Zhang, Liying et al. published their research in European Journal of Inorganic Chemistry in 2015 | CAS: 4546-95-6

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Three Scandium Compounds with Unsaturated Coordinative Metal Sites – Structures and Catalysis was written by Zhang, Liying;Wang, Li;Wang, Peng Cheng;Song, Tianyou;Li, Da;Chen, Xiaobo;Fan, Yong;Xu, Jianing. And the article was included in European Journal of Inorganic Chemistry in 2015.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

Two scandium coordination polymers, a 2-dimensional supramol. structure {[Sc(OH)(L1)2(H2O)]}n (1) (HL1 = isonicotinic acid), a 1-dimensional infinite chain structure {[Sc3(L2)4(H2O)4]·NO3·H2O}n (2) (H2L2 = 4,5-imidazoledicarboxylic acid), as well as a dinuclear scandium complex {[Sc2(OH)2(L3)2(H2O)4]} (3) (H2L3 = 1,2,3-triazole-4,5-dicarboxylic acid), were synthesized and characterized by x-ray crystallog. Compounds 13 are active heterogeneous catalysts for high-yield cyanosilylation of aromatic aldehydes in MeCN, particularly for p-nitrobenzaldehyde. Also, these three catalysts can be reused three times without significant loss in activity or mass. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Aharen, Tomoko et al. published their research in Dalton Transactions in 2013 | CAS: 157069-48-2

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.COA of Formula: C9H7N3O2

Novel Co-based metal-organic frameworks and their magnetic properties using asymmetrically binding 4-(4′-carboxyphenyl)-1,2,4-triazole was written by Aharen, Tomoko;Habib, Fatemah;Korobkov, Ilia;Burchell, Tara J.;Guillet-Nicolas, Remy;Kleitz, Freddy;Murugesu, Muralee. And the article was included in Dalton Transactions in 2013.COA of Formula: C9H7N3O2 This article mentions the following:

Two novel Co-based metal-organic frameworks (MOFs) were synthesized and characterized using an asym. binding ligand, 4-(4′-carboxyphenyl)-1,2,4-triazole (Hcpt). The isolated [CoII33-O)(OH)(cpt)3(H2O)2]n·xH2O·yDMF, Co-MOF1, exhibits a rhombohedral crystal structure (space group, P63/mc), with a trinuclear cobalt core that resembles the MIL88 series. This MOF shows paramagnetic behavior down to 2 K with no saturation of magnetization up to 7 T. This is presumably due to a geometrically frustrated triangular arrangement of Co spins. The two-dimensional complex, [CoII(cpt)(N3)]n, Co-MOF2, crystallizes in a monoclinic crystal system (space group, C2/m). The magnetic measurements reveal metamagnetic behavior for this complex with a critical field at 700-1000 Oe. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2COA of Formula: C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.COA of Formula: C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zhao, Qi et al. published their research in British Journal of Pharmacology in 2019 | CAS: 1614-12-6

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Recommanded Product: 1614-12-6

Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity was written by Zhao, Qi;Zhang, Ting;Xiao, Xue-Rong;Huang, Jian-Feng;Wang, Yan;Gonzalez, Frank J.;Li, Fei. And the article was included in British Journal of Pharmacology in 2019.Recommanded Product: 1614-12-6 This article mentions the following:

Background and Purpose : Sunitinib is a small-mol. TK inhibitor associated with hepatotoxicity. The mechanisms of its toxicity are still unclear. Exptl. Approach : In the present study, mice were treated with 60, 150, and 450 mg·kg-1 sunitinib to evaluate sunitinib hepatotoxicity. Sunitinib metabolites and endogenous metabolites in liver, serum, faeces, and urine were analyzed using ultra-performance LC electrospray ionization quadrupole time-of-flight MS-based metabolomics. Key Results : Four reactive metabolites and impaired clearance of sunitinib in liver played a dominant role in sunitinib-induced hepatotoxicity. Using a non-targeted metabolomics approach, various metabolic pathways, including mitochondrial fatty acid β-oxidation (β-FAO), bile acids, lipids, amino acids, nucleotides, and tricarboxylic acid cycle intermediates, were disrupted after sunitinib treatment. Conclusions and Implications : These studies identified significant alterations in mitochondrial β-FAO and bile acid homeostasis. Activation of PPARa and inhibition of xenobiotic metabolism may be of value in attenuating sunitinib hepatotoxicity. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Recommanded Product: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yamane, Mizuki et al. published their research in Xenobiotica in 2021 | CAS: 1614-12-6

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Reference of 1614-12-6

Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout was written by Yamane, Mizuki;Igarashi, Fumihiko;Yamauchi, Tsuyoshi;Nakagawa, Toshito. And the article was included in Xenobiotica in 2021.Reference of 1614-12-6 This article mentions the following:

UR-1102, a novel uricosuric agent for treating gout, has been confirmed to exhibit a pharmacol. effect in patients. We clarified its metabolic pathway, estimated the contribution of each metabolic enzyme, and assessed the impact of genetic polymorphisms using human in vitro materials. Glucuronide, sulfate and oxidative metabolites of UR-1102 were detected in human hepatocytes. The intrinsic clearance by glucuronidation or oxidation in human liver microsomes was comparable, but sulfation in the cytosol was much lower, indicating that the rank order of contribution was glucuronidation ≥ oxidation > sulfation. Recombinant UGT1A1 and UGT1A3 showed high glucuronidation of UR-1102. We took advantage of a difference in the inhibitory sensitivity of atazanavir to the UGT isoforms and estimated the fraction metabolised (fm) with UGT1A1 to be 70%. Studies using recombinant CYPs and CYP isoform-specific inhibitors showed that oxidation was mediated exclusively by CYP2C9. The effect of UGT1A1 and CYP2C9 inhibitors on UR-1102 metabolism in hepatocytes did not differ markedly between the wild type and variants. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Reference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zhao, Mingjuan et al. published their research in Journal of Molecular Structure in 2017 | CAS: 157069-48-2

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.SDS of cas: 157069-48-2

An unusual 2p-3d-4f heterometallic coordination polymer featuring Ln8Na and Cu8I clusters as nodes was written by Zhao, Mingjuan;Chen, Shimin;Huang, Yutian;Dan, Youmeng. And the article was included in Journal of Molecular Structure in 2017.SDS of cas: 157069-48-2 This article mentions the following:

A new cluster-based three-dimensional 2p-3d-4f heterometallic framework {[Ho8Na(OH)6Cu16I2(CPT)24](NO3)9(H2O)6(MeCN)18}n (1, HCPT = 4-(4-carboxyphenyl)-1,2,4-triazole) has been prepared under solvothermal condition by using a custom-designed bifunctional organic ligand. The single-crystal structure anal. reveals that this framework features novel Ln8Na and Cu8I clusters as nodes, these nodes are further connected by the CPT ligands to give rise to a (6,14)-connected network. The magnetic property of this framework has also been investigated. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2SDS of cas: 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.SDS of cas: 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tian, Qian-qian et al. published their research in Acta Pharmacologica Sinica in 2021 | CAS: 1614-12-6

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Quality Control of 1H-Benzo[d][1,2,3]triazol-1-amine

Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor was written by Tian, Qian-qian;Zhu, Yun-ting;Diao, Xing-xing;Zhang, Xiang-lei;Xu, Ye-chun;Jiang, Xiang-rui;Shen, Jing-shan;Wang, Zhen;Zhong, Da-fang. And the article was included in Acta Pharmacologica Sinica in 2021.Quality Control of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

TPN729 is a novel phosphodiesterase 5 (PDE5) inhibitor used to treat erectile dysfunction in men. Our previous study shows that the plasma exposure of metabolite M3 (N-dealkylation of TPN729) in humans is much higher than that of TPN729. In this study, we compared its metabolism and pharmacokinetics in different species and explored the contribution of its main metabolite M3 to pharmacol. effect. We conducted a combinatory approach of ultra-performance liquid chromatog./quadrupole time-of-flight mass spectrometry-based metabolite identification, and examined pharmacokinetic profiles in monkeys, dogs, and rats following TPN729 administration. A remarkable species difference was observed in the relative abundance of major metabolite M3: i.e., the plasma exposure of M3 was 7.6-fold higher than that of TPN729 in humans, and 3.5-, 1.2-, 1.1-fold in monkeys, dogs, and rats, resp. We incubated liver S9 and liver microsomes with TPN729 and CYP3A inhibitors, and demonstrated that CYP3A was responsible for TPN729 metabolism and M3 formation in humans. The inhibitory activity of M3 on PDE5 was 0.78-fold that of TPN729 (The IC50 values of TPN729 and M3 for PDE5A were 6.17 ± 0.48 and 7.94 ± 0.07 nM, resp.). The plasma protein binding rates of TPN729 and M3 in humans were 92.7% and 98.7%, resp. It was astonishing that the catalyzing capability of CYP3A4 in M3 formation exhibited seven-fold disparity between different species. M3 was an active metabolite, and its pharmacol. contribution was equal to that of TPN729 in humans. These findings provide new insights into the limitation and selection of animal model for predicting the clin. pharmacokinetics of drug candidates metabolized by CYP3A4. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Quality Control of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Quality Control of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yan, Hao-Ran et al. published their research in RSC Advances in 2016 | CAS: 157069-48-2

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Related Products of 157069-48-2

Two cationic [(CuxIy)x-y]n motif based coordination polymers and their photocatalytic properties was written by Yan, Hao-Ran;Wang, Jian;Yu, Ying-Hui;Hou, Guang-Feng;Zhang, Hong-Xing;Gao, Jin-Sheng. And the article was included in RSC Advances in 2016.Related Products of 157069-48-2 This article mentions the following:

Cuprous iodide (CuI)-based coordination compounds with the general chem. formula of CuI(L) are known for their structural diversity and strong photoluminescence and are therefore considered as promising candidates for a number of optical applications. Reported here are two cuprous iodide coordination polymers (CPs), {[Cu3I2TBA]·H2O}n (1) and {[Cu2I(HTBA)TBA]·2H2O}n (2) (HTBA = 4-(4H-1,2,4-triazol-4-yl)benzoic acid). Structures of CPs 1 and 2 are determined by single crystal x-ray diffraction and further characterized by IR spectra (IR), elemental analyses, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. CPs 1 and 2 with a significant feature of novel cationic [(CuxIy)x-y]n motifs were synthesized under controlled reaction conditions via adopting HTBA as ligand. CP 1 displays a 3,6-connected net, while CP 2 shows a coordination chain. Further, the catalytic properties of CPs 1 and 2 were studied in the degradation of Methyl blue. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Related Products of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Related Products of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Moyano, Paula et al. published their research in Food and Chemical Toxicology in 2019 | CAS: 1614-12-6

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeReference of 1614-12-6

Oxidative stress and cell death induction by amitraz and its metabolite BTS-27271 mediated through cytochrome P450 and NRF2 pathway alteration in primary hippocampal cell was written by Moyano, Paula;Ruiz, Matilde;Garcia, Jose Manuel;Frejo, Maria Teresa;Anadon Baselga, Maria Jose;Lobo, Margarita;Garcia, Jimena;Del Pino, Javier. And the article was included in Food and Chemical Toxicology in 2019.Reference of 1614-12-6 This article mentions the following:

Amitraz is a neurotoxic formamidine pesticide that induces cell death in hippocampal neurons, although its mechanisms are unknown. Amitraz produces reactive oxygen species (ROS), which could lead to cell death. Amitraz was shown to induce different cytochrome P 450 (CYP) isoenzymes involved with ROS and apoptotic cell death induction. Finally, amitraz was described to decrease the activity of antioxidant enzymes regulated through KEAP1/NRF2 pathway, thus likely leading to a reduction of ROS elimination and to cell death induction. We evaluated the effect of amitraz or BTS-27271 co-treatment with or without the antioxidant N-acetylcysteine and/or the unspecific CYP inhibitor 1-aminobenzotriazole on cell viability and its related mechanisms in wild type and silenced primary hippocampal neurons after 24 h treatment. We observed that amitraz produced oxidative stress and CYPs induction leading to apoptotic cell death. ROS generation was partially mediated by CYPs induction and downregulation of NRF2-pathway through KEAP1 overexpression. These data could help explain the mechanism by which amitraz induces cell death and oxidative stress and provide a therapeutic strategy to protect against this effect in case of poisoning. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeReference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Boily, Marc-Olivier et al. published their research in Drug Metabolism & Disposition in 2015 | CAS: 1614-12-6

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Formula: C6H6N4

In vitro and in vivo mechanistic studies toward understanding the role of 1-aminobenzotriazole in rat drug-drug interactions was written by Boily, Marc-Olivier;Chauret, Nathalie;Laterreur, Julie;Leblond, Francois A.;Boudreau, Chantal;Duquet, Marie-Claude;Levesque, Jean-Francois;Ste-Marie, Line;Pichette, Vincent. And the article was included in Drug Metabolism & Disposition in 2015.Formula: C6H6N4 This article mentions the following:

1-Aminobenzotriazole (ABT) is regularly used in vivo as a nonspecific and irreversible cytochrome P 450 inhibitor to elucidate the role of metabolism on the pharmacokinetic profile of xenobiotics. However, few reports have considered the recent findings that ABT can alter drug absorption or have investigated the possible differential inhibition of ABT on intestinal and hepatic metabolism To address these uncertainties, pharmacokinetic studies under well controlled and defined ABT pretreatment conditions (50 mg/kg, 1 h ABT i.v. and 16 h ABT p.o.)were conducted prior to the oral administration of metoprolol, a permeable P 450 probe that undergoes extensive intestinal and hepatic metabolism The pharmacokinetic profile of metoprolol was affected differently by the two ABT pretreatments. An increase in area under the curve of 16-fold with ABT p.o. and 6.5-fold with ABT i.v. was observed compared with control. Based on in vitro studies, this difference could not be attributed to a differential inhibition of intestinal and hepatic metabolism In the ABT i.v. pretreatment group, the increase in area under the curve was also associated with a prolonged time at maximal concentration (24-fold vs. control), suggesting a delay in absorption. This was further confirmed by the administration of a charcoal meal, which resulted in a 7-fold increase in stomach weights in the 1-h ABT pretreated groups compared with the untreated or 16-h ABT pretreated rats. Based on these results,we recommend pretreating rats with ABT p.o. 16 h before the administration of a test compound to preserve the inhibitory effect on intestinal and hepatic metabolism and avoid the confounding effect on drug absorption. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Formula: C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Formula: C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yousef, Samy et al. published their research in Science of the Total Environment in 2021 | CAS: 4546-95-6

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Related Products of 4546-95-6

A new strategy for using lint-microfibers generated from clothes dryer as a sustainable source of renewable energy was written by Yousef, Samy;Eimontas, Justas;Zakarauskas, Kestutis;Striugas, Nerijus;Mohamed, Alaa. And the article was included in Science of the Total Environment in 2021.Related Products of 4546-95-6 This article mentions the following:

Lint-microfibers (LMs) generated during clothes drying are classified as primary microplastics and consist mainly of cotton, polyester and lignin. This research aims to convert LMFs into energy products using a pyrolysis treatment. The pyrolysis experiments were performed using a pilot pyrolysis plant. SEM-EDS was used to observe the morphol. and elemental composition of the feedstock and the obtained biochar, while a digital unit of Instantaneous Gas analyzer and Gas chromatog. (GC) were used to observe the concentration of O2, N2, CO2, CO, H2, CH4 gases during the whole conversion process. Finally, a simple math. model was developed to evaluate the economic and environmental performance of the suggested strategy based on the LMFs generated by one million persons. Based on the results of the developed model and yield of pyrolysis process, around 45 tons of LMFs are generated by one million persons annually and this amount is enough to produce 13.8 tons of oil (31%), 21.5 tons of gas (47.7%), and 9.7 ton of char (21.6%) with estimated profitability of 120,400$ and reduction in carbon footprint estimated at -42,039,000 kg CO2-equiv/t of LMFs. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Related Products of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Related Products of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics