Related Products of 103755-58-4, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
General procedure: In a two neck flask of 50 mL under nitrogen atmosphere was added KOH (0.64 g, 5 mmol) and tosyl chloride (0.45 g, 2.2 mmol) dissolved in THF (8 mL). The suspension was cooled to 0 C and the required triazole (2 mmol) was added in one portion. The mixture was stirred for 2 h at room temperature. In the end of reaction the aqueous phase was washed with ethyl acetate, the organic phase obtained was dried with MgSO4, filtered and the solvent evaporated under vacuum. The crude product was purified by column chromatography using as eluent a mixture of hexane/ethyl acetate (7/3). (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl-4-methylbenzenesulfonate (4c): The product was obtained as a white solid in 90% yield:
I am very proud of our efforts over the past few months and hope to (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol help many people in the next few years.
Reference:
Article; Stefani, Helio A.; Canduzini, Hugo A.; Manarin, Flavia; Tetrahedron Letters; vol. 52; 46; (2011); p. 6086 – 6090;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics