Day: January 6, 2023

Study of the vinylation of 1,2,3-triazolecarboxylic acid esters was written by Shatalov, G. V.;Galkin, V. D.;Voishcheva, O. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 1976.Reference of 40594-98-7 This article mentions the following:

Allyl 1-vinyl-1,2,3-triazole-5-carboxylates (I; R = Et [55988-95-9], Pr [55988-97-1], iso-Pr [55989-00-9], Bu [52998-09-1], iso-Bu [55989-02-1], amyl [56597-54-7], isoamyl [56609-82-6]) were prepared by vinylation of the corresponding esters of 1,2,3-triazolecarboxylic acid with acetylene [74-86-2] in the presence of Cu or Zn oxides, or by transvinylation of the esters with vinyl acetate [108-05-4] (I; R = Pr, iso-Pr, amyl, isoamyl). The structures of I were determined by elemental anal., mol. weight, IR and UV spectroscopy, and comparison of the calculated dipole moment with the exptl. determined one (for I, R = Pr). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Reference of 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Reference of 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Metabolic Activation of Cholestatic Drug-Induced Bile Acid-Dependent Toxicity in Human Sandwich-Cultured Hepatocytes was written by Ogimura, Eiichiro;Tokizono, Mayuko;Sekine, Shuichi;Nakagawa, Tetsuya;Bando, Kiyoko;Ito, Kousei. And the article was included in Journal of Pharmaceutical Sciences in 2017.Name: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

We previously reported a cell-based toxicity assay using sandwich-cultured hepatocytes in combination with a titrated amount of human bile acid (BA) species. In this assay, test compound-induced inhibition of BA efflux from sandwich-cultured hepatocytes leads to BA-dependent cell toxicity (BA_tox, i.e., cell death due to the accumulation of BAs). Using this assay, we investigated whether 1-aminobenzotriazole (1-ABT; a nonselective cytochrome P 450 inhibitor) enhanced or suppressed test compound-induced BA_tox. There was a tendency that BA_tox of many compounds was enhanced by 1-ABT in human hepatocytes; in contrast, such a tendency was not observed in rat hepatocytes. In particular, 1-ABT tended to enhance BA_tox of several compounds (clopidogrel, ticlopidine, everolimus, etc.) in human, whereas 1-ABT tended to enhance BA_tox of only ticlopidine in rat. These results indicate that this system can be used to evaluate BA_tox while taking into account drug metabolism and the existence of an interspecies difference in the effect of 1-ABT treatment on BA_tox. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Name: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Name: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics