Day: January 30, 2023

Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites was written by Aracagoek, Y. Doruk;Goeker, Hakan;Cihangir, Niluefer. And the article was included in Zeitschrift fuer Naturforschung, C: Journal of Biosciences in 2017.Recommanded Product: 1614-12-6 This article mentions the following:

Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main byproducts of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, ¹HNMR, and ¹³CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P 450 enzyme system. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Recommanded Product: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Benzyne formation in the mechanism-based inactivation of cytochrome P 450 by 1-aminobenzotriazole and N-benzyl-1-aminobenzotriazole: Computational insights was written by Chuanprasit, Pratanphorn;Goh, Shu Hui;Hirao, Hajime. And the article was included in ACS Catalysis in 2015.Synthetic Route of C6H6N4 This article mentions the following:

Cytochrome P 450 isoforms (P 450s) are ubiquitously distributed heme enzymes that play catalytic roles in the essential oxidative biotransformation of a wide range of exogenous and endogenous organic compounds Strong inhibition of P 450s through mechanism-based inactivation (MBI) essentially should not occur, because it would affect important metabolic processes adversely. However, accumulated evidence shows that the MBI of a P 450 is not a rare event. MBIs can also be exploited for useful applications such as reaction phenotyping. Thus, MBI is clearly one of the major problems concerning P 450s, but the reaction mechanisms underlying MBIs are not very clear in many cases. Here, the authors used DFT calculations to understand how a metabolite (benzyne) is formed from 2 mechanism-based inactivators of P 450s: 1-aminobenzotriazole (ABT) and N-benzyl-1-aminobenzotriazole (BBT). ABT has been widely used for reaction phenotyping. The DFT calculations showed that the formation of benzyne from ABT occurred via 2 sequential H-abstraction reactions from the exocyclic N-H bonds, similar to the reaction of 1,1-dimethylhydrazine. The transition states for these H-abstractions were stabilized by a proton-coupled electron transfer effect. The formation of benzyne from BBT was also triggered by H-abstraction from the N-H bond. However, in this case, the 2nd step was H-abstraction from a benzylic C-H bond. In addition, for the formation of benzyne from BBT, another catalytic cycle should be necessary. A computational study therefore elucidated the difference in reaction mechanisms between ABT and BBT, providing new insights into the processes involved in the MBI caused by these compounds In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Synthetic Route of C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeSynthetic Route of C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Uranyl-containing heterometallic coordination polymers based on 4-(4′-carboxyphenyl)-1,2,4-triazole ligand: structure regulation through subtle changes of the secondary metal centers was written by Zhao, Ran;Mei, Lei;Hu, Kong-Qiu;Wang, Lin;Chai, Zhi-Fang. And the article was included in Journal of Coordination Chemistry in 2018.Reference of 157069-48-2 This article mentions the following:

Three uranyl-containing coordination polymers, Cd(UO₂)₂(cpt)₄(bdc)(H₂O)₂ (1), Zn(UO₂)₂(cpt)₄(bdc)(H₂O)₂ (2) and UO₂(OH)(cpt) (3, Hcpt = 4-(4′-carboxyphenyl)-1,2,4-triazole, H₂bdc = 1,4-benzenedicarboxylic acid), have been synthesized under hydrothermal conditions by employing a bifunctional ligand (Hcpt) with both O-donors and N-donors. Compound 1 represents a 3-D framework with the point symbol of (6²·8⁴)(6²·8)₂ by the intersection of two sets of 1-D [Cd₂(UO₂)₂(cpt)₄(bdc)]_n loop chains extended along different directions. Compound 2 exhibits a 2-nodal (3,4)-connected 2-D network with the point symbol (4·6²)₂(4²·6²·8²). Compound 3 shows a 2-D network by the assembly of uranyl dimers and the cpt^– anions. Although 1 and 2 have similar chem. formulas and the same coordination modes of ligands and metal centers, they possess totally different mol. frameworks, derived from the different radii of the secondary metal centers, Cd(II) and Zn(II). In addition, the optimal synthesis condition, thermal stability, luminescent properties, and IR spectra of 1 and 2 were also investigated. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Reference of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Reference of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

UNAM-1: a robust Cu^I and Cu^II containing 3D-hydrogen-bonded framework with permanent porosity and reversible SO₂ sorption was written by Dominguez-Gonzalez, Ricardo;Rojas-Leon, Iran;Martinez-Ahumada, Eva;Martinez-Otero, Diego;Lara-Garcia, Hugo A.;Balmaseda-Era, Jorge;Ibarra, Ilich A.;Percastegui, Edmundo G.;Jancik, Vojtech. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019.Reference of 4546-95-6 This article mentions the following:

The construction of hydrogen-bonded frameworks (HBFs) that express permanent porosity and functionality is challenging due to the delicateness of hydrogen bonds. Authors present UNAM-1, a robust 3D-HBF fully sustained by charge-assisted H-bonds between [Cu^IICu^I₁₂(HL)₁₂]^10- and [Me₂NH₂]⁺ units, which displays a surface area of 522 m² g^-1 and reversibly adsorbs SO₂ (3.5 mmol g^-1). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Reference of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Reference of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis and crystal structure of a luminescent compound 5-(1H-benzimidazol-2-yl)-3H-[1,2,3]triazole-4-carboxylic acid was written by Sun, Chen-Guang;Zeng, Ming-Hua;Xu, Kang-Zhen;Song, Ji-Rong. And the article was included in Chinese Journal of Structural Chemistry in 2012.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

5-(1H-benzimidazol-2-yl)-3H-[1,2,3]triazole-4-carboxylic acid DMF solvate (C₁₀H₇N₅O₂.C₃H₇NO, M_r 302.30) was synthesized and characterized by FT-IR and ESI-MS, ¹H-NMR spectroscopy and x-ray single-crystal diffraction [orthorhombic, space group Pna2₁, a 6.9635(3), b 19.4398(7), c 30.6165(12) Å, V 4144.5(3) ų, Z 12, D_c 1.454 g/cm³, μ(MoKα) 0.108 mm^-1, F(000) 1896, R 0.0450 and wR 0.0975 for 3578 observed reflections with I > 2σ(I)]. Crystals were grown from DMF by slow diffusion at room temperature Intermol. H bonds and π-π stacking further stabilize the structure. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Syntheses, structures, and photoluminescence of d¹⁰ coordination architectures: From 1D to 3D complexes based on mixed ligands was written by Yuan, Gang;Shao, Kui-Zhan;Du, Dong-Ying;Wang, Xin-Long;Su, Zhong-Min. And the article was included in Solid State Sciences in 2011.Synthetic Route of C4H3N3O4 This article mentions the following:

Six new compounds, namely, {[Cd₃(Himpy)₃(tda)₂]·3H₂O}_n (1), {[Zn₃(bipy)₂(tda)₂(H₂O)₂]·4H₂O}_n (2), {[Cd₃(bipy)₃(tda)₂]·4H₂O}_n (3), {[Cd₃(tda)₂(H₂O)₃Cl]·H₂O}_n (4), {[Zn₂(tz)(tda)(H₂O)₂]·H₂O}_n (5) and {[Cd₇(pz)(tda)₄(OAc)(H₂O)₇]·3H₂O}_n (6) [H₃tda = 1H-1,2,3-triazole-4,5-dicarboxylic acid, Himpy = 2-(1H-imidazol-2-yl)pyridine, bipy = 2,2′-bipyridine, Htz = 1H-1,2,4-triazole, H₂pz = piperazine] were prepared under hydrothermal condition and characterized by elemental analyses, IR spectroscopy, powder x-ray diffraction and single-crystal X-ray diffraction analyses. Compound 1 is a 1D column-like structure and displays a 3D supramol. network via the π···π stacking interaction. The compounds 2 and 3 exhibit similar 2D layer-like structure, which further extend to 3D supermol. structure by the π···π stacking interaction. All of compounds 4–6 display 3D framework with diverse topol. constructed from the tda^3- ligands in different coordination modes and secondary ligands (or bridging atom) connecting metal ions. Furthermore, the thermal stabilities and photoluminescent properties of compounds 1–6 were studied. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A novel three-dimensional heterometallic compound: templated assembly of the unprecedented planar “Na⊂[Cu₄]” metalloporphyrin-like subunits was written by Yue, Yan-Feng;Wang, Bing-Wu;Gao, En-Qing;Fang, Chen-Jie;He, Cheng;Yan, Chun-Hua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

A 3-dimensional heterometallic compound, [Cu₄Na₄(TzDC)₄(H₂O)₇]_n (H₃TzDC = 1,2,3-triazole-4,5-dicarboxylic acid), which contains unprecedented planar Na⊂[Cu₄] metalloporphyrin-like subunits, was synthesized by hydrothermal reactions of but-2-ynedioic acid and NaN₃ involving in situ formation of the ligand and templated assembly of the metalloporphyrin-like subunits. Magnetic susceptibility measurements indicate a dominant antiferromagnetic interaction and SOMO’s acre calculated using DFT methods. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Laccase inducer Mn²⁺ inhibited the intracellular degradation of norfloxacin by Phanerochaete chrysosporium was written by Chen, Zhongwei;Li, Ningjie;Lan, Qi;Zhang, Xuehong;Wu, Lei;Liu, Jie;Yang, Rui. And the article was included in International Biodeterioration & Biodegradation in 2021.HPLC of Formula: 1614-12-6 This article mentions the following:

The effect of extracellular enzyme inducers such as Mn2+ on the intracellular degradation system of white-rot fungi is still unknown. In this study, the effect of Mn2+ on the degradation of norfloxacin (NOR) by Phanerochaete chrysosporium (P. chrysosporium) and its mechanisms were investigated. A higher concentration of Mn2+ led to higher adsorption of NOR but weaker degradation of NOR and, ultimately, lower removal efficiency of NOR by P. chrysosporium. The addition of Mn2+ increased the activities of both laccase (Lac) and manganese peroxidase (MnP), but only Lac played a role in the degradation of NOR, indicating that Mn2+ probably induced a greater contribution of extracellular Lac to NOR degradation by P. chrysosporium. Further investigation demonstrated that Mn2+ displayed a similar inhibitory effect on NOR degradation as the cytochrome P 450 inhibitor 1-aminobenzotriazole (ABT). Mn2+ inhibited the oxidation of the piperazine ring of NOR by P. chrysosporium, which resulted in similar changes in degradation products to those in the ABT-added group. These findings demonstrated that Mn2+ inhibited the intracellular degradation of NOR by cytochrome P 450. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6HPLC of Formula: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.HPLC of Formula: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

APX001 is effective in the treatment of murine invasive pulmonary aspergillosis was written by Gebremariam, Teclegiorgis;Alkhazraji, Sondus;Alqarihi, Abdullah;Jeon, Heewon H.;Gu, Yiyou;Kapoor, Mili;Shaw, Karen J.;Ibrahim, Ashraf S.. And the article was included in Antimicrobial Agents and Chemotherapy in 2019.Product Details of 1614-12-6 This article mentions the following:

Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed. The novel antifungal APX001A targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of APX001A against A. fumigatus and the in vivo activity of its prodrug APX001 in an immunosuppressed mouse model of IPA. APX001A inhibited the growth of A. fumigatus with a min. effective concentration of 0.03. We evaluated the efficacy of APX001 (with ABT) in treating murine IPA compared to posaconazole treatment. Treatment of mice with 78 mg/kg once daily (QD), 78 mg/kg twice daily, or 104 mg/kg QD APX001 significantly enhanced the median survival time and prolonged day 21 postinfection overall survival compared to the placebo. Furthermore, administration of APX001 resulted in a significant reduction in lung fungal burden (4.2 to 7.6 log10 conidial equivalent/g of tissue) vs. the untreated control and resolved the infection, as judged by histopathol. examination The observed survival and tissue clearance were comparable to a clin. relevant posaconazole dose. These results warrant the continued development of APX001 as a broad-spectrum, first-in-class treatment of invasive fungal infections. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hole-mediated photoredox catalysis: tris(p-substituted)biarylaminium radical cations as tunable, precomplexing and potent photooxidants was written by Wu, Shangze;Zurauskas, Jonas;Domanski, Michal;Hitzfeld, Patrick S.;Butera, Valeria;Scott, Daniel J.;Rehbein, Julia;Kumar, Ajeet;Thyrhaug, Erling;Hauer, Juergen;Barham, Joshua P.. And the article was included in Organic Chemistry Frontiers in 2021.Name: Ethyl 1H-1,2,3-triazole-5-carboxylate This article mentions the following:

Herein, a tunable class of electroactivated photoredox catalyst, tri(para-substituted)biarylamines was reported, that became superoxidants in their photoexcited states even able to oxidize mols. beyond the solvent window limits of cyclic voltammetry (such as polyfluorobenzene and trifluorotoluene). Furthermore, precomplexation not only permits the excited state photochem. of tris(para-substituted)biarylaminium cations to overcome picosecond lifetime, but enables and rationalizes the surprising photochem. of their higher-order doublet (Dn) excited states, unlocking extremely high oxidative potentials (up to a record-breaking ∼+4.4 V vs. SCE) was demonstrated. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Name: Ethyl 1H-1,2,3-triazole-5-carboxylate).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Name: Ethyl 1H-1,2,3-triazole-5-carboxylate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics