC-JY1. Escherichia coli BL21 (DE3) cells harboring pET28a-bisdAB achieved the ability to degrade BPA. The bisdB gene knockout strain YC-JY1ΔbisdB was unable to degrade BPA indicating that P 450 bisdB was an essential initiator of BPA metabolism in strain YC-JY1. For BPA polluted soil remediation, strain YC-JY1 considerably stimulated biodegradation of BPA associated with the soil microbial community. These results point out that strain YC-JY1 is a promising microbe for BPA removal and possesses great application potential. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Name: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Name: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics