Day: February 3, 2023

One-pot microwave-assisted solvent free synthesis of simple alkyl 1,2,3-triazole-4-carboxylates by using trimethylsilyl azide was written by Taherpour, Avat Arman;Kheradmand, Khojasteh. And the article was included in Journal of Heterocyclic Chemistry in 2009.COA of Formula: C5H7N3O2 This article mentions the following:

A fast one-pot microwave-assisted solvent-free synthesis of simple alkyl 1,2,3-triazole-4-carboxylate derivatives I (R¹ = H, CO₂Me; R² = CO₂Me, CO₂Et) by 1,3-dipolar cycloaddition reactions of trimethylsilyl azide (Me₃Si-N₃) with alkyl propiolates or DMAD in high yields is described. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7COA of Formula: C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.COA of Formula: C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Assembly of Two 3D Porous Metal-Organic Frameworks Based on 1,2,3-Triazole-4,5-dicarboxylate Exhibiting Novel Coordination Modes was written by Zhao, Tingting;Jing, Xuemin;Wang, Jing;Wang, Dongmei;Li, Guanghua;Huo, Qisheng;Liu, Yunling. And the article was included in Crystal Growth & Design in 2012.Recommanded Product: 4546-95-6 This article mentions the following:

Two novel metal-organic frameworks (MOFs) |(H₃O)_1.5(H₂O)₃|[Cd₂K_0.5(C₄N₃O₄)₂(H₂O)] (1) and |(H₃O)(H₂O)|[Cu₄(C₄N₃O₄)₃(H₂O)₃] (2) were solvothermally synthesized using 1,2,3-triazole-4,5-dicarboxylic acid (H₃tzdc), which exhibited novel and diverse coordination modes. In compound 1, the ligand, which shows three novel types of coordination modes, is coordinated to cadmium atoms to generate a tetranuclear cluster that leads to a 5-connected bnn network with two distinct channels along the [001] and [010] directions. In compound 2, the ligand, which serves as a T-shaped linker, is coordinated to copper atoms to form a unique metalloporphyrin-like plane, resulting in a pto network without interpenetration. Gas adsorption was studied for compound 1. A diverse blue luminescence response toward different guest mols. by compound 1 was observed In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Oxidation of benzotriazole by potassium dichromate in sulfuric acid was written by Tyupalo, N. F.;Stepanyan, A. A.. And the article was included in Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) in 1980.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

The title reaction with 2.5-3 mol K₂Cr₂O₇/mol benzotriazole gave salt I as the product. The structure of the product was determined by mass spectra. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Thermodynamics of proton ionization from some substituted 1,2,3-triazoles in dilute aqueous solution was written by Hansen, Lee Duane;West, Bruce David;Baca, Ernest J.;Blank, Clarence L.. And the article was included in Journal of the American Chemical Society in 1968.Electric Literature of C4H3N3O4 This article mentions the following:

The ΔH°, ΔS°, and pK values valid at 25° and zero ionic strength are reported for 1,2,3-triazole, 4,5-dibromo-1,2,3-triazole, 1,2,3-triazole-4-carboxylic acid, 1,2,3-triazole-4,5-dicarboxylic acid, benzotriazole, 1-phenyl-1,2,3-triazole-4-carboxylic acid, 1-phenyl-1,2,3-triazole-4,5-dicarboxylic acid, and 1-phenyl-5-methyl-1,2,3-triazole-4-carboxylic acid. Unusual substitution effects on the thermodynamics of proton ionization from the triazole ring are found. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Electric Literature of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Electric Literature of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis and characterization of novel binuclear chromium(III) complexes bridged by aromatic heterocyclic compounds was written by Nakahanada, Manabu;Ino, Kazuhito;Kaizaki, Sumio. And the article was included in Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) in 1993.SDS of cas: 4546-95-6 This article mentions the following:

Two novel types of binuclear bis(acetylacetonato)chromium(III) complexes bridged by imidazole-4,5-dicarboxylate, 1,2,3-triazole-4,5-dicarboxylate and pyrazole-3,5-dicarboxylate and a binuclear complex bridged by both pyrazolate and hydroxide ligands were prepared and characterized by elemental anal. and pos.-ion fast atom bombardment mass spectrometry. Their spectroscopic and magnetic properties were examined by luminescence, ²H NMR and magnetic susceptibility measurements. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6SDS of cas: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeSDS of cas: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats was written by Kushida, Hirotaka;Matsumoto, Takashi;Ikarashi, Yasushi;Nishimura, Hiroaki;Yamamoto, Masahiro. And the article was included in Journal of Ethnopharmacology in 2021.Synthetic Route of C6H6N4 This article mentions the following:

Geissoschizine Me ether (GM), an indole alkaloid from Uncaria hook, is an active ingredient in the traditional Japanese Kampo medicine yokukansan, which is used to treat neurosis, insomnia, irritability, and night crying in children. Recent our pharmacokinetic studies suggested that there may be gender differences in the plasma concentrations of GM in rats, but not in humans. However, the details of this difference remain unverified. The purpose of this study was to clarify the reasons for the gender differences in rats. GM plasma pharmacokinetics was compared in male and female rats orally administered yokukansan (4 g/kg). To confirm the involvement of cytochrome P 450 (CYP) in GM liver metabolism, GM was incubated with male and female rat liver S9 fraction in the absence or presence of 1-aminobenzotriazole (a nonspecific CYP inhibitor). CYP isoforms involved in GM metabolism were estimated using recombinant rat CYP isoforms and anti-rat CYP antibodies. The maximum GM plasma concentrations were significantly higher in female than in male rats. When GM was incubated with rat liver S9 fractions, GM reduction was more striking in male S9 (69.3%) than that in female S9 (10.0%) and was completely blocked with nonspecific CYP inhibitor 1-aminobenzotriazole. Screening experiments using recombinant rat cytochrome P 450 (CYP) isoforms showed that CYP1A1, CYP2C6, CYP2C11, CYP2D1, and CYP3A2 were involved in GM metabolism Of these CYP isoforms, the use of anti-rat CYP antibodies indicated that male-dependent CYP2C11 and CYP3A2 were predominantly involved in the liver microsomal GM metabolism with gender differences. These results suggest that the cause of gender differences in plasma GM pharmacokinetics in rats is most likely because of male-dependent CYP2C11 and CYP3A2, and provide also useful information to further evaluate the pharmacol. and toxicol. effects in future. This study is the first to demonstrate that the gender differences in plasma GM pharmacokinetics in rats are caused by the gender-dependent metabolism of GM. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Synthetic Route of C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reactive intermediates. XXII. Formation of 2H-azirines by oxidation of N-aminophthalimide in the presence of alkynes was written by Anderson, David J.;Gilchrist, Thomas L.;Gymer, Geoffrey E.;Rees, Charles W.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1973.Related Products of 4546-95-6 This article mentions the following:

Pb(OAc)4 oxidation of N-aminophthalimide in the presence of HCCMe gave 1% 3-methyl-2-phthalimido-2H-azirine (I); HCCPr, MeCCMe, and EtCCEt formed 5-15% of analogous azirines. 1,2,3-Triazole-4,5-dicarboxylic acid with Ac2O gave 2-methyloxazole-4-carboxylic acid. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Related Products of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Related Products of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist was written by Stringer, Rowan A.;Weber, Eckhard;Culshaw, Andrew;McKenna, Jeff;Williams, Gareth;Rose, Jonathan;Sohal, Bindi. And the article was included in Xenobiotica in 2014.Recommanded Product: 1614-12-6 This article mentions the following:

1. The pharmacokinetic properties and metabolism of NVS-CRF38 [7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole], a novel corticotropin-releasing factor receptor 1 (CRF₁) antagonist, were determined in vitro and in animals. 2. NVS-CRF38 undergoes near complete absorption in rats and dogs. In both species the compound has low hepatic extraction and is extensively distributed to tissues. 3. In rat and human hepatic microsomes and cryopreserved hepatocytes from rat, dog, monkey and human, NVS-CRF38 was metabolized to form O-desmethyl NVS-CRF38 (M7) and several oxygen adducts (M1, M3, M4, M5 and M6). In hepatocytes further metabolites were observed, specifically the carboxylic acid (M2) and conjugates (sulfate and glucuronide) of M7. 4. Formation of primary metabolites in hepatocytes was blocked by the cytochrome P 450 enzyme (P 450) suicide inhibitor 1-aminobenzotriazole, implicating P 450 enzymes in the primary metabolism of this compound 5. NVS-CRF38 is weakly bound to plasma proteins from rat (fu_b = 0.19), dog (fu_b = 0.25), monkey (fu_b = 0.20) and humans (fu_b = 0.23). Blood-to-plasma partition for NVS-CRF38 approaches unity in rat and human blood. 6. The hepatic clearance of NVS-CRF38 in humans is predicted to be low (extraction ratio ∼ 0.2) based on scaling from drug depletion profiles in hepatic microsomes. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Recommanded Product: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tunable Robust pacs-MOFs: a Platform for Systematic Enhancement of the C₂H₂ Uptake and C₂H₂/C₂H₄ Separation Performance was written by Chen, Di-Ming;Sun, Chun-Xiao;Zhang, Nan-Nan;Si, Huan-Huan;Liu, Chun-Sen;Du, Miao. And the article was included in Inorganic Chemistry in 2018.Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid This article mentions the following:

As a modulatable class of porous crystalline materials, metal-organic frameworks (MOFs) have gained intensive research attention in the domain of gas storage and separation In this study, we report on the synthesis and gas adsorption properties of two robust MOFs with the general formula [Co₃(μ₃-OH)(cpt)₃Co₃(μ₃-OH)(L)₃(H₂O)₉](NO₃)₄(guests)_n [L = 3-amino-1,2,4-triazole (1) and 3,5-diamino-1,2,4-triazole (2); Hcpt = 4-(4-carboxyphenyl)-1,2,4-triazole], which show the same pacs topol. Both MOFs are isostructural to each other and show MIL-88-type frameworks whose pore spaces are partitioned by different functionlized trinuclear 1,2,4-triazolate-based clusters. The similar framework components with different amounts of functional groups make them an ideal platform to permit a systematic gas sorption/separation study to evaluate the effects of distinctive parameters on the C₂H₂ uptake and separation performance. Because of the presence of addnl. amido groups, the MOF 2 equipped with a datz-based cluster (Hdatz = 3,5-diamino-1,2,4-triazole) shows a much improved C₂H₂ uptake capacity and separation performance over that of the MOF 1 equipped with atz-based clusters (Hatz = 3-amino-1,2,4-triazole), although the surface area of the MOF 1 is almost twice than that of the MOF 2. Moreover, the high d. of open metal sites, abundant free amido groups, and charged framework give the MOF 2 an excellent C₂H₂ separation performance, with ideal adsorbed solution theory selectivity values reaching up to 11.5 and 13 for C₂H₂/C₂H₄ (1:99) and C₂H₂/CO₂ (50:50) at 298 K and 1 bar, showing potential for use in natural gas purification In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of osmotic pumps for sustained release of 1-aminobenzotriazole and inhibition of cytochrome P450 enzymes in mice: model comparison with the hepatic P450 reductase null mouse was written by Stringer, Rowan A.;Ferreira, Suzie;Rose, Jonathan;Ronseaux, Sebastien. And the article was included in Drug Metabolism & Disposition in 2016.Recommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

The effectiveness of controlled release 1-aminobenzotriazole (ABT) administration to inhibit cytochrome P 450 (P 450) enzymes has been evaluated in mice. To maximize the duration of P 450 inhibition in vivo, ABT was administered via an osmotic pump. The degree of P 450 inhibition was compared with that achieved with a single bolus dose of ABT. Two-hour prior s.c. treatment of mice with ABT (50 mg/kg) inhibited antipyrine clearance by 88%. A less pronounced inhibitory effect (29% reduction in clearance) was observed when ABT was administered 24-h before antipyrine administration, indicating partial restoration of P 450 activity during this longer pretreatment time. The duration of ABT in mice was very short (mean residence time = 1.7 h) after s.c. bolus administration. When the inhibitor was delivered by an osmotic pump, maximum blood concentrations of the inhibitor were observed 24 h after device implantation and were maintained at steady state for 6 days. Inhibition of P 450 activity, as measured by antipyrine clearance, was confirmed at 24 h and 120 h after pump implantation, highlighting the utility of this method as a longer term model for P 450 inhibition in mice. The magnitude of P 450 inhibition in ABT-treated mice was compared with that in hepatic P 450 reductase null mice and both models were comparable. In vivo ABT administration by an osmotic pump offers an effective approach for longer-term P 450 inhibition in mice and avoids the necessity for multiple dosing of the inhibitor. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Recommanded Product: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics