Month: February 2023

4,5-Dicyano-1,2,3-Triazole-A Promising Precursor for a New Family of Energetic Compounds and Its Nitrogen-Rich Derivatives: Synthesis and Crystal Structures was written by Cao, Wenli;Qin, Jian;Zhang, Jianguo;Sinditskii, Valery P.. And the article was included in Molecules in 2021.Application of 4546-95-6 This article mentions the following:

The nitrogen-rich compounds and intermediates with structure of monocyclic, bicyclic, and fused rings based on 1,2,3-triazole were synthesized and prepared by using a promising precursor named 4,5-dicyano-1,2,3-triazole, which was obtained by the cyclization reaction of diaminomaleonitrile. Their structure and configurational integrity were assessed by Fourier transform-IR spectroscopy (FT-IR), mass spectrometry (MS), and elemental anal. (EA). Addnl., fourteen compounds were further confirmed by X-ray single crystal diffraction. Meanwhile, the phys. properties of four selected compounds including thermal stability, detonation parameters, and sensitivity were also estimated All these compounds could be considered to construct more abundant 1,2,3-triazole-based neutral energetic mols., salts, and complex compounds, which need to continue study in the future in the field of energetic materials. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeApplication of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Two threefold Interpenetrating 3D Supramolecular Networks Based on 1D Chains and Hydrogen-bond Interactions was written by Zhu, Ai-Xin;Yang, Li-Bo;Fang, Xiao-Dan;Zhang, Ce;Dou, Ai-Na;Yin, Qi. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2017.Synthetic Route of C9H7N3O2 This article mentions the following:

The coordination compounds, [Cu₂(Htba)(tba)Cl] (1) and [Ag₂(Htba)(tba)(NO₃)] (2), were synthesized under solvothermal conditions by using a triazolate-carboxylate bifunctional organic ligand 4-(4H-1,2,4-triazol-4-yl)benzoic acid (Htba). X-ray single crystal diffraction analyses for the two complexes revealed that compounds 1 and 2 exhibit one-dimensional (1D) chain structures with uncoordinated carboxylic groups, which are further connected by O-H璺矾璺疧 hydrogen bonds into 3D, threefold interpenetrating supramol. frameworks with different topologies belonging to 4-connected and (2,4)-connected nets with the (4²璺?²璺?0²)(4³璺?²璺?)₂(4⁴璺?²) and (12⁵璺?6)(12)₂ Schlaefli symbols, resp. The photoluminescent measurements reveal that both 1 and 2 exhibit bluish-purple emissions in the solid state at room temperature In addition, the compound 2 can serve as an antenna for sensitizing the visible-emitting of the lanthanide cations to display their characteristic emissions. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Synthetic Route of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Synthetic Route of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The ir and uv spectra, and reactivity with inorganic ions, of 1,2,3-triazole-4,5-dicarboxylic acid was written by Capitan, F.;Salinas, F.;Alonso, E. J.. And the article was included in Anales de Quimica (1968-1979) in 1973.Application of 4546-95-6 This article mentions the following:

1,2,3-triazole-4,5-dicarboxylic acid was prepared according to the literature, and its ir and uv spectra was established. The acidity constants were determined from the influence of the pH on the uv spectrum. The reactivity against 45 inorganic ions was studied also. This substance possesses a high selective character, because it only reacts with the cations Ag(I), Pb(II), Hg2(II), Hg(II), Cu(II), Pd(II), Co(II), Cr(III), and Rh(III). The sensitivities of these reactions are low. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Application of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adventitious root primordia formation and development in the stem of Ananas comosus var. bracteatus slip was written by Owusu Adjei, Mark;Xiang, Yixuan;He, Yehua;Zhou, Xuzixin;Mao, Meiqin;Liu, Jiawen;Hu, Hao;Luo, Jiaheng;Zhang, Huiling;Feng, Lijun;Yang, Wei;Li, Xi;Ma, Jun. And the article was included in Plant Signaling & Behavior in 2021.Related Products of 1614-12-6 This article mentions the following:

There are about 4-6 slips on a fruit, and they are good materials for effective regeneration of Ananas comosus var. bracteatus. Adventitious root (AR) induction is essential for the propagation of Ananas comosus var. bracteatus slips. Growth regulator treatment, and culture medium are imperative factors that affect slip growth and rooting. In order to screen the optimal methods for slips rooting and reveal the anat. procedure of slip rooting, this study induced slip rooting by different treatment of growth regulator, culture medium, observed the slip stem structure, AR origination and formation procedure through paraffin sections. The results showed that, slip cuttings treated with 100 mg/L of Aminobenzotriazole (ABT) for 6 h, cultured in river sand: coconut chaff: garden soil 2:2:1 medium is the optimal method for rooting. The proper supplementary of ABT can enhance the soluble sugar content, soluble protein content, polyphenol oxidase (PPO) activity and peroxidase (POD) enzyme activity, which resulted in the improvement of rooting. The slip stem structure is quite different from other monocots, which consists of epidermis, cortex, and stele with vascular tissues distributed in the cortex and stele. The AR primordia originates from the parenchyma cells located on the borderline between the cortex and stele. The vascular tissues in the AR develop and are connected with vascular tissue of the stem before the AR grew out the stem. The number of primary xylem poles in AR is about 30. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Related Products of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Related Products of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A polyhedron-based metal-organic framework with a rare hexanuclear Co(II) cluster for selective sorption and chemical conversion for CO₂ was written by Chen, Di-Ming;Zhang, Xue-Jing. And the article was included in Journal of Solid State Chemistry in 2019.Computed Properties of C9H7N3O2 This article mentions the following:

A new polyhedron-based metal-organic framework (MOF), namely {[Co₆(OH)₂(H₂O)₄(cpt)₉](NO₃)(DMF)₁₃} (1, Hcpt = 4-(4′-carboxyphenyl)-1,2,4-triazole), was constructed by employment of a bifunctional triazolyl-carboxyl ligand Hcpt. Single crystal x-ray structural anal. shows that compound 1 features a rare hexanuclear {Co₆(OH)₂(H₂O)₆}¹⁰⁺ cluster and could be topol. viewed as a 10-connected bct net. Furthermore, compound 1 comprises octahedral cages with the inner diameter of 19.6 × 12.9 Ų and 2D pore systems along the a and b axis with high d. of open metal centers generated by the removal of coordinated water mols., which contribute to a high CO₂ adsorption capacity and significantly selective capture for CO₂ over CH₄ around room temperature In addition, the resulting activated 1a could behave as the heterogeneous Lewis catalyst facilitates the chem. fixation of CO₂ coupling with epoxides into cyclic carbonates under mind conditions. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Computed Properties of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Computed Properties of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

6-(Substituted methylene)penems, potent broad-spectrum inhibitors of bacterial β-lactamase. V. Chiral 1,2,3-triazolyl derivatives was written by Bennett, Isabel S.;Brooks, Gerald;Broom, Nigel J. P.;Calvert, Stephen H.;Coleman, Kenneth;Francois, Irene. And the article was included in Journal of Antibiotics in 1991.SDS of cas: 40594-98-7 This article mentions the following:

A series of (5R)-6-triazolylmethylenepenems I [R = H, Me, Et, Pr, CF₃CH₂, NaO₂CCH₂, Me₂N, MeO, HO, HOCH₂CH₂, HO(CH₂)₃, cyclopropyl] with potent β-lactamase inhibitory activity were prepared and their structure-activity relationships determined In most cases, their in vitro synergistic activity with amoxycillin is superior to that of clavulanic acid, sulbactam and tazobactam. Against an Escherichia coli TEM-1 infection in mice, I showed a broad range of potencies; an optimum polarity was found, however, which gave maximum potency. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7SDS of cas: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.SDS of cas: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Physiological basis for isoxadifen-ethyl induction of nicosulfuron detoxification in maize hybrids was written by Sun, Lanlan;Wu, Renhai;Su, Wangcang;Gao, Zenggui;Lu, Chuantao. And the article was included in PLoS One in 2017.COA of Formula: C6H6N4 This article mentions the following:

Isoxadifen-Et can effectively alleviate nicosulfuron injury in the maize. However, the effects of safener isoxadifen-Et on detoxifying enzymes in maize is unknown. The individual and combined effects of the sulfonylurea herbicide nicosulfuron and the safener isoxadifen- Et on the growth and selected physiol. processes of maize were evaluated. Bioassays showed that the EC50 values of nicosulfuron and nicosulfuron plus isoxadifenethyl for maize cultivar Zhengdan958 were 18.87 and 249.28 mg kg-1, resp., and were 24.8 and 275.51 mg kg-1, resp., for Zhenghuangnuo Number 2 cultivar. Evaluations of the target enzyme of acetolactate synthase showed that the I50 values of nicosulfuron and nicosulfuron plus isoxadifen-Et for the ALS of Zhengdan958 were 15.46 and 28.56 μ mol L-1, resp., and were 0.57 and 2.17 μ mol L-1, resp., for the acetolactate synthase of Zhenghuangnuo Number 2. The safener isoxadifen-Et significantly enhanced tolerance of maize to nicosulfuron. The enhanced tolerance of maize to nicosulfuron in the presence of the safener, coupled with the enhanced injury observed in the presence of piperonyl butoxide, 1-aminobenzotriazole, and malathion, suggested cytochrome P 450 monooxygenases may be involved in metabolism of nicosulfuron. We proposed that isoxadifen- Et increases plant metabolism of nicosulfuron through non-P 450-catalyzed routes or through P 450 monooxygenases not inhibited by piperonyl butoxide, 1-aminobenzotriazole, and malathion. Isoxadifen-Et, at a rate of 33 mg kg-1, completely reversed the effects of all doses (37.5-300 mg kg-1) of nicosulfuron on both of the maize cultivars. When the two compounds were given simultaneously, isoxadifen-Et enhanced activity of glutathione Stransferases (GSTs) and acetolactate synthase activity in maize. The free acid 4,5-dihydro- 5,5-diphenyl-1,2-oxazole-3-carboxylic was equally effective at inducing GSTs as the parent ester and appeared to be the active safener. GST induction in the maize Zhenghuangnuo Number 2 was faster than in Zhengdan 958. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6COA of Formula: C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.COA of Formula: C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A cytochrome P450-independent mechanism of acetaminophen-induced injury in cultured mouse hepatocytes was written by Miyakawa, Kazuhisa;Albee, Ryan;Letzig, Lynda G.;Lehner, Andreas F.;Scott, Michael A.;Buchweitz, John P.;James, Laura P.;Ganey, Patricia E.;Roth, Robert A.. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 2015.Recommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Mouse hepatic parenchymal cells (HPCs) have become the most frequently used in vitro model to study mechanisms of acetaminophen (APAP)-induced hepatotoxicity. It is universally accepted that APAP hepatocellular injury requires bioactivation by cytochromes P 450 (P450s), but this remains unproven in primary mouse HPCs in vitro, especially over the wide range of concentrations that have been employed in published reports. The aim of this work was to test the hypothesis that APAP-induced hepatocellular death in vitro depends solely on P450s. We evaluated APAP cytotoxicity and APAP-protein adducts (a biomarker of metabolic bioactivation by P 450) using primary mouse HPCs in the presence and absence of a broad-spectrum inhibitor of P450s, 1-aminobenzotriazole (1-ABT). 1-ABT abolished formation of APAP-protein adducts at all concentrations of APAP (0-14 mM), but eliminated cytotoxicity only at small concentrations (≤5 mM), indicating the presence of a P 450-independent mechanism at larger APAP concentrations P 450-independent cell death was delayed in onset relative to toxicity observed at smaller concentrations p-Aminophenol was detected in primary mouse HPCs exposed to large concentrations of APAP, and a deacetylase inhibitor [bis (4-nitrophenyl) phosphate (BNPP)] significantly reduced cytotoxicity. In conclusion, APAP hepatocellular injury in vitro occurs by at least two mechanisms, a P 450-dependent mechanism that operates at concentrations of APAP ≤ 5 mM and a P 450-independent mechanism that predominates at larger concentrations and is slower in onset. P-Aminophenol most likely contributes to the latter mechanism. These findings should be considered in interpreting results from APAP cytotoxicity studies in vitro and in selecting APAP concentrations for use in such studies. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1 was written by Kowalski, John P.;McDonald, Matthew G.;Pelletier, Robert D.;Hanenberg, Helmut;Wiek, Constanze;Rettie, Allan E.. And the article was included in Journal of Medicinal Chemistry in 2020.Reference of 1614-12-6 This article mentions the following:

Mammary-tissue-restricted cytochrome P 450 4Z1 (CYP4Z1) has garnered interest for its potential role in breast cancer progression. CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeicosatrienoic acid (14,15-EET), a metabolite known to influence cellular proliferation, migration, and angiogenesis. In this study, we developed time-dependent inhibitors of CYP4Z1 designed as fatty acid mimetics linked to the bioactivatable pharmacophore, 1-aminobenzotriazole (ABT). The most potent analog, 8-[(1H-benzotriazol-1-yl)amino]octanoic acid (7), showed a 60-fold lower shifted-half-maximal inhibitory concentration (IC₅₀) for CYP4Z1 compared to ABT, efficient mechanism-based inactivation of the enzyme evidenced by a K_I = 2.2μM and a k_inact = 0.15 min^-1, and a partition ratio of 14. Furthermore, 7 exhibited low off-target inhibition of other CYP isoenzymes. Finally, low micromolar concentrations of 7 inhibited 14,15-EET production in T47D breast cancer cells transfected with CYP4Z1. This first-generation, selective mechanism-based inhibitor (MBI) will be a useful mol. tool to probe the biochem. role of CYP4Z1 and its association with breast cancer. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Reference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Evaluation of carbazeran 4-oxidation and O6-benzylguanine 8-oxidation as catalytic markers of human aldehyde oxidase: impact of cytosolic contamination of liver microsomes was written by Xie, Jiarong;Saburulla, Nur Fazilah;Chen, Shiyan;Wong, Siew Ying;Yap, Ze Ping;Zhang, Linghua Harris;Lau, Aik Jiang. And the article was included in Drug Metabolism & Disposition in 2019.Reference of 1614-12-6 This article mentions the following:

We investigated contribution of microsomal CYP450, cytosolic AOX-1 to carbazeran 4-oxidation, O6-benzylguanine 8-oxidation in human liver microsomal, cytosolic, S9 fractions. Incubations containing carbazeran and human liver microsomes with or without exogenously added NADPH yielded comparable levels of 4-oxo-carbazeran. O6-Benzylguanine 8-oxidation occurred in microsomal incubations, and extent was increased by NADPH. Human recombinant CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5 did not catalyze carbazeran 4-oxidation, whereas CYP1A2 was active in O6-benzylguanine 8-oxidation 1-1-Aminobenzotriazole, a pan-cytochrome P 450 inhibitor, decreased O6-benzylguanine 8-oxidation, but not carbazeran 4-oxidation, in microsomal incubations, whereas 1-aminobenzotriazole and furafylline did not inhibit carbazeran 4-oxidation or O6-benzylguanine 8-oxidation in human liver S9 fraction. Carbazeran 4-oxidation in incubations containing human liver microsomes was attributed to microsomal preparations contaminated with AOX-1, as suggested by liver microsomal experiments indicating decrease in carbazeran 4-oxidation by an AOX-1 inhibitor (hydralazine), and to detection of AOX-1 protein. Cytosolic contamination of liver microsomes was further demonstrated by formation of dehydroepiandrosterone sulfate in liver microsomal incubations containing dehydroepiandrosterone. Carbazeran 4-oxidation, O6-benzylguanine 8-oxidation are enzyme-selective catalytic markers of AOX-1, as shown in S9 fraction expressing cytochrome P 450 and AOX-1. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Reference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics